{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T18:16:17Z","timestamp":1780856177038,"version":"3.54.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,12,18]],"date-time":"2010-12-18T00:00:00Z","timestamp":1292630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologe"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1007\/s00347-010-2296-3","type":"journal-article","created":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T15:25:41Z","timestamp":1305559541000},"page":"459-462","source":"Crossref","is-referenced-by-count":5,"title":["Kearns-Sayre-Syndrom","Kearns-Sayre syndrome"],"prefix":"10.1007","volume":"108","author":[{"given":"W.J.","family":"Mayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Remy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,12,18]]},"reference":[{"key":"2296_CR1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/biof.5520090221","volume":"9","author":"Barbiroli","year":"1999","unstructured":"Barbiroli B, Iotti S, Lodi R (1999) Improved brain and muscle mitochondrial respiration with CoQ. An in vivo study by 31P-MR spectroscopy in patients with mitochondrial cytopathies. Biofactors 9:253\u2013260","journal-title":"Biofactors"},{"key":"2296_CR2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00019052-200302000-00005","volume":"16","author":"Biousse","year":"2003","unstructured":"Biousse V, Newman NJ (2003) Neuro-ophthalmology of mitochondrial diseases. Curr Opin Neurol 16:35\u201343","journal-title":"Curr Opin Neurol"},{"key":"2296_CR3","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1001\/archneur.1968.00470360076008","volume":"18","author":"Drachman","year":"1968","unstructured":"Drachman DA (1968) Ophthalmoplegia plus. The neurodegenerative disorders associated with progressive external ophthalmoplegia. Arch Neurol 18:654\u2013674","journal-title":"Arch Neurol"},{"key":"2296_CR4","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1093\/clinchem\/44.10.2210","volume":"44","author":"Haufroid","year":"1998","unstructured":"Haufroid V, Clippe A, Knoops B et al (1998) Genotyping in urine: an interesting tool for epidemiological studies. Clin Chem 44:2210\u20132211","journal-title":"Clin Chem"},{"key":"2296_CR5","unstructured":"Kaiser KJ, J. F (1999) Kinderophthalmologie \u2013 Auge und Allgemeinerkrankungen. Hans Huber, Basel"},{"key":"2296_CR6","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1001\/archopht.1958.00940080296016","volume":"60","author":"Kearns","year":"1958","unstructured":"Kearns T, Sayre G (1958) Retinitis pigmentosa, external ophthalmoplegia and complete heart block. Unusual syndrome with histologic study in one of two cases. Arch Ophthalmol 60:280\u2013289","journal-title":"Arch Ophthalmol"},{"key":"2296_CR7","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/path.1863","volume":"207","author":"Lebrecht","year":"2005","unstructured":"Lebrecht D, Kokkori A, Ketelsen UP et al (2005) Tissue-specific mtDNA lesions and radical-associated mitochondrial dysfunction in human hearts exposed to doxorubicin. J Pathol 207:436\u2013444","journal-title":"J Pathol"},{"key":"2296_CR8","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0140-6736(88)91632-7","volume":"1","author":"Lestienne","year":"1988","unstructured":"Lestienne P, Ponsot G (1988) Kearns-Sayre syndrome with muscle mitochondrial DNA deletion. Lancet 1:885","journal-title":"Lancet"},{"key":"2296_CR9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mrfmmm.2007.12.007","volume":"640","author":"Markaryan","year":"2008","unstructured":"Markaryan A, Nelson EG, Hinojosa R (2008) Detection of mitochondrial DNA deletions in the cochlea and its structural elements from archival human temporal bone tissue. Mutat Res 640:38\u201345","journal-title":"Mutat Res"},{"key":"2296_CR10","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0140-6736(92)91442-B","volume":"340","author":"Mashima","year":"1992","unstructured":"Mashima Y, Hiida Y, Oguchi Y (1992) Remission of Leber\u2019s hereditary optic neuropathy with idebenone. Lancet 340:368\u2013369","journal-title":"Lancet"},{"key":"2296_CR11","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1086\/511788","volume":"80","author":"Mayr","year":"2007","unstructured":"Mayr JA, Merkel O, Kohlwein SD et al (2007) Mitochondrial phosphate-carrier deficiency: a novel disorder of oxidative phosphorylation. Am J Hum Genet 80:478\u2013484","journal-title":"Am J Hum Genet"},{"key":"2296_CR12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0022-510X(98)00082-3","volume":"158","author":"Mohri","year":"1998","unstructured":"Mohri I, Taniike M, Fujimura H et al (1998) A case of Kearns-Sayre syndrome showing a constant proportion of deleted mitochondrial DNA in blood cells during 6 years of follow-up. J Neurol Sci 158:106\u2013109","journal-title":"J Neurol Sci"},{"key":"2296_CR13","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3349\/ymj.2004.45.4.727","volume":"45","author":"Park","year":"2004","unstructured":"Park SB, Ma KT, Kook KH et al (2004) Kearns-Sayre syndrome -3 case reports and review of clinical feature. Yonsei Med J 45:727\u2013735","journal-title":"Yonsei Med J"},{"key":"2296_CR14","unstructured":"Rowland L, Hays A, Di Mauro S et al (1983) Diverse cinical disorders associated with morphological abnormalities of mitochondria. In: Scarlato G, Cerri C (Hrsg) Mitochondrial pathology in muscle diseases. Piccin Medical Books, Padova, S 141\u2013158"},{"key":"2296_CR15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/mus.20319","volume":"32","author":"Schaefer","year":"2005","unstructured":"Schaefer AM, Blakely EL, Griffiths PG et al (2005) Ophthalmoplegia due to mitochondrial DNA disease: the need for genetic diagnosis. Muscle Nerve 32:104\u2013107","journal-title":"Muscle Nerve"},{"key":"2296_CR16","doi-asserted-by":"crossref","unstructured":"Serrano M, Garcia-Silva MT, Martin-Hernandez E et al (2010) Kearns-Sayre syndrome: Cerebral folate deficiency, MRI findings and new cerebrospinal fluid biochemical features. Mitochondrion","DOI":"10.1016\/j.mito.2010.04.001"},{"key":"2296_CR17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.nmd.2003.12.004","volume":"14","author":"Taylor","year":"2004","unstructured":"Taylor RW, Schaefer AM, Barron MJ et al (2004) The diagnosis of mitochondrial muscle disease. Neuromuscul Disord 14:237\u2013245","journal-title":"Neuromuscul Disord"},{"key":"2296_CR18","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1007\/s00347-007-1643-5","volume":"105","author":"Wabbels","year":"2008","unstructured":"Wabbels B, Ali N, Kunz WS et al (2008) Chronic progressive external ophthalmoplegia and Kearns-Sayre syndrome: interdisciplinary diagnosis and therapy; Chronisch-progressive externe Ophthalmoplegie und Kearns-Sayre-Syndrom: Interdisziplin\u00e4re Diagnostik und Therapie. Ophthalmologe 105:550\u2013556","journal-title":"Ophthalmologe"}],"container-title":["Der Ophthalmologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-010-2296-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00347-010-2296-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-010-2296-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T05:00:16Z","timestamp":1592542816000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00347-010-2296-3"}},"subtitle":["Eine mitochondriale Erkrankung (OMIM #530000)","A mitochondrial disease (OMIM #530000)"],"short-title":[],"issued":{"date-parts":[[2010,12,18]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["2296"],"URL":"https:\/\/doi.org\/10.1007\/s00347-010-2296-3","relation":{},"ISSN":["0941-293X","1433-0423"],"issn-type":[{"value":"0941-293X","type":"print"},{"value":"1433-0423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,18]]}}}