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Diese kleine, heterogene Zellfamilie vermittelt ein weites Spektrum an Aufgaben \u00fcberwiegend des nicht-bildformenden Sehens.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Fragestellung<\/jats:title>\n                <jats:p>Diese Arbeit soll einen Einblick in das aktuelle Verst\u00e4ndnis der Funktion und der funktionellen Diversit\u00e4t der ipRGCs geben sowie klinisch und translational relevante Aspekte beleuchten.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Narrative \u00dcbersichtsarbeit.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>ipRGCs machen etwa 1\u20132\u202f% aller retinalen Ganglienzellen aus und bilden dabei 6 spezialisierte Subtypen. Mit ihrem Photopigment Melanopsin sind sie in der Lage, unabh\u00e4ngig von synaptischem Input Lichtinformationen an das Gehirn weiterzuleiten oder lichtabh\u00e4ngig zu modifizieren. Je nach Subtyp vermitteln sie so nichtvisuelle Aufgaben wie die Synchronisation der inneren Uhr oder den Pupillenreflex, greifen aber auch in das bildformende System ein. ipRGCs weisen eine differenzielle Widerstandskraft gegen\u00fcber Optikussch\u00e4digung auf, was sie zu einem attraktiven Studienobjekt f\u00fcr die Entwicklung neuroprotektiver Therapieans\u00e4tze macht. Melanopsin r\u00fcckt zudem als optogenetisches Werkzeug, etwa in der prosthetischen Gentherapie, in den Fokus.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerungen<\/jats:title>\n                <jats:p>H\u00e4ufige klinische Beobachtungen lassen sich nur mit Kenntnis des ipRGC-Systems verstehen. Ihre neuronale Vernetzung und die intrazellul\u00e4re Signalverarbeitung sind Gegenstand aktiver Forschung, die neue translationale Ans\u00e4tze hervorbringt.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00347-021-01476-4","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T19:02:35Z","timestamp":1628103755000},"page":"358-366","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intrinsisch photosensitive retinale Ganglienzellen","Intrinsically photosensitive retinal ganglion cells"],"prefix":"10.1007","volume":"119","author":[{"given":"Leonie","family":"Kinder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teele","family":"Palumaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4416-3421","authenticated-orcid":false,"given":"Moritz","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"1476_CR1","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s00018-020-03641-5","volume":"78","author":"ML Aranda","year":"2021","unstructured":"Aranda\u00a0ML, Schmidt\u00a0TM (2021) Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions. 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