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Das Ziel dieser Studie war, den Einfluss systemischer Grunderkrankungen, der systemischen Begleitmedikation, des Hornhautstatus, der Art des Epitheldefekts sowie der Operationstechnik auf den Therapieerfolg zu beurteilen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patienten und Methoden<\/jats:title>\n                    <jats:p>\n                      Insgesamt wurden \u00fcber den Zeitraum von 2013 bis 2019 780 AMT (496 Patienten, 519 Augen) retrospektiv untersucht. Zus\u00e4tzlich wurden die systemische Begleiterkrankung (unterteilt in verschiedene Kategorien) und Begleitmedikation, die Tiefe des Defekts (Erosio\/Ulkus), der Hornhautstatus (eigene Hornhaut [HH]\/Transplantat [TPL]) und die Operationstechnik (Patch\/Sandwich\/Graft) erfasst. Die Zielgr\u00f6\u00dfen waren der Epithelschluss nach 4\u00a0Wochen sowie die Rezidivrate. Der Nachbeobachtungszeitraum betrug ein Jahr. Sp\u00e4ter auftretende Misserfolge wurden nicht ber\u00fccksichtigt. Das Signifikanzniveau betrug\n                      <jats:italic>p<\/jats:italic>\n                      \u202f\u2264\u20090,05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>\n                      Es ergab sich eine Epithelschlussrate von 58,8\u202f% und eine Rezidivrate von 18,7\u202f%. F\u00e4lle mit Schilddr\u00fcsenerkrankung hatten eine signifikant geringere Erfolgsrate (45,0\u202f%) als die restliche Studienpopulation (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090,003). F\u00e4lle mit viraler Infektion hatte eine signifikant h\u00f6here Erfolgsrate (65,7\u202f%,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u2009204) als F\u00e4lle ohne virale Infektion (56,5\u202f%,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u2009326,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090,039). Bez\u00fcglich der Begleitmedikation konnte festgestellt werden, dass bei Einnahme von systemischen Steroiden die Erfolgsrate signifikant h\u00f6her war (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090,001). Verglich man den Erfolg der AMT auf der eigenen HH und einem TPL, so war die Erfolgsrate auf der eigenen HH signifikant h\u00f6her (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090,019) als auf einer Spenderhornhaut. Bei der Operationstechnik ergab sich kein signifikanter Unterschied hinsichtlich der Erfolgs- und Rezidivraten.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Schlussfolgerungen<\/jats:title>\n                    <jats:p>Die AMT ist auch unter allt\u00e4glichen klinischen Bedingungen eine sinnvolle Option bei therapieresistenten Epitheldefekten. Vor allem in F\u00e4llen mit prim\u00e4rem Erfolg (Epithelschluss nach 4\u00a0Wochen) ist ein besseres Langzeitergebnis zu erwarten. Bei begleitender Schilddr\u00fcsenerkrankung zeigte die AMT eine deutlich schlechtere Erfolgsrate. Auf einem TPL ist mit deutlich schlechteren Ergebnissen der AMT zu rechnen als auf der eigenen HH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00347-026-02444-6","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:27:01Z","timestamp":1777472821000},"page":"514-523","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Die Amnionmembrantransplantation bei verschiedenen systemischen Grunderkrankungen","Amniotic membrane transplantation in various systemic diseases"],"prefix":"10.1007","volume":"123","author":[{"given":"Eva","family":"S\u00fc\u00dfmaier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Kahraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassandra","family":"Xanthopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Munteanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"issue":"1","key":"2444_CR1","first-page":"58","volume":"2","author":"A Baradaran-Rafii","year":"2007","unstructured":"Baradaran-Rafii\u00a0A, Aghayan\u00a0HR, Arjmand\u00a0B, Javadi\u00a0MA (2007) Amniotic Membrane Transplantation. 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