{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:38:20Z","timestamp":1787067500629,"version":"build-2736575974"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Freiburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologe"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die nodul\u00e4re Skleritis und die nekrotisierende Skleritis sind seltene Komplikationen der Akantham\u00f6benkeratitis. Wir pr\u00e4sentieren den Fall einer 61-j\u00e4hrigen Patientin, die seit mehr als 4\u00a0Monaten an einer persistierenden Keratitis am rechten Auge litt. Es wurde eine perforierende Limbokeratoplastik durchgef\u00fchrt. Die Untersuchung des Hornhautexplantates zeigte Akantham\u00f6benzysten. In den folgenden 5\u00a0Monaten zeigte die Sklera rezidivierende Abszedierungen. Wir f\u00fchrten insgesamt 2\u00a0Thermokauterisationen und 3\u00a0Amnionmembrantransplantationen durch. Nach unserem Wissen ist dies der erste Fall einer Sklerokeratitis nach einer Akantham\u00f6benkeratitis, welcher mit einer Kombination aus Thermokauterisation und Amnionmembrantransplantation behandelt wurde. Weitere Studien sind notwendig, um dieses Verfahren als Alternative zur etablierten Kryotherapie zu untersuchen.<\/jats:p>","DOI":"10.1007\/s00347-020-01080-y","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T14:03:36Z","timestamp":1583935416000},"page":"50-52","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nekrotisierende Skleritis nach Akantham\u00f6benkeratitis","Necrotizing scleritis after acanthamoeba keratitis"],"prefix":"10.1007","volume":"118","author":[{"given":"Stefan J.","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"B\u00f6hringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reinhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"1080_CR1","doi-asserted-by":"publisher","first-page":"300","DOI":"10.4103\/0301-4738.99844","volume":"61","author":"S Chatterjee","year":"2013","unstructured":"Chatterjee\u00a0S, Agrawal\u00a0D, Vemuganti\u00a0GK (2013) Granulomatous inflammation in acanthamoeba sclerokeratitis. Indian J Ophthalmol 61:300\u2013302. https:\/\/doi.org\/10.4103\/0301-4738.99844","journal-title":"Indian J Ophthalmol"},{"key":"1080_CR2","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S0002-9394(14)70007-8","volume":"117","author":"PJ Dougherty","year":"1994","unstructured":"Dougherty\u00a0PJ, Binder\u00a0PS, Mondino\u00a0BJ, Glasgow\u00a0BJ (1994) Acanthamoeba sclerokeratitis. Am J Ophthalmol 117:475\u2013479","journal-title":"Am J Ophthalmol"},{"key":"1080_CR3","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3109\/01676830903297563","volume":"29","author":"A Karalezli","year":"2010","unstructured":"Karalezli\u00a0A, Kucukerdonmez\u00a0C, Borazan\u00a0M, Akova\u00a0YA (2010) Successful treatment of necrotizing scleritis after conjunctival autografting for pterygium with amniotic membrane transplantation. Orbit 29:88\u201390. https:\/\/doi.org\/10.3109\/01676830903297563","journal-title":"Orbit"},{"key":"1080_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2016.217","author":"SJ Lang","year":"2016","unstructured":"Lang\u00a0SJ, B\u00f6hringer\u00a0D, Geerling\u00a0G, Reinhard\u00a0T (2016) Long-term results of allogenic penetrating limbo-keratoplasty: 20 years of experience. Eye (Lond). https:\/\/doi.org\/10.1038\/eye.2016.217","journal-title":"Eye (Lond)"},{"key":"1080_CR5","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1034\/j.1600-0420.1999.770611.x","volume":"77","author":"T Reinhard","year":"1999","unstructured":"Reinhard\u00a0T, Sundmacher\u00a0R, Spelsberg\u00a0H, Althaus\u00a0C (1999) Homologous penetrating central limbo-keratoplasty (HPCLK) in bilateral limbal stem cell insufficiency. Acta Ophthalmol Scand 77:663\u2013667","journal-title":"Acta Ophthalmol Scand"}],"container-title":["Der Ophthalmologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-020-01080-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00347-020-01080-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-020-01080-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T19:19:56Z","timestamp":1615403996000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00347-020-01080-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,11]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["1080"],"URL":"https:\/\/doi.org\/10.1007\/s00347-020-01080-y","relation":{},"ISSN":["0941-293X","1433-0423"],"issn-type":[{"value":"0941-293X","type":"print"},{"value":"1433-0423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,11]]},"assertion":[{"value":"11 March 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"S.J.\u00a0Lang, D.\u00a0B\u00f6hringer und T.\u00a0Reinhard geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patienten zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}