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Maes and L. De Smedt are employees of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, who may own stock and\/or hold stock options in Merck & Co., Inc., Rahway, NJ, USA.G. Grisay has served as a paid lecturer for BMS, Bayer, and Johnson & Johnson, served as a scientific advisor or consultant to Bayer and Johnson & Johnson. T Roumegu\u00e8re served as scientific advisor or paid lecturer for Accord, Astellas, Bayer, Ferring Johnson & Johnson, MSD, Recordati B. 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