{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:45:15Z","timestamp":1783694715599,"version":"3.55.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum des Saarlandes und Medizinische Fakult\u00e4t der Universit\u00e4t des Saarlandes"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund und Ziele<\/jats:title>\n                <jats:p>Bei der Phakovitrektomie wird in der Regel zuerst die Katarakt operiert und die Kunstlinse meist vor Beginn der Vitrektomie implantiert. Man kann die Kunstlinse aber auch erst am Ende der Vitrektomie in den Kapselsack implantieren. Damit entfallen optische Beeintr\u00e4chtigungen durch Hornhauttr\u00fcbungen und Linsenrand w\u00e4hrend der Vitrektomie, und Komplikationen wie periphere Netzhautrisse oder Intraokularlinse-Subluxation lassen sich leichter vermeiden. Da diese Variante aber das Hornhautendothel zus\u00e4tzlich belasten k\u00f6nnte, war das Ziel der vorliegenden Studie, den postoperativen Endothelzellverlust nach Standardphakovitrektomie mit dem nach der alternativen Variante zu vergleichen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methoden<\/jats:title>\n                <jats:p>In dieser retrospektiven Studie entfielen je 41\u00a0Augen auf Gruppe\u00a0I (Standardphakovitrektomie) oder Gruppe\u00a0II (Variante). Prim\u00e4re Zielgr\u00f6\u00dfen waren der absolute und relative Hornhautendothelzellverlust von pr\u00e4- nach 5\u202f\u00b1\u20091\u00a0Wochen postoperativ. Zu den sekund\u00e4ren Zielgr\u00f6\u00dfen geh\u00f6rten Sehsch\u00e4rfe, Augeninnendruck, Variationskoeffizient der Zellfl\u00e4che des Endothels (CV), Anteil der hexagonalen Zellform des Endothels (6A), Pachymetrie, intra- und postoperative Komplikationen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Der absolute und der relative Endothelzellverlust in Gruppe\u00a0I (\u2212108\u202f\u00b1\u2009146 bzw. \u22124,1\u202f\u00b1\u20095,7\u202f%) unterschieden sich nicht signifikant von dem in Gruppe\u00a0II (\u221273\u202f\u00b1\u2009122 bzw. \u22123,1\u202f\u00b1\u20095,3\u202f%) (<jats:italic>p<\/jats:italic>\u202f=\u20090,299; <jats:italic>p<\/jats:italic>\u202f=\u20090,388). Auch die sekund\u00e4ren Zielgr\u00f6\u00dfen zeigten keine signifikanten Unterschiede.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerungen<\/jats:title>\n                <jats:p>Die hier vorgestellte Variante der Phakovitrektomie erweitert die chirurgischen Optionen und zeigt im Vergleich zum Standardverfahren keinen signifikant abweichenden postoperativen kornealen Endothelzellverlust.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00347-021-01533-y","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T05:02:37Z","timestamp":1637730157000},"page":"591-598","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phakovitrektomie\u00a0\u2013 Einfluss des Zeitpunktes der Kunstlinsenimplantation auf das korneale Endothel","Phacovitrectomy\u2014Influence of the timing of intraocular lens implantation on the corneal endothelium"],"prefix":"10.1007","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0619-2034","authenticated-orcid":false,"given":"Anastasia","family":"Seifert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Wagenpfeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"1533_CR1","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/sj.eye.6700559","volume":"17","author":"WM Bourne","year":"2003","unstructured":"Bourne\u00a0WM (2003) Biology of the corneal endothelium in health and disease. 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