{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:36:12Z","timestamp":1740184572526,"version":"3.37.3"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum M\u00fcnster"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Das Susac-Syndrom (SS)\u00a0stellt eine Endotheliopathie der Gef\u00e4\u00dfe im Bereich des zentralen Nervensystems dar. Die Beteiligung der Netzhaut spielt in der Krankheitsmanifestation eine zentrale Rolle.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Arbeit<\/jats:title>\n                <jats:p>Ziel dieser Fall-Kontroll-Studie ist die Untersuchung der makul\u00e4ren Gef\u00e4\u00dfstruktur bei Patienten mit chronischem SS im Vergleich zu Kontrollpersonen mittels optischer Koh\u00e4renztomographie Angiographie (OCTA).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Es wurden 12\u00a0Augen von 12\u00a0Susac-Patienten mit altersgleichen gesunden Kontrollpersonen hinsichtlich ihrer OCT-angiographischen Parameter verglichen. Die Flussdichte (FD) verschiedener makul\u00e4rer Schichten, Parameter der fovealen avaskul\u00e4ren Zone (FAZ) sowie die Werte der zentralen Netzhautdicke und des zentralen Netzhautvolumens wurden zwischen den beiden Gruppen verglichen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Die FD-Werte der Choriokapillaris waren in Susac-Patienten im Vergleich zu gesunden Kontrollen signifikant verringert. Die FD-Werte des oberfl\u00e4chlichen und tiefen Kapillarplexus der inneren Netzhaut, die Parameter der FAZ sowie die zentrale Netzhautdicke und -volumen zeigten keine signifikanten Unterschiede zwischen den beiden Gruppen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Diskussion<\/jats:title>\n                <jats:p>Das therapierte, chronische SS scheint keinen signifikanten Einfluss auf den vaskul\u00e4ren und strukturellen Aufbau der zentralen, inneren Netzhaut zu haben. Unterschiede der Choriokapillaris deuten jedoch auf Ver\u00e4nderungen in tiefer liegenden, stark vaskularisierten Kapillarschichten hin.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00347-024-02029-1","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T07:01:56Z","timestamp":1713423716000},"page":"487-493","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Auswirkungen des Susac-Syndroms auf die zentrale Gef\u00e4\u00dfstruktur der Netzhaut\u00a0\u2013 eine optische Koh\u00e4renztomographie-Angiographie-Studie","Effects of Susac syndrome on the central vascular structure of the retina\u2014An optical coherence tomography angiography study"],"prefix":"10.1007","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8063-6548","authenticated-orcid":false,"given":"Jens Julian","family":"Storp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena Anna","family":"Englmaier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian Alexander","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Eter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Lahme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maged","family":"Alnawaiseh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"2029_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/ICB.0000000000000308","volume":"11","author":"A Agarwal","year":"2017","unstructured":"Agarwal\u00a0A, Soliman\u00a0M, Sarwar\u00a0S et\u00a0al (2017) Spectral-domain optical coherence tomography evaluation of retinal structure in patients with Susacs syndrome. 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