{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:02:07Z","timestamp":1778565727837,"version":"3.51.4"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,1,27]],"date-time":"2013-01-27T00:00:00Z","timestamp":1359244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"},{"start":{"date-parts":[[2013,1,27]],"date-time":"2013-01-27T00:00:00Z","timestamp":1359244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologe"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n          <jats:sec>\n            <jats:title>Hintergrund<\/jats:title>\n            <jats:p>Blepharitis als Folge der Dysfunktion der Meibom-Dr\u00fcsen (\u201eMeibom gland dysfunction\u201c, MGD) wird als weltweit h\u00e4ufigste Ursache des trockenen Auges angesehen. Wahrscheinlich ist die MGD auch eine wichtige Ursache der Symptome des trockenen Auges bei Kontaktlinsentr\u00e4gern. Von den Beschwerden und Symptomen des trockenen Auges sind 50\u201375% der Kontaktlinsentr\u00e4ger betroffen. In der hier vorgestellten prospektiven, randomisierten und verblindeten Beobachtungsstudie soll die Wirksamkeit bekannter Therapieoptionen zur Behandlung der MGD bei Kontaktlinsentr\u00e4gern anhand objektiver und subjektiver Methoden verglichen und ihre Wirksamkeit hinsichtlich der Beschwerdelinderung bei Kontaktlinsentr\u00e4gern \u00fcberpr\u00fcft werden.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methoden<\/jats:title>\n            <jats:p>An der Untersuchung nahmen 53\u00a0symptomatische Kontaktlinsentr\u00e4ger teil, die per Los auf die beiden Behandlungsgruppen \u201eLidrandhygiene mit verd\u00fcnntem Babyshampoo\u201c oder \u201eLidrandhygiene mit liposomaler Lidrandreinigungsl\u00f6sung\u201c verteilt wurden. Der Behandlungszeitraum betrug 4\u00a0Wochen.<\/jats:p>\n            <jats:p>Die vergleichenden Untersuchungen zu Studienbeginn und nach 4\u00a0Wochen umfassten die verblindete Bewertung von Spaltlampenfotografien zur Beurteilung der Lidr\u00e4nder, die Bewertung der lidkantenparallelen konjunktivalen Falten (LIPCOF), die Messung der Tr\u00e4nenfilmaufrei\u00dfzeit (NiBUT) und die subjektive Bewertung durch die Studienteilnehmer anhand des standardisierten Ocular-Surface-Disease-Index(OSDI)-Fragebogens.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Ergebnisse<\/jats:title>\n            <jats:p>Von den an der Studie beteiligten 53\u00a0Kontaktlinsentr\u00e4ger wurden 32 (60,4%) mit der Phospholipidl\u00f6sung und 21 (39,6%) mit dem Babyshampoo behandelt. Beide Gruppen zeigten Befund- und Symptomverbesserungen. Die Verbesserungen waren sowohl objektiv als auch subjektiv signifikant st\u00e4rker in der Phospholipidl\u00f6sung- als in der Babyshampoo-Behandlungsgruppe ausgepr\u00e4gt.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Schlussfolgerung<\/jats:title>\n            <jats:p>Die g\u00e4ngige klinische Praxis der zumeist einseitig auf die Substitution der w\u00e4ssrigen Tr\u00e4nenfilmphase abzielenden Therapie wird infrage gestellt. Vielmehr ist f\u00fcr Kontaktlinsentr\u00e4ger mit Siccabeschwerden auf evidenzbasierter Grundlage zu empfehlen, die Restitution der Lipidphase des Tr\u00e4nenfilms in den Vordergrund zu stellen. Im Falle einer assoziierten Blepharitis sollte die g\u00e4ngige klinische Praxis, einfach Babyshampoo f\u00fcr die Lidrandhygiene zu empfehlen, \u00fcberdacht werden, denn die regelm\u00e4\u00dfige Lidrandhygiene mit einer phospholiposomalen Reinigungsl\u00f6sung, hier Blepha Cura, ist therapeutisch am wirksamsten.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00347-012-2725-6","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T12:29:41Z","timestamp":1359116981000},"page":"146-153","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Lidrandhygiene bei Kontaktlinsentr\u00e4gern mit Blepharitis","Eyelid hygiene for contact lens wearers with blepharitis"],"prefix":"10.1007","volume":"110","author":[{"given":"R.","family":"Khaireddin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,1,27]]},"reference":[{"key":"2725_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","volume":"5","author":"Anonymous","year":"2007","unstructured":"Anonymous (2007) The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop. 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