{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:20:26Z","timestamp":1786980026671,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T00:00:00Z","timestamp":1638576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T00:00:00Z","timestamp":1638576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Hintergrund<\/jats:title>\n                    <jats:p>Die Thermo-Pulsation (LipiFlow\u00ae, Johnson\u00a0&amp;\u00a0Johnson, Santa Ana, CA, USA) wurde zur Behandlung der Meibom-Dr\u00fcsen-Dysfunktion (MDD) empfohlen und in mehreren Studien f\u00fcr n\u00fctzlich befunden. Ziel dieser Studie war es, die Wirksamkeit der Methode an sich und im Vergleich zur t\u00e4glichen Lidrandmassage in einer nichtuniversit\u00e4ren Einrichtung darzustellen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methoden<\/jats:title>\n                    <jats:p>Eine nicht verblindete, Single-center-Interventionsstudie, die die Thermo-Pulsation mit einer Lidrandmassage zur Behandlung von MDD vergleicht: 30\u00a0Patienten wurden im Zuge der t\u00e4glichen Sprechstunde rekrutiert. Die Symptome (OSDI) und die Augenoberfl\u00e4che (NIK-BUT, Farnkraut-Test, Tr\u00e4nenmeniskus, LIPKO-Falten, Meibographie, Meibomian-Gland-Evaluator) wurden vor der Behandlung untersucht.; 15\u00a0Patienten (9\u00a0Frauen) unterzogen sich der Thermo-Pulsation (einmalige Sitzung), w\u00e4hrend 15\u00a0Patienten (8\u00a0Frauen) 3\u00a0Monate lang eine Lidrandmassage (1-mal t\u00e4glich) nach Anweisung f\u00fcr 3\u00a0Monate durchf\u00fchrten.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>Vor den beiden Behandlungsmethoden bestanden keine Unterschiede in oben genannten Parametern, ebenfalls waren Geschlecht und Alter normverteilt. Nach der Behandlung verbesserten sich zwar in beiden Gruppen die subjektiven als auch die objektiven Kriterien, allerdings im Thermo-Pulsation-Arm signifikant st\u00e4rker. Insbesondere ist die eingeschr\u00e4nkte Compliance von 30\u202f% im Lidrandmassagearm zu beachten. Sicherheitsparameter wie Visus und IOD blieben bei allen Patienten unauff\u00e4llig.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Schlussfolgerungen<\/jats:title>\n                    <jats:p>Eine einzige Sitzung der Thermo-Pulsation f\u00fchrte in ihrer Wirksamkeit und ihrem Sicherheitsprofil nach 3\u00a0Monaten im Vergleich zu einer 1\u2011mal t\u00e4glichen Lidrandmassage zu signifikant besseren Ergebnissen. Zu beachten sind allerdings die hohen Kosten f\u00fcr die Patienten, da die zu applizierenden Aktivatoren als Einmalprodukte zu behandeln sind.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00347-021-01541-y","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T07:02:57Z","timestamp":1638601377000},"page":"605-610","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Thermo-Pulsations-System (LipiFLow\u00ae) zur Behandlung der Meibom-Dr\u00fcsen-Dysfunktion (MDD) aus der Sicht eines niedergelassenen Augenfacharztes","Thermal pulsation system (LipiFlow\u00ae) for treatment of meibomian gland dysfunction (MGD) from the perspective of an ophthalmologist in private practice"],"prefix":"10.1007","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0562-2867","authenticated-orcid":false,"given":"Christoph","family":"Laufenb\u00f6ck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,4]]},"reference":[{"key":"1541_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S1542-0124(12)70082-4","volume":"5","author":"DEWS","year":"2007","unstructured":"DEWS (2007) The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop. Ocul Surf 5:93\u2013107","journal-title":"Ocul Surf"},{"issue":"3 Suppl","key":"1541_CR2","first-page":"102","volume":"14","author":"SC Pflugfelder","year":"2008","unstructured":"Pflugfelder\u00a0SC (2008) Prevalence, burden, and pharmacoeconomics of dry eye disease. Am J Manag Care 14(3 Suppl):102\u2013106","journal-title":"Am J Manag Care"},{"key":"1541_CR3","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S1542-0124(12)70043-5","volume":"4","author":"P Buchholz","year":"2006","unstructured":"Buchholz\u00a0P, Steeds\u00a0CS, Stern\u00a0LS et\u00a0al (2006) Utility assessment to measure the impact of dry eye disease. Ocul Surf 4:155\u2013161","journal-title":"Ocul Surf"},{"key":"1541_CR4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1080\/09286580600801044","volume":"13","author":"JP Clegg","year":"2006","unstructured":"Clegg\u00a0JP, Guest\u00a0JF, Lehman\u00a0A, Smith\u00a0AF (2006) The annual cost of dry eye syndrome in France, Germany, Italy, Spain, Sweden and the United Kingdom among patients managed by ophthalmologists. Ophthalmic Epidemiol 13:263\u2013274","journal-title":"Ophthalmic Epidemiol"},{"key":"1541_CR5","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","volume":"15","author":"F Stapleton","year":"2017","unstructured":"Stapleton\u00a0F, Alves\u00a0M, Bunya\u00a0VY et\u00a0al (2017) TFOS DEWS II epidemiology report. Ocul Surf 15:334\u2013365","journal-title":"Ocul Surf"},{"key":"1541_CR6","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1136\/bjophthalmol-2014-305201","volume":"98","author":"J Vehof","year":"2014","unstructured":"Vehof\u00a0J, Kozareva\u00a0D, Hysi\u00a0PG, Hammond\u00a0CJ (2014) Prevalence and risk factors of dry eye disease in a\u00a0British female cohort. Br J Ophthalmol 98:1712\u20131717","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"1541_CR7","doi-asserted-by":"publisher","first-page":"e504","DOI":"10.1111\/aos.14300","volume":"98","author":"C Siffel","year":"2020","unstructured":"Siffel\u00a0C, Hennies\u00a0N, Joseph\u00a0C, Lascano\u00a0V, Horvat\u00a0P, Scheider\u00a0M, Ganzera\u00a0F (2020) Burden of dry eye disease in Germany: a retrospective observational study using German claims data. Acta Ophthalmol 98(4):e504\u2013e512. https:\/\/doi.org\/10.1111\/aos.14300","journal-title":"Acta Ophthalmol"},{"key":"1541_CR8","first-page":"269e75","volume":"15","author":"JD Nelson","year":"2017","unstructured":"Nelson\u00a0JD, Craig\u00a0JP, Akpek\u00a0E, Azar\u00a0DT, Belmonte\u00a0C, Bron\u00a0AJ et\u00a0al (2017) TFOS DEWS II introduction. Ocul Surf 15:269e75","journal-title":"Ocul Surf"},{"issue":"5","key":"1541_CR9","first-page":"75","volume":"2007","author":"DEWS","year":"2007","unstructured":"DEWS (2007) The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop. Ocul Surf 2007(5):75\u201392","journal-title":"Ocul Surf"},{"key":"1541_CR10","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.ajo.2013.12.023","volume":"157","author":"AJ Paulsen","year":"2014","unstructured":"Paulsen\u00a0AJ, Cruickshanks\u00a0KJ, Fischer\u00a0ME, Huang\u00a0GH, Klein\u00a0BE, Klein\u00a0R, Dalton\u00a0DS (2014) Dry eye in the Beaver Dam Offspring Study: prevalence, risk factors, and health-related quality of life. Am J Ophthalmol 157:799\u2013806","journal-title":"Am J Ophthalmol"},{"key":"1541_CR11","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","volume":"15","author":"AJ Bron","year":"2017","unstructured":"Bron\u00a0AJ, de Paiva\u00a0CS, Chauhan\u00a0SK et\u00a0al (2017) TFOS DEWS II pathophysiology report. Ocul Surf 15:438\u2013510","journal-title":"Ocul Surf"},{"key":"1541_CR12","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/ICL.0000000000000228","volume":"42","author":"Y Zhao","year":"2016","unstructured":"Zhao\u00a0Y et\u00a0al (2016) Clinical trial of thermal pulsation (LipiFlow) in Meibomian gland dysfunction with preteatment Meibography. Eye Contact Lens 42:339\u2013346","journal-title":"Eye Contact Lens"},{"key":"1541_CR13","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1167\/iovs.10-6997a","volume":"52","author":"KK Nichols","year":"2011","unstructured":"Nichols\u00a0KK, Foulks\u00a0GN, Bron\u00a0AJ et\u00a0al (2011) The International Workshop on Meibomian Gland Dysfunction: executive summary. Invest Ophthalmol Vis Sci 52:1922\u20131929","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1541_CR14","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.exer.2003.09.019","volume":"78","author":"AJ Bron","year":"2004","unstructured":"Bron\u00a0AJ, Tiffany\u00a0JM, Gouveia\u00a0SM et\u00a0al (2004) Functional aspects of the tear filmlipid layer. Exp Eye Res 78:347\u2013360","journal-title":"Exp Eye Res"},{"key":"1541_CR15","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S1542-0124(12)70150-7","volume":"2","author":"AJ Bron","year":"2004","unstructured":"Bron\u00a0AJ, Tiffany\u00a0JM (2004) The contribution of meibomian disease to dry eye. Ocul Surf 2:149\u2013165","journal-title":"Ocul Surf"},{"key":"1541_CR16","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1097\/01.ICL.0000060998.20142.8D","volume":"29","author":"MC Olson","year":"2003","unstructured":"Olson\u00a0MC, Korb\u00a0DR, Greiner\u00a0JV (2003) Increase in tear film lipid layer thickness following treatment with warm compresses in patients with meibomian gland dysfunction. Eye Contact Lens 29:96\u201399","journal-title":"Eye Contact Lens"},{"key":"1541_CR17","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/S0021-5155(03)00142-4","volume":"47","author":"A Mori","year":"2003","unstructured":"Mori\u00a0A, Shimazaki\u00a0J, Shimmura\u00a0S et al (2003) Disposable eyelid-warming device for the treatment of meibomian gland dysfunction. Jpn J Ophthalmol 47:578\u2013586","journal-title":"Jpn J Ophthalmol"},{"key":"1541_CR18","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1136\/bjo.86.12.1403","volume":"86","author":"E Goto","year":"2002","unstructured":"Goto\u00a0E, Monden\u00a0Y, Takano\u00a0Y et al (2002) Treatment of non-inflamed obstructive meibomian gland dysfunction by an infrared warm compression device. Br J Ophthalmol 86:1403\u20131407","journal-title":"Br J Ophthalmol"},{"key":"1541_CR19","series-title":"Abstract TFOSVA","volume-title":"Changes in visual acuity following Meibomian gland heat therapy","author":"EI Pearce","year":"2007","unstructured":"Pearce\u00a0EI, Pentland\u00a0A, Shabbir\u00a0S (2007) Changes in visual acuity following Meibomian gland heat therapy. Abstract TFOSVA"},{"issue":"4","key":"1541_CR20","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/ICL.0000000000000258","volume":"43","author":"YA Alghamdi","year":"2017","unstructured":"Alghamdi\u00a0YA et\u00a0al (2017) Compliance and subjective patient responses to eyelid hygiene. Eye Contact Lens 43(4):213\u2013217","journal-title":"Eye Contact Lens"},{"key":"1541_CR21","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.clae.2013.02.009","volume":"36","author":"C Purslow","year":"2013","unstructured":"Purslow\u00a0C (2013) Evaluation of the ocular tolerance of a\u00a0novel eyelid-warming device used for meibomian gland dysfunction. Cont Lens Anterior Eye 36:226\u2013231","journal-title":"Cont Lens Anterior Eye"},{"key":"1541_CR22","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jtos.2013.12.001","volume":"12","author":"D Finis","year":"2014","unstructured":"Finis\u00a0D, Hayajneh\u00a0J, K\u00f6nig\u00a0C et al (2014) Evaluation of an automated thermodynamic treatment (LipiFlow(R)) system for meibomian gland dysfunction: a prospective, randomized, observer-masked trial. Ocul Surf 12:146\u2013154","journal-title":"Ocul Surf"},{"key":"1541_CR23","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.jfo.2013.12.007","volume":"37","author":"A Baumann","year":"2014","unstructured":"Baumann\u00a0A, Cochener\u00a0B (2014) Meibomian gland dysfunction: a comparative study of modern treatments. J\u00a0Fr Ophtalmol 37:303\u2013312","journal-title":"J Fr Ophtalmol"},{"key":"1541_CR24","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3109\/02713683.2010.509529","volume":"36","author":"BR Friedland","year":"2011","unstructured":"Friedland\u00a0BR, Fleming\u00a0CP, Blackie\u00a0CA et\u00a0al (2011) A novel thermodynamic treatment for meibomian gland dysfunction. Curr Eye Res 36:79\u201387","journal-title":"Curr Eye Res"},{"key":"1541_CR25","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1111\/ceo.12033","volume":"41","author":"JV Greiner","year":"2013","unstructured":"Greiner\u00a0JV (2013) Long-term (12-month) improvement in meibomian gland function and reduced dry eye symptoms with a\u00a0single thermal pulsation treatment. Clin Exp Ophthalmol 41:524\u2013530","journal-title":"Clin Exp Ophthalmol"},{"issue":"4","key":"1541_CR26","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1007\/s40123-020-00304-3","volume":"9","author":"L Valencia-Nieto","year":"2020","unstructured":"Valencia-Nieto\u00a0L et al (2020) Therapeutic instruments targeting Meibomian gland dysfunction. Ophthalmol Ther 9(4):797\u2013807","journal-title":"Ophthalmol Ther"},{"issue":"1","key":"1541_CR27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/ICL.0000000000000544","volume":"45","author":"X Zhang","year":"2019","unstructured":"Zhang\u00a0X et\u00a0al (2019) Ocular surface disease and glaucoma medications: a clinical approach. Eye Contact Lens 45(1):11\u201318","journal-title":"Eye Contact Lens"},{"key":"1541_CR28","first-page":"CD013333","volume":"6","author":"K Savla","year":"2020","unstructured":"Savla\u00a0K, Le\u00a0JT, Pucker\u00a0AD (2020) Tea tree oil for Demodex blepharitis (Review). Cochrane Database Syst Rev 6:CD13333","journal-title":"Cochrane Database Syst Rev"},{"key":"1541_CR29","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1186\/s12886-020-01557-z","volume":"20","author":"J Li","year":"2020","unstructured":"Li\u00a0J et\u00a0al (2020) Effects of chalazion and its treatments on the meibomian glands: a nonrandomized, prospective observation clinical study. BMC Ophthalmol 20:278","journal-title":"BMC Ophthalmol"},{"issue":"1","key":"1541_CR30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/ICL.0000000000000009","volume":"40","author":"P Ramamoorthy","year":"2014","unstructured":"Ramamoorthy\u00a0P, Nichols\u00a0JJ (2014) Compliance factors associated with contact lens-related dry eye. Eye Contact Lens 40(1):17\u201322","journal-title":"Eye Contact Lens"},{"key":"1541_CR31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000455087","volume":"8","author":"CJ Kenrick","year":"2017","unstructured":"Kenrick\u00a0CJ et\u00a0al (2017) The limitation of applying heat to the external lid surface: a case of recalcitrant Meibomian gland dysfunction. Case Rep Ophthalmol 8:7\u201312","journal-title":"Case Rep Ophthalmol"},{"key":"1541_CR32","doi-asserted-by":"publisher","DOI":"10.1007\/s00717-020-00475-1","author":"C Laufenb\u00f6ck","year":"2020","unstructured":"Laufenb\u00f6ck\u00a0C (2020) Influence of eyelid tattooing on meibomian glands and tear film. Spektrum Augenheilkd. https:\/\/doi.org\/10.1007\/s00717-020-00475-1","journal-title":"Spektrum Augenheilkd"},{"issue":"3","key":"1541_CR33","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.jtos.2019.04.003","volume":"17","author":"E Daniel","year":"2019","unstructured":"Daniel\u00a0E et\u00a0al (2019) Grading and baseline characteristics of meibomian glands in meibography images and their clinical associations in the Dry Eye Assessment and Management (DREAM) study. Ocul Surf 17(3):491\u2013501","journal-title":"Ocul Surf"},{"issue":"3","key":"1541_CR34","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.clae.2013.09.011","volume":"37","author":"AM Masmali","year":"2014","unstructured":"Masmali\u00a0AM et\u00a0al (2014) Development of a\u00a0new grading scale for tear ferning. Cont Lens Anterior Eye 37(3):178\u2013184","journal-title":"Cont Lens Anterior Eye"},{"key":"1541_CR35","doi-asserted-by":"publisher","DOI":"10.1055\/a-1353-5747","author":"R Fagehi","year":"2021","unstructured":"Fagehi R et al (2021) Bewertung der Bedeutung von Tr\u00e4nenfarnmustern bei Patienten mit Beta-Thalass\u00e4mie. Klin Monbl Augenheilkd. https:\/\/doi.org\/10.1055\/a-1353-5747","journal-title":"Klin Monbl Augenheilkd"},{"issue":"3","key":"1541_CR36","first-page":"CD013559","volume":"3","author":"S Cote","year":"2020","unstructured":"Cote S et al (2020) Intense pulsed light (IPL) therapy for the treatment of meibomian gland dysfunction. Cochrane Database Syst Rev. 3(3):CD013559.","journal-title":"Cochrane Database Syst Rev"},{"key":"1541_CR37","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S1542-0124(12)70138-6","volume":"1","author":"JP McCulley","year":"2003","unstructured":"McCulley\u00a0JP, Shine\u00a0WE (2003) Meibomian gland function and the tear lipid layer. Ocul Surf 1:97\u2013106","journal-title":"Ocul Surf"},{"issue":"3","key":"1541_CR38","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","volume":"15","author":"AJ Bron","year":"2017","unstructured":"Bron\u00a0AJ et\u00a0al (2017) TFOS DEWS II pathophysiology report. Ocul Surf 15(3):438\u2013510","journal-title":"Ocul Surf"},{"key":"1541_CR39","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/978-1-4615-5359-5_40","volume":"438","author":"AK Bron","year":"1998","unstructured":"Bron\u00a0AK, Tiffany\u00a0JM (1998) The meibomian glands and tear film lipids: structure, function and control. Adv Exp Med Biol 438:281\u2013295","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"1541_CR40","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1186\/s12886-020-01557-z","volume":"20","author":"J Li","year":"2020","unstructured":"Li\u00a0J et\u00a0al (2020) Effects of chalazion and its treatments on the meibomian glands: a nonrandomized, prospective observation clinical study. BMC Ophthalmol 20(1):278","journal-title":"BMC Ophthalmol"},{"key":"1541_CR41","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3109\/02713683.2011.631721","volume":"37","author":"JV Greiner","year":"2012","unstructured":"Greiner\u00a0JV (2012) A single LipiFlow(R) thermal pulsation system treatment improves meibomian gland function and reduces dry eye symptoms for 9\u00a0months. Curr Eye Res 37:272\u2013278","journal-title":"Curr Eye Res"},{"key":"1541_CR42","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/ICL.0000000000000166","volume":"42","author":"JV Greiner","year":"2016","unstructured":"Greiner\u00a0JV et al (2016) Long-Term (3\u00a0year) effects of a\u00a0single thermal pulsation system treatment on meibomian gland function and dry eye symptoms. Eye Contact Lens 42:99\u2013107","journal-title":"Eye Contact Lens"},{"key":"1541_CR43","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4280543","author":"I Imsuwan","year":"2020","unstructured":"Imsuwan\u00a0I et al (2020) The study of incidence and characteristics of patients with eye-related chief complaints at the emergency department of Thammasat University Hospital. Emerg Med Int. https:\/\/doi.org\/10.1155\/2020\/4280543","journal-title":"Emerg Med Int"}],"container-title":["Die Ophthalmologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-021-01541-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00347-021-01541-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-021-01541-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T14:32:45Z","timestamp":1654698765000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00347-021-01541-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,4]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["1541"],"URL":"https:\/\/doi.org\/10.1007\/s00347-021-01541-y","relation":{},"ISSN":["2731-720X","2731-7218"],"issn-type":[{"value":"2731-720X","type":"print"},{"value":"2731-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,4]]},"assertion":[{"value":"7 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"C.\u00a0Laufenb\u00f6ck gibt an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der zust\u00e4ndigen Ethikkommission, im Einklang mit nationalem Recht sowie gem\u00e4\u00df der Deklaration von Helsinki von 1975 (in der aktuellen, \u00fcberarbeiteten Fassung) durchgef\u00fchrt. Von allen beteiligten Patienten liegt eine Einverst\u00e4ndniserkl\u00e4rung vor. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patienten zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}