{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:47:50Z","timestamp":1786117670319,"version":"build-2736575974"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Hintergrund<\/jats:title>\n                    <jats:p>In Deutschland legt jedes operative Hornhautzentrum individuelle Kriterien f\u00fcr die Indikationsstellung zur Descemet-Membran-Endothel-Keratoplastik (DMEK) fest. Klinische Erfahrungen zeigen eine deutliche Diskrepanz zwischen dem bestkorrigierten Visus (BCVA) und subjektiven Beschwerden wie erh\u00f6hter Blendempfindlichkeit. Eine zunehmende Symptomatik bei scheinbar stabilem Visus legt nahe, dass der BCVA allein nicht ausreicht, um die gesamte visuelle Beeintr\u00e4chtigung ad\u00e4quat zu erfassen. Ziel dieser Studie ist es daher, subjektive Beschwerden \u2013\u00a0insbesondere das wahrgenommene Streulicht\u00a0\u2013 mittels quantitativer Parameter messbar zu machen und deren longitudinalen Verlauf pr\u00e4- und postoperativ im Rahmen einer DMEK zu analysieren sowie zu evaluieren, inwieweit die okul\u00e4re Vorw\u00e4rtsstreuung den optimalen Zeitpunkt f\u00fcr eine operative Intervention besser determinieren kann.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patienten und Methode<\/jats:title>\n                    <jats:p>In diese retrospektive Studie wurden 149 Patienten mit Fuchs-Endotheldystrophie eingeschlossen, die zwischen 2018 und 2020 an der Klinik f\u00fcr Augenheilkunde des Universit\u00e4tsklinikums des Saarlandes mittels DMEK oder Triple-DMEK operiert wurden. Voraussetzung f\u00fcr die Teilnahme war das Vorliegen pr\u00e4operativer sowie postoperativer Messdaten nach 6\u00a0Wochen und 6\u00a0Monaten. Bei allen Patienten wurden der BCVA, die zentrale Hornhautdicke (CCT), die korneale Densitometrie (R\u00fcckw\u00e4rtsstreuung) mittels Pentacam sowie die okul\u00e4re Vorw\u00e4rtsstreuung mittels C\u2011Quant (Oculus Optikger\u00e4te, Wetzlar-Dutenhofen, Deutschland) untersucht.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>Die okul\u00e4re Vorw\u00e4rtsstreuung zeigte eine signifikante Verbesserung im Vergleich zwischen dem pr\u00e4operativen und dem 6\u2011Monats-Wert. Die okul\u00e4re Vorw\u00e4rtsstreuung korreliert zu keinem Zeitpunkt mit BCVA oder CCT. Die CCT und die R\u00fcckw\u00e4rtsstreuung nahmen nach 6\u00a0Wochen signifikant ab und blieben im weiteren Verlauf stabil. Der BCVA verbesserte sich signifikant bereits nach 6\u00a0Wochen postoperativ. Es bestand zu allen Messzeitpunkten eine signifikant positive Korrelation zwischen okul\u00e4rer Vorw\u00e4rtsstreuung und R\u00fcckw\u00e4rtsstreuung. Zudem zeigte sich eine signifikante positive Korrelation zwischen der pr\u00e4operativen R\u00fcckw\u00e4rtsstreuung sowohl mit der CCT als auch mit dem BCVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Schlussfolgerung<\/jats:title>\n                    <jats:p>Die alleinige Messung der okul\u00e4ren Vorw\u00e4rtsstreuung mittels C\u2011Quant erweist sich nicht als verl\u00e4ssliches Kriterium zur Indikationsstellung f\u00fcr eine DMEK oder Triple-DMEK. Beide Operationsverfahren f\u00fchrten jedoch zu einer anhaltenden Reduktion der CCT und der R\u00fcckw\u00e4rtsstreuung (Densitometrie) sowie zu einer signifikanten Verbesserung des Visus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00347-026-02422-y","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:35:04Z","timestamp":1774276504000},"page":"368-374","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["C-Quant-Streulichtmessung und korneale Densitometrie bei Fuchs-Endotheldystrophie vor und nach DMEK","C-Quant scattered light measurement and corneal densitometry in Fuchs endothelial dystrophy before and after DMEK"],"prefix":"10.1007","volume":"123","author":[{"given":"Melanie","family":"Da Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Munteanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loay","family":"Daas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"2422_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1177\/1120672118785282","volume":"29","author":"VA Augustin","year":"2019","unstructured":"Augustin\u00a0VA, Weller\u00a0JM, Kruse\u00a0FE, Tourtas\u00a0T (2019) Can we predict the refractive outcome after triple Descemet membrane endothelial keratoplasty? Eur J Ophthalmol 29:165\u2013170","journal-title":"Eur J Ophthalmol"},{"key":"2422_CR2","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.oftal.2016.12.017","volume":"92","author":"B Casta\u00f1o-Mart\u00edn","year":"2017","unstructured":"Casta\u00f1o-Mart\u00edn\u00a0B, Gros-Otero\u00a0J, Mart\u00ednez\u00a0J, Teus\u00a0M (2017) Study of light scattering using C\u2011Quant \u00ae in patients with Fuchs\u2019 endothelial dystrophy: A\u00a0pilot study. Arch Soc Esp Oftalmol Engl Ed 92:516\u2013520","journal-title":"Arch Soc Esp Oftalmol Engl Ed"},{"key":"2422_CR3","doi-asserted-by":"publisher","DOI":"10.1117\/1.2209555","volume":"11","author":"J Coppens","year":"2006","unstructured":"Coppens\u00a0J, Franssen\u00a0L, van Rijn\u00a0LJ, van den Berg\u00a0TJTP (2006) Reliability of the compensation comparison stray-light measurement method. J\u00a0Biomed Opt 11:034027","journal-title":"J Biomed Opt"},{"key":"2422_CR4","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/ICO.0000000000003002","volume":"42","author":"B de Jong","year":"2023","unstructured":"de Jong\u00a0B, Brandi-Dohrn\u00a0F, van der Meulen\u00a0IJE, van den Berg\u00a0TJTP, Wacker\u00a0K (2023) Diurnal Variation in Straylight in Patients With Fuchs Endothelial Corneal Dystrophy and Controls. Cornea 42:164\u2013171","journal-title":"Cornea"},{"key":"2422_CR5","doi-asserted-by":"publisher","first-page":"e1127","DOI":"10.1111\/aos.14741","volume":"99","author":"SL Dunker","year":"2021","unstructured":"Dunker\u00a0SL, Dickman\u00a0MM, Wisse\u00a0RPL, Nobacht\u00a0S, Wijdh\u00a0RHJ, Bartels\u00a0MC, Tang\u00a0NEM, van den Biggelaar\u00a0FJHM, Kruit\u00a0PJ, Winkens\u00a0B, Nuijts\u00a0RMMA (2021) Quality of vision and vision-related quality of life after Descemet membrane endothelial keratoplasty: a randomized clinical trial. Acta Ophthalmol (Copenh) 99:e1127\u2013e1134","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"2422_CR6","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1167\/iovs.05-0690","volume":"47","author":"L Franssen","year":"2006","unstructured":"Franssen\u00a0L, Coppens\u00a0JE, van den Berg\u00a0TJ (2006) Compensation comparison method for assessment of retinal straylight. Invest Ophthalmol Vis Sci 47:768\u2013776","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2422_CR7","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1007\/s10792-016-0397-y","volume":"37","author":"N Garz\u00f3n","year":"2017","unstructured":"Garz\u00f3n\u00a0N, Poyales\u00a0F, Illarramendi\u00a0I, Mendicute\u00a0J, J\u00e1\u00f1ez \u00d3, Caro\u00a0P, L\u00f3pez\u00a0A, Arg\u00fceso\u00a0F (2017) Corneal densitometry and its correlation with age, pachymetry, corneal curvature, and refraction. Int Ophthalmol 37:1263\u20131268","journal-title":"Int Ophthalmol"},{"key":"2422_CR8","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1097\/ICO.0000000000002035","volume":"38","author":"A Lazaridis","year":"2019","unstructured":"Lazaridis\u00a0A, Giallouros\u00a0E, Sekundo\u00a0W, Schroeder\u00a0FM, Sklavos\u00a0S, Droutsas\u00a0K (2019) Spatial Analysis of Corneal Densitometry, Thickness Profile, and Volume Distribution After Uneventful Descemet Membrane Endothelial Keratoplasty. Cornea 38:1215\u20131221","journal-title":"Cornea"},{"key":"2422_CR9","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev-vision-091718-014852","volume":"5","author":"M Matthaei","year":"2019","unstructured":"Matthaei\u00a0M, Hribek\u00a0A, Clahsen\u00a0T, Bachmann\u00a0B, Cursiefen\u00a0C, Jun\u00a0AS (2019) Fuchs Endothelial Corneal Dystrophy: Clinical, Genetic, Pathophysiologic, and Therapeutic Aspects. Annu Rev Vis Sci 5:151\u2013175","journal-title":"Annu Rev Vis Sci"},{"key":"2422_CR10","doi-asserted-by":"publisher","first-page":"5545","DOI":"10.1167\/iovs.12-10011","volume":"53","author":"JW McLaren","year":"2012","unstructured":"McLaren\u00a0JW, Patel\u00a0SV (2012) Modeling the effect of forward scatter and aberrations on visual acuity after endothelial keratoplasty. Invest Ophthalmol Vis Sci 53:5545\u20135551","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2422_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154312","volume":"11","author":"A Morelli","year":"2022","unstructured":"Morelli\u00a0A, Ferrandina\u00a0R, Favuzza\u00a0E, Cennamo\u00a0M, Mencucci\u00a0R (2022) 3D Visualization System in Descemet Membrane Endothelial Keratoplasty (DMEK): A Six-Month Comparison with Conventional Microscope. J\u00a0Clin Med 11:4312","journal-title":"J Clin Med"},{"key":"2422_CR12","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1097\/ICO.0000000000002723","volume":"40","author":"I Moshiri","year":"2021","unstructured":"Moshiri\u00a0I, Karimi-Golkar\u00a0D, Schrittenlocher\u00a0S, Cursiefen\u00a0C, Bachmann\u00a0B (2021) Outcomes of Pseudophakic, Phakic, and Triple DMEK. Cornea 40:1253\u20131257","journal-title":"Cornea"},{"key":"2422_CR13","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1167\/iovs.13-13236","volume":"55","author":"S N\u00ed Dhubhghaill","year":"2014","unstructured":"N\u00ed Dhubhghaill\u00a0S, Rozema\u00a0JJ, Jongenelen\u00a0S, Ruiz Hidalgo\u00a0I, Zakaria\u00a0N, Tassignon\u00a0MJ (2014) Normative Values for Corneal Densitometry Analysis by Scheimpflug Optical Assessment. Invest Ophthalmol Vis Sci 55:162\u2013168","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2422_CR14","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ajo.2018.03.036","volume":"190","author":"S Schrittenlocher","year":"2018","unstructured":"Schrittenlocher\u00a0S, Schaub\u00a0F, Hos\u00a0D, Siebelmann\u00a0S, Cursiefen\u00a0C, Bachmann\u00a0B (2018) Evolution of Consecutive Descemet Membrane Endothelial Keratoplasty Outcomes Throughout a\u00a05-Year Period Performed by Two Experienced Surgeons. Am J Ophthalmol 190:171\u2013178","journal-title":"Am J Ophthalmol"},{"key":"2422_CR15","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00347-020-01134-1","volume":"117","author":"B Seitz","year":"2020","unstructured":"Seitz\u00a0B, Daas\u00a0L, Flockerzi\u00a0E, Suffo\u00a0S (2020) Descemet membrane endothelial keratoplasty\u201c DMEK \u2013 Spender und Empf\u00e4nger Schritt f\u00fcr Schritt [Descemet membrane endothelial keratoplasty DMEK - Donor and recipient step by step]. Ophthalmol 117:811\u2013828","journal-title":"Ophthalmol"},{"key":"2422_CR16","doi-asserted-by":"crossref","unstructured":"van den Berg TJTP, van Rijn LJ, Michael R, Heine C, Coeckelbergh T, Nischler C, Wilhelm H, Grabner G, Emesz M, Barraquer RI, Coppens JE, Franssen L (2007) Straylight Effects with Aging and Lens Extraction. Am J Ophthalmol 144:","DOI":"10.1016\/j.ajo.2007.05.037"},{"key":"2422_CR17","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ophtha.2015.09.023","volume":"123","author":"K Wacker","year":"2016","unstructured":"Wacker\u00a0K, Baratz\u00a0KH, Maguire\u00a0LJ, McLaren\u00a0JW, Patel\u00a0SV (2016) Descemet Stripping Endothelial Keratoplasty for Fuchs\u2019 Endothelial Corneal Dystrophy. Ophthalmology 123:154\u2013160","journal-title":"Ophthalmology"},{"key":"2422_CR18","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1016\/j.ophtha.2018.06.018","volume":"125","author":"K Wacker","year":"2018","unstructured":"Wacker\u00a0K, Baratz\u00a0KH, Bourne\u00a0WM, Patel\u00a0SV (2018) Patient-Reported Visual Disability in Fuchs\u2019 Endothelial Corneal Dystrophy Measured by the Visual Function and Corneal Health Status Instrument. Ophthalmology 125:1854\u20131861","journal-title":"Ophthalmology"}],"container-title":["Die Ophthalmologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-026-02422-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00347-026-02422-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-026-02422-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:26:27Z","timestamp":1786026387000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00347-026-02422-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["2422"],"URL":"https:\/\/doi.org\/10.1007\/s00347-026-02422-y","relation":{},"ISSN":["2731-720X","2731-7218"],"issn-type":[{"value":"2731-720X","type":"print"},{"value":"2731-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"27 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dieser Artikel wurde urspr\u00fcnglich im Abonnement-Modell ver\u00f6ffentlicht, wird jedoch jetzt unter einer Open-Access-Lizenz ver\u00f6ffentlicht.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M.\u00a0Da Costa, B. Seitz, C.\u00a0Munteanu und L.\u00a0Daas geben an, dass kein Interessenkonflikt besteht.","order":1,"name":"Ethics","label":"Interessenkonflikt","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"Die Studie wurde gem\u00e4\u00df den Grunds\u00e4tzen der Deklaration von Helsinki durchgef\u00fchrt und durch die Ethikkommission der \u00c4rztekammer des Saarlandes genehmigt (Kennnummer 217\/20).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}}]}}