{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:25:49Z","timestamp":1771644349624,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005722","name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005722","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Einf\u00fchrung<\/jats:title>\n                <jats:p>Die phototherapeutische Keratektomie gilt heute als etabliertes Therapieverfahren f\u00fcr Patienten, welche unter therapierefrakt\u00e4ren genetisch bedingten Hornhautdystrophien oder rezidivierenden Erosiones ohne zugrunde liegende Basalmembrandystrophie leiden.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Arbeit<\/jats:title>\n                <jats:p>Ziel der Arbeit war es, \u00c4nderungen der Refraktion und der Pachymetrie nach phototherapeutischer Keratektomie bei Patienten, welche  eine epitheliale Basalmembrandystrophie oder rezidivierende Erosiones ohne zugrunde liegende Basalmembrandystrophie (traumatisch\/nichttraumatisch bedingt) aufweisen, zu analysieren.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Die Patientendaten wurden retrospektiv aus dem Smart-Eye-Data-Datenbank-System der Augenklinik der LMU in den Jahren 2014 bis 2020 zusammen mit diagnostischen Daten aus Pentacam HR und Autorefraktometer ausgewertet. Als festes Therapieregime wurde eine Photoablation von 10\u202f\u03bcm f\u00fcr epitheliale Basalmembrandystrophie und 6\u202f\u03bcm f\u00fcr Patienten ohne Basalmembrandystrophie gew\u00e4hlt.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>In beiden Kollektiven konnte eine Abnahme der Pachymetrie am Apex nachgewiesen werden (epitheliale Basalmembrandystrophie: Abnahme 25,8\u202f\u03bcm, \u00b119,6\u202f\u03bcm SD, Bandbreite \u221212\u201397\u202f\u03bcm; keine Basalmembrandystrophie: Abnahme 12,3\u202f\u03bcm, \u00b117,6\u202f\u03bcm SD, Bandbreite \u221239\u201368\u202f\u03bcm). Es kam zu keiner signifikanten Zu- oder Abnahme der \u201etotal corneal refractive power\u201c im epitheliale Basalmembrandystrophie-Kollektiv, im Kollektiv der rezidivierenden Erosiones ohne Basalmembrandystrophie zu einer signifikanten Zunahme von 42,3\u202fdpt auf 42,6\u202fdpt (Ver\u00e4nderung \u00b10,8\u202fdpt SD, <jats:italic>p<\/jats:italic>\u202f&lt;\u20090,05). Das sph\u00e4rische \u00c4quivalent zeigte keine Ver\u00e4nderung im Follow-up-Intervall f\u00fcr das epitheliale Basalmembrandystrophie Kollektiv. Hingegen zeigte das Kollektiv ohne Basalmembrandystrophie  eine statistisch signifikante Abnahme des SE um 0,4\u202fdpt (\u00b10,7\u202fdpt SD, <jats:italic>p<\/jats:italic>\u202f&lt;\u20090,05). Das mittlere Follow-up-Intervall betrug 126\u00a0Tage (CI 95\u202f%: 104 bis 147\u00a0Tage).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Ein signifikanter Einfluss auf die Refraktion konnte in der durchgef\u00fchrten Studie in Bezug auf die \u201etotal corneal refractive power\u201c f\u00fcr beide Kollektive nur in geringem Ma\u00dfe festgestellt werden. Der finale Abtrag anhand der Pachymetrie am Apex hingegen kann auf das 2,3- bis 2,6-Fache der urspr\u00fcnglichen Ablationstiefe gesch\u00e4tzt werden. Ursachen hierf\u00fcr sind einerseits der Laserabtrag selbst sowie der Einfluss der reaktiven Wundheilung des kornealen Epithels.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00347-022-01638-y","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T13:11:50Z","timestamp":1651497110000},"page":"1041-1046","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phototherapeutische Keratektomie bei rezidivierenden Hornhauterosionen verschiedener epithelialer Genese: Einfluss der Ablationstiefe auf Pachymetrie und Refraktion","Phototherapeutic keratectomy for recurrent corneal erosion of various epithelial origins: influence of depth of ablation on pachymetry and refraction"],"prefix":"10.1007","volume":"119","author":[{"given":"Vitus","family":"Grauvogl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Luft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Nobl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian J.","family":"Gerhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Siedlecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Shajari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8891-4875","authenticated-orcid":false,"given":"Wolfgang J.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"issue":"3","key":"1638_CR1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3928\/1081597X-20161123-01","volume":"33","author":"SE Wilson","year":"2017","unstructured":"Wilson\u00a0SE et\u00a0al (2017) Phototherapeutic keratectomy: science and art. 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J.\u00a0Siedlecki: Vortragshonorare und Reisekostenerstattung von Carl Zeiss Meditec AG, Novartis Pharma GmbH, Bayer AG, Pharm-Allergan GmbH, Oculentis OSD Medical GmbH, Heidelberg Engineering GmbH. Beraterhonorare von Novartis GmbH, Apellis Pharmaceuticals, Bayer AG, Pharm-Allergan GmbH. Reisekostenerstattung von Oertli AG. M.\u00a0Gerhardt: Vortragshonorare und Reisekostenerstattung von Novartis GmbH. M.\u00a0Nobl: Reisekostenerstattung von Alcon Pharmaceuticals AG, Santen GmbH.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}