{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:16:02Z","timestamp":1760368562123},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologe"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1007\/s00347-006-1335-6","type":"journal-article","created":{"date-parts":[[2006,4,19]],"date-time":"2006-04-19T07:02:43Z","timestamp":1145430163000},"page":"393-400","source":"Crossref","is-referenced-by-count":5,"title":["Morphologie, Familienanamnese und Diagnosezeitpunkt bei 26\u00a0Patienten mit Axenfeld-Rieger-Syndrom und Glaukom oder okul\u00e4rer Hypertension"],"prefix":"10.1007","volume":"103","author":[{"given":"P.","family":"Dre\u00dfler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Gramer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"1335_CR1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0002-9394(00)00525-0","volume":"130","author":"Alward","year":"2000","unstructured":"Alward WLM (2000) Axenfeld-Rieger-Syndrome in the age of molecular Genetics. Am J Ophthalmol 130: 107\u2013115","journal-title":"Am J Ophthalmol"},{"key":"1335_CR2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00061198-200202000-00010","volume":"11","author":"Borges","year":"2002","unstructured":"Borges AS, Susanna R, Carani JC et al. (2002) Genetic analysis of PITX2 and FOXC1 in Rieger Syndrome patients from Brazil. J Glaucoma 11: 51\u201356","journal-title":"J Glaucoma"},{"key":"1335_CR3","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1600-0714.1986.tb00572.x","volume":"15","author":"Childers","year":"1986","unstructured":"Childers NK, Wright JT (1986) Dental and craniofacial anomalies of Axenfeld-Rieger-Syndrome. J Oral Pathology 15: 534\u2013539","journal-title":"J Oral Pathology"},{"key":"1335_CR4","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1177\/00220345650440053301","volume":"44","author":"Emrich","year":"1965","unstructured":"Emrich RE, Brodie AG, Blayney JR (1965) Prevalence of class I, class II, class III malocclusion in urban population, an epidemiological study. J Dent Res 44: 947\u2013953","journal-title":"J Dent Res"},{"key":"1335_CR5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/hmg\/11.7.743","volume":"Genet","author":"Espinoza","year":"2002","unstructured":"Espinoza HM, Cox CJ, Semina EV, Amendt BA (2002) A molecular basis for differential developmental anomalies in Axenfeld-Rieger syndrome. Hum Mol Genet (England) 11: 743\u2013753","journal-title":"Hum Mol"},{"key":"1335_CR6","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1093\/hmg\/ddi365","volume":"14","author":"Evans","year":"2005","unstructured":"Evans AL, Gage PJ (2005) Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development. Hum Mol Genet 14(22): 3347\u20133359","journal-title":"Hum Mol Genet"},{"key":"1335_CR7","unstructured":"Fleischer-Peters A, Lang GE (1999) Fehlende obere Schneidez\u00e4hne als Leitsymptom des Rieger-Syndroms. Dtsch Zahn\u00e4rtzl Z 44: 228\u2013231"},{"key":"1335_CR8","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1242\/dev.126.20.4643","volume":"126","author":"Gage","year":"1999","unstructured":"Gage PJ, Suh H, Camper SA (1999) Dosage requirement of PITX 2 for development of multiple organs. Development 126: 4643\u20134651","journal-title":"Development"},{"key":"1335_CR9","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/hmg\/11.10.1185","volume":"11","author":"Gould","year":"2002","unstructured":"Gould DB, John SW (2002) Anterior segment dysgenesis and the developmental glaucomas are complex traits. Hum Mol Genet 11: 1185\u20131193","journal-title":"Hum Mol Genet"},{"key":"1335_CR10","doi-asserted-by":"crossref","unstructured":"Gramer E, Gramer G (1999) A new unification hypothesis of the pathogenesis of the glaucomas based on clinical studies on disc appearance in relation to the stage of visual field loss in different types of glaucoma. In: Gramer E, Grehn F (eds) Pathogenesis and risk factors of glaucoma. Springer, Berlin Heidelberg New York Tokio, pp 170\u2013203","DOI":"10.1007\/978-3-642-60203-0_20"},{"key":"1335_CR11","unstructured":"Gramer E, Gramer G (2001) Stage-related evaluation of some risk factors in Primary Open Angle Glaucoma (POAG) and Normal Tension Glaucoma (NTG) [ARVO Abstract]. Invest Ophthalmol Vis Sci 42(4), Abstract nr 2970"},{"key":"1335_CR12","first-page":"ARVO","volume":"43","author":"Gramer","year":"2002","unstructured":"Gramer E, Gramer G (2002) Age of patients at the time of diagnosis in different types of glaucoma. A prospective study. Invest Ophthalmol Vis Sci 43: ARVO E-Abstract 3422","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1335_CR13","first-page":"ARVO","volume":"44","author":"Gramer","year":"2003","unstructured":"Gramer E, Gramer G (2003) Significance of family history of glaucoma for glaucoma screening. Invest Ophthalmol Vis Sci 44: ARVO E-Abstract 2189","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1335_CR14","first-page":"S282","volume":"41","author":"Gramer","year":"2000","unstructured":"Gramer E, Gramer G, Buescher A (2000) Efficacy of mono- and combination therapy with brimonidine 0,2% and frequency of cardiac diseases and family history of glaucoma in the glaucomas. A prospective study [ARVO Abstract]. Invest Ophthalmol Vis Sci 41(4): S282, Abstract nr 1482","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1335_CR15","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1055\/s-2008-1034930","volume":"212","author":"Gramer","year":"1998","unstructured":"Gramer E, Thiele H, Ritch R (1998) Familienanamnese Glaukom und Risikofaktoren bei Pigmentglaukom. Eine klinische Studie. Klin Monatsbl Augenheilkd 212: 454\u2013464","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"1335_CR16","first-page":"ARVO","volume":"45","author":"Gramer","year":"2004","unstructured":"Gramer G, Gramer E, Weber BHF (2004) Evaluation of 2170 patients with glaucoma or ocular hypertension \u2013 Disease risk in siblings and children. Invest Ophthalmol Vis Sci 45: ARVO E-Abstract 5539","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1335_CR17","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1001\/archopht.1979.01020020438004","volume":"97","author":"Judisch","year":"1979","unstructured":"Judisch GF, Phelps CD, Hanson J (1979) Rieger\u2019s syndrome: a case report with a 15 year follow up. Arch Ophthalmol 97: 2120\u20132122","journal-title":"Arch Ophthalmol"},{"key":"1335_CR18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00061198-200112000-00007","volume":"10","author":"Kawase","year":"2001","unstructured":"Kawase C, Kawase K, Taniguchi T et al. (2001) Screening for mutations of Axenfeld-Rieger-Syndrome caused by FOXC1 gene in Japanese patients. J Glaucoma 10: 477\u2013482","journal-title":"J Glaucoma"},{"key":"1335_CR19","first-page":"43","volume":"Vis","author":"Komatireddy","year":"2003","unstructured":"Komatireddy S, Chakrabarti S, Mandal AK et al. (2003) Mutation spectrum of FOXC1 and clinical genetic heterogeneity of Axenfeld-Rieger anomaly in India. Mol Vis (United States) 9: 43\u201348","journal-title":"Mol"},{"key":"1335_CR20","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s000560050002","volume":"61","author":"Korbmacher","year":"2000","unstructured":"Korbmacher H, Kahl-Nieke B, Schnabel S (2000) Die kieferorthop\u00e4dische Fr\u00fchbehandlung in Deutschland bei Anomalien des progenen Formenkreises. J Orofac Orthop 61: 168","journal-title":"J Orofac Orthop"},{"key":"1335_CR21","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1093\/hmg\/9.14.2131","volume":"14","author":"Kozlowski","year":"2000","unstructured":"Kozlowski K, Walter MA (2000) Variation in residual PITX 2 activity underlies the phenotypic spectrum of anterior segment developmental disorders. Hum Mol Genet 14: 2131\u20132139","journal-title":"Hum Mol Genet"},{"key":"1335_CR22","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/11.10.1177","volume":"11","author":"Lines","year":"2002","unstructured":"Lines MA, Kozlowski K, Walter MA (2002) Molecular genetics of Axenfeld-Rieger malformations. Hum Mol Genet 11: 1177\u20131184","journal-title":"Hum Mol Genet"},{"key":"1335_CR23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1034\/j.1600-0420.2000.078001101.x","volume":"78","author":"Necdet","year":"2000","unstructured":"Necdet A, Ginng\u00f6r B, Ginng\u00f6r K (2000) Atrial septal defect with interatrial aneurysm and Axenfeld-Rieger syndrome. Acta Ophthalmol Scand 78: 101\u2013103","journal-title":"Acta Ophthalmol Scand"},{"key":"1335_CR24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/493","volume":"19","author":"Nishimura","year":"1998","unstructured":"Nishimura DY, Swiderski RE, Alward WLM et al. (1998) The forkhead transcription factor gene FKHL 7 is responsible for glaucoma phenotypes which map to 6p25. Nat Genet 19: 140\u2013147","journal-title":"Nat Genet"},{"key":"1335_CR25","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1007\/s004170050304","volume":"237","author":"Ozeki","year":"1999","unstructured":"Ozeki H, Shirai S, Keda K, Ogura Y (1999) Anomalies associated with Axenfeld-Rieger-Syndrome. Graefes Arch Clin Exp Ophthalmol 237: 730\u2013734","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1335_CR26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/BF01997767","volume":"40","author":"Sch","year":"1979","unstructured":"Sch\u00f6neberger G, Fleischer-Peters A (1979) Vorkommen von Nichtanlagen mittlerer oberer Schneidez\u00e4hne. Fortschr Kieferorthop 40: 46","journal-title":"Fortschr Kieferorthop"},{"key":"1335_CR27","unstructured":"Schroeder HE (1997) Numerische und morphologische Anomalien der Z\u00e4hne. In: Huber E, Schroeder HE (Hrsg) Pathobiologie oraler Strukturen: Z\u00e4hne, Pulpa, Parodont, 3. Aufl. Karger, Basel Berlin Freiburg London New York New Delhi Bangkok Singapore Tokyo Sydney, S 5\u201316"},{"key":"1335_CR28","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ng1296-392","volume":"14","author":"Semina","year":"1996","unstructured":"Semina EV, Reiter R, Leyseus NJ et al. (1996) Cloning and characterization of a novel bicoid-related homebox transcription factor gene, RIEG, involved in Rieger Syndrome. Nat Genet 14: 392\u2013399","journal-title":"Nat Genet"},{"key":"1335_CR29","first-page":"736","volume":"81","author":"Shields","year":"1983","unstructured":"Shields MB (1983) Axenfeld-Rieger-Syndrome: a theory of mechanism and distinctions from the iridocorneal endothelia syndrome. Trans Am Ophthalmol Soc 81: 736\u2013784","journal-title":"Trans Am Ophthalmol Soc"},{"key":"1335_CR30","doi-asserted-by":"crossref","unstructured":"Shields MB, Krieglstein GK (1993) Entwicklungsbedingte Glaukome mit weiteren Anomalien. In: Shields MB, Krieglstein GK (Hrsg) Glaukom: Grundlagen, Differentialdiagnose, Therapie. Springer, Berlin Heidelberg New York Tokio, S 226\u2013231","DOI":"10.1007\/978-3-642-77053-1_12"},{"key":"1335_CR31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0039-6257(85)90205-X","volume":"29","author":"Shields","year":"1985","unstructured":"Shields MB, Buckley E, Klintworth GK, Thresher R (1985) Axenfeld-Rieger-Syndrome. A spectrum of the developmental disorders. Surv Ophthalmol 29: 387\u2013409","journal-title":"Surv Ophthalmol"},{"key":"1335_CR32","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/hmg\/9.7.1021","volume":"9","author":"Smith","year":"2000","unstructured":"Smith RS, Zabaleta A, Kume T et al. (2000) Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. Hum Mol Genet 9: 1021\u20131032","journal-title":"Hum Mol Genet"},{"key":"1335_CR33","first-page":"284","volume":"11","author":"Weisschuh","year":"2005","unstructured":"Weisschuh N, Neumann D, Wolf C et al. (2005) Prevalence of myocilin and optineurin sequence variants in German normal tension glaucoma patients. Mol Vis 11: 284\u2013287","journal-title":"Mol Vis"}],"container-title":["Der Ophthalmologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-006-1335-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00347-006-1335-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-006-1335-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T19:56:06Z","timestamp":1627242966000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00347-006-1335-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["1335"],"URL":"https:\/\/doi.org\/10.1007\/s00347-006-1335-6","relation":{},"ISSN":["0941-293X","1433-0423"],"issn-type":[{"value":"0941-293X","type":"print"},{"value":"1433-0423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}