{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:15:38Z","timestamp":1776107738905,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"DOI":"10.1007\/s00345-025-05985-8","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T09:29:36Z","timestamp":1759570176000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thulium fiber laser enucleation of the prostate (ThuFLEP) for the treatment of benign prostatic obstruction: a comparative study of men with prostate volumes\u2009\u2265\u2009150 mL and &lt;\u2009150 mL"],"prefix":"10.1007","volume":"43","author":[{"given":"Mehmet","family":"Yilmaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil Cagri","family":"Aybal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan Safak","family":"Barlas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Duvarci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Akdagcik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcuk","family":"Guven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutfi","family":"Tunc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"5985_CR1","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.eururo.2014.12.038","volume":"67","author":"C Gratzke","year":"2015","unstructured":"Gratzke C, Bachmann A, Descazeaud A, Drake MJ, Madersbacher S, Mamoulakis C, Oelke M, Tikkinen KAO, Gravas S (2015) EAU guidelines on the assessment of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. Eur Urol 67:1099\u20131109. https:\/\/doi.org\/10.1016\/j.eururo.2014.12.038","journal-title":"Eur Urol"},{"key":"5985_CR2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1159\/000019535","volume":"33","author":"MR Fraundorfer","year":"1998","unstructured":"Fraundorfer MR, Gilling PJ (1998) Holmium:YAG laser enucleation of the prostate combined with mechanical morcellation: preliminary results. Eur Urol 33:69\u201372. https:\/\/doi.org\/10.1159\/000019535","journal-title":"Eur Urol"},{"key":"5985_CR3","doi-asserted-by":"publisher","first-page":"169","DOI":"10.5301\/uj.5000232","volume":"84","author":"PV Glybochko","year":"2017","unstructured":"Glybochko PV, Rapoport LM, Enikeev ME, Enikeev DV (2017) Holmium laser enucleation of the prostate (HoLEP) for small, large and giant prostatic hyperplasia: tips and tricks. Urologia 84:169\u2013173. https:\/\/doi.org\/10.5301\/uj.5000232","journal-title":"Urologia"},{"key":"5985_CR4","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1016\/j.juro.2008.08.019","volume":"180","author":"MR Humphreys","year":"2008","unstructured":"Humphreys MR, Miller NL, Handa SE, Terry C, Munch LC, Lingeman JE (2008) Holmium laser enucleation of the prostate\u2013outcomes independent of prostate size? J Urol 180:2431\u20132435. https:\/\/doi.org\/10.1016\/j.juro.2008.08.019","journal-title":"J Urol"},{"key":"5985_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/and.14125","volume":"53","author":"E Kaya","year":"2021","unstructured":"Kaya E, Y\u0131lmaz S, A\u00e7\u0131kg\u00f6z O, Aybal HC, Y\u0131lmaz M, Gazel E, Yalc\u0131n S, Suarez-Ibarrola R, Tunc L (2021) Laser enucleation for prostates larger than 100 mL: comparison of HoLEP and ThuLEP. Andrologia 53:e14125. https:\/\/doi.org\/10.1111\/and.14125","journal-title":"Andrologia"},{"key":"5985_CR6","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1089\/end.2009.0147","volume":"24","author":"AE Krambeck","year":"2010","unstructured":"Krambeck AE, Handa SE, Lingeman JE (2010) Holmium laser enucleation of the prostate for prostates larger than 175 grams. J Endourol 24:433\u2013437. https:\/\/doi.org\/10.1089\/end.2009.0147","journal-title":"J Endourol"},{"key":"5985_CR7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00345-020-03156-5","volume":"39","author":"MA Zell","year":"2021","unstructured":"Zell MA, Abdul-Muhsin H, Navaratnam A, Cumsky J, Girardo M, Cornella J, Nevo A, Cheney S, Humphreys MR (2021) Holmium laser enucleation of the prostate for very large benign prostatic hyperplasia (>\/= 200 cc). World J Urol 39:129\u2013134. https:\/\/doi.org\/10.1007\/s00345-020-03156-5","journal-title":"World J Urol"},{"key":"5985_CR8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/lsm.20126","volume":"36","author":"NM Fried","year":"2005","unstructured":"Fried NM (2005) High-power laser vaporization of the canine prostate using a 110\u00a0W thulium fiber laser at 1.91 microm. Lasers Surg Med 36:52\u201356. https:\/\/doi.org\/10.1002\/lsm.20126","journal-title":"Lasers Surg Med"},{"key":"5985_CR9","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.euros.2024.03.004","volume":"63","author":"D Castellani","year":"2024","unstructured":"Castellani D, Enikeev D, Gokce MI, Petov V, Gadzhiev N, Mahajan A, Maheshwari PN, Fong KY, Tursunkulov AN, Malkhasyan V, Zawadzki M, Sofer M, Cormio L, Busetto GM, Somani BK, Herrmann TRW, Gauhar V (2024) Influence of prostate volume on the incidence of complications and urinary incontinence following thulium fiber laser enucleation of the prostate: results from multicenter, real-world experience of 2732 patients. Eur Urol Open Sci 63:38\u201343. https:\/\/doi.org\/10.1016\/j.euros.2024.03.004","journal-title":"Eur Urol Open Sci"},{"key":"5985_CR10","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.euf.2024.06.005","volume":"10","author":"A Uleri","year":"2024","unstructured":"Uleri A, Long Depaquit T, Farr\u00e9 A, Cornu JN, Schwartzmann I, Castellani D, Gauhar V, Misrai V, Diana P, Saita A, Doizi S, Rajwa P, Herrmann TRW, Baboudjian M (2024) Thulium fiber versus Holmium:Yttrium-aluminum-garnet laser for endoscopic enucleation of the prostate: a systematic review and meta-analysis. Eur Urol Focus 10:914\u2013921. https:\/\/doi.org\/10.1016\/j.euf.2024.06.005","journal-title":"Eur Urol Focus"},{"key":"5985_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-023-04748-7","volume":"42","author":"M Kosiba","year":"2024","unstructured":"Kosiba M, Filzmayer M, Welte MN, H\u00fcgenell L, Keller AC, Traumann MI, M\u00fcller MJ, Kluth LA, Mandel PC, Chun FK, Becker A (2024) Thulium fiber laser vs. holmium laser enucleation of the prostate: results of a prospective randomized non-inferiority trial. World J Urol 42:49. https:\/\/doi.org\/10.1007\/s00345-023-04748-7","journal-title":"World J Urol"},{"key":"5985_CR12","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1007\/s00345-022-04046-8","volume":"40","author":"D Enikeev","year":"2022","unstructured":"Enikeev D, Taratkin M, Babaevskaya D, Morozov A, Petov V, Sukhanov R, Shpot E, Misrai V, Chinenov D, Enikeev M, Herrmann T (2022) Randomized prospective trial of the severity of irritative symptoms after HOLEP vs THUFLEP. World J Urol 40:2047\u20132053. https:\/\/doi.org\/10.1007\/s00345-022-04046-8","journal-title":"World J Urol"},{"key":"5985_CR13","doi-asserted-by":"publisher","first-page":"S398","DOI":"10.21037\/tau.2019.08.01","volume":"8","author":"P Kronenberg","year":"2019","unstructured":"Kronenberg P, Traxer O (2019) The laser of the future: reality and expectations about the new thulium fiber laser-a systematic review. Transl Androl Urol 8:S398\u2013s417. https:\/\/doi.org\/10.21037\/tau.2019.08.01","journal-title":"Transl Androl Urol"},{"key":"5985_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-025-01851-2","volume":"25","author":"K Zhang","year":"2025","unstructured":"Zhang K, Yang K, Zuo C, He Y, Li Z, Che X, Meng Y (2025) Double rings En-bloc technique with early anatomical apical release in thuflep for the patients with large glands (\u2265 80 mL): the outcomes from single center. BMC Urol 25:159. https:\/\/doi.org\/10.1186\/s12894-025-01851-2","journal-title":"BMC Urol"},{"key":"5985_CR15","doi-asserted-by":"publisher","first-page":"711","DOI":"10.19723\/j.issn.1671-167X.2025.04.013","volume":"57","author":"C Zuo","year":"2025","unstructured":"Zuo C, Wang G, Yang K, Che X, Meng Y, Zhang K (2025) [Comparison of efficacy and safety of transurethral thulium fiber laser enucleation of prostate in patients with different prostate volumes]. Beijing Da Xue Xue Bao Yi Xue Ban 57:711\u2013716. https:\/\/doi.org\/10.19723\/j.issn.1671-167X.2025.04.013","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"5985_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00192-022-05397-x","volume":"34","author":"SK Doumouchtsis","year":"2023","unstructured":"Doumouchtsis SK, de Tayrac R, Lee J, Daly O, Melendez-Munoz J, Lindo FM, Cross A, White A, Cichowski S, Falconi G, Haylen B (2023) An international continence society (ICS)\/ international urogynecological association (IUGA) joint report on the terminology for the assessment and management of obstetric pelvic floor disorders. Int Urogynecol J 34:1\u201342. https:\/\/doi.org\/10.1007\/s00192-022-05397-x","journal-title":"Int Urogynecol J"},{"key":"5985_CR17","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00345-020-03152-9","volume":"39","author":"L Tunc","year":"2021","unstructured":"Tunc L, Yalcin S, Kaya E, Gazel E, Yilmaz S, Aybal HC, Yilmaz M, Tokas T (2021) The omega sign: a novel holep technique that improves continence outcomes after enucleation. World J Urol 39:135\u2013141. https:\/\/doi.org\/10.1007\/s00345-020-03152-9","journal-title":"World J Urol"},{"key":"5985_CR18","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1007\/s00345-021-03708-3","volume":"39","author":"NE Boxall","year":"2021","unstructured":"Boxall NE, Georgiades F, Miah S, Dragos L, Armitage J, Aho TF (2021) A call for holep: AEEP for mega-prostates (>\/= 200\u00a0cc). World J Urol 39:2347\u20132353. https:\/\/doi.org\/10.1007\/s00345-021-03708-3","journal-title":"World J Urol"},{"key":"5985_CR19","doi-asserted-by":"publisher","first-page":"218","DOI":"10.4111\/kju.2015.56.3.218","volume":"56","author":"M Kim","year":"2015","unstructured":"Kim M, Piao S, Lee HE, Kim SH, Oh SJ (2015) Efficacy and safety of holmium laser enucleation of the prostate for extremely large prostatic adenoma in patients with benign prostatic hyperplasia. Korean J Urol 56:218\u2013226. https:\/\/doi.org\/10.4111\/kju.2015.56.3.218","journal-title":"Korean J Urol"},{"key":"5985_CR20","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s00345-024-05082-2","volume":"42","author":"HC Aybal","year":"2024","unstructured":"Aybal HC, Yilmaz M, Barlas IS, Duvarci M, Tuncel A, Tunc L (2024) Comparison of HoLEP, thulep and thuflep in the treatment of benign prostatic obstruction: a propensity score-matched analysis. World J Urol 42:374. https:\/\/doi.org\/10.1007\/s00345-024-05082-2","journal-title":"World J Urol"},{"key":"5985_CR21","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.euf.2021.03.024","volume":"8","author":"FO Hartung","year":"2022","unstructured":"Hartung FO, Kowalewski KF, von Hardenberg J, Worst TS, Kriegmair MC, Nuhn P, Herrmann TRW, Michel MS, Herrmann J (2022) Holmium versus thulium laser enucleation of the prostate: a systematic review and meta-analysis of randomized controlled trials. Eur Urol Focus 8:545\u2013554. https:\/\/doi.org\/10.1016\/j.euf.2021.03.024","journal-title":"Eur Urol Focus"},{"key":"5985_CR22","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1089\/end.2022.0029","volume":"36","author":"V Petov","year":"2022","unstructured":"Petov V, Babaevskaya D, Taratkin M, Chuvalov L, Lusuardi L, Misrai V, Sukhanov R, Scoffone CM, Enikeev D (2022) Thulium fiber laser enucleation of the prostate: prospective study of mid- and long-term outcomes in 1328 patients. J Endourol 36:1231\u20131236. https:\/\/doi.org\/10.1089\/end.2022.0029","journal-title":"J Endourol"},{"key":"5985_CR23","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00345-025-05478-8","volume":"43","author":"HC Aybal","year":"2025","unstructured":"Aybal HC, Yilmaz M, Barlas IS, Duvarci M, Guven S, Tunc L (2025) HoLEP versus thuflep in men with very large prostates (>175 ml). World J Urol 43:109. https:\/\/doi.org\/10.1007\/s00345-025-05478-8","journal-title":"World J Urol"},{"key":"5985_CR24","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1089\/end.2018.0791","volume":"33","author":"D Enikeev","year":"2019","unstructured":"Enikeev D, Okhunov Z, Rapoport L, Taratkin M, Enikeev M, Snurnitsyna O, Capretz T, Inoyatov J, Glybochko P (2019) Novel thulium fiber laser for enucleation of prostate: a retrospective comparison with open simple prostatectomy. J Endourol 33:16\u201321. https:\/\/doi.org\/10.1089\/end.2018.0791","journal-title":"J Endourol"},{"key":"5985_CR25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.prnil.2023.12.001","volume":"12","author":"EJ Lim","year":"2024","unstructured":"Lim EJ, Castellani D, Somani BK, G\u00f6kce MI, Fong KY, Sancha FG, Herrmann TRW, Biligere S, Tursunkulov AN, Dellabella M, Sofer M, Enikeev D, Petov V, Gadzhiev N, Elterman D, Mahajan A, Socarras MR, Yunusov DS, Nasirov F, Teoh JYC, Gauhar V (2024) High-power holmium laser versus thulium fiber laser for endoscopic enucleation of the prostate in patients with glands larger than 80\u00a0ml: results from the prostate endoscopic enucleation study group. Prostate Int 12:40\u201345. https:\/\/doi.org\/10.1016\/j.prnil.2023.12.001","journal-title":"Prostate Int"},{"key":"5985_CR26","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1089\/end.2022.0851","volume":"37","author":"J Van der Jeugt","year":"2023","unstructured":"Van der Jeugt J, Umari P, Mottaran A, Ribeiro L, Lambert E, Vollemaere J, Develtere D, Veys R, Goossens M, Pauwaert K, Scarcella S, Van Praet C, Pauwels E, De Groote R, D\u2019Hondt F, De Naeyer G, Mottrie A, Schatteman P (2023) Holmium laser enucleation of the prostate vs Robot-Assisted simple prostatectomy for lower urinary tract symptoms in patients with extremely large prostates\u2009\u2265\u2009200\u00a0cc: A comparative analysis. J Endourol 37:895\u2013902. https:\/\/doi.org\/10.1089\/end.2022.0851","journal-title":"J Endourol"},{"key":"5985_CR27","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.ajur.2023.04.005","volume":"11","author":"F Endo","year":"2024","unstructured":"Endo F, Shimbo M, Komatsu K, Ohwaki K, Hattori K (2024) Optimal interval for delayed retrieval surgery with reciprocating morcellators after enucleation of giant prostatic hyperplasia in holmium laser enucleation of the prostate. Asian J Urol 11:423\u2013428. https:\/\/doi.org\/10.1016\/j.ajur.2023.04.005","journal-title":"Asian J Urol"}],"container-title":["World Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-025-05985-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00345-025-05985-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00345-025-05985-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:02:53Z","timestamp":1767999773000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00345-025-05985-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,4]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5985"],"URL":"https:\/\/doi.org\/10.1007\/s00345-025-05985-8","relation":{},"ISSN":["1433-8726"],"issn-type":[{"value":"1433-8726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,4]]},"assertion":[{"value":"22 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Approval was obtained from Acibadem University Faculty of Medicine Institutional Review Board (Approval Number ID: ID: 2024-12\/531). The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"592"}}