{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T06:28:04Z","timestamp":1648621684937},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,5,10]],"date-time":"2009-05-10T00:00:00Z","timestamp":1241913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologe"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1007\/s00347-009-1932-2","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:33:57Z","timestamp":1241800437000},"page":"557-562","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutische Optionen bei Keratoconjunctivitis vernalis"],"prefix":"10.1007","volume":"106","author":[{"given":"E. M.","family":"Messmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,5,10]]},"reference":[{"key":"1932_CR1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1089\/10807680260362759","volume":"18","author":"Abelson","year":"2002","unstructured":"Abelson MB, Berdy GJ, Mundorf T et al (2002) Pemirolast potassium 0.1% ophthalmic solution is an effective treatment for allergic conjunctivitis: a pooled analysis of two prospective, randomized, double-masked, placebo-controlled, phase III studies. J Ocul Pharmacol Ther 18:475\u2013488","journal-title":"J Ocul Pharmacol Ther"},{"key":"1932_CR2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0161-6420(99)00096-2","volume":"107","author":"Akpek","year":"2000","unstructured":"Akpek EK, Hasiripi H, Christen WG, Kalayci D (2000) A randomized trial of low-dose, topical mitomycin-C in the treatment of severe vernal keratoconjunctivitis. Ophthalmology 107:263\u2013269","journal-title":"Ophthalmology"},{"key":"1932_CR3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.exer.2004.11.006","volume":"80","author":"Asano-Kato","year":"2005","unstructured":"Asano-Kato N, Fukagawa K, Okada N et al (2005) TGF-beta1, IL-1beta, and Th2 cytokines stimulate vascular endothelial growth factor production from conjunctival fibroblasts. Exp Eye Res 80:555\u2013560","journal-title":"Exp Eye Res"},{"key":"1932_CR4","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0002-9394(86)90819-6","volume":"101","author":"BenEzra","year":"1986","unstructured":"BenEzra D, Pe\u2019er J, Brodsky M, Cohen E (1986) Cyclosporine eyedrops for the treatment of severe vernal keratoconjunctivitis. Am J Ophthalmol 101:278\u2013282","journal-title":"Am J Ophthalmol"},{"key":"1932_CR5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mcna.2005.08.013","volume":"90","author":"Bielory","year":"2006","unstructured":"Bielory L (2006) Allergic diseases of the eye. Med Clin North Am 90:129\u2013148","journal-title":"Med Clin North Am"},{"key":"1932_CR6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2165\/00003495-200565020-00004","volume":"65","author":"Bielory","year":"2005","unstructured":"Bielory L, Lien KW, Bigelsen S (2005) Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis. Drugs 65:215\u2013228","journal-title":"Drugs"},{"key":"1932_CR7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00130832-200310000-00011","volume":"3","author":"Bonini","year":"2003","unstructured":"Bonini S, Lambiase A, Sgrulletta R, Bonini S (2003) Allergic chronic inflammation of the ocular surface in vernal keratoconjunctivitis. Curr Opin Allergy Clin Immunol 3:381\u2013387","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"1932_CR8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1749-6632.2000.tb05525.x","volume":"923","author":"Chan","year":"2000","unstructured":"Chan CC, Tuaillon N, Li Q, Shen DF (2000) Therapeutic applications of antiflammin peptides in experimental ocular inflammation. Ann N Y Acad Sci 923:141\u2013146","journal-title":"Ann N Y Acad Sci"},{"key":"1932_CR9","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00130832-200210000-00009","volume":"2","author":"Church","year":"2002","unstructured":"Church MK, McGill JI (2002) Human ocular mast cells. Curr Opin Allergy Clin Immunol 2:419\u2013422","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"1932_CR10","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1089\/jop.2005.21.400","volume":"21","author":"Corum","year":"2005","unstructured":"Corum I, Yeniad B, Bilgin LK, Ilhan R (2005) Efficiency of olopatadine hydrochloride 0.1% in the treatment of vernal keratoconjunctivitis and goblet cell density. J Ocul Pharmacol Ther 21:400\u2013405","journal-title":"J Ocul Pharmacol Ther"},{"key":"1932_CR11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00417-002-0612-6","volume":"241","author":"D","year":"2003","unstructured":"D\u2019Angelo G, Lambiase A, Cortes M et al (2003) Preservative-free diclofenac sodium 0.1% for vernal keratoconjunctivitis. Graefes Arch Clin Exp Ophthalmol 241:192\u2013195","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1932_CR12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1177\/112067219200200306","volume":"2","author":"Fahy","year":"1992","unstructured":"Fahy GT, Easty DL, Collum LM et al (1992) Randomised double-masked trial of lodoxamide and sodium cromoglycate in allergic eye disease. A multicentre study. Eur J Ophthalmol 2:144\u2013149","journal-title":"Eur J Ophthalmol"},{"key":"1932_CR13","first-page":"58","volume":"43","author":"Fukagawa","year":"2002","unstructured":"Fukagawa K, Okada N, Fujishima H et al (2002) CC-chemokine receptor 3: a possible target in treatment of allergy-related corneal ulcer. Invest Ophthalmol Vis Sci 43:58\u201362","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1932_CR14","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1006\/exer.1998.0528","volume":"67","author":"Hingorani","year":"1998","unstructured":"Hingorani M, Calder VL, Buckley RJ, Lightman SL (1998) The role of conjunctival epithelial cells in chronic ocular allergic disease. Exp Eye Res 67:491\u2013500","journal-title":"Exp Eye Res"},{"key":"1932_CR15","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/S0161-6420(97)30144-4","volume":"104","author":"Hoang-Xuan","year":"1997","unstructured":"Hoang-Xuan T, Prisant O, Hannouche D, Robin H (1997) Systemic cyclosporine A in severe atopic keratoconjunctivitis. Ophthalmology 104:1300\u20131305","journal-title":"Ophthalmology"},{"key":"1932_CR16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/01.ICL.0000092071.82938.46","volume":"30","author":"Ilyas","year":"2004","unstructured":"Ilyas H, Slonim CB, Braswell GR et al (2004) Long-term safety of loteprednol etabonate 0.2% in the treatment of seasonal and perennial allergic conjunctivitis. Eye Contact Lens 30:10\u201313","journal-title":"Eye Contact Lens"},{"key":"1932_CR17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s11882-003-0098-2","volume":"3","author":"Irkec","year":"2003","unstructured":"Irkec M, Bozkurt B (2003) Epithelial cells in ocular allergy. Curr Allergy Asthma Rep 3:352\u2013357","journal-title":"Curr Allergy Asthma Rep"},{"key":"1932_CR18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.iac.2007.12.007","volume":"28","author":"Jun","year":"2008","unstructured":"Jun J, Bielory L, Raizman MB (2008) Vernal conjunctivitis. Immunol Allergy Clin North Am 28:59\u201382, vi","journal-title":"Immunol Allergy Clin North Am"},{"key":"1932_CR19","unstructured":"Kumar S (2008) Vernal keratoconjunctivitis: a major review. Acta Ophthalmol"},{"key":"1932_CR20","first-page":"2127","volume":"36","author":"Lambiase","year":"1995","unstructured":"Lambiase A, Bonini S, Bonini S et al (1995) Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. Invest Ophthalmol Vis Sci 36:2127\u20132132","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1932_CR21","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archopht.121.5.615","volume":"121","author":"Lambiase","year":"2003","unstructured":"Lambiase A, Bonini S, Rasi G et al (2003) Montelukast, a leukotriene receptor antagonist, in vernal keratoconjunctivitis associated with asthma. Arch Ophthalmol 121:615\u2013620","journal-title":"Arch Ophthalmol"},{"key":"1932_CR22","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1517\/14712598.5.4.525","volume":"5","author":"Lazarczyk","year":"2005","unstructured":"Lazarczyk M, Grzela K, Grzela T (2005) Immunostimulatory oligonucleotides in therapy of allergic diseases. Expert Opin Biol Ther 5:525\u2013536","journal-title":"Expert Opin Biol Ther"},{"key":"1932_CR23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/bjo.81.1.23","volume":"81","author":"Leonardi","year":"1997","unstructured":"Leonardi A, Borghesan F, Avarello A et al (1997) Effect of lodoxamide and disodium cromoglycate on tear eosinophil cationic protein in vernal keratoconjunctivitis. Br J Ophthalmol 81:23\u201326","journal-title":"Br J Ophthalmol"},{"key":"1932_CR24","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1167\/iovs.02-0766","volume":"44","author":"Leonardi","year":"2003","unstructured":"Leonardi A, Brun P, Abatangelo G et al (2003) Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitis. Invest Ophthalmol Vis Sci 44:3052\u20133058","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1932_CR25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1167\/iovs.02-0420","volume":"44","author":"Leonardi","year":"2003","unstructured":"Leonardi A, Cortivo R, Fregona I et al (2003) Effects of Th2 cytokines on expression of collagen, MMP-1, and TIMP-1 in conjunctival fibroblasts. Invest Ophthalmol Vis Sci 44:183\u2013189","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1932_CR26","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1001\/archopht.119.10.1512","volume":"119","author":"Leonardi","year":"2001","unstructured":"Leonardi A, DeFranchis G, Fregona IA et al (2001) Effects of cyclosporin A on human conjunctival fibroblasts. Arch Ophthalmol 119:1512\u20131517","journal-title":"Arch Ophthalmol"},{"key":"1932_CR27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2249.2008.03716.x","volume":"153","author":"Leonardi","year":"2008","unstructured":"Leonardi A, Motterle L, Bortolotti M (2008) Allergy and the eye. Clin Exp Immunol 153 (Suppl 1):17\u201321","journal-title":"Clin Exp Immunol"},{"key":"1932_CR28","first-page":"19","volume":"41","author":"Lisanework","year":"2003","unstructured":"Lisanework M (2003) Supra-tarsal injection of dexamethasone in the treatment of patients with refractory vernal keratoconjunctivitis. Ethiop Med J 41:19\u201324","journal-title":"Ethiop Med J"},{"key":"1932_CR29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10792-004-1818-x","volume":"25","author":"McGill","year":"2004","unstructured":"McGill JI (2004) A review of the use of olopatadine in allergic conjunctivitis. Int Ophthalmol 25:171\u2013179","journal-title":"Int Ophthalmol"},{"key":"1932_CR30","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00347-005-1181-y","volume":"102","author":"Messmer","year":"2005","unstructured":"Messmer EM (2005) [Ocular allergies]. Ophthalmologe 102:527\u2013543","journal-title":"Ophthalmologe"},{"key":"1932_CR31","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0002-9394(02)01726-9","volume":"134","author":"Messmer","year":"2002","unstructured":"Messmer EM, May CA, Stefani FH et al (2002) Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. Am J Ophthalmol 134:816\u2013821","journal-title":"Am J Ophthalmol"},{"key":"1932_CR32","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1034\/j.1600-0420.1999.770516.x","volume":"77","author":"Montan","year":"1999","unstructured":"Montan PG, Ekstrom K, Hedlin G et al (1999) Vernal keratoconjunctivitis in a Stockholm ophthalmic centre--epidemiological, functional, and immunologic investigations. Acta Ophthalmol Scand 77:559\u2013563","journal-title":"Acta Ophthalmol Scand"},{"key":"1932_CR33","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1167\/iovs.04-1494","volume":"46","author":"Okada","year":"2005","unstructured":"Okada N, Fukagawa K, Takano Y et al (2005) The implications of the upregulation of ICAM-1\/VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic keratopathy. Invest Ophthalmol Vis Sci 46:4512\u20134518","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1932_CR34","doi-asserted-by":"crossref","unstructured":"Ozbek Z, Burakgazi AZ, Rapuano CJ (2006) Rapid healing of vernal shield ulcer after surgical debridement: A case report Cornea 25:472\u2013473","DOI":"10.1097\/01.ico.0000178725.04070.87"},{"key":"1932_CR35","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/112067210801800123","volume":"18","author":"Pelegrin","year":"2008","unstructured":"Pelegrin L, Gris O, Adan A, Plazas A (2008) Superficial keratectomy and amniotic membrane patch in the treatment of corneal plaque of vernal keratoconjunctivitis. Eur J Ophthalmol 18:131\u2013133","journal-title":"Eur J Ophthalmol"},{"key":"1932_CR36","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S1081-1206(10)61958-8","volume":"89","author":"Pucci","year":"2002","unstructured":"Pucci N, Novembre E, Cianferoni A et al (2002) Efficacy and safety of cyclosporine eyedrops in vernal keratoconjunctivitis. Ann Allergy Asthma Immunol 89:298\u2013303","journal-title":"Ann Allergy Asthma Immunol"},{"key":"1932_CR37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1055\/s-2002-26727","volume":"219","author":"Reinhard","year":"2002","unstructured":"Reinhard T, Reis A, Mayweg S et al (2002) [Topical Fk506 in inflammatory corneal and conjunctival diseases. A pilot study.]. Klin Monatsbl Augenheilkd 219:125\u2013131","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"1932_CR38","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0181-5512(04)96277-8","volume":"27","author":"Rouher","year":"2004","unstructured":"Rouher N, Pilon F, Dalens H et al (2004) [Implantation of preserved human amniotic membrane for the treatment of shield ulcers and persistent corneal epithelial defects in chronic allergic keratoconjunctivitis]. J Fr Ophtalmol 27:1091\u20131097","journal-title":"J Fr Ophtalmol"},{"key":"1932_CR39","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1034\/j.1600-0420.1999.770505.x","volume":"77","author":"Saini","year":"1999","unstructured":"Saini JS, Gupta A, Pandey SK et al (1999) Efficacy of supratarsal dexamethasone versus triamcinolone injection in recalcitrant vernal keratoconjunctivitis. Acta Ophthalmol Scand 77:515\u2013518","journal-title":"Acta Ophthalmol Scand"},{"key":"1932_CR40","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0002-9394(14)77061-8","volume":"110","author":"Secchi","year":"1990","unstructured":"Secchi AG, Tognon MS, Leonardi A (1990) Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis. Am J Ophthalmol 110:641\u2013645","journal-title":"Am J Ophthalmol"},{"key":"1932_CR41","first-page":"177","volume":"45","author":"Sharma","year":"1997","unstructured":"Sharma A, Gupta R, Ram J, Gupta A (1997) Topical ketorolac 0.5% solution for the treatment of vernal keratoconjunctivitis. Indian J Ophthalmol 45:177\u2013180","journal-title":"Indian J Ophthalmol"},{"key":"1932_CR42","first-page":"241","volume":"49","author":"Singh","year":"2001","unstructured":"Singh S, Pal V, Dhull CS (2001) Supratarsal injection of corticosteroids in the treatment of refractory vernal keratoconjunctivitis. Indian J Ophthalmol 49:241\u2013245","journal-title":"Indian J Ophthalmol"},{"key":"1932_CR43","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/00130832-200310000-00012","volume":"3","author":"Solomon","year":"2003","unstructured":"Solomon A, Puxeddu I, Levi-Schaffer F (2003) Fibrosis in ocular allergic inflammation: recent concepts in the pathogenesis of ocular allergy. Curr Opin Allergy Clin Immunol 3:389\u2013393","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"1932_CR44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2165\/00003495-198631020-00003","volume":"31","author":"Sorkin","year":"1986","unstructured":"Sorkin EM, Ward A (1986) Ocular sodium cromoglycate. An overview of its therapeutic efficacy in allergic eye disease. Drugs 31:131\u2013148","journal-title":"Drugs"},{"key":"1932_CR45","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1046\/j.1365-2222.1999.00501.x","volume":"29","author":"Verin","year":"1999","unstructured":"Verin PH, Dicker ID, Mortemousque B (1999) Nedocromil sodium eye drops are more effective than sodium cromoglycate eye drops for the long-term management of vernal keratoconjunctivitis. Clin Exp Allergy 29:529\u2013536","journal-title":"Clin Exp Allergy"},{"key":"1932_CR46","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jaci.2003.10.065","volume":"113","author":"Vichyanond","year":"2004","unstructured":"Vichyanond P, Tantimongkolsuk C, Dumrongkigchaiporn P et al (2004) Vernal keratoconjunctivitis: Result of a novel therapy with 0.1% topical ophthalmic FK-506 ointment. J Allergy Clin Immunol 113:355\u2013358","journal-title":"J Allergy Clin Immunol"}],"container-title":["Der Ophthalmologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-009-1932-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00347-009-1932-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-009-1932-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T13:50:55Z","timestamp":1559051455000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00347-009-1932-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,10]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["1932"],"URL":"https:\/\/doi.org\/10.1007\/s00347-009-1932-2","relation":{},"ISSN":["0941-293X","1433-0423"],"issn-type":[{"value":"0941-293X","type":"print"},{"value":"1433-0423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,10]]}}}