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This study aimed to compare the safety, effectiveness, and functional outcomes of transperitoneal (SP-TPRP) and extraperitoneal (SP-EPRP) approaches in SP-RARP using propensity score matching (PSM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analyzed 211 consecutive patients who underwent SP-RARP at a tertiary referral center (2018\u20132024): 58 SP-TPRP and 153 SP-EPRP. PSM was performed to balance baseline covariates. Perioperative outcomes were compared between the two groups. Time to urinary continence recovery was assessed using Kaplan-Meier analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After PSM, 55 patients per group were analyzed. The SP-EPRP group demonstrated significantly higher estimated blood loss (150.0 vs. 100.0 mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021) and a shorter hospital stay (1 vs. 2 days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and lower pain scores(0.0 vs. 4.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Gastrointestinal complications occurred exclusively in SP-TPRP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095), while lymphoceles only in SP-EPRP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094). No significant differences were found in operative time, overall complications, short-term oncological outcomes or function recovery. Kaplan-Meier analysis showed no significant difference in time to continence recovery between approaches (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.32).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both approaches achieve comparable oncological outcomes, perioperative safety, and functional recovery. SP-EPRP was associated with shorter hospital stay and lower early postoperative pain, but higher estimated blood loss. Both approaches appear clinically feasible, and prospective studies with longer follow-up are warranted to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00345-026-06583-y","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:33:36Z","timestamp":1782992016000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and efficacy of different surgical approaches in single-port robot-assisted radical prostatectomy based on propensity score matching analysis"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6600-170X","authenticated-orcid":false,"given":"Jin-Chun","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Xuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Santodirocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ran","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca Alfredo","family":"Morgantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Sauer Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Bao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Crivellaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"issue":"3","key":"6583_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2020","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2020) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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The remaining authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration. Approval was obtained from the Institutional Review Board (IRB protocol number: 2017\u2009\u2212\u20090152).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all individual participants included in the study. Participants were informed of the study\u2019s objectives, procedures, potential risks and benefits, and their rights, including the right to withdraw at any time. Confidentiality was strictly maintained throughout the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"478"}}