{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:32:03Z","timestamp":1770741123311,"version":"3.49.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T00:00:00Z","timestamp":1481587200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologe"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s00347-016-0415-5","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T04:16:40Z","timestamp":1481602600000},"page":"922-929","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transkorneale Elektrostimulation bei prim\u00e4rem Offenwinkelglaukom","Transcorneal electrical stimulation in primary open angle glaucoma"],"prefix":"10.1007","volume":"114","author":[{"given":"T.","family":"R\u00f6ck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Naycheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Willmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Zrenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. U.","family":"Bartz-Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Gekeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schatz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,12,13]]},"reference":[{"key":"415_CR1","first-page":"1649","volume":"28","author":"C Belmonte","year":"1987","unstructured":"Belmonte C, Bartels SP, Liu JH et\u00a0al (1987) Effects of stimulation of the ocular sympathetic nerves on IOP and aqueous humor flow. Invest Ophthalmol Vis Sci 28:1649\u20131654","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"415_CR2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7326\/0003-4819-158-4-201302190-00008","volume":"158","author":"MV Boland","year":"2013","unstructured":"Boland MV, Ervin AM, Friedman DS et al (2013) Comparative effectiveness of treatments for open-angle glaucoma: a\u00a0systematic review for the U.S. Preventive Services Task Force. Ann Intern Med 158:271\u2013279","journal-title":"Ann. Intern. Med."},{"key":"415_CR3","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1001\/archopht.122.4.460","volume":"122","author":"AY Chow","year":"2004","unstructured":"Chow AY, Chow VY, Packo KH et\u00a0al (2004) The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa. Arch Ophthalmol 122:460\u2013469","journal-title":"Arch. Ophthalmol."},{"key":"415_CR4","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1167\/iovs.08-2072","volume":"50","author":"VT Ciavatta","year":"2009","unstructured":"Ciavatta VT, Kim M, Wong P et\u00a0al (2009) Retinal expression of Fgf2 in RCS rats with subretinal microphotodiode array. Invest Ophthalmol Vis Sci 50:4523\u20134530","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"415_CR5","first-page":"988","volume":"18","author":"WW Dawson","year":"1979","unstructured":"Dawson WW, Trick GL, Litzkow CA (1979) Improved electrode for electroretinography. Invest Ophthalmol Vis Sci 18:988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1113\/jphysiol.1974.sp010766","volume":"243","author":"WH Dobelle","year":"1974","unstructured":"Dobelle WH, Mladejovsky MG (1974) Phosphenes produced by electrical stimulation of human occipital cortex, and their application to the development of a\u00a0prosthesis for the blind. J\u00a0Physiol 243:553\u2013576","journal-title":"J Physiol"},{"key":"415_CR7","first-page":"352","volume":"19","author":"H Dor","year":"1873","unstructured":"Dor H (1873) Beitr\u00e4ge zur Electrotherapie der Augenkrankheiten. Graefes Arch Clin Exp Ophthalmol 19:352","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"415_CR8","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s10384-005-0304-y","volume":"50","author":"T Fujikado","year":"2006","unstructured":"Fujikado T, Morimoto T, Matsushita K et\u00a0al (2006) Effect of transcorneal electrical stimulation in patients with nonarteritic ischemic optic neuropathy or traumatic optic neuropathy. Jpn J Ophthalmol 50:266\u2013273","journal-title":"Jpn J Ophthalmol"},{"key":"415_CR9","doi-asserted-by":"crossref","first-page":"e0156134","DOI":"10.1371\/journal.pone.0156134","volume":"11","author":"C Gall","year":"2016","unstructured":"Gall C, Schmidt S, Schittkowski MP et\u00a0al (2016) Alternating current stimulation for vision restoration after optic nerve damage: A\u00a0randomized clinical trial. PLOS ONE 11:e0156134","journal-title":"PLOS ONE"},{"key":"415_CR10","first-page":"596","volume":"34","author":"J Gallar","year":"1993","unstructured":"Gallar J, Liu JH (1993) Stimulation of the cervical sympathetic nerves increases intraocular pressure. Invest Ophthalmol Vis Sci 34:596\u2013605","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR11","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1167\/iovs.06-0459","volume":"47","author":"F Gekeler","year":"2006","unstructured":"Gekeler F, Messias A, Ottinger M et\u00a0al (2006) Phosphenes electrically evoked with DTL electrodes: a\u00a0study in patients with retinitis pigmentosa, glaucoma, and homonymous visual field loss and normal subjects. Invest Ophthalmol Vis Sci 47:4966\u20134974","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/bjo.41.9.513","volume":"41","author":"J Gloster","year":"1957","unstructured":"Gloster J, Greaves DP (1957) Effect of diencephalic stimulation upon intra-ocular pressure. Br J Ophthalmol 41:513\u2013532","journal-title":"Br J Ophthalmol"},{"key":"415_CR13","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","volume":"120","author":"A Heijl","year":"2002","unstructured":"Heijl A, Leske MC, Bengtsson B et\u00a0al (2002) Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol 120:1268\u20131279","journal-title":"Arch Ophthalmol"},{"key":"415_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2013.03.013","volume":"543","author":"P Henrich-Noack","year":"2013","unstructured":"Henrich-Noack P, Voigt N, Prilloff S et al (2013) Transcorneal electrical stimulation alters morphology and survival of retinal ganglion cells after optic nerve damage. Neurosci Lett 543:1\u20136","journal-title":"Neurosci Lett"},{"key":"415_CR15","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1007\/s00417-007-0610-9","volume":"245","author":"K Inomata","year":"2007","unstructured":"Inomata K, Shinoda K, Ohde H et\u00a0al (2007) Transcorneal electrical stimulation of retina to treat longstanding retinal artery occlusion. Graefes Arch Clin Exp Ophthalmol 245:1773\u20131780","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"415_CR16","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archopht.120.6.701","volume":"120","author":"MA Kass","year":"2002","unstructured":"Kass MA, Heuer DK, Higginbotham EJ et al (2002) The Ocular Hypertension Treatment Study: a\u00a0randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol 120:701\u2013713","journal-title":"Arch Ophthalmol"},{"key":"415_CR17","first-page":"5","volume":"110","author":"B Kumar","year":"1994","unstructured":"Kumar B, Nesterov AP (1994) The effect of noninvasive electrostimulation of the optic nerve and retina on visual functions in patients with primary open-angle glaucoma. Vestn Oftalmol 110:5\u20137","journal-title":"Vestn Oftalmol"},{"key":"415_CR18","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.2147\/OPTH.S14573","volume":"4","author":"T Kurimoto","year":"2010","unstructured":"Kurimoto T, Oono S, Oku H et\u00a0al (2010) Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects. Clin Ophthalmol 4:1441\u20131446","journal-title":"Clin Ophthalmol"},{"key":"415_CR19","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1167\/iovs.06-1329","volume":"48","author":"K Miyake","year":"2007","unstructured":"Miyake K, Yoshida M, Inoue Y et\u00a0al (2007) Neuroprotective effect of transcorneal electrical stimulation on the acute phase of optic nerve injury. Invest Ophthalmol Vis Sci 48:2356\u20132361","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR20","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1167\/iovs.06-1404","volume":"48","author":"T Morimoto","year":"2007","unstructured":"Morimoto T, Fujikado T, Choi JS et\u00a0al (2007) Transcorneal electrical stimulation promotes the survival of photoreceptors and preserves retinal function in royal college of surgeons rats. Invest Ophthalmol Vis Sci 48:4725\u20134732","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR21","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1167\/iovs.04-1339","volume":"46","author":"T Morimoto","year":"2005","unstructured":"Morimoto T, Miyoshi T, Matsuda S et al (2005) Transcorneal electrical stimulation rescues axotomized retinal ganglion cells by activating endogenous retinal IGF-1 system. Invest Ophthalmol Vis Sci 46:2147\u20132155","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1620\/tjem.195.219","volume":"195","author":"A Naito","year":"2001","unstructured":"Naito A, Izumi H, Karita K et al (2001) Effects of a\u00a0beta-adrenergic blocking agent timolol on intra ocular pressure responses induced by stimulation of cervical sympathetic nerve in the cat. Tohoku J Exp Med 195:219\u2013225","journal-title":"Tohoku J. Exp. Med."},{"key":"415_CR23","doi-asserted-by":"crossref","first-page":"7440","DOI":"10.1167\/iovs.12-9612","volume":"53","author":"L Naycheva","year":"2012","unstructured":"Naycheva L, Schatz A, Rock T et\u00a0al (2012) Phosphene thresholds elicited by transcorneal electrical stimulation in healthy subjects and patients with retinal diseases. Invest Ophthalmol Vis Sci 53:7440\u20137448","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s40123-013-0012-5","volume":"2","author":"L Naycheva","year":"2013","unstructured":"Naycheva L, Schatz A, Willmann G et al (2013) Transcorneal electrical stimulation in patients with retinal artery occlusion: A\u00a0prospective, randomized, sham-controlled pilot study. Ophthalmol Ther 2:25\u201339","journal-title":"Ophthalmol Ther"},{"key":"415_CR25","first-page":"12","volume":"113","author":"AP Nesterov","year":"1997","unstructured":"Nesterov AP, Khadikova EV (1997) Effect of ciliary muscle electrical stimulation on ocular hydrodynamics and visual function in patients with glaucoma. Vestn Oftalmol 113:12\u201314","journal-title":"Vestn Oftalmol"},{"key":"415_CR26","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.expneurol.2009.06.016","volume":"219","author":"YQ Ni","year":"2009","unstructured":"Ni YQ, Gan DK, Xu HD et al (2009) Neuroprotective effect of transcorneal electrical stimulation on light-induced photoreceptor degeneration. Exp Neurol 219:439\u2013452","journal-title":"Exp Neurol"},{"key":"415_CR27","first-page":"397","volume":"5","author":"S Oono","year":"2011","unstructured":"Oono S, Kurimoto T, Kashimoto R et\u00a0al (2011) Transcorneal electrical stimulation improves visual function in eyes with branch retinal artery occlusion. Clin Ophthalmol 5:397\u2013402","journal-title":"Clin Ophthalmol"},{"key":"415_CR28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s10384-012-0203-y","volume":"57","author":"T Osako","year":"2013","unstructured":"Osako T, Chuman H, Maekubo T et\u00a0al (2013) Effects of steroid administration and transcorneal electrical stimulation on the anatomic and electrophysiologic deterioration of nonarteritic ischemic optic neuropathy in a\u00a0rodent model. Jpn J Ophthalmol 57:410\u2013415","journal-title":"Jpn J Ophthalmol"},{"key":"415_CR29","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s00417-013-2341-4","volume":"251","author":"N Ozeki","year":"2013","unstructured":"Ozeki N, Shinoda K, Ohde H et\u00a0al (2013) Improvement of visual acuity after transcorneal electrical stimulation in case of best vitelliform macular dystrophy. Graefes Arch Clin Exp Ophthalmol 251:1867\u20131870","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"415_CR30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/0-387-32442-9_45","volume":"572","author":"MT Pardue","year":"2006","unstructured":"Pardue MT, Phillips MJ, Hanzlicek B et\u00a0al (2006) Neuroprotection of photoreceptors in the RCS rat after implantation of a\u00a0subretinal implant in the superior or inferior retina. Adv Exp Med Biol 572:321\u2013326","journal-title":"Adv Exp Med Biol"},{"key":"415_CR31","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1088\/1741-2560\/2\/1\/006","volume":"2","author":"MT Pardue","year":"2005","unstructured":"Pardue MT, Phillips MJ, Yin H et\u00a0al (2005) Possible sources of neuroprotection following subretinal silicon chip implantation in RCS rats. J\u00a0Neural Eng 2:S39\u201347","journal-title":"J Neural Eng"},{"key":"415_CR32","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1167\/iovs.04-0515","volume":"46","author":"MT Pardue","year":"2005","unstructured":"Pardue MT, Phillips MJ, Yin H et\u00a0al (2005) Neuroprotective effect of subretinal implants in the RCS rat. Invest Ophthalmol Vis Sci 46:674\u2013682","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR33","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","volume":"90","author":"HA Quigley","year":"2006","unstructured":"Quigley HA, Broman AT (2006) The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 90:262\u2013267","journal-title":"Br J Ophthalmol"},{"key":"415_CR34","first-page":"505","volume":"19","author":"HA Quigley","year":"1980","unstructured":"Quigley HA, Flower RW, Addicks EM et\u00a0al (1980) The mechanism of optic nerve damage in experimental acute intraocular pressure elevation. Invest Ophthalmol Vis Sci 19:505\u2013517","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR35","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00347-012-2749-y","volume":"110","author":"T Rock","year":"2013","unstructured":"Rock T, Schatz A, Naycheva L et\u00a0al (2013) Effects of transcorneal electrical stimulation in patients with Stargardt\u2019s disease. Ophthalmologe 110:68\u201373","journal-title":"Ophthalmologe"},{"key":"415_CR36","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1167\/iovs.12-10037","volume":"53","author":"A Schatz","year":"2012","unstructured":"Schatz A, Arango-Gonzalez B, Fischer D et al (2012) Transcorneal electrical stimulation shows neuroprotective effects in retinas of light-exposed rats. Invest Ophthalmol Vis Sci 53:5552\u20135561","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR37","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1167\/iovs.10-6932","volume":"52","author":"A Schatz","year":"2011","unstructured":"Schatz A, Rock T, Naycheva L et al (2011) Transcorneal electrical stimulation for patients with retinitis pigmentosa: A\u00a0prospective, randomized, sham-controlled exploratory study. Invest Ophthalmol Vis Sci 52:4485\u20134496","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR38","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1167\/iovs.08-2229","volume":"50","author":"U Schiefer","year":"2009","unstructured":"Schiefer U, Pascual JP, Edmunds B et al (2009) Comparison of the new perimetric GATE strategy with conventional full-threshold and SITA standard strategies. Invest Ophthalmol Vis Sci 50:488\u2013494","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.brainresbull.2008.12.013","volume":"79","author":"H Schmid","year":"2009","unstructured":"Schmid H, Herrmann T, Kohler K et\u00a0al (2009) Neuroprotective effect of transretinal electrical stimulation on neurons in the inner nuclear layer of the degenerated retina. Brain Res Bull 79:15\u201325","journal-title":"Brain Res Bull"},{"key":"415_CR40","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/S0161-6420(96)30572-1","volume":"103","author":"SW Siegner","year":"1996","unstructured":"Siegner SW, Netland PA (1996) Optic disc hemorrhages and progression of glaucoma. Ophthalmology 103:1014\u20131024","journal-title":"Ophthalmology"},{"key":"415_CR41","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1001\/archopht.1991.01080080050026","volume":"109","author":"A Sommer","year":"1991","unstructured":"Sommer A, Tielsch JM, Katz J et\u00a0al (1991) Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore Eye Survey. Arch Ophthalmol 109:1090\u20131095","journal-title":"Arch Ophthalmol"},{"key":"415_CR42","first-page":"553","volume":"4","author":"M Standish","year":"1887","unstructured":"Standish M (1887) A\u00a0case of Retinitis Pigmentosa treated electrically. Trans Am Ophthalmol Soc 4:553\u2013558","journal-title":"Trans Am Ophthalmol Soc"},{"key":"415_CR43","doi-asserted-by":"crossref","first-page":"6860","DOI":"10.1167\/iovs.13-12781","volume":"54","author":"CA Strohmaier","year":"2013","unstructured":"Strohmaier CA, Reitsamer HA, Kiel JW (2013) Episcleral venous pressure and IOP responses to central electrical stimulation in the rat. Invest Ophthalmol Vis Sci 54:6860\u20136866","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR44","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10384-009-0657-8","volume":"53","author":"Y Tagami","year":"2009","unstructured":"Tagami Y, Kurimoto T, Miyoshi T et\u00a0al (2009) Axonal regeneration induced by repetitive electrical stimulation of crushed optic nerve in adult rats. Jpn J Ophthalmol 53:257\u2013266","journal-title":"Jpn J Ophthalmol"},{"key":"415_CR45","doi-asserted-by":"crossref","first-page":"7529","DOI":"10.1167\/iovs.11-7838","volume":"52","author":"G Willmann","year":"2011","unstructured":"Willmann G, Schaferhoff K, Fischer MD et al (2011) Gene expression profiling of the retina after transcorneal electrical stimulation in wild-type Brown Norway rats. Invest Ophthalmol Vis Sci 52:7529\u20137537","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"415_CR46","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1098\/rspb.2010.1747","volume":"278","author":"E Zrenner","year":"2011","unstructured":"Zrenner E, Bartz-Schmidt KU, Benav H et al (2011) Subretinal electronic chips allow blind patients to read letters and combine them to words. Proc Biol Sci 278:1489\u20131497","journal-title":"Proc. Biol. Sci."}],"container-title":["Der Ophthalmologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00347-016-0415-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-016-0415-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-016-0415-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T12:16:08Z","timestamp":1507810568000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00347-016-0415-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,13]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["415"],"URL":"https:\/\/doi.org\/10.1007\/s00347-016-0415-5","relation":{},"ISSN":["0941-293X","1433-0423"],"issn-type":[{"value":"0941-293X","type":"print"},{"value":"1433-0423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,13]]}}}