{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:13:49Z","timestamp":1772781229597,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologe"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1007\/s00347-013-2988-6","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T15:11:17Z","timestamp":1407942677000},"page":"715-721","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multiple Sklerose","Multiple sclerosis"],"prefix":"10.1007","volume":"111","author":[{"given":"S.","family":"Beer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kesselring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,8,15]]},"reference":[{"key":"2988_CR1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/1352458512458605","volume":"19","author":"Bansi","year":"2013","unstructured":"Bansi J, Bloch W, Gamper U et al (2013) Training in MS: influence of two different endurance training protocols (aquatic versus overland) on cytokine and neurotrophin concentrations during three week randomized controlled trial. Mult Scler 19:613\u2013621","journal-title":"Mult Scler"},{"key":"2988_CR2","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1212\/WNL.57.5.892","volume":"57","author":"Beenakker","year":"2001","unstructured":"Beenakker EA, Oparina TI, Hartgring A et al (2001) Cooling garment treatment in MS: clinical improvement and decrease in leukocyte NO production. Neurology 57:892\u2013894","journal-title":"Neurology"},{"key":"2988_CR3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/1352458507082358","volume":"14","author":"Beer","year":"2008","unstructured":"Beer S, Aschbacher B, Manoglou D et al (2008) Robot-assisted gait training in multiple sclerosis: a pilot randomized trial. Mult Scler 14:231\u2013236","journal-title":"Mult Scler"},{"key":"2988_CR4","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1007\/s00415-012-6577-4","volume":"259","author":"Beer","year":"2012","unstructured":"Beer S, Khan F, Kesselring J (2012) Rehabilitation interventions in multiple sclerosis: an overview. J Neurol 259:1994\u20132008","journal-title":"J Neurol"},{"key":"2988_CR5","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1177\/1352458513507358","volume":"20","author":"Briken","year":"2014","unstructured":"Briken S, Gold S, Patra S et al (2014) Effects of exercise on fitness and cognition in progressive MS: a randomized, controlled pilot trial. Mult Scler 20:382\u2013390","journal-title":"Mult Scler"},{"key":"2988_CR6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12160-010-9236-y","volume":"41","author":"Cosio","year":"2011","unstructured":"Cosio D, Jin L, Siddique J et al (2011) The effect of telephone-administered cognitive-behavioral therapy on quality of life among patients with multiple sclerosis. Ann Behav Med 41:227\u2013234","journal-title":"Ann Behav Med"},{"key":"2988_CR7","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1212\/WNL.0b013e3181bf98b4","volume":"73","author":"Dalgas","year":"2009","unstructured":"Dalgas U, Stenager E, Jakobsen J et al (2009) Resistance training improves muscle strength and functional capacity in multiple sclerosis. Neurology 73:1478\u20131484","journal-title":"Neurology"},{"key":"2988_CR8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1212\/WNL.52.1.50","volume":"52","author":"Freeman","year":"1999","unstructured":"Freeman JA, Langdon DW, Hobart JC et al (1999) Inpatient rehabilitation in multiple sclerosis: do the benefits carry over into the community? Neurology 52:50\u201356","journal-title":"Neurology"},{"key":"2988_CR9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1586\/14737175.6.3.347","volume":"6","author":"Heesen","year":"2006","unstructured":"Heesen C, Romberg A, Gold S et al (2006) Physical exercise in multiple sclerosis: supportive care or a putative disease-modifying treatment. Expert Rev Neur 6:347\u2013355","journal-title":"Expert Rev Neur"},{"key":"2988_CR10","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1212\/WNL.0b013e3182050225","volume":"76","author":"Hurwitz","year":"2011","unstructured":"Hurwitz BJ (2011) Registry studies of long-term multiple sclerosis outcomes: description of key registries. Neurology 76:S3\u2013S6","journal-title":"Neurology"},{"key":"2988_CR11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.17925\/ENR.2010.05.01.56","volume":"5","author":"Kesselring","year":"2010","unstructured":"Kesselring J (2010) Disease progression in multiple sclerosis. I. Impaired mobility and its impact on limitations of activities and social participation. Eur Neurol Rev 5:56\u201360","journal-title":"Eur Neurol Rev"},{"key":"2988_CR12","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1474-4422(05)70193-9","volume":"4","author":"Kesselring","year":"2005","unstructured":"Kesselring J, Beer S (2005) Symptomatic therapy and neurorehabilitation in multiple sclerosis. Lancet Neurol 4:643\u2013652","journal-title":"Lancet Neurol"},{"key":"2988_CR13","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1136\/jnnp.2007.133777","volume":"79","author":"Khan","year":"2008","unstructured":"Khan F, Pallant JF, Brand C et al (2008) Effectiveness of rehabilitation intervention in persons with multiple sclerosis: a randomised controlled trial. J Neurol Neurosurg Psychiatry 79:1230\u20131235","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2988_CR14","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1136\/jnnp.2010.206623","volume":"81","author":"Khan","year":"2010","unstructured":"Khan F, Pallant JF, Pallant JI et al (2010) A randomised controlled trial: outcomes of bladder rehabilitation in persons with multiple sclerosis. J Neurol Neurosurg Psychiatry 81:1033\u20131038","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2988_CR15","unstructured":"Khan F, Turner-Stokes L, Ng L et al (2011) Multidisciplinary rehabilitation for adults with multiple sclerosis. Cochrane Database Syst Rev CD006036"},{"key":"2988_CR16","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/jnnp.2006.090365","volume":"77","author":"Kobelt","year":"2006","unstructured":"Kobelt G, Berg J, Lindgren P et al (2006) Costs and quality of life of patients with multiple sclerosis in Europe. J Neurol Neurosurg Psychiatry 77:918\u2013926","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2988_CR17","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S1474-4422(10)70064-8","volume":"9","author":"Koch-Henriksen","year":"2010","unstructured":"Koch-Henriksen N, Sorensen PS (2010) The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurol 9:520\u2013532","journal-title":"Lancet Neurol"},{"key":"2988_CR18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/1545968306298934","volume":"22","author":"Kos","year":"2008","unstructured":"Kos D, Kerckhofs E, Nagels G et al (2008) Origin of fatigue in multiple sclerosis: review of the literature. Neurorehabil Neural Repair 22:91\u2013100","journal-title":"Neurorehabil Neural Repair"},{"key":"2988_CR19","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","volume":"13","author":"Kurtzke","year":"1983","unstructured":"Kurtzke JF (1983) Rating neurological impairment in multiple sclerosis: an expanded disability rating scale (EDSS). Neurology 13:1444\u20131452","journal-title":"Neurology"},{"key":"2988_CR20","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/jnnp-2012-303291","volume":"84","author":"La","year":"2013","unstructured":"La Mantia L, Vacchi L, Rovaris M et al (2013) Interferon beta for secondary progressive multiple sclerosis: a systematic review. J Neurol Neurosurg Psychiatry 84:420\u2013426","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2988_CR21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1750-3639.2007.00064.x","volume":"17","author":"Lassmann","year":"2007","unstructured":"Lassmann H, Bruck W, Lucchinetti CF (2007) The immunopathology of multiple sclerosis: an overview. Brain Pathol 17:210\u2013218","journal-title":"Brain Pathol"},{"key":"2988_CR22","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1007\/s00415-003-0187-0","volume":"250","author":"Liu","year":"2003","unstructured":"Liu C, Playford ED, Thompson AJ (2003) Does neurorehabilitation have a role in relapsing-remitting multiple sclerosis? J Neurol 250:1214\u20131218","journal-title":"J Neurol"},{"key":"2988_CR23","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1177\/1352458506070648","volume":"13","author":"Meyer-Heim","year":"2007","unstructured":"Meyer-Heim A, Rothmaier M, Weder M et al (2007) Advanced lightweight cooling-garment technology: functional improvements in thermosensitive patients with multiple sclerosis. Mult Scler 13:232\u2013237","journal-title":"Mult Scler"},{"key":"2988_CR24","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1474-4422(07)70243-0","volume":"6","author":"Miller","year":"2007","unstructured":"Miller DH, Leary SM (2007) Primary-progressive multiple sclerosis. Lancet Neurol 6:903\u2013912","journal-title":"Lancet Neurol"},{"key":"2988_CR25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/1352458506071169","volume":"13","author":"Newman","year":"2007","unstructured":"Newman MA, Dawes H, Van Den Berg M et al (2007) Can aerobic treadmill training reduce the effort of walking and fatigue in people with multiple sclerosis: a pilot study. Mult Scler 13:113\u2013119","journal-title":"Mult Scler"},{"key":"2988_CR26","doi-asserted-by":"crossref","first-page":"II53","DOI":"10.1007\/s00415-007-2013-6","volume":"254","author":"Penner","year":"2007","unstructured":"Penner IK, Opwis K, Kappos L (2007) Relation between functional brain imaging, cognitive impairment and cognitive rehabilitation in patients with multiple sclerosis. J Neurol 254(Suppl 2):II53\u2013II57","journal-title":"J Neurol"},{"key":"2988_CR27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/1352458509352196","volume":"16","author":"Pfleger","year":"2010","unstructured":"Pfleger CC, Flachs EM, Koch-Henriksen N (2010) Social consequences of multiple sclerosis (1): early pension and temporary unemployment \u2013 a historical prospective cohort study. Mult Scler 16:121\u2013126","journal-title":"Mult Scler"},{"key":"2988_CR28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/practneurol-2013-000601","volume":"14","author":"Rice","year":"2014","unstructured":"Rice CM (2014) Disease modification in multiple sclerosis: an update. Pract Neurol 14:6\u201313","journal-title":"Pract Neurol"},{"key":"2988_CR29","unstructured":"Rietberg MB, Brooks D, Uitdehaag BM et al (2011) Exercise therapy for multiple sclerosis. Cochrane Database Syst Rev CD003980"},{"key":"2988_CR30","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/ana.10120","volume":"51","author":"Rocca","year":"2002","unstructured":"Rocca MA, Falini A, Colombo B et al (2002) Adaptive functional changes in the cerebral cortex of patients with nondisabling multiple sclerosis correlate with the extent of brain structural damage. Ann Neurol 51:330\u2013339","journal-title":"Ann Neurol"},{"key":"2988_CR31","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s00415-010-5821-z","volume":"258","author":"Sacco","year":"2011","unstructured":"Sacco R, Bussman R, Oesch P et al (2011) Assessment of gait parameters and fatigue in MS patients during inpatient rehabilitation: a pilot trial. J Neurol 258:889\u2013894","journal-title":"J Neurol"},{"key":"2988_CR32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1191\/1352458505ms1190oa","volume":"11","author":"Sloka","year":"2005","unstructured":"Sloka JS, Stefanelli M (2005) The mechanism of action of methylprednisolone in the treatment of multiple sclerosis. Mult Scler 11:425\u2013432","journal-title":"Mult Scler"},{"key":"2988_CR33","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00415-008-0818-6","volume":"255","author":"Thickbroom","year":"2008","unstructured":"Thickbroom GW, Sacco P, Faulkner DL et al (2008) Enhanced corticomotor excitability with dynamic fatiguing exercise of the lower limb in multiple sclerosis. J Neurol 255:1001\u20131005","journal-title":"J Neurol"},{"key":"2988_CR34","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S1474-4422(10)70249-0","volume":"9","author":"Thompson","year":"2010","unstructured":"Thompson AJ, Toosy AT, Ciccarelli O (2010) Pharmacological management of symptoms in multiple sclerosis: current approaches and future directions. Lancet Neurol 9:1182\u20131199","journal-title":"Lancet Neurol"},{"key":"2988_CR35","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1177\/1352458507084264","volume":"14","author":"Tremlett","year":"2008","unstructured":"Tremlett H, Yinshan Z, Devonshire V (2008) Natural history of secondary-progressive multiple sclerosis. Mult Scler 14:314\u2013324","journal-title":"Mult Scler"},{"key":"2988_CR36","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1212\/WNL.0b013e3181e3973f","volume":"74","author":"Tremlett","year":"2010","unstructured":"Tremlett H, Zhao Y, Rieckmann P et al (2010) New perspectives in the natural history of multiple sclerosis. Neurology 74:2004\u20132015","journal-title":"Neurology"},{"key":"2988_CR37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1477-7525-8-55","volume":"8","author":"Twork","year":"2010","unstructured":"Twork S, Wiesmeth S, Spindler M et al (2010) Disability status and quality of life in multiple sclerosis: non-linearity of the Expanded Disability Status Scale (EDSS). Health Qual Life Outcomes 8:55","journal-title":"Health Qual Life Outcomes"},{"key":"2988_CR38","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1177\/135245850000600307","volume":"6","author":"White","year":"2000","unstructured":"White AT, Wilson TE, Davis SL et al (2000) Effect of precooling on physical performance in multiple sclerosis. Mult Scler 6:176\u2013180","journal-title":"Mult Scler"},{"key":"2988_CR39","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/jnnp.70.2.174","volume":"70","author":"Wiles","year":"2001","unstructured":"Wiles CM, Newcombe RG, Fuller KJ et al (2001) Controlled randomised crossover trial of the effects of physiotherapy on mobility in chronic multiple sclerosis. J Neurol Neurosurg Psychiatry 70:174\u2013179","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Der Ophthalmologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-013-2988-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00347-013-2988-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-013-2988-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T13:51:54Z","timestamp":1559051514000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00347-013-2988-6"}},"subtitle":["Rehabilitation und Langzeitverlauf","Rehabilitation and long-term course"],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["2988"],"URL":"https:\/\/doi.org\/10.1007\/s00347-013-2988-6","relation":{},"ISSN":["0941-293X","1433-0423"],"issn-type":[{"value":"0941-293X","type":"print"},{"value":"1433-0423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}