{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:43:42Z","timestamp":1740185022589,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Klinikum rechts der Isar der Technischen Universit\u00e4t M\u00fcnchen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Bei Patienten mit chronischer Chorioretinopathia centralis serosa (cCRCS) soll die \u201elow-dose photodynamische Therapie\u201c (PDT) \u00fcber eine kurzfristige choriokapill\u00e4re Minderperfusion zu einem langfristigen vaskul\u00e4ren Umbau mit konsekutiver Reduktion der vaskul\u00e4ren Hyperpermeabilit\u00e4t und Leckage f\u00fchren. Ob sich die verminderte Perfusion g\u00e4nzlich normalisiert, bleibt jedoch ungekl\u00e4rt. Hauptziel der retrospektiv angelegten Studie war es, das choriokapill\u00e4re Flusssignal nach \u201elow-dose PDT\u201c mittels optischer Koh\u00e4renztomographie-Angiographie (OCT\u2011A) zu analysieren.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Patienten und Methoden<\/jats:title>\n                <jats:p>Eingeschlossen wurden 19\u00a0im Rahmen der \u201elow-dose PDT\u201c belichtete Areale an 16\u00a0Augen. Neben der Erhebung von Visus und Metamorphopsien wurden ein \u201eenhanced depth imaging-OCT\u201c (EDI-OCT) und eine OCT-Angiographie mit Zentrierung auf das bei der \u201elow-dose PDT\u201c belichtete Areal angefertigt. Im Rahmen der vorliegenden Studie wurden das choriokapill\u00e4re Flusssignal sowie die chorioidale Dicke innerhalb eines genormten Bezirks sowohl im Bereich der PDT-Applikation als auch in einem unbeleuchteten Referenzareal in direkter N\u00e4he mit gleicher Exzentrizit\u00e4t in Bezug auf die Fovea centralis retrospektiv ausgewertet.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Es konnten im Mittel eine Abnahme des choriokapill\u00e4ren Flusssignals um 33\u202f% (<jats:italic>p<\/jats:italic>\u202f&lt;\u20090,001) im belichteten Areal gegen\u00fcber dem Referenzareal sowie eine im Durchschnitt um 71\u202f\u00b5m (<jats:italic>p<\/jats:italic>\u202f=\u20090,001) verminderte Aderhautdicke im Vergleich zum Referenzareal gezeigt werden; 7\u00a0von 10\u00a0Patienten beklagten trotz \u201elow-dose PDT\u201c langfristig Metamorphopsien, jedoch ergab sich durch die Therapie bei fast der H\u00e4lfte der Patienten eine Visusverbesserung.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerungen<\/jats:title>\n                <jats:p>Durch die OCT-Angiographie konnte gezeigt werden, dass die \u201elow-dose PDT\u201c im Bereich der Choriokapillaris ein vermindertes Blutflusssignal zur\u00fcckl\u00e4sst und somit das vaskul\u00e4re Remodelling die thrombosebedingte Hypoperfusion nicht g\u00e4nzlich kompensiert.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00347-021-01552-9","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T09:06:12Z","timestamp":1640163972000},"page":"699-704","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effekt der \u201elow-dose PDT\u201c auf die choriokapill\u00e4re Perfusion bei cCRCS","Effect of low-dose PDT on perfusion of the choriocapillaris in cCSCR"],"prefix":"10.1007","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4358-9831","authenticated-orcid":false,"given":"E.","family":"Reifeltshammer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Feucht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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