{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:06:43Z","timestamp":1775642803405,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s00347-026-02412-0","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:59:47Z","timestamp":1772798387000},"page":"269-275","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Remodeling der inneren Netzhaut\u00a0\u2013 Implikationen f\u00fcr zielgerichtete Optogenetik","Remodeling of the internal retina\u2014Implications for targeted optogenetics"],"prefix":"10.1007","volume":"123","author":[{"given":"Feros","family":"Bator","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreshth","family":"Shekhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Hoerauf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3998-533X","authenticated-orcid":false,"given":"Tim","family":"Gollisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3237-3803","authenticated-orcid":false,"given":"Christian","family":"van Oterendorp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4416-3421","authenticated-orcid":false,"given":"Moritz","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"2412_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2025.100767","volume":"5","author":"H Ameri","year":"2025","unstructured":"Ameri\u00a0H, Hong\u00a0AT, Chwa\u00a0J (2025) Loss of Peripheral Retinal Vessels in Retinitis Pigmentosa. Ophthalmol Sci 5:100767","journal-title":"Ophthalmol Sci"},{"key":"2412_CR2","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1038\/s41592-021-01252-x","volume":"18","author":"Z Avsec","year":"2021","unstructured":"Avsec\u00a0Z, Agarwal\u00a0V, Visentin\u00a0D et\u00a0al (2021) Effective gene expression prediction from sequence by integrating long-range interactions. Nat Methods 18:1196\u20131203","journal-title":"Nat Methods"},{"key":"2412_CR3","doi-asserted-by":"crossref","unstructured":"Carpentiero E, Hughes S, Rodgers J et\u00a0al. (2025) Interaction between native and prosthetic visual responses in optogenetic visual restoration. JCI Insight 10","DOI":"10.1172\/jci.insight.190785"},{"key":"2412_CR4","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/gt.2016.54","volume":"23","author":"SR De Silva","year":"2016","unstructured":"De Silva\u00a0SR, Charbel Issa\u00a0CI, Singh\u00a0MS et\u00a0al (2016) Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4(-\/-) mouse and bipolar cells in the rd1 mouse and human retina ex vivo. Gene Ther 23:767\u2013774","journal-title":"Gene Ther"},{"key":"2412_CR5","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.cub.2023.03.007","volume":"33","author":"EM Ellis","year":"2023","unstructured":"Ellis\u00a0EM, Paniagua\u00a0AE, Scalabrino\u00a0ML et\u00a0al (2023) Cones and cone pathways remain functional in advanced retinal degeneration. Curr Biol 33:1513\u20131522","journal-title":"Curr Biol"},{"key":"2412_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007857","volume":"16","author":"U Ferrari","year":"2020","unstructured":"Ferrari\u00a0U, Deny\u00a0S, Sengupta\u00a0A et\u00a0al (2020) Towards optogenetic vision restoration with high resolution. PLoS Comput Biol 16:e1007857","journal-title":"PLoS Comput Biol"},{"key":"2412_CR7","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/S0161-6420(82)34620-5","volume":"89","author":"S Gartner","year":"1982","unstructured":"Gartner\u00a0S, Henkind\u00a0P (1982) Pathology of retinitis pigmentosa. Ophthalmology 89:1425\u20131432","journal-title":"Ophthalmology"},{"key":"2412_CR8","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.omtm.2022.03.003","volume":"25","author":"MJ Gilhooley","year":"2022","unstructured":"Gilhooley\u00a0MJ, Lindner\u00a0M, Palumaa\u00a0T et\u00a0al (2022) A systematic comparison of optogenetic approaches to visual restoration. Mol Ther Methods Clin Dev 25:111\u2013123","journal-title":"Mol Ther Methods Clin Dev"},{"key":"2412_CR9","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.neuron.2009.12.009","volume":"65","author":"T Gollisch","year":"2010","unstructured":"Gollisch\u00a0T, Meister\u00a0M (2010) Eye smarter than scientists believed: neural computations in circuits of the retina. Neuron 65:150\u2013164","journal-title":"Neuron"},{"key":"2412_CR10","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41586-023-06638-9","volume":"624","author":"J Hahn","year":"2023","unstructured":"Hahn\u00a0J, Monavarfeshani\u00a0A, Qiao\u00a0M et\u00a0al (2023) Evolution of neuronal cell classes and types in the vertebrate retina. Nature 624:415\u2013424","journal-title":"Nature"},{"key":"2412_CR11","doi-asserted-by":"crossref","unstructured":"Hughes S, Rodgers J, Lindner M et\u00a0al. (2025) Optogenetic vision restoration in the face of secondary and tertiary remodeling in the rd1 mouse retina. Mol Ther","DOI":"10.1016\/j.ymthe.2025.07.056"},{"key":"2412_CR12","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.omtm.2020.03.003","volume":"17","author":"EC Hulliger","year":"2020","unstructured":"Hulliger\u00a0EC, Hostettler\u00a0SM, Kleinlogel\u00a0S (2020) Empowering Retinal Gene Therapy with a\u00a0Specific Promoter for Human Rod and Cone ON-Bipolar Cells. Mol Ther Methods Clin Dev 17:505\u2013519","journal-title":"Mol Ther Methods Clin Dev"},{"key":"2412_CR13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.exer.2016.03.018","volume":"150","author":"BW Jones","year":"2016","unstructured":"Jones\u00a0BW, Pfeiffer\u00a0RL, Ferrell\u00a0WD et\u00a0al (2016) Retinal remodeling in human retinitis pigmentosa. Exp Eye Res 150:149\u2013165","journal-title":"Exp Eye Res"},{"key":"2412_CR14","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nature13240","volume":"509","author":"JS Kim","year":"2014","unstructured":"Kim\u00a0JS, Greene\u00a0MJ, Zlateski\u00a0A et\u00a0al (2014) Space-time wiring specificity supports direction selectivity in the retina. Nature 509:331\u2013336","journal-title":"Nature"},{"key":"2412_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2022.101089","volume":"91","author":"M Lindner","year":"2022","unstructured":"Lindner\u00a0M, Gilhooley\u00a0MJ, Hughes\u00a0S et\u00a0al (2022) Optogenetics for visual restoration: From proof of principle to translational challenges. Prog Retin Eye Res 91:101089","journal-title":"Prog Retin Eye Res"},{"key":"2412_CR16","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.1167\/iovs.07-0032","volume":"48","author":"RE Marc","year":"2007","unstructured":"Marc\u00a0RE, Jones\u00a0BW, Anderson\u00a0JR et\u00a0al (2007) Neural reprogramming in retinal degeneration. Invest Ophthalmol Vis Sci 48:3364\u20133371","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2412_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2022.984052","volume":"16","author":"N Martinez-Gil","year":"2022","unstructured":"Martinez-Gil\u00a0N, Maneu\u00a0V, Kutsyr\u00a0O et\u00a0al (2022) Cellular and molecular alterations in neurons and glial cells in inherited retinal degeneration. Front Neuroanat 16:984052","journal-title":"Front Neuroanat"},{"key":"2412_CR18","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.neuron.2012.10.002","volume":"76","author":"RH Masland","year":"2012","unstructured":"Masland\u00a0RH (2012) The neuronal organization of the retina. Neuron 76:266\u2013280","journal-title":"Neuron"},{"key":"2412_CR19","doi-asserted-by":"publisher","first-page":"14282","DOI":"10.1523\/JNEUROSCI.4968-08.2008","volume":"28","author":"F Mazzoni","year":"2008","unstructured":"Mazzoni\u00a0F, Novelli\u00a0E, Strettoi\u00a0E (2008) Retinal ganglion cells survive and maintain normal dendritic morphology in a mouse model of inherited photoreceptor degeneration. J\u00a0Neurosci 28:14282\u201314292","journal-title":"J Neurosci"},{"key":"2412_CR20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1350-9462(97)00012-8","volume":"17","author":"AH Milam","year":"1998","unstructured":"Milam\u00a0AH, Li\u00a0ZY, Fariss\u00a0RN (1998) Histopathology of the human retina in retinitis pigmentosa. Prog Retin Eye Res 17:175\u2013205","journal-title":"Prog Retin Eye Res"},{"key":"2412_CR21","doi-asserted-by":"publisher","first-page":"15012","DOI":"10.1073\/pnas.1207035109","volume":"109","author":"S Nirenberg","year":"2012","unstructured":"Nirenberg\u00a0S, Pandarinath\u00a0C (2012) Retinal prosthetic strategy with the capacity to restore normal vision. Proc Natl Acad Sci U S A 109:15012\u201315017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2412_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.07.004","volume":"74","author":"RL Pfeiffer","year":"2020","unstructured":"Pfeiffer\u00a0RL, Marc\u00a0RE, Jones\u00a0BW (2020) Persistent remodeling and neurodegeneration in late-stage retinal degeneration. Prog Retin Eye Res 74:100771","journal-title":"Prog Retin Eye Res"},{"key":"2412_CR23","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.ymthe.2025.01.030","volume":"33","author":"J Rodgers","year":"2025","unstructured":"Rodgers\u00a0J, Hughes\u00a0S, Ebrahimi\u00a0AS et\u00a0al (2025) Enhanced restoration of visual code after targeting ON bipolar cells compared with retinal ganglion cells with optogenetic therapy. Mol Ther 33:1264\u20131281","journal-title":"Mol Ther"},{"key":"2412_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2016.04.032","volume":"329","author":"S Saha","year":"2016","unstructured":"Saha\u00a0S, Greferath\u00a0U, Vessey\u00a0KA et\u00a0al (2016) Changes in ganglion cells during retinal degeneration. Neuroscience 329:1\u201311","journal-title":"Neuroscience"},{"key":"2412_CR25","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/s41591-021-01351-4","volume":"27","author":"JA Sahel","year":"2021","unstructured":"Sahel\u00a0JA, Boulanger-Scemama\u00a0E, Pagot\u00a0C et\u00a0al (2021) Partial recovery of visual function in a blind patient after optogenetic therapy. Nat Med 27:1223\u20131229","journal-title":"Nat Med"},{"key":"2412_CR26","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s10571-022-01243-2","volume":"43","author":"DJ Song","year":"2023","unstructured":"Song\u00a0DJ, Bao\u00a0XL, Fan\u00a0B et\u00a0al (2023) Mechanism of Cone Degeneration in Retinitis Pigmentosa. Cell Mol Neurobiol 43:1037\u20131048","journal-title":"Cell Mol Neurobiol"},{"key":"2412_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2023.108260","volume":"209","author":"K Takahashi","year":"2023","unstructured":"Takahashi\u00a0K, Kwok\u00a0JC, Sato\u00a0Y et\u00a0al (2023) Extended functional rescue following AAV gene therapy in a canine model of LRIT3-congenital stationary night blindness. Vision Res 209:108260","journal-title":"Vision Res"},{"key":"2412_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.618019","volume":"14","author":"M Telias","year":"2020","unstructured":"Telias\u00a0M, Nawy\u00a0S, Kramer\u00a0RH (2020) Degeneration-Dependent Retinal Remodeling: Looking for the Molecular Trigger. Front Neurosci 14:618019","journal-title":"Front Neurosci"},{"key":"2412_CR29","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2017.00161","volume":"11","author":"M Van Wyk","year":"2017","unstructured":"Van Wyk\u00a0M, Hulliger\u00a0EC, Girod\u00a0L et\u00a0al (2017) Present Molecular Limitations of ON-Bipolar Cell Targeted Gene Therapy. Front Neurosci 11:161","journal-title":"Front Neurosci"},{"key":"2412_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66092-9","volume":"10","author":"W Yan","year":"2020","unstructured":"Yan\u00a0W, Peng\u00a0YR, Van Zyl\u00a0T et\u00a0al (2020) Cell Atlas of The Human Fovea and Peripheral Retina. Sci Rep 10:9802","journal-title":"Sci Rep"},{"key":"2412_CR31","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.ajo.2022.05.002","volume":"241","author":"CK Yoon","year":"2022","unstructured":"Yoon\u00a0CK, Bae\u00a0K, Yu\u00a0HG (2022) Longitudinal Microstructure Changes of the Retina and Choroid in Retinitis Pigmentosa. Am J Ophthalmol 241:149\u2013159","journal-title":"Am J Ophthalmol"}],"container-title":["Die Ophthalmologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-026-02412-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00347-026-02412-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-026-02412-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:30:17Z","timestamp":1775640617000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00347-026-02412-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,6]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["2412"],"URL":"https:\/\/doi.org\/10.1007\/s00347-026-02412-0","relation":{},"ISSN":["2731-720X","2731-7218"],"issn-type":[{"value":"2731-720X","type":"print"},{"value":"2731-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,6]]},"assertion":[{"value":"2 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"M.\u00a0Lindner hat Forschungsf\u00f6rderung von Bayer Healthcare ohne Bezug zu dieser Arbeit erhalten. F.\u00a0Bator, S.\u00a0Shekhar, H.\u00a0Hoerauf, T.\u00a0Gollisch und C.\u00a0van Oterendorp geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}