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As surgical treatment evolves toward less invasive and more precise modalities, the emergence of the da Vinci Single-Port (SP) robotic system has marked a significant milestone in urologic oncology. Single-port robot-assisted radical prostatectomy (SP-RARP) aims to further minimize surgical trauma, enhance cosmesis, and expedite recovery\u2014while preserving oncologic and functional outcomes. This review synthesizes the current literature on SP-RARP, detailing the technological advancements of the da Vinci SP system, surgical technique refinements, perioperative metrics, oncologic and functional results, and comparative outcomes versus multiport and conventional approaches. We also address the procedural limitations, the learning curve, and future directions, offering a comprehensive insight into the potential of single-port robotics in transforming prostate cancer surgery.<\/jats:p>","DOI":"10.1007\/s00345-025-06018-0","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:34:50Z","timestamp":1763703290000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Single-port robotic-assisted radical prostatectomy: evaluating the Da Vinci SP system in minimally invasive urologic oncology"],"prefix":"10.1007","volume":"43","author":[{"given":"Kirolos","family":"Eskandar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"6018_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2025.03.005","author":"D Manorom","year":"2025","unstructured":"Manorom D (2025) Trends and projections in prostate cancer epidemiology in thailand: A population-based cancer registry analysis. 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