{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:12:04Z","timestamp":1792696324219,"version":"4.5.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Fakult\u00e4t Mannheim der Universit\u00e4t Heidelberg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Urol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aims to compare the impact of biological versus chronological age on postoperative risk after radical cystectomy (RC) by evaluating whether age\u2009\u2265\u200980 years independently predicts short-term mortality, complications and readmission rates beyond physiological status and comorbidity burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed 879 patients undergoing open RC at a high-volume centre between 2015 and 2024. Propensity score matching (PSM; 1:1 nearest neighbor) was performed to balance octogenarians (80\u201389 years) and patients\u2009&lt;\u200980 years for key covariates including ASA score, CCI score, BMI, renal function, preoperative albumin levels and urinary diversion. Primary endpoints were 30-day and 90-day mortality. Secondary endpoints included major complications (Clavien-Dindo \u2265IIIb), 30- and 90-day readmission rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 879 patients, 114 (13%) were octogenarians. Primary analyses demonstrated a higher 30-day (6.1% vs. 1.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and 90-day mortality (10.5% vs. 3.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) in octogenarians compared to patients\u2009&lt;\u200980 years. After PSM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009194), mortality remained numerically higher in octogenarians (30-day: 6.2% vs. 2.1%; 90-day: 10.3% vs. 4.1%); however, these differences did not reach statistical significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.28 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.165). Major complication and readmission rates were comparable between matched cohorts. In the multivariable regression analysis, age\u2009\u2265\u200980 years was not an independent predictor of any adverse outcome. Limitations include the retrospective design, single-centre setting and limited number of events after PSM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>When comorbidity burden and physiological fitness are comparable, octogenarians undergoing RC achieve short-term outcomes similar to those of younger patients. Chronological age alone should not preclude consideration of RC. Individualised risk assessment, treatment in experienced, high-volume centres and most likely, increasing adoption of robot-assisted RC are essential for safe surgical care for older RC candidates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00345-026-06513-y","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:29:11Z","timestamp":1780478951000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Radical cystectomy in octogenarians: a propensity score-matched analysis of short-term outcomes"],"prefix":"10.1007","volume":"44","author":[{"given":"Maurin Helen","family":"Mangold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Egen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Carl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Vivienne","family":"Renner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Studier-Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cael\u00e1n Max","family":"Haney-Aubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren Juliane","family":"Wenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice Stephan","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Westhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Friedrich","family":"Kowalewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"6513_CR1","unstructured":"Economic UNDoI (2014) World population ageing, 2013: UN"},{"key":"6513_CR2","unstructured":"Institute NC (2025) Surveillance, epidemiology, and end results program"},{"key":"6513_CR3","unstructured":"EAU Guidelines (2025) Edn. 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