{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T09:50:56Z","timestamp":1756893056031,"version":"3.40.5"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"name":"Universit\u00e4tsklinikum Freiburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n          <jats:p>Diabetes mellitus ist eine chronische Stoffwechselerkrankung, die mit zahlreichen Komplikationen verbunden ist, darunter auch die diabetische Keratopathie. Diese oft untersch\u00e4tzte Erkrankung kann zu verminderter Hornhautsensibilit\u00e4t, neurotrophen Ulzera und potenziell sehbedrohenden Infektionen f\u00fchren. In dieser retrospektiven Analyse der Untergruppe von 136.992 maschinenlesbaren Gesundheitsakten, rekrutiert aus allen Patienten, die zwischen Januar 2003 und Februar 2024 in unserer Hochschulambulanz vorstellig waren, untersuchten wir die Assoziation zwischen Diabetes mellitus, neurotropher Keratopathie und Hornhautulzera. Von den Patienten wiesen 3168 Hornhautulzera (Pr\u00e4valenz: 2,3\u202f%) und 11.338 Diabetes mellitus (8\u202f%) auf. Die Ergebnisse zeigten, dass Diabetes mellitus das Risiko f\u00fcr Hornhautulzera (OR 1,18; 95\u202f%-KI 1,04\u20131,32) und neurotrophe Keratopathie (OR 1,78; 95\u202f%-KI 1,20\u20132,56) signifikant erh\u00f6ht. Zudem waren h\u00f6heres Alter und m\u00e4nnliches Geschlecht Risikofaktoren. In der umgekehrten Analyse zeigten sich Hornhautulzera als signifikante Pr\u00e4diktoren f\u00fcr das Vorliegen eines Diabetes mellitus. Unsere Ergebnisse unterstreichen die Notwendigkeit regelm\u00e4\u00dfiger augen\u00e4rztlicher Kontrollen und Diabetes-mellitus-Screenings bei Patienten mit erworbenen Hornhautwundheilungsst\u00f6rungen, um fr\u00fchzeitig zu intervenieren und schwere Folgen wie einen Visusverlust zu verhindern.<\/jats:p>","DOI":"10.1007\/s00347-025-02198-7","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T11:17:18Z","timestamp":1741173438000},"page":"378-382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neurotrophe Keratopathie und Hornhautulzera bei Diabetes mellitus","Neurotrophic keratopathy and corneal ulcers in diabetes mellitus"],"prefix":"10.1007","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7667-0270","authenticated-orcid":false,"given":"C.","family":"Haubold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Agostini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Reinhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"B\u00f6hringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"2198_CR1","doi-asserted-by":"publisher","first-page":"100762","DOI":"10.1016\/j.preteyeres.2019.05.003","volume":"73","author":"MA Al-Aqaba","year":"2019","unstructured":"Al-Aqaba\u00a0MA, Dhillon\u00a0VK, Mohammed\u00a0I, Said\u00a0DG, Dua\u00a0HS (2019) Corneal nerves in health and disease. 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F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}