{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:14:52Z","timestamp":1785237292451,"version":"3.55.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00347-025-02361-0","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T02:46:34Z","timestamp":1767494794000},"page":"95-103","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostische Innovationen zur Fr\u00fcherkennung und Charakterisierung des Keratokonus","Diagnostic innovations for the early detection and characterization of keratoconus"],"prefix":"10.1007","volume":"123","author":[{"given":"Maximilian","family":"Friedrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeck-Soo","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd Uwe","family":"Auffarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6315-8484","authenticated-orcid":false,"given":"Victor Aristide","family":"Augustin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"2361_CR1","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3928\/1081597X-20170426-02","volume":"33","author":"R Ambr\u00f3sio Jr.","year":"2017","unstructured":"Ambr\u00f3sio\u00a0R Jr., Lopes\u00a0BT, Faria-Correia\u00a0F et\u00a0al (2017) Integration of Scheimpflug-Based Corneal Tomography and Biomechanical Assessments for Enhancing Ectasia Detection. J\u00a0Refract Surg 33:434\u2013443","journal-title":"J Refract Surg"},{"key":"2361_CR2","doi-asserted-by":"crossref","unstructured":"Augustin VA, Son HS, Baur I et\u00a0al (2021) Detecting subclinical keratoconus by biomechanical analysis in tomographically regular keratoconus fellow eyes. Eur J Ophthalmol (11206721211063740)","DOI":"10.1177\/11206721211063740"},{"key":"2361_CR3","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1055\/a-2130-7503","volume":"240","author":"VA Augustin","year":"2023","unstructured":"Augustin\u00a0VA, Son\u00a0HS, Kovalchuk\u00a0B et\u00a0al (2023) Biomechanical Analysis of Tomographically Regular Keratoconus Fellow Eyes Using Corvis ST. Klin Monbl Augenheilkd 240:944\u2013951","journal-title":"Klin Monbl Augenheilkd"},{"key":"2361_CR4","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1055\/s-0042-100626","volume":"233","author":"MW Belin","year":"2016","unstructured":"Belin\u00a0MW, Duncan\u00a0JK (2016) Keratoconus: The ABCD Grading System. Klin Monbl Augenheilkd 233:701\u2013707","journal-title":"Klin Monbl Augenheilkd"},{"key":"2361_CR5","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1097\/ICO.0000000000000529","volume":"34","author":"C Chan","year":"2015","unstructured":"Chan\u00a0C, Ang\u00a0M, Saad\u00a0A et\u00a0al (2015) Validation of an Objective Scoring System for Forme Fruste Keratoconus Detection and Post-LASIK Ectasia Risk Assessment in Asian Eyes. Cornea 34:996\u20131004","journal-title":"Cornea"},{"key":"2361_CR6","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1136\/bjophthalmol-2020-317547","volume":"106","author":"A Ferdi","year":"2022","unstructured":"Ferdi\u00a0A, Nguyen\u00a0V, Kandel\u00a0H et\u00a0al (2022) Predictors of progression in untreated keratoconus: a\u00a0Save Sight Keratoconus Registry study. Br J Ophthalmol 106:1206\u20131211","journal-title":"Br J Ophthalmol"},{"key":"2361_CR7","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3928\/1081597X-20100415-02","volume":"27","author":"BM Fontes","year":"2011","unstructured":"Fontes\u00a0BM, Ambr\u00f3sio\u00a0R Jr., Velarde\u00a0GC et\u00a0al (2011) Ocular response analyzer measurements in keratoconus with normal central corneal thickness compared with matched normal control eyes. J\u00a0Refract Surg 27:209\u2013215","journal-title":"J Refract Surg"},{"key":"2361_CR8","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/eye.2015.63","volume":"29","author":"V Galvis","year":"2015","unstructured":"Galvis\u00a0V, Sherwin\u00a0T, Tello\u00a0A et\u00a0al (2015) Keratoconus: an inflammatory disorder? Eye 29:843\u2013859","journal-title":"Eye"},{"key":"2361_CR9","first-page":"9","volume-title":"Tragende Gr\u00fcnde zum Beschluss des Gemeinsamen Bundesausschusses \u00fcber eine \u00c4nderung der Richtlinie Methoden vertrags\u00e4rztliche Versorgung: UV-Vernetzung mit Riboflavin bei Keratokonus","author":"Gemeinsamer Bundesausschuss","year":"2018","unstructured":"Gemeinsamer Bundesausschuss (2018) Tragende Gr\u00fcnde zum Beschluss des Gemeinsamen Bundesausschusses \u00fcber eine \u00c4nderung der Richtlinie Methoden vertrags\u00e4rztliche Versorgung: UV-Vernetzung mit Riboflavin bei Keratokonus, S\u00a09"},{"key":"2361_CR10","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.ajo.2016.12.015","volume":"175","author":"DA Godefrooij","year":"2017","unstructured":"Godefrooij\u00a0DA, De Wit\u00a0GA, Uiterwaal\u00a0CS et\u00a0al (2017) Age-specific Incidence and Prevalence of Keratoconus: A\u00a0Nationwide Registration Study. Am J Ophthalmol 175:169\u2013172","journal-title":"Am J Ophthalmol"},{"key":"2361_CR11","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/ICO.0000000000000408","volume":"34","author":"JA Gomes","year":"2015","unstructured":"Gomes\u00a0JA, Tan\u00a0D, Rapuano\u00a0CJ et\u00a0al (2015) Global consensus on keratoconus and ectatic diseases. Cornea 34:359\u2013369","journal-title":"Cornea"},{"key":"2361_CR12","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/cxo.12035","volume":"96","author":"A Grzybowski","year":"2013","unstructured":"Grzybowski\u00a0A, Mcghee\u00a0CN (2013) The early history of keratoconus prior to Nottingham\u2019s landmark 1854 treatise on conical cornea: a\u00a0review. Clin Exp Optom 96:140\u2013145","journal-title":"Clin Exp Optom"},{"key":"2361_CR13","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1080\/08820538.2021.1896752","volume":"36","author":"LL Guo","year":"2021","unstructured":"Guo\u00a0LL, Tian\u00a0L, Cao\u00a0K et\u00a0al (2021) Comparison of the morphological and biomechanical characteristics of keratoconus, forme fruste keratoconus, and normal corneas. Semin Ophthalmol 36:671\u2013678","journal-title":"Semin Ophthalmol"},{"key":"2361_CR14","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.survophthal.2010.03.001","volume":"55","author":"R Gutmark","year":"2010","unstructured":"Gutmark\u00a0R, Guyton\u00a0DL (2010) Origins of the keratometer and its evolving role in ophthalmology. Surv Ophthalmol 55:481\u2013497","journal-title":"Surv Ophthalmol"},{"key":"2361_CR15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/ICO.0000000000002150","volume":"39","author":"H Hashemi","year":"2020","unstructured":"Hashemi\u00a0H, Heydarian\u00a0S, Hooshmand\u00a0E et\u00a0al (2020) The Prevalence and Risk Factors for Keratoconus: A\u00a0Systematic Review and Meta-Analysis. Cornea 39:263\u2013270","journal-title":"Cornea"},{"key":"2361_CR16","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.jcrs.2006.12.025","volume":"33","author":"R Khoramnia","year":"2007","unstructured":"Khoramnia\u00a0R, Rabsilber\u00a0TM, Auffarth\u00a0GU (2007) Central and peripheral pachymetry measurements according to age using the Pentacam rotating Scheimpflug camera. J\u00a0Cataract Refract Surg 33:830\u2013836","journal-title":"J Cataract Refract Surg"},{"key":"2361_CR17","doi-asserted-by":"publisher","first-page":"e48","DOI":"10.3928\/1081597X-20231204-01","volume":"40","author":"B Kovalchuk","year":"2024","unstructured":"Kovalchuk\u00a0B, Khoramnia\u00a0R, Son\u00a0HS et\u00a0al (2024) Longitudinal Evaluation of Biomechanical Indices in Fellow Eyes of Patients With Keratoconus Classified as Having Very Asymmetric Ectasia With Normal Topography. J\u00a0Refract Surg 40:e48\u2013e56","journal-title":"J Refract Surg"},{"key":"2361_CR18","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1111\/ceo.13852","volume":"48","author":"JJ Mathan","year":"2020","unstructured":"Mathan\u00a0JJ, Gokul\u00a0A, Simkin\u00a0SK et\u00a0al (2020) Topographic screening reveals keratoconus to be extremely common in Down syndrome. Clin Exp Ophthalmol 48:1160\u20131167","journal-title":"Clin Exp Ophthalmol"},{"key":"2361_CR19","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1097\/ICO.0000000000003518","volume":"43","author":"T Naujokaitis","year":"2024","unstructured":"Naujokaitis\u00a0T, Augustin\u00a0VA, Son\u00a0HS et\u00a0al (2024) Ectasia Detection by Anterior Segment Optical Coherence Tomography in Scheimpflug Tomographically Normal Keratoconus Fellow Eyes. Cornea 43:812\u2013819","journal-title":"Cornea"},{"key":"2361_CR20","doi-asserted-by":"publisher","first-page":"2968","DOI":"10.1038\/s41433-024-03199-7","volume":"38","author":"T Naujokaitis","year":"2024","unstructured":"Naujokaitis\u00a0T, Khoramnia\u00a0R, Friedrich\u00a0M et\u00a0al (2024) Inter-zonal epithelial thickness differences for early keratoconus detection using optical coherence tomography. Eye 38:2968\u20132975","journal-title":"Eye"},{"key":"2361_CR21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ajo.2025.03.013","volume":"275","author":"JB Randleman","year":"2025","unstructured":"Randleman\u00a0JB, Susanna\u00a0BN, Hammoud\u00a0B et\u00a0al (2025) Evaluating the Global Consensus on Keratoconus and Ectatic Diseases Agreements Reached on Subclinical Keratoconus. Am J Ophthalmol 275:27\u201335","journal-title":"Am J Ophthalmol"},{"key":"2361_CR22","doi-asserted-by":"publisher","first-page":"736","DOI":"10.3928\/1081597X-20151021-02","volume":"31","author":"DZ Reinstein","year":"2015","unstructured":"Reinstein\u00a0DZ, Archer\u00a0TJ, Urs\u00a0R et\u00a0al (2015) Detection of Keratoconus in Clinically and Algorithmically Topographically Normal Fellow Eyes Using Epithelial Thickness Analysis. J\u00a0Refract Surg 31:736\u2013744","journal-title":"J Refract Surg"},{"key":"2361_CR23","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1097\/ICO.0000000000001639","volume":"37","author":"MR Sedaghat","year":"2018","unstructured":"Sedaghat\u00a0MR, Momeni-Moghaddam\u00a0H, Ambr\u00f3sio\u00a0R Jr. et\u00a0al (2018) Diagnostic Ability of Corneal Shape and Biomechanical Parameters for Detecting Frank Keratoconus. Cornea 37:1025\u20131034","journal-title":"Cornea"},{"key":"2361_CR24","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.ajo.2019.02.010","volume":"202","author":"TG Seiler","year":"2019","unstructured":"Seiler\u00a0TG, Shao\u00a0P, Eltony\u00a0A et\u00a0al (2019) Brillouin Spectroscopy of Normal and Keratoconus Corneas. Am J Ophthalmol 202:118\u2013125","journal-title":"Am J Ophthalmol"},{"key":"2361_CR25","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1442-9071.2004.00805.x","volume":"32","author":"T Sherwin","year":"2004","unstructured":"Sherwin\u00a0T, Brookes\u00a0NH (2004) Morphological changes in keratoconus: pathology or pathogenesis. Clin Exp Ophthalmol 32:211\u2013217","journal-title":"Clin Exp Ophthalmol"},{"key":"2361_CR26","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ajo.2023.03.018","volume":"254","author":"H Zhang","year":"2023","unstructured":"Zhang\u00a0H, Asroui\u00a0L, Tarib\u00a0I et\u00a0al (2023) Motion-Tracking Brillouin Microscopy Evaluation of Normal, Keratoconic, and Post-Laser Vision Correction Corneas. Am J Ophthalmol 254:128\u2013140","journal-title":"Am J Ophthalmol"},{"key":"2361_CR27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/s41433-020-1039-1","volume":"35","author":"X Zhang","year":"2021","unstructured":"Zhang\u00a0X, Munir\u00a0SZ, Karim\u00a0SSA et\u00a0al (2021) A review of imaging modalities for detecting early keratoconus. Eye (Lond) 35:173\u2013187","journal-title":"Eye (Lond)"}],"container-title":["Die Ophthalmologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-025-02361-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00347-025-02361-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-025-02361-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:19:41Z","timestamp":1770139181000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00347-025-02361-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,4]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["2361"],"URL":"https:\/\/doi.org\/10.1007\/s00347-025-02361-0","relation":{},"ISSN":["2731-720X","2731-7218"],"issn-type":[{"value":"2731-720X","type":"print"},{"value":"2731-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,4]]},"assertion":[{"value":"26 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"H.-S.\u00a0Son: Relevante Interessenkonflikte: Keine. Finanzielle Unterst\u00fctzung: Klaus-Tschira Stiftung, Heidelberg. G.U.\u00a0Auffarth: Zusch\u00fcsse\/Vertr\u00e4ge: Alcon, J&J, Biotech, Carl Zeiss Meditec, Contamac, Cristalens, EyeD, Eyedeal, EyeYon, Hanita, Hoya, Kowa, Oculus, Physiol, Rayner, Rheacell, Teleon. Beratungsgeb\u00fchren: Alcon, J&J, Carl Zeiss Meditec, Cristalens, Eyebright, EyeYon, Hanita, Presbia, Rayner, VSY. Honorare f\u00fcr Vortr\u00e4ge, Pr\u00e4sentationen, Referentenb\u00fcros, Schreiben oder Fortbildungsveranstaltungen: AcuFocus, Alcon, J&J, Biotech, Carl Zeiss Meditec, Cristalens, Eyebright, Hoya, Kowa, Oculus, Rayner, SIFI, Teleon, VSY. Reisekostenerstattung: Alcon, J&J, Carl Zeiss Meditec, EyeYon, Hoya, Kowa, Rayner, SIFI, Teleon. V.A.\u00a0Augustin: Zusch\u00fcsse\/Vertr\u00e4ge: Kowa; Reisekostenerstattung: Roche. M.\u00a0Friedrich gibt an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}