{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T11:10:08Z","timestamp":1751368208214,"version":"3.41.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"name":"Universit\u00e4tsklinikum Halle (Saale)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n          <jats:sec>\n            <jats:title>Hintergrund<\/jats:title>\n            <jats:p>Die DMEK hat sich als Goldstandard zur Therapie endothelial bedingter Hornhautdekompensationen in den letzten Jahren durchgesetzt. Die schnelle postoperative Visusbesserung und die im Vergleich zur perforierenden Keratoplastik niedrigere Absto\u00dfungsrate bei diesem minimal-invasiven Verfahren begr\u00fcnden die hohe Akzeptanz der DMEK.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Fragestellung<\/jats:title>\n            <jats:p>Ziel dieser Studie war es, durch das Erfassen von patienten- und transplantatabh\u00e4ngigen Einflussgr\u00f6\u00dfen die Rahmenbedingungen f\u00fcr ein optimales visuelles Outcome nach einer DMEK zu analysieren.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Studiendesign und Untersuchungsmethoden<\/jats:title>\n            <jats:p>Es wurden retrospektiv 72\u00a0Augen untersucht, bei denen die Fuchs-Endotheldystrophie mittels DMEK in den Jahren 2019 und 2020 an der Universit\u00e4tsaugenklinik in Halle versorgt wurde. Die Datenerhebung umfasste die pr\u00e4operative Transplantatuntersuchung sowie die Voruntersuchung zur Operation und je eine Untersuchung innerhalb des ersten halben Jahres postoperativ und im zweiten postoperativen Jahr. Verglichen wurden insbesondere die BCVA und die Endothelzelldichte. Die Patientenbefragung erfolgte, um den subjektiv empfundenen Therapieerfolg zu evaluieren. Das Hauptaugenmerk lag auf dem Erfragen des R\u00fcckgangs der Beschwerden und der zur\u00fcckgewonnenen Selbstst\u00e4ndigkeit und Teilhabe am gesellschaftlichen Leben.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Ergebnisse<\/jats:title>\n            <jats:p>Der bestkorrigierte Visus stieg von 0,37\u202f\u00b1\u20090,15 (logMAR 0,43\u202f\u00b1\u20090,82) pr\u00e4operativ auf 0,65\u202f\u00b1\u20090,18 (logMAR 0,19\u202f\u00b1\u20090,74) im zweiten postoperativen Jahr. Die Endothelzelldichte des Transplantates reduzierte sich von 2503\u202f\u00b1\u2009206 Zellen\/mm<jats:sup>2<\/jats:sup> pr\u00e4operativ auf 1441\u202f\u00b1\u2009516 Zellen\/mm<jats:sup>2<\/jats:sup> im zweiten postoperativen Jahr und nahm somit im Mittel um 42\u202f% ab. Die Hornhautdicke reduzierte sich von 599\u202f\u00b1\u200958\u202f\u00b5m pr\u00e4operativ auf 521\u202f\u00b1\u200948\u202f\u00b5m im zweiten postoperativen Jahr und nahm im Mittel\u00a078\u202f\u00b1\u200971\u202f\u00b5m ab. Mehr als 70\u202f% der befragten Patienten klagten jeweils \u00fcber Lichtempfindlichkeit (<jats:italic>n<\/jats:italic>\u202f=\u200966), Verschwommensehen (<jats:italic>n<\/jats:italic>\u202f=\u200964) und vermindertes Farbempfinden (<jats:italic>n<\/jats:italic>\u202f=\u200959); 57\u202f% (<jats:italic>n<\/jats:italic>\u202f=\u200950) gaben Blendungserscheinungen an; 50\u202f% der Patienten (<jats:italic>n<\/jats:italic>\u202f=\u200950) empfinden ihre Sehkraft zum Befragungszeitpunkt besser als pr\u00e4operativ, 40\u202f% (<jats:italic>n<\/jats:italic>\u202f=\u200940) empfinden sie als optimal; 84\u202f% (<jats:italic>n<\/jats:italic>\u202f=\u200984) der Befragten beschreiben ihre Lebensqualit\u00e4t postoperativ als besser oder sogar als optimal.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Schlussfolgerung<\/jats:title>\n            <jats:p>Die DMEK ist ein effektives und sicheres Verfahren. Das visuelle Outcome kann durch verschiedene patienten- und transplantatabh\u00e4ngige Faktoren beeinflusst werden. So erreichen Patienten bei denen vorher andere Augenoperationen durchgef\u00fchrt wurden oder andere Augenerkrankungen vorlagen im Mittel einen geringeren postoperativen Visusanstieg. Au\u00dferdem l\u00e4sst sich ein Zusammenhang zwischen dem Spendergeschlecht und der Endothelzelldichteabnahme erkennen. Der Endothelzellverlust bei weiblichen Spendern ist gr\u00f6\u00dfer als bei m\u00e4nnlichen Spendern.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00347-025-02238-2","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T08:59:41Z","timestamp":1747126781000},"page":"524-532","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patienten- und spenderabh\u00e4ngige Faktoren bei der DMEK und deren Auswirkung auf Sehsch\u00e4rfe und Lebensqualit\u00e4t","Patient- and donor-dependent factors in descemet membrane endothelial keratoplasty and their impact on visual acuity and quality of life"],"prefix":"10.1007","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2515-137X","authenticated-orcid":false,"given":"Thomas","family":"Hammer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Wieland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Horn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Viestenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Viestenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"2238_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ajo.2018.01.018","volume":"188","author":"E Flockerzi","year":"2018","unstructured":"Flockerzi\u00a0E, Maier\u00a0P, B\u00f6hringer\u00a0D et\u00a0al (2018) Trends in corneal transplantation from 2001 to 2016 in Germany: a\u00a0report of the DOG-Section Cornea and its Keratoplasty Registry. Am J Ophthalmol 188:91\u201398","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"2238_CR2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1055\/s-0033-1358098","volume":"232","author":"C Meltendorf","year":"2015","unstructured":"Meltendorf\u00a0C, Torun\u00a0N, Thieme\u00a0H (2015) Therapeutische Hornhautchirurgie. Teil\u00a01: Keratoplastik. Klin Monbl Augenheilkd 232(3):313\u2013332","journal-title":"Klin Monbl Augenheilkd"},{"issue":"6","key":"2238_CR3","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1055\/s-0031-1299545","volume":"229","author":"W Lisch","year":"2012","unstructured":"Lisch\u00a0W, Seitz\u00a0B (2012) Endotheliale Hornhautdystrophien (HD) \u2013 Diagnose und Therapie. Klin Monbl Augenheilkd 229(6):594\u2013602","journal-title":"Klin Monbl Augenheilkd"},{"issue":"9","key":"2238_CR4","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1055\/s-0041-110448","volume":"233","author":"C Cursiefen","year":"2016","unstructured":"Cursiefen\u00a0C, Schaub\u00a0F, Bachmann\u00a0BO (2016) Update minimalinvasive lamell\u00e4re Keratoplastik: DMEK, DSAEK und DALK. Klin Monbl Augenheilkd 233(9):1033\u20131042","journal-title":"Klin Monbl Augenheilkd"},{"issue":"3","key":"2238_CR5","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1055\/s-0042-105156","volume":"234","author":"N Luft","year":"2017","unstructured":"Luft\u00a0N, Dirisamer\u00a0M, Priglinger\u00a0S (2017) Descemet-Membran-Endothelkeratoplastik (DMEK). Klin Monbl Augenheilkd 234(3):354\u2013364","journal-title":"Klin Monbl Augenheilkd"},{"issue":"6","key":"2238_CR6","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1055\/a-1774-4862","volume":"239","author":"B Seitz","year":"2022","unstructured":"Seitz\u00a0B, Daas\u00a0L, Wykrota\u00a0AA et\u00a0al (2022) Graft failure after PKP and DMEK: What is the best option? Klin Monbl Augenheilkd 239(6):775\u2013785","journal-title":"Klin Monbl Augenheilkd"},{"issue":"1","key":"2238_CR7","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s00717-015-0258-5","volume":"29","author":"N Luft","year":"2015","unstructured":"Luft\u00a0N, Priglinger\u00a0S, Pretzl\u00a0J et\u00a0al (2015) Descemet-Membran-Endothelkeratoplastik (DMEK) \u2013 Klinische Ergebnisse der ersten 120 F\u00e4lle. Spektrum Augenheilkd 29(1):10\u201318","journal-title":"Spektrum Augenheilkd"},{"issue":"2","key":"2238_CR8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1755-3768.2012.02504.x","volume":"91","author":"M Dirisamer","year":"2013","unstructured":"Dirisamer\u00a0M, Parker\u00a0J, Naveiras\u00a0M (2013) Identifying causes for poor visual outcome after DSEK\/DSAEK following secondary DMEK in the same eye. Acta Ophthalmol 91(2):131\u2013139","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"2238_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/ICO.0000000000000288","volume":"34","author":"E Yoeruek","year":"2015","unstructured":"Yoeruek\u00a0E, Rubino\u00a0G, Bayyoud\u00a0T, Bartz-Schmidt\u00a0KU (2015) Descemet membrane endothelial keratoplasty in vitrectomized eyes: clinical results. Cornea 34(1):1\u20135","journal-title":"Cornea"},{"issue":"12","key":"2238_CR10","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1016\/j.ophtha.2018.06.018","volume":"125","author":"K Wacker","year":"2018","unstructured":"Wacker\u00a0K, Baratz\u00a0KH, Bourne\u00a0WM, Patel\u00a0SV (2018) Patient-Reported visual disability in Fuchs\u2019 Endothelial Corneal Dystrophy measured by the visual function and corneal health status instrument. Ophthalmology 125(12):1854\u20131861","journal-title":"Ophthalmology"},{"issue":"2","key":"2238_CR11","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s00347-019-0938-7","volume":"117","author":"V Grewing","year":"2020","unstructured":"Grewing\u00a0V, Fritz\u00a0M, M\u00fcller\u00a0C et\u00a0al (2020) Visual function and corneal health status (V-FUCHS) auf Deutsch: Ein Fragebogen spezifisch f\u00fcr Fuchs-Endotheldystrophie. Ophthalmologe 117(2):140\u2013146","journal-title":"Ophthalmologe"},{"issue":"3","key":"2238_CR12","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1001\/archophthalmol.2008.619","volume":"127","author":"L Ham","year":"2009","unstructured":"Ham\u00a0L, Balachandran\u00a0C, Verschoor\u00a0CA et\u00a0al (2009) Visual rehabilitation rate after isolated descemet membrane transplantation: descemet membrane endothelial keratoplasty. Arch Ophthalmol 127(3):252\u2013255","journal-title":"Arch Ophthalmol"},{"issue":"11","key":"2238_CR13","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s00347-013-3014-8","volume":"111","author":"PP Ciechanowski","year":"2014","unstructured":"Ciechanowski\u00a0PP, Droutsas\u00a0K, Baydoun\u00a0L et\u00a0al (2014) Standardisierte Descemet-Membran-Endothelkeratoplastik (DMEK): Technik und aktuelle Ergebnisse. Ophthalmologe 111(11):1041\u20131049","journal-title":"Ophthalmologe"},{"issue":"6","key":"2238_CR14","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1055\/s-0029-1245446","volume":"227","author":"K Droutsas","year":"2010","unstructured":"Droutsas\u00a0K, Ham\u00a0L, Dapena\u00a0I et\u00a0al (2010) Visus nach Descemet-Membran Endothelkeratoplastik (DMEK): Ergebnisse der ersten 100 Eingriffe bei Fuchs\u2019scher Endotheldystrophie. Klin Monbl Augenheilkd 227(6):467\u2013477","journal-title":"Klin Monbl Augenheilkd"},{"issue":"1","key":"2238_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.clae.2012.10.066","volume":"36","author":"K van Dijk","year":"2013","unstructured":"van Dijk\u00a0K, Ham\u00a0L, Tse\u00a0WH et\u00a0al (2013) Near complete visual recovery and refractive stability in modern corneal transplantation: Descemet membrane endothelial keratoplasty (DMEK). Cont Lens Anterior Eye 36(1):13\u201321","journal-title":"Cont Lens Anterior Eye"},{"issue":"3","key":"2238_CR16","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.ophtha.2014.09.004","volume":"122","author":"M Rodr\u00edguez-Calvo-de-Mora","year":"2015","unstructured":"Rodr\u00edguez-Calvo-de-Mora\u00a0M, Quilendrino\u00a0R, Ham\u00a0L et\u00a0al (2015) Clinical outcome of 500 consecutive cases undergoing Descemet\u2019s membrane endothelial keratoplasty. Ophthalmology 122(3):464\u2013470","journal-title":"Ophthalmology"},{"issue":"6","key":"2238_CR17","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1055\/s-0029-1245447","volume":"227","author":"LM Heindl","year":"2010","unstructured":"Heindl\u00a0LM, Kruse\u00a0FE, Cursiefen\u00a0C (2010) Komplikationen nach posteriorer lamell\u00e4rer Keratoplastik (DSAEK): Vermeiden, Erkennen und Behandeln. Klin Monbl Augenheilkd 227(6):478\u2013482","journal-title":"Klin Monbl Augenheilkd"}],"container-title":["Die Ophthalmologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-025-02238-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00347-025-02238-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-025-02238-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T10:33:41Z","timestamp":1751366021000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00347-025-02238-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["2238"],"URL":"https:\/\/doi.org\/10.1007\/s00347-025-02238-2","relation":{},"ISSN":["2731-720X","2731-7218"],"issn-type":[{"type":"print","value":"2731-720X"},{"type":"electronic","value":"2731-7218"}],"subject":[],"published":{"date-parts":[[2025,5,13]]},"assertion":[{"value":"29 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"T.\u00a0Hammer, P.\u00a0Wieland, J.\u00a0Horn, A.\u00a0Viestenz und A.\u00a0Viestenz geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Diese retrospektive Studie erfolgte nach Konsultation der zust\u00e4ndigen Ethikkommission und im Einklang mit nationalem Recht.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}