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Anhand der folgenden Studie m\u00f6chten wir gegen\u00fcber dem klinischen Krankheitsbild sensibilisieren sowie diagnostische und therapeutische M\u00f6glichkeiten aufzeigen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methodik<\/jats:title>\n                <jats:p>In dieser monozentrischen, retrospektiven Fallserie wurden alle Patienten der Universit\u00e4ts-Augenklinik Heidelberg im Zeitraum von 2011 bis 2021 eingeschlossen, bei denen ein mikrobiologischer Nachweis von <jats:italic>Fusarium<\/jats:italic> Spezies gelang.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Insgesamt 13\u00a0F\u00e4lle mit mikrobiologischem Nachweis von <jats:italic>Fusarium<\/jats:italic> Spezies konnten identifiziert werden, auff\u00e4llig war eine H\u00e4ufung im Jahr 2021. Die Patienten waren zu 76,9\u202f% weiblich und zu 76,9\u202f% Kontaktlinsentr\u00e4ger. Nur in 4\u00a0F\u00e4llen gelang die Erregeridentifizierung aus dem initialen Hornhautabradat. Die durchschnittliche Dauer bis zur Verdachtsdiagnose einer mykotischen Genese betrug 13,1\u00a0Tage, die mittlere Dauer bis zum Erregernachweis 14,6\u00a0Tage ab Symptombeginn. Alle getesteten Erreger wiesen Resistenzen gegen mindestens ein g\u00e4ngiges Antimykotikum auf. Die Therapie mittels perforierender Keratoplastik war bei 70\u202f% der F\u00e4lle erforderlich, in 57,1\u202f% kam es dabei zu einem Rezidiv. In 80\u202f% betrug der beste dokumentierte Visus nach Fusarien-Keratitis in unserer Fallserie \u2264\u202f0,4.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Bei erschwerten Nachweism\u00f6glichkeiten und hoher Resistenzlage kommt es bei der Fusarien-Keratitis meist zu einem versp\u00e4teten Therapiebeginn mit reduzierter Visusprognose. Bei Vorliegen von Risikofaktoren und Nicht-Ansprechen auf Antibiotika muss fr\u00fchzeitig eine antimykotische Therapie eingeleitet und ggf. eine Keratoplastik erwogen werden.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00347-022-01646-y","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T12:02:31Z","timestamp":1653480151000},"page":"1022-1034","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Keratitis durch Fusarien\u00a0\u2013 eine zunehmende Bedrohung in Deutschland?","Fusarium Keratitis\u2014an upcoming threat in Germany?"],"prefix":"10.1007","volume":"119","author":[{"given":"Bogdana","family":"Kovalchuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramin","family":"Khoramnia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcell","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Horner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd U.","family":"Auffarth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6315-8484","authenticated-orcid":false,"given":"Victor A.","family":"Augustin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"1646_CR1","doi-asserted-by":"publisher","first-page":"698780","DOI":"10.3389\/fcimb.2021.698780","volume":"11","author":"K Ahmadikia","year":"2021","unstructured":"Ahmadikia\u00a0K, Aghaei Gharehbolagh\u00a0S, Fallah\u00a0B et al (2021) Distribution, prevalence, and causative agents of fungal keratitis: a systematic review and meta-analysis (1990 to 2020). 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B.\u00a0Kovalchuk, M.\u00a0T\u00f3th, S.\u00a0Horner, G.U.\u00a0Auffarth und V.A.\u00a0Augustin geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der zust\u00e4ndigen Ethikkommission, im Einklang mit nationalem Recht sowie gem\u00e4\u00df der Deklaration von Helsinki von 1975 (in der aktuellen, \u00fcberarbeiteten Fassung) durchgef\u00fchrt. Von allen beteiligten Patienten liegt eine Einverst\u00e4ndniserkl\u00e4rung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}