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Bei der okul\u00e4ren Manifestation der SZE ist am bekanntesten die periphere Sichelzellretinopathie (SZR). Unabh\u00e4ngig davon kann es bereits fr\u00fch im Krankheitsverlauf zur Sichelzellmakulopathie (SZM) kommen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methoden<\/jats:title>\n                <jats:p>Review der internationalen und deutschsprachigen Literatur zur okul\u00e4ren Beteiligung bei SZE mit Fokus auf die SZR und SZM sowie \u00dcberblick \u00fcber aktuelle systemische Therapieans\u00e4tze bei SZE anl\u00e4sslich der Vorstellung zweier Patienten mit HbSS-SZE.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnis und Schlussfolgerung<\/jats:title>\n                <jats:p>Im Gegensatz zur SZR ist die SZM mit temporaler Verd\u00fcnnung der inneren Netzhautschichten erst in den letzten 5\u00a0Jahren mit der Einf\u00fchrung von SD-OCT und OCTA vermehrt in die Literatur eingegangen. Unabh\u00e4ngig vom Vorliegen einer SZR kann es immerhin bei etwa der H\u00e4lfte der Patienten bereits fr\u00fch im Krankheitsverlauf zu einer SZM kommen. Das Krankheitsbild wird auch in Deutschland durch den Fortschritt der systemischen Therapiem\u00f6glichkeiten und aufgrund von Migration pr\u00e4senter werden. Durch Wissen um diese Komplikation der SZE kann eine fr\u00fchzeitige Diagnosestellung erfolgen und unn\u00f6tige Diagnostik vermieden werden.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00347-020-01319-8","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T14:03:53Z","timestamp":1611756233000},"page":"1013-1023","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Makulopathie bei Sichelzellerkrankung","Maculopathy in sickle cell disease"],"prefix":"10.1007","volume":"118","author":[{"given":"Isabel","family":"Bachmeier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Blecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"F\u00f6ll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"J\u00e4gle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"1319_CR1","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1007\/s00417-019-04294-2","volume":"257","author":"MEA Abdalla Elsayed","year":"2019","unstructured":"Abdalla Elsayed\u00a0MEA, Mura\u00a0M, Al Dhibi\u00a0H et\u00a0al (2019) Sickle cell retinopathy. 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