{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:20:26Z","timestamp":1786980026798,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005713","name":"Technische Universit\u00e4t M\u00fcnchen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005713","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the feasibility of using a 365\u00a0\u03bcm fiber for Thulium Fiber Laser Enucleation of the Prostate (ThuFLEP) in terms of settings, baseline characteristics, patient\u2019s peri-operative outcomes and surgeon\u2019s feelings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective single-center analysis of benign prostatic hyperplasia (BPH) patients that underwent ThuFLEP using a 365\u00a0\u03bcm fiber over an observation period of 14 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analysis included 123 patients with mean age 72.4 years old (\u00b1\u20098.9) and average prostate size 94.8\u00a0cc (\u00b1\u200951.1); 34.1% of patients were undergoing antiplatelet or anticoagulant treatment before surgical intervention, and 50% maintained their antithrombotic during surgery. All had en-bloc enucleation of the prostate, with mean operation time of 115\u00a0min (\u00b1\u200941) and average resected tissue of 67.9\u00a0g (\u00b1\u200943). After the procedure, average catheterization time and hospital length of stay were 3 (\u00b1\u20090.9) and 3.6 days (\u00b1\u20091.4), respectively. Early post-operative complications occurred in 23 patients (18.7%). Twenty patients (16.3%) were readmitted to the hospital for check-up (6.5%) or emergency (9.8%), mainly due to catheter removal or macrohematuria respectively. Re-admission rate after one month was 4.9% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096), mainly due to macrohematuria. The surgeon described a very precise and more focused laser beam compared to the 550\u00a0\u03bcm fiber with excellent instant coagulation during the enucleation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ThuFLEP using a 365\u00a0\u03bcm fiber allowed safe and effective enucleation of the prostate regardless of prostate size. While over a third of patients were under antithrombotic\/anticoagulant treatment, half underwent surgery on continued medication without a significant increase of risks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00345-025-05854-4","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T13:14:05Z","timestamp":1755090845000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety in enucleation of the prostate with thulium fiber laser (TFL) using a 365\u00a0\u03bcm fiber: a retrospective study in a real-world, risk-diverse population"],"prefix":"10.1007","volume":"43","author":[{"given":"Thomas","family":"Amiel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricarda","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Straub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"issue":"6","key":"5854_CR1","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.eururo.2006.03.028","volume":"49","author":"RM Kuntz","year":"2006","unstructured":"Kuntz RM (2006) Current role of lasers in the treatment of benign prostatic hyperplasia (BPH). Eur Urol 49(6):961\u2013969. https:\/\/doi.org\/10.1016\/j.eururo.2006.03.028","journal-title":"Eur Urol"},{"issue":"2","key":"5854_CR2","doi-asserted-by":"publisher","first-page":"180","DOI":"10.4081\/aiua.2022.2.180","volume":"94","author":"H Elmansy","year":"2022","unstructured":"Elmansy H, Hodhod A, Elshafei A, Noureldin YA, Mehrnoush V, Zakaria AS, Hadi RA, Fathy M, Abbas L, Kotb A et al (2022) Comparative analysis of MOSES(TM) technology versus novel thulium fiber laser (TFL) for transurethral enucleation of the prostate: A single-institutional study. Arch Ital Urol Androl 94(2):180\u2013185. https:\/\/doi.org\/10.4081\/aiua.2022.2.180","journal-title":"Arch Ital Urol Androl"},{"issue":"12","key":"5854_CR3","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1111\/iju.14115","volume":"26","author":"D Enikeev","year":"2019","unstructured":"Enikeev D, Netsch C, Rapoport L, Gazimiev M, Laukhtina E, Snurnitsyna O, Alekseeva T, Becker B, Taratkin M, Glybochko P (2019) Novel thulium fiber laser for endoscopic enucleation of the prostate: A prospective comparison with conventional transurethral resection of the prostate. Int J Urol 26(12):1138\u20131143. https:\/\/doi.org\/10.1111\/iju.14115","journal-title":"Int J Urol"},{"key":"5854_CR4","doi-asserted-by":"publisher","unstructured":"Fried, N. M., & Murray, K. E. (2005). High-power thulium fiber laser ablation of urinary tissues at 1.94 microm. Journal of endourology, 19(1), 25\u201331. https:\/\/doi.org\/10.1089\/end.2005.19.25","DOI":"10.1089\/end.2005.19.25"},{"issue":"4","key":"5854_CR5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s11934-024-01197-6","volume":"25","author":"DC Dalton","year":"2024","unstructured":"Dalton DC, Shelton TM, Rivera M (2024) Laser technology advancements in the treatment of benign prostatic hypertrophy. Curr Urol Rep 25(4):71\u201378. https:\/\/doi.org\/10.1007\/s11934-024-01197-6","journal-title":"Curr Urol Rep"},{"issue":"11","key":"5854_CR6","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1007\/s00345-023-04565-y","volume":"41","author":"G Ortner","year":"2023","unstructured":"Ortner G, Guven S, Somani BK, Nicklas A, Scoffone CM, Gracco C, Goumas IK, Bach T, Sancha FG, Figueredo FCA et al (2023) Experts\u2019 recommendations in laser use for the endoscopic treatment of prostate hypertrophy: a comprehensive guide by the European section of Uro-Technology (ESUT) and Training-Research in urological surgery and technology (T.R.U.S.T.)-Group. World J Urol 41(11):3277\u20133285. https:\/\/doi.org\/10.1007\/s00345-023-04565-y","journal-title":"World J Urol"},{"issue":"1","key":"5854_CR7","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s00345-022-04201-1","volume":"41","author":"G Bozzini","year":"2023","unstructured":"Bozzini G, Berti L, Maltagliati M, Besana U, Micali S, Roche JB, Romero-Otero J, Pacchetti A, Perri D, Morini E et al (2023) Thulium: YAG vs continuous-wave thulium fiber laser enucleation of the prostate: do potential advantages of thulium fiber lasers translate into relevant clinical differences? World J Urol 41(1):143\u2013150. https:\/\/doi.org\/10.1007\/s00345-022-04201-1","journal-title":"World J Urol"},{"key":"5854_CR8","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.urology.2023.05.013","volume":"178","author":"D Perri","year":"2023","unstructured":"Perri D, Mazzoleni F, Besana U, Pacchetti A, Morini E, Berti L, Calandriello M, Pastore AL, Romero-Otero J, Bruyere F et al (2023) Pulsed-wave vs Continuous-wave thulium fiber laser enucleation of the prostate (ThuFLEP): A comparison of perioperative outcomes. Urology 178:120\u2013124. https:\/\/doi.org\/10.1016\/j.urology.2023.05.013","journal-title":"Urology"},{"issue":"11","key":"5854_CR9","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.1007\/s00345-023-04524-7","volume":"41","author":"D Castellani","year":"2023","unstructured":"Castellani D, Di Rosa M, Gomez Sancha F, Rodriguez Socarras M, Mahajan A, Taif Bendigeri M, Taratkin M, Enikeev D, Dellabella M, Gadzhiev N et al (2023) Holmium laser with MOSES technology (MoLEP) vs thulium fiber laser enucleation of the prostate (ThuFLEP) in a real-world setting. Mid-term outcomes from a multicenter propensity score analysis. World J Urol 41(11):2915\u20132923. https:\/\/doi.org\/10.1007\/s00345-023-04524-7","journal-title":"World J Urol"},{"issue":"1","key":"5854_CR10","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12894-018-0400-1","volume":"18","author":"D Enikeev","year":"2018","unstructured":"Enikeev D, Glybochko P, Rapoport L, Okhunov Z, O\u2019Leary M, Potoldykova N, Sukhanov R, Enikeev M, Laukhtina E, Taratkin M (2018) Impact of endoscopic enucleation of the prostate with thulium fiber laser on the erectile function. BMC Urol 18(1):87. https:\/\/doi.org\/10.1186\/s12894-018-0400-1","journal-title":"BMC Urol"},{"issue":"12","key":"5854_CR11","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1007\/s11255-018-2007-6","volume":"50","author":"D Enikeev","year":"2018","unstructured":"Enikeev D, Glybochko P, Rapoport L, Snurnitsyna O, Potoldykova N, Novoselova T, Laukhtina E, Taratkin M, Margulis V (2018) Need for upper urinary tract stenting in cases of ureteral orifice injury during laser enucleation of the prostate. Int Urol Nephrol 50(12):2173\u20132177. https:\/\/doi.org\/10.1007\/s11255-018-2007-6","journal-title":"Int Urol Nephrol"},{"issue":"1","key":"5854_CR12","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00345-023-04748-7","volume":"42","author":"M Kosiba","year":"2024","unstructured":"Kosiba M, Filzmayer M, Welte MN, Hugenell L, Keller AC, Traumann MI, Muller MJ, Kluth LA, Mandel PC, Chun FK et al (2024) Thulium fiber laser vs. holmium laser enucleation of the prostate: results of a prospective randomized non-inferiority trial. World J Urol 42(1):49. https:\/\/doi.org\/10.1007\/s00345-023-04748-7","journal-title":"World J Urol"},{"issue":"4","key":"5854_CR13","doi-asserted-by":"publisher","first-page":"181","DOI":"10.4103\/uros.Uros_92_22","volume":"34","author":"AD Mahajan","year":"2023","unstructured":"Mahajan AD, Mahajan SA (2023) A comparative study of the efficacy of thulium fiber laser enucleation and transurethral resection for Medium- to Large-Size prostate. Urol Sci 34(4):181\u2013186. https:\/\/doi.org\/10.4103\/uros.Uros_92_22","journal-title":"Urol Sci"},{"issue":"9","key":"5854_CR14","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1089\/end.2022.0029","volume":"36","author":"V Petov","year":"2022","unstructured":"Petov V, Babaevskaya D, Taratkin M, Chuvalov L, Lusuardi L, Misrai V, Sukhanov R, Scoffone CM, Enikeev D (2022) Thulium fiber laser enucleation of the prostate: prospective study of Mid- and Long-Term outcomes in 1328 patients. J Endourol 36(9):1231\u20131236. https:\/\/doi.org\/10.1089\/end.2022.0029","journal-title":"J Endourol"},{"issue":"3","key":"5854_CR15","doi-asserted-by":"publisher","first-page":"102867","DOI":"10.1016\/j.fjurol.2025.102867","volume":"35","author":"S Serezo","year":"2025","unstructured":"Serezo S, Lenfant L, Chartier-Kastler E, Beaugerie A, Mozer P, Dubourg Q, Felber M, Parra J, Seisen T, Roupret M et al (2025) Initial experience of endoscopic thulium fiber laser enucleation of the prostate: perioperative outcomes and learning curve. Fr J Urol 35(3):102867. https:\/\/doi.org\/10.1016\/j.fjurol.2025.102867","journal-title":"Fr J Urol"},{"key":"5854_CR16","doi-asserted-by":"publisher","unstructured":"Yilmaz M, Karaaslan M, Aybal HC, Ferry von Bargen M, Tonyali S, Toprak T, Gratzke C, Miernik A (2022) Laser enucleation of the prostate in men with very large glands >\/=175\u00a0ml: A systematic review. Ann Med Surg (Lond) 80104279. https:\/\/doi.org\/10.1016\/j.amsu.2022.104279","DOI":"10.1016\/j.amsu.2022.104279"},{"issue":"1","key":"5854_CR17","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00345-025-05478-8","volume":"43","author":"HC Aybal","year":"2025","unstructured":"Aybal HC, Yilmaz M, Barlas IS, Duvarci M, Guven S, Tunc L (2025) HoLEP versus thuflep in men with very large prostates (>\u2009175\u00a0ml). World J Urol 43(1):109. https:\/\/doi.org\/10.1007\/s00345-025-05478-8","journal-title":"World J Urol"},{"issue":"3","key":"5854_CR18","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1089\/end.2018.0693","volume":"33","author":"B Becker","year":"2019","unstructured":"Becker B, Netsch C, Hansen J, Bohme A, Gross AJ, Zacharias M, Lehrich K (2019) Perioperative safety in patient under oral anticoagulation during holmium laser enucleation of the prostate. J Endourol 33(3):219\u2013224. https:\/\/doi.org\/10.1089\/end.2018.0693","journal-title":"J Endourol"},{"issue":"4","key":"5854_CR19","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1159\/000336874","volume":"88","author":"S Hauser","year":"2012","unstructured":"Hauser S, Rogenhofer S, Ellinger J, Strunk T, Muller SC, Fechner G (2012) Thulium laser (Revolix) vapoenucleation of the prostate is a safe procedure in patients with an increased risk of hemorrhage. Urol Int 88(4):390\u2013394. https:\/\/doi.org\/10.1159\/000336874","journal-title":"Urol Int"},{"key":"5854_CR20","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.urology.2020.01.008","volume":"138","author":"J Zhang","year":"2020","unstructured":"Zhang J, Li J, Wang X, Shi C, Tu M, Shi G (2020) Efficacy and safety of 1470-nm diode laser enucleation of the prostate in individuals with benign prostatic hyperplasia continuously administered oral anticoagulants or antiplatelet drugs. Urology 138:129\u2013133. https:\/\/doi.org\/10.1016\/j.urology.2020.01.008","journal-title":"Urology"},{"key":"5854_CR21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.urology.2018.06.045","volume":"121","author":"D Enikeev","year":"2018","unstructured":"Enikeev D, Glybochko P, Rapoport L, Gahan J, Gazimiev M, Spivak L, Enikeev M, Taratkin M (2018) A randomized trial comparing the learning curve of 3 endoscopic enucleation techniques (HoLEP, thuflep, and MEP) for BPH using mentoring Approach-Initial results. Urology 121:51\u201357. https:\/\/doi.org\/10.1016\/j.urology.2018.06.045","journal-title":"Urology"},{"issue":"1","key":"5854_CR22","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1089\/end.2018.0791","volume":"33","author":"D Enikeev","year":"2019","unstructured":"Enikeev D, Okhunov Z, Rapoport L, Taratkin M, Enikeev M, Snurnitsyna O, Capretz T, Inoyatov J, Glybochko P (2019) Novel thulium fiber laser for enucleation of prostate: A retrospective comparison with open simple prostatectomy. J Endourol 33(1):16\u201321. https:\/\/doi.org\/10.1089\/end.2018.0791","journal-title":"J Endourol"},{"issue":"2","key":"5854_CR23","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1089\/end.2019.0630","volume":"34","author":"A Morozov","year":"2020","unstructured":"Morozov A, Taratkin M, Kozlov V, Tarasov A, Bezrukov E, Enikeev M, Afyouni AS, Okhunov Z, Glybochko P, Enikeev D (2020) Retrospective assessment of endoscopic enucleation of prostate complications: A Single-Center experience of more than 1400 patients. J Endourol 34(2):192\u2013197. https:\/\/doi.org\/10.1089\/end.2019.0630","journal-title":"J Endourol"},{"issue":"7","key":"5854_CR24","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.jcin.2021.01.040","volume":"14","author":"P Capranzano","year":"2021","unstructured":"Capranzano P, Angiolillo DJ (2021) Antithrombotic management of elderly patients with coronary artery disease. JACC Cardiovasc Interv 14(7):723\u2013738. https:\/\/doi.org\/10.1016\/j.jcin.2021.01.040","journal-title":"JACC Cardiovasc Interv"},{"key":"5854_CR25","unstructured":"Beauregard KM, Carper K (2009) Outpatient prescription anticoagulants utilization and expenditures for the U.S. Civilian noninstitutionalized population age 18 and older, 2007. In., vol. Statistical brief #268. Agency for Healthcare Research and Quality, Rockville, MD. http:\/\/www.meps.ahrq.gov\/mepsweb\/data_files\/publications\/st268\/stat268.pdf"},{"key":"5854_CR26","unstructured":"Liang Xiongfa WW, Huang Y, Shike Z, Jian H, Tao Z, Fangling Z, Xiaolu LYD, Chao C, Tuo G, Wu Wenqi (2021) Safety of Surgery in Benign Prostatic Hyperplasia Patients on Antiplatelet or Anticoagulant Therapy. A Systematic Review and Meta-Analysis. Urology Journal, Volume 18(2):9"},{"issue":"3","key":"5854_CR27","doi-asserted-by":"publisher","first-page":"193","DOI":"10.5173\/ceju.2023.50","volume":"76","author":"S Morsy","year":"2023","unstructured":"Morsy S, Kamal I, Meshref A, Abdel-Mohsen M, Abdel-Hakim M, Yehia A (2023) Surgical outcomes of low-power thulium laser enucleation of prostates\u2009>\u200980\u00a0g. One-year of follow-up. Cent Eur J Urol 76(3):193\u2013198. https:\/\/doi.org\/10.5173\/ceju.2023.50","journal-title":"Cent Eur J Urol"},{"key":"5854_CR28","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.urology.2023.11.014","volume":"183","author":"A Sakai","year":"2024","unstructured":"Sakai A, Borza T, Antar A, Richmond E, Allen GO, Knoedler M, Manakas C, Huang W, Gralnek D, Grimes MD (2024) Incidental prostate cancer diagnosis is common after holmium laser enucleation of the prostate. Urology 183:170\u2013175. https:\/\/doi.org\/10.1016\/j.urology.2023.11.014","journal-title":"Urology"},{"issue":"1","key":"5854_CR29","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ajur.2022.05.008","volume":"11","author":"M Marchioni","year":"2024","unstructured":"Marchioni M, Primiceri G, Veccia A, Di Nicola M, Carbonara U, Crocerossa F, Falagario U, Rizzoli A, Autorino R, Schips L (2024) Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality rates. Asian J Urol 11(1):48\u201354. https:\/\/doi.org\/10.1016\/j.ajur.2022.05.008","journal-title":"Asian J Urol"},{"issue":"3","key":"5854_CR30","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1089\/end.2013.0432","volume":"28","author":"A Becker","year":"2014","unstructured":"Becker A, Placke A, Kluth L, Schwarz R, Isbarn H, Chun F, Heuer R, Schlomm T, Seiler D, Engel O et al (2014) Holmium laser enucleation of the prostate is safe in patients with prostate cancer and lower urinary tract symptoms\u2013a retrospective feasibility study. J Endourol 28(3):335\u2013341. https:\/\/doi.org\/10.1089\/end.2013.0432","journal-title":"J Endourol"}],"container-title":["World Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-025-05854-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00345-025-05854-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-025-05854-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:03:33Z","timestamp":1767996213000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00345-025-05854-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5854"],"URL":"https:\/\/doi.org\/10.1007\/s00345-025-05854-4","relation":{},"ISSN":["1433-8726"],"issn-type":[{"value":"1433-8726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,13]]},"assertion":[{"value":"15 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors Michael Straub and Thomas Amiel are consultats for Coloplast A\/S. Thomas Amiel reports having received financial compensation for consulting expertise from Coloplast A\/S.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by our local ethical committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"491"}}