{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:21:58Z","timestamp":1740108118365,"version":"3.37.3"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003484","name":"Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003484","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologe"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Der Sicca-F\u00f6rderpreis unterst\u00fctzt die Entwicklung wissenschaftlicher Arbeiten zu Pathogenese, Diagnostik und Therapie des trockenen Auges und Augenoberfl\u00e4chenerkrankungen. Er wird nach befristeter Ausschreibung im deutschsprachigen Raum, schriftlicher Antragstellung und Preistr\u00e4gerauswahl nach Begutachtung durch ein Jurorengremium aus grundlagen- und klinisch-wissenschaftlich arbeitenden Augen\u00e4rzten vergeben. In diesem Beitrag werden beispielhaft die Ergebnisse gef\u00f6rderter Projekte des Sicca-F\u00f6rderpreises 2016 kursorisch dargestellt, deren Ergebnisse im Rahmen der Augen\u00e4rztliche Akademie Deutschland 2019 vorgestellt wurden, und damit ein Einblick in die aktuellen wissenschaftlichen Entwicklungen skizziert. Dabei wird die Rolle der Muskarinrezeptoren sowie jene des Harnstoffs in der Pathogenese des trockenen Auges ebenso beleuchtet wie die (fehlende) Korrelation der Tr\u00e4nenfilminstabilit\u00e4t, -viskosit\u00e4t und Oberfl\u00e4chenspannung. Wegweisend sind auch ein Projekt zur Fr\u00fchdetektion der okul\u00e4ren Beteiligung bei der Graft-versus-Host-Disease und der Gedanke, eine Meibom-Dr\u00fcsen-Dysfunktion mit lidchirurgischen Techniken zu behandeln. Die skizzierten Projekte stellen das Potenzial f\u00fcr weitere substanzielle Entwicklungen zu Verst\u00e4ndnis, Diagnostik und Therapie des trockenen Auges dar. Ihre langfristige klinische Relevanz muss jedoch noch etabliert werden.<\/jats:p>","DOI":"10.1007\/s00347-020-01163-w","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T14:02:59Z","timestamp":1594130579000},"page":"337-344","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ergebnisse der Sicca-Forschungsf\u00f6rderung 2016","Results of the Dry Eye Research Grant Award 2016"],"prefix":"10.1007","volume":"118","author":[{"given":"A.","family":"Musayeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gericke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Paulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Fabry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Pauly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Holtmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2034-3687","authenticated-orcid":false,"given":"G.","family":"Geerling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Sicca-Preis-Jury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Geerling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Goldblum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Horwath-Winter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Jacobi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Kaden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kaercher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Messmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Paulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Schwarzkopff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Zierhut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"issue":"6","key":"1163_CR1","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1006\/exer.2001.1076","volume":"73","author":"DA Dartt","year":"2001","unstructured":"Dartt\u00a0DA (2001) Regulation of lacrimal gland secretion by neurotransmitters and the EGF family of growth factors. Exp Eye Res 73(6):741\u2013752","journal-title":"Exp Eye Res"},{"issue":"3","key":"1163_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1089\/jop.2008.0126","volume":"25","author":"SM Choi","year":"2009","unstructured":"Choi\u00a0SM, Lee\u00a0YG, Seo\u00a0MJ, Kang\u00a0KK, Ahn\u00a0BO, Yoo\u00a0M (2009) Effects of DA-6034 on aqueous tear fluid secretion and conjunctival goblet cell proliferation. J\u00a0Ocul Pharmacol Ther 25(3):209\u2013214","journal-title":"J Ocul Pharmacol Ther"},{"issue":"11","key":"1163_CR3","doi-asserted-by":"publisher","first-page":"6981","DOI":"10.1167\/iovs.15-17497","volume":"56","author":"SA Aicher","year":"2015","unstructured":"Aicher\u00a0SA, Hermes\u00a0SM, Hegarty\u00a0DM (2015) Denervation of the lacrimal gland leads to corneal hypoalgesia in a novel rat model of aqueous dry eye disease. Invest Ophthalmol Vis Sci 56(11):6981\u20136989","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"1163_CR4","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/nrd4295","volume":"13","author":"AC Kruse","year":"2014","unstructured":"Kruse\u00a0AC, Kobilka\u00a0BK, Gautam\u00a0D, Sexton\u00a0PM, Christopoulos\u00a0A, Wess\u00a0J (2014) Muscarinic acetylcholine receptors: novel opportunities for drug development. Nat Rev Drug Discov 13(7):549\u2013560","journal-title":"Nat Rev Drug Discov"},{"issue":"6 Pt 1","key":"1163_CR5","doi-asserted-by":"publisher","first-page":"C1550","DOI":"10.1152\/ajpcell.1993.264.6.C1550","volume":"264","author":"P Mauduit","year":"1993","unstructured":"Mauduit\u00a0P, Jammes\u00a0H, Rossignol\u00a0B (1993) M3 muscarinic acetylcholine receptor coupling to PLC in rat exorbital lacrimal acinar cells. Am J Physiol 264(6 Pt 1):C1550\u201360","journal-title":"Am J Physiol"},{"issue":"6","key":"1163_CR6","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1076\/ceyr.16.6.614.5077","volume":"16","author":"M Nakamura","year":"1997","unstructured":"Nakamura\u00a0M, Tada\u00a0Y, Akaishi\u00a0T, Nakata\u00a0K (1997) M3 muscarinic receptor mediates regulation of protein secretion in rabbit lacrimal gland. Curr Eye Res 16(6):614\u2013619","journal-title":"Curr Eye Res"},{"issue":"1","key":"1163_CR7","first-page":"151","volume":"39","author":"S Bacman","year":"1998","unstructured":"Bacman\u00a0S, Perez Leiros\u00a0C, Sterin-Borda\u00a0L, Hubscher\u00a0O, Arana\u00a0R, Borda\u00a0E (1998) Autoantibodies against lacrimal gland M3 muscarinic acetylcholine receptors in patients with primary Sjogren\u2019s syndrome. Invest Ophthalmol Vis Sci 39(1):151\u2013156","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"1163_CR8","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1369\/jhc.2008.952101","volume":"56","author":"W Pradidarcheep","year":"2008","unstructured":"Pradidarcheep\u00a0W, Labruyere\u00a0WT, Dabhoiwala\u00a0NF, Lamers\u00a0WH (2008) Lack of specificity of commercially available antisera: better specifications needed. J\u00a0Histochem Cytochem 56(12):1099\u20131111","journal-title":"J Histochem Cytochem"},{"issue":"1","key":"1163_CR9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1615\/CritRevNeurobiol.v10.i1.40","volume":"10","author":"J Wess","year":"1996","unstructured":"Wess\u00a0J (1996) Molecular biology of muscarinic acetylcholine receptors. Crit Rev Neurobiol 10(1):69\u201399","journal-title":"Crit Rev Neurobiol"},{"issue":"3","key":"1163_CR10","first-page":"1427","volume":"41","author":"QC Yang","year":"2018","unstructured":"Yang\u00a0QC, Bao\u00a0J, Li\u00a0C et\u00a0al (2018) A murine model of dry eye induced by topical administration of erlotinib eye drops. Int J Mol Med 41(3):1427\u20131436","journal-title":"Int J Mol Med"},{"issue":"1","key":"1163_CR11","doi-asserted-by":"publisher","first-page":"e000078","DOI":"10.1136\/bmjophth-2017-000078","volume":"1","author":"HS Lee","year":"2017","unstructured":"Lee\u00a0HS, Amouzegar\u00a0A, Dana\u00a0R (2017) Kinetics of corneal antigen presenting cells in experimental dry eye disease. BMJ Open Ophthalmol 1(1):e78","journal-title":"BMJ Open Ophthalmol"},{"issue":"4","key":"1163_CR12","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.jemermed.2003.09.013","volume":"26","author":"RG Hendrickson","year":"2004","unstructured":"Hendrickson\u00a0RG, Morocco\u00a0AP, Greenberg\u00a0MI (2004) Pilocarpine toxicity and the treatment of xerostomia. J\u00a0Emerg Med 26(4):429\u2013432","journal-title":"J Emerg Med"},{"issue":"4","key":"1163_CR13","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.arcped.2013.01.012","volume":"20","author":"A Princelle","year":"2013","unstructured":"Princelle\u00a0A, Hue\u00a0V, Pruvost\u00a0I, Potey\u00a0C, Dubos\u00a0F, Martinot\u00a0A (2013) Systemic adverse effects of topical ocular instillation of atropine in two children. Arch Pediatr 20(4):391\u2013394","journal-title":"Arch Pediatr"},{"issue":"2","key":"1163_CR14","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1055\/s-2008-1055175","volume":"181","author":"G Gallasch","year":"1982","unstructured":"Gallasch\u00a0G, Schutz\u00a0R, Gotz\u00a0ML, Kraus-Mackiw\u00a0E (1982) Side-effects of atropine: pharmacological, allergic, pseudo-allergic or toxic reactions? Klin Monatsbl Augenheilkd 181(2):96\u201399","journal-title":"Klin Monatsbl Augenheilkd"},{"issue":"4","key":"1163_CR15","first-page":"217","volume":"11","author":"F Ridley","year":"1930","unstructured":"Ridley\u00a0F (1930) The intraocular pressure and drainage of the aqueous humour. Br J Exp Pathol 11(4):217\u2013240","journal-title":"Br J Exp Pathol"},{"issue":"5","key":"1163_CR16","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1172\/JCI103854","volume":"38","author":"NG Levinsky","year":"1959","unstructured":"Levinsky\u00a0NG, Berliner\u00a0RW (1959) The role of urea in the urine concentrating mechanism. J\u00a0Clin Invest 38(5):741\u2013748","journal-title":"J Clin Invest"},{"issue":"3 Pt 2","key":"1163_CR17","first-page":"F321","volume":"273","author":"JM Sands","year":"1997","unstructured":"Sands\u00a0JM, Timmer\u00a0RT, Gunn\u00a0RB (1997) Urea transporter in kidney and erythrocytes. Am J Physiol 273(3 Pt 2):F321\u2013F339","journal-title":"Am J Physiol"},{"issue":"28","key":"1163_CR18","first-page":"11194","volume":"109","author":"SM Bagnasco","year":"2003","unstructured":"Bagnasco\u00a0SM (2003) Gene structure of urea transporters. Am J Physiol Renal Physiol 109(28):11194\u201311199","journal-title":"Am J Physiol Renal Physiol"},{"issue":"8","key":"1163_CR19","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1007\/s00417-013-2391-7","volume":"251","author":"C J\u00e4ger","year":"2013","unstructured":"J\u00e4ger\u00a0C, Kielstein\u00a0H, Dunse\u00a0M, Nass\u00a0M, Paulsen\u00a0P (2013) Enzymes of urea synthesis are expressed at the ocular surface and decreased urea in the tear fluid is associates with dry eye syndrome. Graefes Arch Clin Exp Ophthalmol 251(8):1995\u20132002","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"4","key":"1163_CR20","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.jtos.2017.08.003","volume":"15","author":"JP Craig","year":"2017","unstructured":"Craig\u00a0JP, Nelson\u00a0JD, Azar\u00a0DT et\u00a0al (2017) TFOS DEWS II report executive summary. Ocul Surf 15(4):802\u2013812","journal-title":"Ocul Surf"},{"key":"1163_CR21","series-title":"Micro & nano technologies series","volume-title":"Microfluidics: Modeling, mechanics, and mathematics","year":"2017","unstructured":"Rapp\u00a0BE (Hrsg) (2017) Microfluidics: Modeling, mechanics, and mathematics. Micro & nano technologies series. William Andrew, Kidlington"},{"issue":"5","key":"1163_CR22","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1167\/iovs.13-13423","volume":"55","author":"U Schulze","year":"2014","unstructured":"Schulze\u00a0U, Hampel\u00a0U, Sel\u00a0S et\u00a0al (2014) Trefoil factor family peptide 3 (TFF3) is upregulated under experimental conditions similar to dry eye disease and supports corneal wound healing effects in vitro. Invest Ophthalmol Vis Sci 55(5):3037\u20133042","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"1163_CR23","doi-asserted-by":"publisher","first-page":"9791","DOI":"10.1038\/s41598-018-28005-9","volume":"8","author":"M Schicht","year":"2018","unstructured":"Schicht\u00a0M, Garreis\u00a0F, Hartjen\u00a0N et\u00a0al (2018) SFTA3\u2014a novel surfactant protein of the ocular surface and its role in corneal wound healing and tear film surface tension. Sci Rep 8(1):9791","journal-title":"Sci Rep"},{"key":"1163_CR24","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.aanat.2017.11.006","volume":"216","author":"A Posa","year":"2018","unstructured":"Posa\u00a0A, Paulsen\u00a0F, Dietz\u00a0R et\u00a0al (2018) Quantification of surfactant proteins in tears of patients suffering from dry eye disease compared to healthy subjects. Ann Anat 216:90\u201394","journal-title":"Ann Anat"},{"issue":"2","key":"1163_CR25","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1006\/exer.1998.0600","volume":"68","author":"JC Pandit","year":"1999","unstructured":"Pandit\u00a0JC, Nagyova\u00a0B, Bron\u00a0AJ, Tiffany\u00a0JM (1999) Physical properties of stimulated and unstimulated tears. Exp Eye Res 68(2):247\u2013253","journal-title":"Exp Eye Res"},{"issue":"1","key":"1163_CR26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1046\/j.1475-097X.2002.00389.x","volume":"22","author":"J Zhao","year":"2002","unstructured":"Zhao\u00a0J, Manthorpe\u00a0R, Wollmer\u00a0P (2002) Surface activity of tear fluid in patients with primary Sjogren\u2019s syndrome. Clin Physiol Funct Imaging 22(1):24\u201327","journal-title":"Clin Physiol Funct Imaging"},{"issue":"8","key":"1163_CR27","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/j.ophtha.2019.03.014","volume":"126","author":"A McDonnell","year":"2019","unstructured":"McDonnell\u00a0A, Lee\u00a0J\u2011H, Makrai\u00a0E, Yeo\u00a0LY, Downie\u00a0LE (2019) Tear film extensional viscosity is a novel potential biomarker of dry eye disease. Ophthalmology 126(8):1196\u20131198","journal-title":"Ophthalmology"},{"key":"1163_CR28","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1053\/bbmt.2003.50026","volume":"9","author":"SJ Lee","year":"2003","unstructured":"Lee\u00a0SJ, Vogelsang\u00a0G, Flowers\u00a0ME (2003) Chronic graft-versus-host-disease. Biol Blood Marrow Transplant 9:215\u2013233","journal-title":"Biol Blood Marrow Transplant"},{"issue":"43","key":"1163_CR29","first-page":"732","volume":"108","author":"D Wolff","year":"2011","unstructured":"Wolff\u00a0D, Bertz\u00a0H, Greinix\u00a0H et al (2011) The treatment of chronic graft-versus-host disease: consensus recommendations of experts from Germany, Austria and Switzerland. Dtsch Arztbl Int 108(43):732\u2013740","journal-title":"Dtsch Arztbl Int"},{"issue":"2","key":"1163_CR30","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1167\/iovs.15-18615","volume":"57","author":"L Cocho","year":"2016","unstructured":"Cocho\u00a0L, Fern\u00e1ndez\u00a0I, Calonge\u00a0M et al (2016) Biomarkers in ocular chronic graft versus host disease: tear cytokine- and chemokine-based predictive model. Invest Ophthalmol Vis Sci 57(2):746\u2013758","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"1163_CR31","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1182\/blood-2013-08-520072","volume":"123","author":"CL Kitko","year":"2014","unstructured":"Kitko\u00a0CL, Levine\u00a0JE, Storer\u00a0BE et\u00a0al (2014) Plasma CXCL9 elevations correlate with chronic GVHD diagnosis. Blood 123(5):786\u2013793","journal-title":"Blood"},{"issue":"8","key":"1163_CR32","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1038\/bmt.2009.346","volume":"45","author":"H Westekemper","year":"2010","unstructured":"Westekemper\u00a0H, Meller\u00a0S, Citak\u00a0S et\u00a0al (2010) Differential chemokine expression in chronic GVHD of the conjunctiva. Bone Marrow Transplant 45(8):1340\u20131346","journal-title":"Bone Marrow Transplant"},{"issue":"12","key":"1163_CR33","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1038\/bmt.2015.191","volume":"50","author":"SS Ahmed","year":"2015","unstructured":"Ahmed\u00a0SS, Wang\u00a0XN, Norden\u00a0J et\u00a0al (2015) Identification and validation of biomarkers associated with acute and chronic graft versus host disease. Bone Marrow Transplant 50(12):1563\u20131571","journal-title":"Bone Marrow Transplant"},{"issue":"12","key":"1163_CR34","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1016\/j.bbmt.2015.08.020","volume":"21","author":"JW Jung","year":"2015","unstructured":"Jung\u00a0JW, Han\u00a0SJ, Song\u00a0MK et al (2015) Tear cytokines as biomarkers for chronic graft-versus-host disease. Biol Blood Marrow Transplant 21(12):2079\u20132085","journal-title":"Biol Blood Marrow Transplant"},{"key":"1163_CR35","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.bbmt.2015.01.003","volume":"21","author":"S Paczesny","year":"2015","unstructured":"Paczesny\u00a0S, Hakim\u00a0FT, Pidala\u00a0J et al (2015) National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. The 2014 Biomarker Working Group report. Biol Blood Marrow Transplant 21:780\u2013792","journal-title":"Biol Blood Marrow Transplant"},{"issue":"14","key":"1163_CR36","first-page":"456","volume":"7","author":"KB Green-Church","year":"2008","unstructured":"Green-Church\u00a0KB, Nichols\u00a0KK, Kleinholz\u00a0NM et al (2008) Investigation of the human tear film proteome using multiple proteomic approaches. Mol Vis 7(14):456\u2013470","journal-title":"Mol Vis"},{"issue":"17","key":"1163_CR37","first-page":"1056","volume":"27","author":"KR VanDerMeid","year":"2011","unstructured":"VanDerMeid\u00a0KR, Su\u00a0SP, Krenzer\u00a0KL et\u00a0al (2011) A method to extract cytokines and matrix metalloproteinases from Schirmer strips and analyze using Luminex. Mol Vis 27(17):1056\u20131063","journal-title":"Mol Vis"},{"issue":"6","key":"1163_CR38","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.preteyeres.2012.06.002","volume":"31","author":"L Zhou","year":"2012","unstructured":"Zhou\u00a0L, Beuerman\u00a0RW (2012) Tear analysis in ocular surface diseases. Prog Retin Eye Res 31(6):527\u2013550","journal-title":"Prog Retin Eye Res"},{"issue":"2","key":"1163_CR39","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.aanat.2012.10.001","volume":"195","author":"A Posa","year":"2013","unstructured":"Posa\u00a0A, Br\u00e4uer\u00a0L, Schicht\u00a0M et al (2013) Schirmer strip vs. capillary tube method: non-invasive methods of obtaining proteins from tear fluid. Ann Anat 195(2):137\u2013142","journal-title":"Ann Anat"},{"key":"1163_CR40","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00717-013-0197-y","volume":"27","author":"H Aminfar","year":"2013","unstructured":"Aminfar\u00a0H et\u00a0al (2013) The prevalence of meibomian gland dysfunction in a clinical population of dry eye patients. Spektrum Augenheilkd 27:281\u2013285","journal-title":"Spektrum Augenheilkd"},{"key":"1163_CR41","first-page":"73","volume-title":"Entz\u00fcndliche Augenerkrankungen","year":"2014","unstructured":"Pleyer\u00a0U (Hrsg) (2014) Entz\u00fcndliche Augenerkrankungen. Springer, Berlin, S\u00a073"},{"issue":"2","key":"1163_CR42","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3109\/02713683.2015.1015142","volume":"41","author":"SH Oh","year":"2016","unstructured":"Oh\u00a0SH et\u00a0al (2016) Lower lid laxity is negatively correlated with improvement of the ocular surface disease index in dry eye treatment. Curr Eye Res 41(2):165\u2013170","journal-title":"Curr Eye Res"}],"container-title":["Der Ophthalmologe"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-020-01163-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00347-020-01163-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-020-01163-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T23:26:57Z","timestamp":1625614017000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00347-020-01163-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["1163"],"URL":"https:\/\/doi.org\/10.1007\/s00347-020-01163-w","relation":{},"ISSN":["0941-293X","1433-0423"],"issn-type":[{"type":"print","value":"0941-293X"},{"type":"electronic","value":"1433-0423"}],"subject":[],"published":{"date-parts":[[2020,7,7]]},"assertion":[{"value":"7 July 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"A.\u00a0Musayeva, A.\u00a0Gericke, F.\u00a0J\u00e4ger, M.\u00a0Braun, B.\u00a0Fabry, R.\u00a0Braun, D.\u00a0Pauly und C.\u00a0Holtmann haben Drittmittel und Reiskostenerstattungen von der Firma Bausch\u202f+\u2009Lomb erhalten. Alle Mitglieder der Sicca-Preis-Jury haben f\u00fcr ihre Jury-T\u00e4tigkeit Reisekostenerstattungen der Firma Bausch\u202f+\u2009Lomb erhalten. Dar\u00fcber hinaus werden die folgenden Interessenkonflikte angegeben: C. Jacobi, R.\u00a0Kaden und T.\u00a0Kaercher geben an, dass keine Interessenkonflikte bestehen. G.\u00a0Geerling gibt an, als Referent f\u00fcr die Firmen Santen, Chiesi, Novartis, Alcon, Domp\u00e9, Allergan, Tearlab Inc., Oculus Pharma und Tear Science t\u00e4tig gewesen zu sein. Er erh\u00e4lt\/erhielt Beraterhonorare von den Firmen Santen, Chiesi, Med1Ventures, Alcon, Domp\u00e9, Sun Pharma, Allergan, Shire, Thea Pharma, VISUfarma und Bausch\u202f+\u2009Lomb. Drittmittel hat er erhalten von den Firmen Santen, Novartis, Domp\u00e9 und Tear Science und ist an der Firma Tear Labs beteiligt. F\u00fcr seine T\u00e4tigkeit als Herausgeber erhielt er Honorare der Verlagsh\u00e4user Taylor\u00a0&\u00a0Francis und Thieme. D.\u00a0Goldblum war als Referent f\u00fcr die Firmen Santen, Novartis und Th\u00e9a die letzten 2\u00a0Jahre t\u00e4tig und erhielt Drittmittel von Roche und Haag-Streit. Er ist Vorstandsmitglied der Schweizerischen Ophthalmologischen Gesellschaft (SOG-SSO). J.\u00a0Horwath-Winter hat Referenten- und Beraterhonorare der Firmen Allergan, Bausch\u202f+\u2009Lomb, Croma-Pharma, Mc2 Therapeutics, Omnivision, Santen, Shire, Th\u00e9a, TRB Chemedica und Ursapharm erhalten. E.\u00a0Messmer hat Referenten- und Beraterhonorare der Firmen Alcon, DMG, Domp\u00e9, Kala, Novartis, Pharm-Allergan, Santen, Shire, Sifi, Sun Pharmaceuticals, Th\u00e9a, TRB-Chemedica Ursapharm und VISUfarma erhalten. F.\u00a0Paulsen ist als Referent f\u00fcr die Firmen TRB und Ulrich Medical t\u00e4tig. Er erh\u00e4lt Beraterhonorare von den Firmen TRB und IMPP. F\u00fcr seine T\u00e4tigkeit als Herausgeber erh\u00e4lt oder erhielt er Honorare der Verlagsh\u00e4user Elsevier und Thieme.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der zust\u00e4ndigen Ethikkommission, im Einklang mit nationalem Recht sowie gem\u00e4\u00df der Deklaration von Helsinki von 1975 (in der aktuellen, \u00fcberarbeiteten Fassung) durchgef\u00fchrt. Von allen beteiligten Patienten liegt eine Einverst\u00e4ndniserkl\u00e4rung vor. Die Arbeiten wurden teilweise in Erf\u00fcllung f\u00fcr die Voraussetzung einer Dissertation durchgef\u00fchrt (M.B.).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}