{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:43:14Z","timestamp":1791229394153,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s00347-023-01934-1","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:02:01Z","timestamp":1696590121000},"page":"992-998","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Die Rolle des Glask\u00f6rpers in der Pathogenese der exsudativen altersabh\u00e4ngigen Makuladegeneration","Role of vitreous in the pathogenesis of neovascular age-related macular degeneration"],"prefix":"10.1007","volume":"120","author":[{"given":"Stefaniya","family":"Boneva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Haritoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Schultheiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sebag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"1934_CR1","doi-asserted-by":"publisher","first-page":"4151","DOI":"10.1167\/iovs.04-0118","volume":"45","author":"S Binder","year":"2004","unstructured":"Binder\u00a0S, Krebs\u00a0I, Hilgers\u00a0R\u2011D et al (2004) Outcome of transplantation of autologous retinal pigment epithelium in age-related acular degeneration: a\u00a0prospective trial. Invest Ophthalmol Vis Sci 45:4151","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1934_CR2","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/17469899.2022.2100763","volume":"17","author":"SK Boneva","year":"2022","unstructured":"Boneva\u00a0SK, Wolf\u00a0J, Wieghofer\u00a0P et\u00a0al (2022) Hyalocyte functions and immunology. Expert Rev Ophthalmol 17:249\u2013262","journal-title":"Expert Rev Ophthalmol"},{"key":"1934_CR3","doi-asserted-by":"publisher","first-page":"2920","DOI":"10.1172\/JCI31692","volume":"117","author":"C Combadi\u00e8re","year":"2007","unstructured":"Combadi\u00e8re\u00a0C, Feumi\u00a0C, Raoul\u00a0W et al (2007) CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J\u00a0Clin Invest 117:2920\u20132928","journal-title":"J Clin Invest"},{"key":"1934_CR4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-1-4939-1086-1_6","volume-title":"Vitreous: in health & disease","author":"S Crafoord","year":"2014","unstructured":"Crafoord\u00a0S, Ghosh\u00a0F, Sebag\u00a0J (2014) Vitreous biochemistry and artificial vitreous. In: Vitreous: in health & disease. Springer, New York, S\u00a081\u201394"},{"key":"1934_CR5","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1097\/01.iae.0000244722.35073.7c","volume":"26","author":"WR Freeman","year":"2006","unstructured":"Freeman\u00a0WR, Falkenstein\u00a0I (2006) Avastin and new treatments for AMD: where are we? Retina 26:853\u2013858","journal-title":"Retina"},{"key":"1934_CR6","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ajo.2009.07.036","volume":"149","author":"NM Holekamp","year":"2010","unstructured":"Holekamp\u00a0NM (2010) The vitreous gel: more than meets the eye. Am J Ophthalmol 149:32\u201336.e1","journal-title":"Am J Ophthalmol"},{"key":"1934_CR7","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.ajo.2009.11.022","volume":"149","author":"MW Johnson","year":"2010","unstructured":"Johnson\u00a0MW (2010) Posterior vitreous detachment: evolution and complications of its early stages. Am J Ophthalmol 149:371\u2013382.e1","journal-title":"Am J Ophthalmol"},{"key":"1934_CR8","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.ajo.2008.10.003","volume":"147","author":"JS Lee","year":"2009","unstructured":"Lee\u00a0JS, Lee\u00a0CS, Koh\u00a0JH (2009) Posterior vitreomacular adhesion and risk of exudative age-related macular degeneration: paired eye study. Am J Ophthalmol 147:621\u2013626.e1","journal-title":"Am J Ophthalmol"},{"key":"1934_CR9","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.ajo.2007.07.024","volume":"144","author":"I Krebs","year":"2007","unstructured":"Krebs\u00a0I, Brannath\u00a0W, Glittenberg\u00a0C et al (2007) Posterior vitreomacular adhesion: a\u00a0potential risk factor for exudative age-related macular degeneration? Am J Ophthalmol 144:741\u2013746.e1","journal-title":"Am J Ophthalmol"},{"key":"1934_CR10","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/978-1-4939-1086-1_19","volume-title":"Vitreous\u2014in health & disease","author":"I Krebs","year":"2014","unstructured":"Krebs\u00a0I, Glittenberg\u00a0C, Binder\u00a0S (2014) Vitreous in age-related macular degeneration. In: Sebag\u00a0J (Hrsg) Vitreous\u2014in health & disease. Springer, New York, S 329\u2013346"},{"key":"1934_CR11","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1136\/bjo.2010.192385","volume":"95","author":"I Krebs","year":"2011","unstructured":"Krebs\u00a0I, Glittenberg\u00a0C, Zeiler\u00a0F, Binder\u00a0S (2011) Spectral domain optical coherence tomography for higher precision in the evaluation of vitreoretinal adhesions in exudative age-related macular degeneration. Br J Ophthalmol 95:1415\u20131418","journal-title":"Br J Ophthalmol"},{"key":"1934_CR12","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.ophtha.2014.10.006","volume":"122","author":"RL Novack","year":"2015","unstructured":"Novack\u00a0RL, Staurenghi\u00a0G, Girach\u00a0A et al (2015) Safety of intravitreal ocriplasmin for focal vitreomacular adhesion in patients with exudative age-related macular degeneration. Ophthalmology 122:796\u2013802","journal-title":"Ophthalmology"},{"key":"1934_CR13","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ajo.2009.01.014","volume":"148","author":"CD Robison","year":"2009","unstructured":"Robison\u00a0CD, Krebs\u00a0I, Binder\u00a0S et al (2009) Vitreomacular adhesion in active and end-stage age-related macular degeneration. Am J Ophthalmol 148:79\u201382.e2","journal-title":"Am J Ophthalmol"},{"key":"1934_CR14","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1016\/j.ophtha.2009.11.007","volume":"117","author":"AB Roller","year":"2010","unstructured":"Roller\u00a0AB, Mahajan\u00a0VB, Boldt\u00a0HC et al (2010) Effects of vitrectomy on age-related macular degeneration. Ophthalmology 117:1381\u20131386","journal-title":"Ophthalmology"},{"key":"1934_CR15","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1097\/IAE.0b013e3181c969cb","volume":"30","author":"T Sakamoto","year":"2010","unstructured":"Sakamoto\u00a0T, Sheu\u00a0S\u2011J, Arimura\u00a0N et al (2010) Vitrectomy for exudative age-related macular degeneration with vitreous hemorrhage. Retina 30:856\u2013864","journal-title":"Retina"},{"key":"1934_CR16","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1016\/j.ajpath.2020.04.004","volume":"190","author":"A Schlecht","year":"2020","unstructured":"Schlecht\u00a0A, Boneva\u00a0S, Gruber\u00a0M et al (2020) Transcriptomic characterization of human choroidal neovascular membranes identifies calprotectin as a\u00a0novel biomarker for patients with age-related macular degeneration. Am J Pathol 190:1632\u20131642","journal-title":"Am J Pathol"},{"key":"1934_CR17","doi-asserted-by":"publisher","first-page":"618598","DOI":"10.3389\/fcell.2020.618598","volume":"8","author":"A Schlecht","year":"2021","unstructured":"Schlecht\u00a0A, Zhang\u00a0P, Wolf\u00a0J et\u00a0al (2021) Secreted phosphoprotein 1 expression in retinal mononuclear phagocytes links murine to human choroidal neovascularization. Front Cell Dev Biol 8:618598","journal-title":"Front Cell Dev Biol"},{"key":"1934_CR18","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/BF02160337","volume":"225","author":"J Sebag","year":"1987","unstructured":"Sebag\u00a0J (1987) Age-related changes in human vitreous structure. Graefes Arch Clin Exp Ophthalmol 225:89\u201393","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1934_CR19","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1007\/s00417-004-0980-1","volume":"242","author":"J Sebag","year":"2004","unstructured":"Sebag\u00a0J (2004) Anomalous posterior vitreous detachment: a\u00a0unifying concept in vitreo-retinal disease. Graefes Arch Clin Exp Ophthalmol 242:690\u2013698","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1934_CR20","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1097\/IAE.0b013e3181ac7b3c","volume":"29","author":"J Sebag","year":"2009","unstructured":"Sebag\u00a0J (2009) Pharmacologic vitreolysis\u2014premise and promise of the first decade. Retina 29:871\u2013874","journal-title":"Retina"},{"key":"1934_CR21","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/978-1-4939-1086-1_47","volume-title":"Vitreous\u2014in health & disease","author":"J Sebag","year":"2014","unstructured":"Sebag\u00a0J (2014) Pharmacologic vitreolysis. In: Sebag\u00a0J (Hrsg) Vitreous\u2014in health & disease. Springer, New York, S\u00a0799\u2013816"},{"key":"1934_CR22","first-page":"534","volume-title":"Ryan\u2019s retina","author":"J Sebag","year":"2022","unstructured":"Sebag\u00a0J (2022) Vitreous & vitreo-retinal interface. In: Sadda\u00a0SR (Hrsg) Ryan\u2019s retina, 7.\u00a0Aufl. Elsevier, S 534\u2013571","edition":"7"},{"key":"1934_CR23","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.survophthal.2012.01.011","volume":"57","author":"ARH Simpson","year":"2012","unstructured":"Simpson\u00a0ARH, Petrarca\u00a0R, Jackson\u00a0TL (2012) Vitreomacular adhesion and neovascular age-related macular degeneration. Surv Ophthalmol 57:498\u2013509","journal-title":"Surv Ophthalmol"},{"key":"1934_CR24","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00417-008-0980-7","volume":"247","author":"E Stef\u00e1nsson","year":"2009","unstructured":"Stef\u00e1nsson\u00a0E (2009) Physiology of vitreous surgery. Graefes Arch Clin Exp Ophthalmol 247:147\u2013163","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1934_CR25","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/978-1-4939-1086-1_25","volume-title":"Vitreous\u2014in health & disease","author":"E Stef\u00e1nsson","year":"2014","unstructured":"Stef\u00e1nsson\u00a0E (2014) Vitreous physiology. In: Sebag\u00a0J (Hrsg) Vitreous\u2014in health & disease. Springer, New York, S\u00a0437\u2013457"},{"key":"1934_CR26","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s00441-021-03514-8","volume":"387","author":"L Tenbrock","year":"2022","unstructured":"Tenbrock\u00a0L, Wolf\u00a0J, Boneva\u00a0S et al (2022) Subretinal fibrosis in neovascular age-related macular degeneration: current concepts, therapeutic avenues, and future perspectives. Cell Tissue Res 387:361\u2013375","journal-title":"Cell Tissue Res"},{"key":"1934_CR27","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/978-1-4939-1086-1_9","volume-title":"Vitreous\u2014in health & disease","author":"K Tozer","year":"2014","unstructured":"Tozer\u00a0K, Johnson\u00a0M, Sebag\u00a0J (2014) Vitreous aging and posterior vitreous detachment. In: Vitreous\u2014in health & disease. Springer, New York, S\u00a0131\u2013150"},{"key":"1934_CR28","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1001\/archopht.119.10.1475","volume":"119","author":"E Uchino","year":"2001","unstructured":"Uchino\u00a0E (2001) Initial stages of posterior vitreous detachment in healthy eyes of older persons evaluated by optical coherence tomography. Arch Ophthalmol 119:1475","journal-title":"Arch Ophthalmol"},{"key":"1934_CR29","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1007\/s003470050054","volume":"93","author":"B Weber-Krause","year":"1996","unstructured":"Weber-Krause\u00a0B, Eckardt\u00a0U (1996) H\u00e4ufigkeit einer hinteren Glask\u00f6rperabhebung bei Augen mit und ohne altersabh\u00e4ngiger Makuladegeneration Eine echographische Studie * (Incidence of posterior vitreous detachment in eyes with and without age-related macular degeneration: an ultrasound study). Ophthalmologe 93:660\u2013665","journal-title":"Ophthalmologe"},{"key":"1934_CR30","doi-asserted-by":"publisher","first-page":"e105123","DOI":"10.15252\/embj.2020105123","volume":"40","author":"P Wieghofer","year":"2021","unstructured":"Wieghofer\u00a0P, Hagemeyer\u00a0N, Sankowski\u00a0R et al (2021) Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling. EMBO\u00a0J 40:e105123","journal-title":"EMBO J"}],"container-title":["Die Ophthalmologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-023-01934-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00347-023-01934-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-023-01934-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T15:04:54Z","timestamp":1697727894000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00347-023-01934-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["1934"],"URL":"https:\/\/doi.org\/10.1007\/s00347-023-01934-1","relation":{},"ISSN":["2731-720X","2731-7218"],"issn-type":[{"value":"2731-720X","type":"print"},{"value":"2731-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"6 September 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"S.\u00a0Boneva, C.\u00a0Haritoglou, M.\u00a0Schultheiss, S.\u00a0Binder und J.\u00a0Sebag geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}