{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:01:26Z","timestamp":1778756486789,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Freiburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Die Entschl\u00fcsselung des Transkriptoms hat in den letzten Jahren unser Verst\u00e4ndnis zahlreicher Erkrankungen verbessert. \u00d6ffentlich zug\u00e4ngliche Datenbanken, wie z.\u202fB. die <jats:italic>Gene Expression Omnibus<\/jats:italic>-Datenbank des <jats:italic>National Center for Biotechnology Information<\/jats:italic>, sammeln Transkriptomrohdaten aus einer Vielfalt von Proben, ohne jedoch dem bioinformatischen Laien einen intuitiven Zugang zu den Daten zu gew\u00e4hren. Daher wurden in den vergangenen Jahren spezielle Transkriptomdatenbanken programmiert, die eine benutzerfreundliche Web-basierte Datenanalyse erm\u00f6glichen und damit niederschwellig molekulare Einblicke in okul\u00e4re Gewebe erm\u00f6glichen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Fragestellung<\/jats:title>\n                <jats:p>Ziel dieser Arbeit ist es, einen \u00dcberblick \u00fcber die aktuell verf\u00fcgbaren okul\u00e4ren Transkriptomdatenbanken zu geben und diese mit dem in Freiburg neu etablierten <jats:italic>Human Eye Transcriptome Atlas<\/jats:italic> zu vergleichen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methoden<\/jats:title>\n                <jats:p>Literatursuche in PubMed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Neun okul\u00e4re Transkriptomdatenbanken mit unterschiedlichem Anwendungsschwerpunkt wurden identifiziert. Die Plattformen <jats:italic>iSyTE<\/jats:italic> und <jats:italic>Express <\/jats:italic>spezialisieren sich auf die Genexpression w\u00e4hrend der Linsen- und Netzhautentwicklung der Maus, wohingegen <jats:italic>retina.tigem.it, Eye in a\u00a0Disk<\/jats:italic> und <jats:italic>Spectacle<\/jats:italic> ihren Fokus auf einzelne okul\u00e4re Gewebe wie die Netzhaut legen. <jats:italic>Spectacle, UCSC Cell Browser <\/jats:italic>und <jats:italic>Single Cell Portal <\/jats:italic>erlauben die intuitive Exploration von Einzelzell-RNA-Sequenzierungsdaten von Netzhaut\u2011, Aderhaut\u2011, Kornea\u2011, Iris\u2011, Trabekelmaschenwerk- und Skleragewebe. Die Microarray-Profile verschiedener gesunder okul\u00e4rer Gewebe werden in der <jats:italic>Ocular Tissue Database <\/jats:italic>bereitgestellt. Der <jats:italic>Human Eye Transcriptome Atlas<\/jats:italic> erfasst derzeit die gr\u00f6\u00dfte Vielfalt an Augengeweben und Erkrankungen des Auges. Er zeichnet sich durch einen hohen Qualit\u00e4tsstandard aus, der durch methodische Homogenit\u00e4t erreicht wird.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerungen<\/jats:title>\n                <jats:p>Okul\u00e4re Transkriptomdatenbanken bieten einen umfassenden und intuitiven Einblick in die Transkriptionsprofile verschiedener gesunder und erkrankter Augengewebe. So verbessern sie unser Verst\u00e4ndnis der zugrunde liegenden molekularen Krankheitsprozesse, unterst\u00fctzen die Hypothesengenerierung und helfen bei der Suche nach neuen diagnostischen und therapeutischen Zielen f\u00fcr verschiedene Augenerkrankungen.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00347-022-01592-9","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T18:03:01Z","timestamp":1645552981000},"page":"929-936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Webbasierte Genexpressionsanalysen\u00a0\u2013 auf dem Weg zur molekularen Entschl\u00fcsselung gesunder und erkrankter Augengewebe","Web-based gene expression analysis\u2014paving the way to decode healthy and diseased ocular tissue"],"prefix":"10.1007","volume":"119","author":[{"given":"Julian","family":"Wolf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thabo","family":"Lapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Reinhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hansj\u00fcrgen","family":"Agostini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnther","family":"Schlunck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"1592_CR1","doi-asserted-by":"publisher","first-page":"e0151615","DOI":"10.1371\/journal.pone.0151615","volume":"11","author":"JA Blair","year":"2016","unstructured":"Blair\u00a0JA, Wang\u00a0C, Hernandez\u00a0D et\u00a0al (2016) Individual case analysis of postmortem interval time on brain tissue preservation. 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