{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:19:34Z","timestamp":1787509174448,"version":"build-2736575974"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Hintergrund<\/jats:title>\n                    <jats:p>Kristalline Retinopathien sind durch refraktile Ablagerungen in verschiedenen Netzhautschichten gekennzeichnet und k\u00f6nnen genetische, systemische, toxische oder iatrogene Ursachen haben. Eine gut beschriebene toxische Form ist die Talc-Retinopathie im Zusammenhang mit intraven\u00f6sem Drogenkonsum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Fallbericht<\/jats:title>\n                    <jats:p>Ein 44-j\u00e4hriger Patient stellte sich mit intermittierender beidseitiger Visusminderung seit vier Wochen vor. Die bestkorrigierte Sehsch\u00e4rfe betrug beidseits 0,8. Funduskopisch zeigten sich multiple feine, glitzernde kristalline Ablagerungen im Bereich der zentralen Netzhaut ohne Hinweise auf eine intraokulare Entz\u00fcndung. In der optischen Koh\u00e4renztomographie (OCT) fanden sich hyperreflektive kristalline Ablagerungen in inneren und \u00e4u\u00dferen Netzhautschichten. Es ergaben sich keine Hinweise auf eine retinale Isch\u00e4mie oder vaskul\u00e4re Okklusion. Eine gezielte Anamnese ergab einen zur\u00fcckliegenden intraven\u00f6sen Drogenabusus mit Amphetamin und Kokain, zuletzt im Jahr 2023. Eine Medikamentenexposition als Ursache ergab sich anamnestisch nicht; eine heredit\u00e4re Genese erschien aufgrund der klinischen und apparativen Befunde unwahrscheinlich.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Schlussfolgerung<\/jats:title>\n                    <jats:p>Die Befunde sprechen f\u00fcr eine nicht-entz\u00fcndliche toxische kristalline Retinopathie, am ehesten im Sinne einer Talc-Retinopathie. Der Fall unterstreicht die Bedeutung multimodaler Bildgebung und einer gezielten Anamnese f\u00fcr die korrekte Diagnosestellung.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00347-025-02378-5","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T15:08:41Z","timestamp":1768489721000},"page":"396-400","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Wenn die Netzhaut glitzert\u00a0\u2013 kristalline Ablagerungen der Netzhaut","When the retina sparkles\u2014Crystalline deposits in the retina"],"prefix":"10.1007","volume":"123","author":[{"given":"V. B. N.","family":"Wei\u00df","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Schir\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"issue":"1","key":"2378_CR1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/aos.12814","volume":"94","author":"N Bagheri","year":"2016","unstructured":"Bagheri\u00a0N, Shahlaee\u00a0A, Sridhar\u00a0J, Ho\u00a0AC (2016) En face optical coherence tomography and angiography of talc retinopathy. Acta Ophthalmol 94(1):103\u2013104","journal-title":"Acta Ophthalmol"},{"key":"2378_CR2","first-page":"86","volume":"120","author":"B Khalil","year":"2023","unstructured":"Khalil\u00a0B, M\u00fcllner\u00a0G, Pickl\u00a0F, Sch\u00f6nherr\u00a0U, Reinelt\u00a0P (2023) Seltene kristalline Makulopathie. Ophthalmologe 120:86\u201388","journal-title":"Ophthalmologe"},{"issue":"6","key":"2378_CR3","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1097\/ICU.0000000000000714","volume":"31","author":"MJ Khan","year":"2020","unstructured":"Khan\u00a0MJ, Papakostas\u00a0T, Kovacs\u00a0K, Gupta\u00a0MP (2020) Drug-induced maculopathy. Curr Opin Ophthalmol 31(6):563\u2013571","journal-title":"Curr Opin Ophthalmol"},{"key":"2378_CR4","doi-asserted-by":"publisher","first-page":"953","DOI":"10.2147\/OPTH.S388292","volume":"17","author":"AO Saatci","year":"2023","unstructured":"Saatci\u00a0AO, Atas\u00a0F, Cetin\u00a0GO, Kayabasi\u00a0M (2023) Diagnostic and Management Strategies of Bietti Crystalline Dystrophy: Current Perspectives. Clin Ophthalmol 17:953\u2013967","journal-title":"Clin Ophthalmol"},{"issue":"4","key":"2378_CR5","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/S0002-9394(99)00175-0","volume":"128","author":"MC Sharma","year":"1999","unstructured":"Sharma\u00a0MC, Ho\u00a0AC (1999) Macular fibrosis associated with talc retinopathy. Am J Ophthalmol 128(4):517\u2013519","journal-title":"Am J Ophthalmol"}],"container-title":["Die Ophthalmologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-025-02378-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00347-025-02378-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-025-02378-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:46:56Z","timestamp":1781257616000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00347-025-02378-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["2378"],"URL":"https:\/\/doi.org\/10.1007\/s00347-025-02378-5","relation":{},"ISSN":["2731-720X","2731-7218"],"issn-type":[{"value":"2731-720X","type":"print"},{"value":"2731-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]},"assertion":[{"value":"30 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dieser Artikel wurde urspr\u00fcnglich im Abonnement-Modell ver\u00f6ffentlicht, wird jedoch jetzt unter einer Open-Access-Lizenz ver\u00f6ffentlicht.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"V.B.N.\u00a0Wei\u00df, R.\u00a0Schir\u00f2 und J.M.\u00a0Weller geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autorinnen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Das im Manuskript verwendete Bildmaterial enth\u00e4lt keine personbezogenen oder identifizierbaren Daten. Eine schriftliche Einwilligung des Patienten war daher nicht erforderlich.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}