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Triple-DMEK (<jats:italic>n<\/jats:italic>\u202f=\u2009187) operiert wurden. Der Nachbeobachtungszeitraum erstreckte sich bis Ende 2020. Die untersuchten Zielgr\u00f6\u00dfen waren: Auftreten einer endothelialen IR, eines Re-Bubblings und die Gr\u00f6\u00dfe des postoperativen ECL (6\u00a0Wochen, 6\u00a0Monate, 1\u00a0Jahr) in Abh\u00e4ngigkeit des Verh\u00e4ltnisses von Transplantat- zu Hornhautgr\u00f6\u00dfe (VTH).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Das VTH in dieser Studie schwankte von 0,35 bis 0,62 (0,46\u202f\u00b1\u20090,04). Es traten 33\u00a0(7,2\u202f%) postoperative IR auf (DMEK <jats:italic>n<\/jats:italic>\u202f=\u200925; Triple-DMEK <jats:italic>n<\/jats:italic>\u202f=\u20098). Das durchschnittliche VTH war ohne IR (0,46\u202f\u00b1\u20090,04) signifikant (<jats:italic>p<\/jats:italic>\u202f=\u20090,038) kleiner als in der Gruppe mit IR (0,47\u202f\u00b1\u20090,05). Ein Re-Bubbling war bei 159 von 457 Patientenaugen n\u00f6tig (34,8\u202f%). Das VTH der Augen mit Re-Bubbling (0,47\u202f\u00b1\u20090,04) war signifikant (<jats:italic>p<\/jats:italic>\u202f=\u20090,014) gr\u00f6\u00dfer als das VTH der Augen ohne Re-Bubbling (0,45\u202f\u00b1\u20090,04). Die durchschnittliche pr\u00e4operative Endothelzellzahl (ECD) betrug 2603\u202f\u00b1\u2009251 Zellen\/mm<jats:sup>2<\/jats:sup> (Min: 2161, Max: 3500 Zellen\/mm<jats:sup>2<\/jats:sup>). Ein gr\u00f6\u00dferer VTH hatte keinen positiven Einfluss auf den Endothelzellverlust (r\u202f=\u20090,001; <jats:italic>p<\/jats:italic>\u202f=\u20090,974).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Unsere Ergebnisse deuten an, dass ein gr\u00f6\u00dferer Transplantatdurchmesser im Vergleich zu Hornhautgr\u00f6\u00dfe mit einer erh\u00f6hten Rate von IR und Re-Bubblings nach DMEK einhergeht. Dagegen hatte das VTH keinen Einfluss auf den Endothelzellverlust nach DMEK. Aus diesem Grund sollte der Transplantatdurchmesser f\u00fcr DMEK gerade bei der Fuchs-Dystrophie nicht unn\u00f6tig gro\u00df gew\u00e4hlt werden.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00347-024-02030-8","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T12:01:30Z","timestamp":1713528090000},"page":"565-570","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Einfluss des Verh\u00e4ltnisses von Transplantatgr\u00f6\u00dfe zu Hornhautgr\u00f6\u00dfe auf Immunreaktion, Re-Bubbling-Rate und postoperativen Endothelzellverlust bei 457 Augen nach Descemet-Membrane-Endothelial-Keratoplastik (DMEK)","Impact of the ratio between graft and host corneal size on immune rejection, re-bubbling rate and postoperative endothelial cell loss in 457 eyes after Descemet membrane endothelial keratoplasty (DMEK)"],"prefix":"10.1007","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5872-1265","authenticated-orcid":false,"given":"Ursula","family":"Reinert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Munteanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loay","family":"Daas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"2030_CR1","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.ophtha.2011.09.019","volume":"119","author":"A Anshu","year":"2012","unstructured":"Anshu\u00a0A, Price\u00a0MO, Price\u00a0FW Jr. (2012) Risk of corneal transplant rejection significantly reduced with Descemet\u2019s membrane endothelial keratoplasty. 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