{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:41:09Z","timestamp":1779291669979,"version":"3.51.4"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein - Campus Kiel"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Neoplasien der Bindehaut umfassen eine Vielzahl verschiedener Entit\u00e4ten mit jeweils unterschiedlicher klinischer Pr\u00e4sentation. Diese sind anhand klinischer Merkmale nicht immer eindeutig voneinander zu unterscheiden. Die R0-Resektion stellt den Goldstandard f\u00fcr die meisten malignen Tumoren der Bindehaut dar, aber nicht jede benigne L\u00e4sion muss mittels Exzision behandelt werden. Im klinischen Alltag muss h\u00e4ufig ein konservatives Vorgehen gegen eine operative Exzision abgewogen werden.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel<\/jats:title>\n                <jats:p>Ziel dieser Arbeit war es, die Genauigkeit klinischer Diagnosen bei Neoplasien der Bindehaut zu ermitteln.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methoden<\/jats:title>\n                <jats:p>In einer retrospektiven Untersuchung wurden im Zeitraum zwischen 2011 und 2020 die Daten aller Patienten nach Exzision eines Bindehautbefundes, die an der Klinik f\u00fcr Ophthalmologie am UKSH Campus Kiel operiert wurden, extrahiert und ausgewertet. Es wurde jeweils die Spezifit\u00e4t, Sensitivit\u00e4t und der positive und negative Vorhersagewert f\u00fcr die pr\u00e4operative klinische Einsch\u00e4tzung der Dignit\u00e4t und die diagnostische Gruppe anhand des histopathologischen Befundes ermittelt.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Von 220 eingeschlossenen F\u00e4llen waren nach histologischer Beurteilung 75\u202f% benigne, 25\u202f% maligne. Die h\u00e4ufigste Neoplasie war der benigne Bindehautn\u00e4vus (12,3\u202f%). Die Sensitivit\u00e4t f\u00fcr die klinische Vorhersage einer benignen L\u00e4sion lag bei 0,86 (95%-Konfidenzintervall [95%-KI] 0,59\u20130,92), die Spezifit\u00e4t bei 0,95 (95%-KI: 0,85\u20130,99) und der positive Vorhersagewert bei 0,98 (95%-KI: 0,94\u20131,0). Die Sensitivit\u00e4t f\u00fcr die klinische Vorhersage maligner Dignit\u00e4t ergab 0,95 (95%-KI: 0,85\u20130,99), Spezifit\u00e4t 0,88 (95%-KI: 0,83\u20130,93) und der positive Vorhersagewert 0,73 (95%-KI: 0,61\u20130,83).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Die ermittelten Werte f\u00fcr die klinische Diagnose sind als gut zu bewerten. Dennoch sollte im klinischen Alltag, insbesondere bei untypischen L\u00e4sionen, die Verdachtsdiagnose kritisch \u00fcberpr\u00fcft werden und im Zweifel eine Exzision angestrebt werden.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00347-024-02009-5","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T12:02:08Z","timestamp":1709726528000},"page":"391-396","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Untersuchung der Genauigkeit klinischer Diagnosen von Neoplasien der Konjunktiva","Evaluation of the accuracy of clinical diagnosis of conjunctival neoplasms"],"prefix":"10.1007","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4619-9983","authenticated-orcid":false,"given":"Arved Rikus","family":"Gruben","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"H\u00f6sel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann","family":"Roider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Ehlken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"2009_CR1","unstructured":"Westekemper M Bechrakis, Benigne und maligne Bindehauttumoren in Diagnostik und Therapie. 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Von allen beteiligten Patient\/-innen liegt eine Einverst\u00e4ndniserkl\u00e4rung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}