{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:25:05Z","timestamp":1773282305852,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,4,6]],"date-time":"2013-04-06T00:00:00Z","timestamp":1365206400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologe"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1007\/s00347-012-2737-2","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:42:35Z","timestamp":1365082955000},"page":"44-52","source":"Crossref","is-referenced-by-count":48,"title":["Zuverl\u00e4ssigkeit und Sicherheit von intravitrealen Ozurdex-Injektionen","Reliability and safety of intravitreal Ozurdex injections"],"prefix":"10.1007","volume":"111","author":[{"name":"German Retinal Vein Occlusion Group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.R.","family":"Clemens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"H\u00f6hn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wachtlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bertelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"R\u00fcdiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Horn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bezatis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Spital","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.H.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,4,6]]},"reference":[{"key":"2737_CR1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ophtha.2009.07.017","volume":"117","author":"Rogers","year":"2010","unstructured":"Rogers S, McIntosh RL, Cheung N et al (2010) The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology 117:313\u2013319","journal-title":"Ophthalmology"},{"key":"2737_CR2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/archopht.126.4.513","volume":"126","author":"Klein","year":"2008","unstructured":"Klein R, Moss SE, Meuer SM, Klein BE (2008) The 15-year cumulative incidence of retinal vein occlusion: the Beaver Dam Eye Study. Arch Ophthalmol 126:513\u2013518","journal-title":"Arch Ophthalmol"},{"key":"2737_CR3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1755-3768.2009.01578.x","volume":"88","author":"Ritch","year":"2010","unstructured":"Ritch R, Prata TS, Moraes CG de et al (2010) Association of exfoliation syndrome and central retinal vein occlusion: an ultrastructural analysis. Acta Ophthalmol 88:91\u201395","journal-title":"Acta Ophthalmol"},{"key":"2737_CR4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1755-3768.2011.02292.x","volume":"90","author":"Koss","year":"2012","unstructured":"Koss MJ, Pfister M, Rothweiler F et al (2012) Comparison of cytokine levels from undiluted vitreous of untreated patients with retinal vein occlusion. Acta Ophthalmol 90:98\u2013103","journal-title":"Acta Ophthalmol"},{"key":"2737_CR5","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1097\/IAE.0b013e3181d37539","volume":"30","author":"Stahl","year":"2010","unstructured":"Stahl A, Buchwald A, Martin G et al (2010) Vitreal levels of erythropoietin are increased in patients with retinal vein occlusion and correlate with vitreal VEGF and the extent of macular edema. Retina 30:1524\u20131529","journal-title":"Retina"},{"key":"2737_CR6","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1055\/s-0029-1245606","volume":"227","author":"Feltgen","year":"2010","unstructured":"Feltgen N, Pielen A, Hansen L et al (2010) Intravitreal drug therapy for retinal vein occlusion \u2013pathophysiological mechanisms and routinely used drugs. Klin Monatsbl Augenheilkd 227:681\u2013693","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"2737_CR7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1055\/s-0031-1281712","volume":"228","author":"Lang","year":"2011","unstructured":"Lang GE (2011) New developments in the pharmacological treatment of macular oedema due to retinal vein occlusion. Klin Monatsbl Augenheilkd 228:793\u2013800","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"2737_CR8","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.ophtha.2010.02.022","volume":"117","author":"Brown","year":"2010","unstructured":"Brown DM, Campochiaro PA, Singh RP et al (2010) Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study. Ophthalmology 117:1124\u20131133","journal-title":"Ophthalmology"},{"key":"2737_CR9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00417-010-1470-2","volume":"249","author":"Jaissle","year":"2010","unstructured":"Jaissle GB, Szurman P, Feltgen N et al (2010) Predictive factors for functional improvement after intravitreal bevacizumab therapy for macular edema due to branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 249:183\u2013192","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2737_CR10","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.ophtha.2010.02.021","volume":"117","author":"Campochiaro","year":"2010","unstructured":"Campochiaro PA, Heier JS, Feiner L et al (2010) Ranibizumab for macular edema following branch retinal vein occlusion: six-month primary end point results of a phase III study. Ophthalmology 117:1102\u20131112","journal-title":"Ophthalmology"},{"key":"2737_CR11","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.ophtha.2010.03.032","volume":"117","author":"Haller","year":"2010","unstructured":"Haller JA, Bandello F, Belfort R Jr et al (2010) Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology 117:1134\u20131146","journal-title":"Ophthalmology"},{"key":"2737_CR12","first-page":"417","volume":"32","author":"Bezatis","year":"2011","unstructured":"Bezatis T, Meyer CH (2011) Erste Ergebnisse nach Ozurdex-Injektionen bei retinalen Gef\u00e4ssverschl\u00fcssen. Z Prakt Augenheilkd 32:417\u2013422","journal-title":"Z Prakt Augenheilkd"},{"key":"2737_CR13","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1755-3768.2011.02238.x","volume":"90","author":"Parodi","year":"2012","unstructured":"Parodi MB, Iacono P, Cascavilla M et al (2012) Compassionate use of dexamethasone implant for the treatment of macular edema secondary to central retinal vein occlusion in a clinical setting. Acta Ophthalmol 90:322\u2013323","journal-title":"Acta Ophthalmol"},{"key":"2737_CR14","doi-asserted-by":"crossref","unstructured":"Bezatis A, Spital G, H\u00f6hn F et al (2013) Functional and anatomical results after a single intravitreal Ozurdex injection in retinal vein occlusion: a 6-months follow-up study. The SOLO-Study. Acta Ophthalmol (angenommen)","DOI":"10.1111\/aos.12020"},{"key":"2737_CR15","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1055\/s-0029-1245534","volume":"227","author":"German","year":"2010","unstructured":"German Ophthalmological Society; Retinological Society; Professional Association of German Ophthalmologists (2010) Statement of the German Ophthalmological Society, the Retinological Society and the Professional Association of German Ophthalmologists on therapy for macular oedema in cases of retinal vein occlusion. Klin Monatsbl Augenheilkd 227:542\u2013556","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"2737_CR16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1089\/jop.2010.0082","volume":"27","author":"Rodrigues","year":"2011","unstructured":"Rodrigues EB, Grumann A, Penha FM et al (2011) Effect of needle type and injection technique on pain level and vitreal reflux in intravitreal injection. J Ocul Pharmacol Ther 27:197\u2013203","journal-title":"J Ocul Pharmacol Ther"},{"key":"2737_CR17","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1097\/IAE.0b013e31825699e5","volume":"32","author":"Meyer","year":"2012","unstructured":"Meyer CH, Klein A, Alten F et al (2012) Release and velocity of micronized dexamethasone intravitreal implants with an intravitreal drug delivery system \u2013 kinematic analysis with a high-speed camera. Retina 32:2133\u20132140","journal-title":"Retina"},{"key":"2737_CR18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00347-010-2290-9","volume":"108","author":"Mirshahi","year":"2011","unstructured":"Mirshahi A, Lorenz K, Kramann C et al (2011) Ophthalmologic diagnostic procedures and imaging of retinal vein occlusions. Ophthalmologe 108:111\u2013116","journal-title":"Ophthalmologe"},{"key":"2737_CR19","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1755-3768.2009.01602.x","volume":"88","author":"Helb","year":"2010","unstructured":"Helb HM, Charbel Issa P, Fleckenstein M et al (2010) Clinical evaluation of simultaneous confocal scanning laser ophthalmoscopy imaging combined with high-resolution, spectral-domain optical coherence tomography. Acta Ophthalmol 88:842\u2013849","journal-title":"Acta Ophthalmol"},{"key":"2737_CR20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00417-009-1167-6","volume":"248","author":"Ach","year":"2010","unstructured":"Ach T, Hoeh AE, Schaal KB et al (2010) Predictive factors for changes in macular edema in intravitreal bevacizumab therapy of retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 248:155\u2013159","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2737_CR21","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1001\/archopht.123.8.1075","volume":"123","author":"Westfall","year":"2005","unstructured":"Westfall AC, Osborn A, Kuhl D et al (2005) Acute endophthalmitis incidence: intravitreal triamcinolone. Arch Ophthalmol 123:1075\u20131077","journal-title":"Arch Ophthalmol"},{"key":"2737_CR22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ajo.2011.11.035","volume":"153","author":"Goldberg","year":"2012","unstructured":"Goldberg RA, Flynn HW Jr, Isom RF et al (2012) An outbreak of streptococcus endophthalmitis after intravitreal injection of bevacizumab. Am J Ophthalmol 153:204\u2013208","journal-title":"Am J Ophthalmol"},{"key":"2737_CR23","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/IAE.0b013e3181baf691","volume":"30","author":"Ness","year":"2010","unstructured":"Ness T, Feltgen N, Agostini H et al (2010) Toxic vitreitis outbreak after intravitreal injection. Retina 30:332\u2013338","journal-title":"Retina"},{"key":"2737_CR24","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/IAE.0b013e31821067c4","volume":"31","author":"Moshfeghi","year":"2011","unstructured":"Moshfeghi AA, Rosenfeld PJ, Flynn HW Jr et al (2011) Endophthalmitis after intravitreal anti-vascular endothelial growth factor antagonists: a six-year experience at a university referral center. Retina 31:662\u2013668","journal-title":"Retina"},{"key":"2737_CR25","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1007\/s00347-007-1634-6","volume":"104","author":"Mennel","year":"2007","unstructured":"Mennel S, Meyer CH, Eter N (2007) Incidence of endophthalmitis after intravitreal Avastin injection with and without postoperative topical antibiotic application. Ophthalmologe 104:952\u2013957","journal-title":"Ophthalmologe"},{"key":"2737_CR26","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1097\/IAE.0b013e31820f4b4f","volume":"31","author":"Bhatt","year":"2011","unstructured":"Bhatt SS, Stepien KE, Joshi K (2011) Prophylactic antibiotic use after intravitreal injection: effect on endophthalmitis rate. Retina 31:2032\u20132036","journal-title":"Retina"},{"key":"2737_CR27","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.ophtha.2012.02.014","volume":"119","author":"Cheung","year":"2012","unstructured":"Cheung CS, Wong AW, Lui A et al (2012) Incidence of endophthalmitis and use of antibiotic prophylaxis after intravitreal injections. Ophthalmology 119(8):1609\u20131614","journal-title":"Ophthalmology"},{"key":"2737_CR28","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1089\/jop.2010.0045","volume":"26","author":"Meyer","year":"2010","unstructured":"Meyer CH, Rodrigues EB, Michels S et al (2010) Incidence of damage to the crystalline lens during intravitreal injections. J Ocul Pharmacol Ther 26:491\u2013495","journal-title":"J Ocul Pharmacol Ther"},{"key":"2737_CR29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1755-3768.2010.02064.x","volume":"89","author":"Meyer","year":"2011","unstructured":"Meyer CH, Michels S, Rodrigues EB, Hager A et al (2011) Incidence of rhegmatogenous retinal detachments after intravitreal antivascular endothelial factor injections. Acta Ophthalmol 89:70\u201375","journal-title":"Acta Ophthalmol"},{"key":"2737_CR30","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s00347-012-2650-8","volume":"109","author":"Koller","year":"2012","unstructured":"Koller S, Neuhann T, Neuhann I (2012) Auff\u00e4lliger Linsenfremdk\u00f6rper nach intravitrealer Injektion \u2013 In die nat\u00fcrliche Augenlinse fehlimplantiertes Ozurdex\u00ae-Pellet. Ophthalmologe 109:1119\u20131121","journal-title":"Ophthalmologe"},{"key":"2737_CR31","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ophtha.2008.10.002","volume":"116","author":"Roth","year":"2009","unstructured":"Roth DB, Verma V, Realini T et al (2009) Long-term incidence and timing of intraocular hypertension after intravitreal triamcinolone acetonide injection. Ophthalmology 116:455\u2013460","journal-title":"Ophthalmology"},{"key":"2737_CR32","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ajo.2008.05.034","volume":"146","author":"Lau","year":"2008","unstructured":"Lau LI, Chen KC, Lee FL et al (2008) Intraocular pressure elevation after intravitreal triamcinolone acetonide injection in a Chinese population. Am J Ophthalmol 146:573\u2013578","journal-title":"Am J Ophthalmol"},{"key":"2737_CR33","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s00417-008-0819-2","volume":"246","author":"Bakri","year":"2008","unstructured":"Bakri SJ, McCannel CA, Edwards AO, Moshfeghi DM (2008) Persisent ocular hypertension following intravitreal ranibizumab. Graefes Arch Clin Exp Ophthalmol 246:955\u2013958","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2737_CR34","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1097\/IAE.0b013e318217ffde","volume":"31","author":"Choi","year":"2011","unstructured":"Choi DY, Ortube MC, McCannel CA et al (2011) Sustained elevated intraocular pressures after intravitreal injection of bevacizumab, ranibizumab, and pegaptanib. Retina 31:1028\u20131035","journal-title":"Retina"},{"key":"2737_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12348-011-0042-x","volume":"2","author":"Bansal","year":"2012","unstructured":"Bansal R, Bansal P, Kulkarni P et al (2012) Wandering Ozurdex(\u00ae) implant. J Ophthalmic Inflamm Infect 2:1\u20135","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"2737_CR36","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1007\/s00417-011-1802-x","volume":"250","author":"Pardo-L\u00f3pez","year":"2012","unstructured":"Pardo-L\u00f3pez D, Franc\u00e9s-Mu\u00f1oz E, Gallego-Pinazo R, D\u00edaz-Llopis M (2012) Anterior chamber migration of dexametasone intravitreal implant (Ozurdex\u00ae). Graefes Arch Clin Exp Ophthalmol 250:1704\u201304","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2737_CR37","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1089\/jop.2011.0184","volume":"28","author":"Bakri","year":"2012","unstructured":"Bakri SJ, Omar AF (2012) Evolution of vitreomacular traction following the use of the dexamethasone intravitreal implant (Ozurdex) in the treatment of macular edema secondary to central retinal vein occlusion. J Ocul Pharmacol Ther 28:547\u2013549","journal-title":"J Ocul Pharmacol Ther"},{"key":"2737_CR38","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1755-3768.2010.02101.x","volume":"89","author":"Bertelmann","year":"2011","unstructured":"Bertelmann T, Ki\u010dov\u00e1 N, Messerschmidt-Roth A et al (2011) The vitreomacular interface in retinal vein occlusion. Acta Ophthalmol 89:327\u2013331","journal-title":"Acta Ophthalmol"},{"key":"2737_CR39","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1159\/000313304","volume":"224","author":"Guthoff","year":"2010","unstructured":"Guthoff R, Meigen T, Hennemann K, Schrader W (2010) Comparison of bevacizumab and triamcinolone for treatment of macular edema secondary to branch retinal vein occlusion in a pair-matched analysis. Ophthalmologica 224:319\u2013324","journal-title":"Ophthalmologica"},{"key":"2737_CR40","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1097\/IAE.0b013e318217373c","volume":"31","author":"Meyer","year":"2011","unstructured":"Meyer CH, Krohne TU, Holz FG (2011) Intraocular pharmacokinetics after a single intravitreal injection of 1.5\u00a0mg versus 3.0\u00a0mg of bevacizumab in humans. Retina 31:1877\u20131884","journal-title":"Retina"},{"key":"2737_CR41","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ajo.2012.03.047","volume":"154","author":"Krohne","year":"2012","unstructured":"Krohne TU, Liu Z, Holz FG, Meyer CH (2012) Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans. Am J Ophthalmol 154:682\u2013686","journal-title":"Am J Ophthalmol"},{"key":"2737_CR42","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00006982-200605000-00005","volume":"26","author":"Kim","year":"2006","unstructured":"Kim H, Csaky KG, Gravlin L et al (2006) Safety and pharmacokinetics of a preservative-free triamcinolone acetonide formulation for intravitreal administration. Retina 26:523\u2013530","journal-title":"Retina"},{"key":"2737_CR43","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.ophtha.2008.01.019","volume":"115","author":"Kamppeter","year":"2008","unstructured":"Kamppeter BA, Cej A, Jonas JB (2008) Intraocular concentration of triamcinolone acetonide after intravitreal injection in the rabbit eye. Ophthalmology 115:1372\u20131375","journal-title":"Ophthalmology"},{"key":"2737_CR44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1167\/iovs.10-5285","volume":"52","author":"Chang-Lin","year":"2011","unstructured":"Chang-Lin JE, Attar M, Acheampong AA et al (2011) Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant. Invest Ophthalmol Vis Sci 52:80\u201386","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Der Ophthalmologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-012-2737-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00347-012-2737-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-012-2737-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T20:45:29Z","timestamp":1562877929000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00347-012-2737-2"}},"subtitle":["Die ZERO-Studie","The ZERO study"],"short-title":[],"issued":{"date-parts":[[2013,4,6]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["2737"],"URL":"https:\/\/doi.org\/10.1007\/s00347-012-2737-2","relation":{},"ISSN":["0941-293X","1433-0423"],"issn-type":[{"value":"0941-293X","type":"print"},{"value":"1433-0423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,6]]}}}