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Neben infekti\u00f6sen Ursachen k\u00f6nnen Tumorerkrankungen wie intraokulare Lymphome entz\u00fcndliche Krankheitsbilder imitieren. Das Vorderkammeraspirat erm\u00f6glicht den direkten Erregernachweis und kann Hinweise auf Tumorerkrankungen liefern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ziel der Studie<\/jats:title>\n                    <jats:p>Ziel dieser Studie war es, den diagnostischen Nutzen des Vorderkammeraspirats bei Patienten mit Uveitis im klinischen Alltag eines terti\u00e4ren universit\u00e4ren Zentrums zu evaluieren.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methoden<\/jats:title>\n                    <jats:p>In einer retrospektiven monozentrischen Studie wurden 59\u00a0Vorderkammeraspirate analysiert, die zwischen 2015 und 2020 an der Universit\u00e4tsaugenklinik Essen durchgef\u00fchrt wurden. Die Kohorte umfasste anteriore, intermedi\u00e4re und posteriore Uveitiden sowie Panuveitiden. Erfasst wurden demografische Daten, klinischer Verlauf, Vorbehandlung sowie virologische und mikrobiologische Befunde des Vorderkammeraspirats und erg\u00e4nzende Befunde aus Glask\u00f6rper- oder Gewebebiopsien.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>\n                      In 18\u00a0F\u00e4llen (30,5\u202f%) konnte ein \u00e4tiologisch relevanter Befund erhoben werden, darunter 16\u00a0direkte Erregernachweise im Vorderkammeraspirat sowie 2 intraokulare Lymphome, die im weiteren Verlauf mittels Glask\u00f6rper- bzw. Gewebebiopsie gesichert wurden. Am h\u00e4ufigsten wurden\n                      <jats:italic>Toxoplasma gondii<\/jats:italic>\n                      und Herpesviren nachgewiesen. Deskriptiv zeigten sich vergleichbare Nachweisraten bei vorbehandelten und therapienaiven Patienten. In ausgew\u00e4hlten klinischen Verl\u00e4ufen erm\u00f6glichte die Kammerwasser-Polymerasekettenreaktion (PCR) die fr\u00fche \u00e4tiologische Zuordnung einer\u00a0Herpes-simplex-Virus Typ 1 (HSV-1)-assoziierten Retinitis sowie den Nachweis einer Zytomegalievirus (CMV)-assoziierten Uveitis mit unmittelbaren therapeutischen Konsequenzen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Schlussfolgerung<\/jats:title>\n                    <jats:p>Das Vorderkammeraspirat stellt ein wertvolles diagnostisches Instrument in der Uveitisabkl\u00e4rung dar und kann insbesondere bei infekti\u00f6sen Ursachen eine zielgerichtete Therapie erm\u00f6glichen. Bei atypischen oder therapieresistenten Verl\u00e4ufen tr\u00e4gt es im Rahmen eines stufenweisen diagnostischen Vorgehens zur Erkennung tumorassoziierter intraokularer Erkrankungen bei.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00347-026-02463-3","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:44:29Z","timestamp":1781178269000},"page":"631-637","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Der Stellenwert des Vorderkammeraspirats in der Uveitisdiagnostik\u00a0\u2013 Erfahrungen aus einem terti\u00e4ren universit\u00e4ren Zentrum","The value of aqueous humor aspiration in the diagnostics of uveitis\u2014Experience from a\u00a0tertiary university center"],"prefix":"10.1007","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7996-7800","authenticated-orcid":false,"given":"Melih","family":"Tarhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Ilan","family":"Wunderlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos E.","family":"Bechrakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Rahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"issue":"5","key":"2463_CR1","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1055\/a-1120-8787","volume":"237","author":"E Biewald","year":"2020","unstructured":"Biewald\u00a0E, Rating\u00a0P, Bechrakis\u00a0NE, Lommatzsch\u00a0AP (2020) Uveitis Masquerade Syndrome: Typical Symptoms and Presentations. 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