{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:25:09Z","timestamp":1783481109741,"version":"3.55.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Glaukom-Drainage-Implantate (GDI) stellen ein invasives Verfahren zur Behandlung beim Glaukom dar. Neben dem Baerveldt- und Ahmed-Glaukom-Implantat wurde das PAUL\u00ae-Glaukom-Implantat (PGI) als neues, innovatives Therapieverfahren entwickelt. Dieses unterscheidet sich v.\u202fa. hinsichtlich der geringeren Gr\u00f6\u00dfe des Drainager\u00f6hrchens von den bisherigen Pr\u00e4paraten.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Arbeit<\/jats:title>\n                <jats:p>Sechs-Monats-Ergebnisse des PGI wurden hinsichtlich Effektivit\u00e4t und Komplikationsrate analysiert.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methoden<\/jats:title>\n                <jats:p>Eine Datenbank von Patienten, die mit dem PGI an der Universit\u00e4ts-Augenklinik Bonn versorgt wurden, wurde zur Dokumentation aller wesentlichen Parameter erstellt und kontinuierlich anhand der Verlaufskontrollen vervollst\u00e4ndigt. Die statistische Auswertung erfolgte mittels SPSS Statistics for Windows.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Insgesamt wurden in dieser Studie 53\u00a0Augen der ersten 51\u00a0konsekutiv mit dem PGI behandelten Patienten eingeschlossen. Der durchschnittliche Augeninnendruck lag pr\u00e4operativ bei 26,62\u202fmmHg (7\u201348\u202fmmHg) und reduzierte sich auf 12,20\u202fmmHg (3\u201322\u202fmmHg) nach sechs Monaten. Die lokale drucksenkende Therapie konnte von 3,37 Wirkstoffen pr\u00e4operativ auf 0,30 Wirkstoffe nach sechs Monaten gesenkt werden. Die Komplikationsrate war insgesamt gering, bei drei Patienten (5,7\u202f%) kam es zu einer persistierenden Hypotonie. Bei 16\u00a0Patienten wurde im postoperativen Verlauf nach durchschnittlich 2,9\u00a0Monaten der intraluminale Prolenefaden entfernt. Danach kam es bei diesen Patienten zu einer Drucksenkung von 22,21\u202fmmHg auf 11,07\u202fmmHg.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Das PAUL\u00ae-Glaukom-Implantat stellt eine sichere Behandlungsmethode dar, die erfolgreich den Augeninnendruck auf ein niedriges Niveau senkt, die drucksenkende Lokaltherapie reduziert und mit einer geringen Komplikationsrate, besonders hinsichtlich postoperativer Hypotonien, einhergeht.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00347-022-01669-5","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T16:04:32Z","timestamp":1655309072000},"page":"1267-1274","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Erste klinische Ergebnisse mit dem PAUL\u00ae-Glaukom-Implantat an der Universit\u00e4ts-Augenklinik Bonn","First clinical results with the PAUL\u00ae Glaucoma Implant at the University Eye Hospital Bonn"],"prefix":"10.1007","volume":"119","author":[{"given":"Constance","family":"Weber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hundertmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Brinken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank G.","family":"Holz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Mercieca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"issue":"3","key":"1669_CR1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1136\/bjo.53.3.161","volume":"53","author":"AC Molteno","year":"1969","unstructured":"Molteno\u00a0AC (1969) New implant for drainage in glaucoma. 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