{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:24:36Z","timestamp":1785543876582,"version":"3.56.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmologie"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00347-026-02467-z","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:16:24Z","timestamp":1783948584000},"page":"605-610","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Crosslinking-Therapie bei ultrad\u00fcnnen Hornh\u00e4uten: das ELZA-sub400-Protokoll","Cross-linking treatment of ultrathin corneas: the ELZA-sub400 protocol"],"prefix":"10.1007","volume":"123","author":[{"given":"F.","family":"Hafezi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1277-9309","authenticated-orcid":false,"given":"M.","family":"Hillen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. L.","family":"Hafezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Aydemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"Torres-Netto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"issue":"5","key":"2467_CR1","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/s0002-9394(02)02220-1","volume":"135","author":"G Wollensak","year":"2003","unstructured":"Wollensak\u00a0G, Spoerl\u00a0E, Seiler\u00a0T (2003) Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 135(5):620\u2013627. https:\/\/doi.org\/10.1016\/s0002-9394(02)02220-1","journal-title":"Am J Ophthalmol"},{"issue":"11","key":"2467_CR2","doi-asserted-by":"publisher","first-page":"768","DOI":"10.3928\/1081597X-20180830-01","volume":"34","author":"EA Torres-Netto","year":"2018","unstructured":"Torres-Netto\u00a0EA, Kling\u00a0S, Hafezi\u00a0N, Vinciguerra\u00a0P, Randleman\u00a0JB, Hafezi\u00a0F (2018) Oxygen Diffusion May Limit the Biomechanical Effectiveness of Iontophoresis-Assisted Transepithelial Corneal Cross-linking. J\u00a0Refract Surg 34(11):768\u2013774. https:\/\/doi.org\/10.3928\/1081597X-20180830-01","journal-title":"J Refract Surg"},{"issue":"9","key":"2467_CR3","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1097\/01.ico.0000225720.38748.58","volume":"25","author":"T Seiler","year":"2006","unstructured":"Seiler\u00a0T, Hafezi\u00a0F (2006) Corneal cross-linking-induced stromal demarcation line. Cornea 25(9):1057\u20131059. https:\/\/doi.org\/10.1097\/01.ico.0000225720.38748.58","journal-title":"Cornea"},{"key":"2467_CR4","doi-asserted-by":"publisher","DOI":"10.3928\/jrscr-20210527-01","author":"F Hafezi","year":"2021","unstructured":"Hafezi\u00a0F, Torres-Netto\u00a0EA, Randleman\u00a0JB, Hafezi\u00a0NL, Mazzotta\u00a0C, Ambr\u00f3sio\u00a0R, Kollros\u00a0L (2021) Corneal Cross-linking for Keratoglobus Using Individualized Fluence. Journal of Refractive Surgery Case Reports. https:\/\/doi.org\/10.3928\/jrscr-20210527-01","journal-title":"Journal of Refractive Surgery Case Reports"},{"issue":"11","key":"2467_CR5","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3928\/1081597X-20121011-01","volume":"28","author":"N Chatzis","year":"2012","unstructured":"Chatzis\u00a0N, Hafezi\u00a0F (2012) Progression of keratoconus and efficacy of pediatric [corrected] corneal collagen cross-linking in children and adolescents. J\u00a0Refract Surg 28(11):753\u2013758. https:\/\/doi.org\/10.3928\/1081597X-20121011-01","journal-title":"J Refract Surg"},{"issue":"4","key":"2467_CR6","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.jcrs.2008.10.060","volume":"35","author":"F Hafezi","year":"2009","unstructured":"Hafezi\u00a0F, Mrochen\u00a0M, Iseli\u00a0HP, Seiler\u00a0T (2009) Collagen crosslinking with ultraviolet\u2011A and hypoosmolar riboflavin solution in thin corneas. J\u00a0Cataract Refract Surg 35(4):621\u2013624. https:\/\/doi.org\/10.1016\/j.jcrs.2008.10.060","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"2467_CR7","doi-asserted-by":"publisher","first-page":"e84","DOI":"10.1111\/aos.13828","volume":"97","author":"G Wollensak","year":"2019","unstructured":"Wollensak\u00a0G, Sporl\u00a0E, Herbst\u00a0H (2019) Biomechanical efficacy of contact lens-assisted collagen cross-linking in porcine eyes. Acta Ophthalmol Suppl 97(1):e84\u2013e90. https:\/\/doi.org\/10.1111\/aos.13828","journal-title":"Acta Ophthalmol"},{"issue":"6","key":"2467_CR8","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3928\/1081597X-20140523-01","volume":"30","author":"S Jacob","year":"2014","unstructured":"Jacob\u00a0S, Kumar\u00a0DA, Agarwal\u00a0A, Basu\u00a0S, Sinha\u00a0P, Agarwal\u00a0A (2014) Contact lens-assisted collagen cross-linking (CACXL): A new technique for cross-linking thin corneas. J\u00a0Refract Surg 30(6):366\u2013372. https:\/\/doi.org\/10.3928\/1081597X-20140523-01","journal-title":"J Refract Surg"},{"issue":"12","key":"2467_CR9","doi-asserted-by":"publisher","first-page":"840","DOI":"10.3928\/1081597X-20151111-08","volume":"31","author":"S Kling","year":"2015","unstructured":"Kling\u00a0S, Richoz\u00a0O, Hammer\u00a0A, Tabibian\u00a0D, Jacob\u00a0S, Agarwal\u00a0A, Hafezi\u00a0F (2015) Increased Biomechanical Efficacy of Corneal Cross-linking in Thin Corneas Due to Higher Oxygen Availability. J\u00a0Refract Surg 31(12):840\u2013846. https:\/\/doi.org\/10.3928\/1081597X-20151111-08","journal-title":"J Refract Surg"},{"key":"2467_CR10","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.2147\/OPTH.S66372","volume":"8","author":"C Mazzotta","year":"2014","unstructured":"Mazzotta\u00a0C, Ramovecchi\u00a0V (2014) Customized epithelial debridement for thin ectatic corneas undergoing corneal cross-linking: epithelial island cross-linking technique. Clin Ophthalmol 8:1337\u20131343. https:\/\/doi.org\/10.2147\/OPTH.S66372","journal-title":"Clin Ophthalmol"},{"issue":"5","key":"2467_CR11","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.jcrs.2015.04.007","volume":"41","author":"MS Sachdev","year":"2015","unstructured":"Sachdev\u00a0MS, Gupta\u00a0D, Sachdev\u00a0G, Sachdev\u00a0R (2015) Tailored stromal expansion with a refractive lenticule for crosslinking the ultrathin cornea. J\u00a0Cataract Refract Surg 41(5):918\u2013923. https:\/\/doi.org\/10.1016\/j.jcrs.2015.04.007","journal-title":"J Cataract Refract Surg"},{"issue":"12","key":"2467_CR12","doi-asserted-by":"publisher","first-page":"3403","DOI":"10.1007\/s10792-020-01526-x","volume":"40","author":"C Cagini","year":"2020","unstructured":"Cagini\u00a0C, Riccitelli\u00a0F, Messina\u00a0M, Piccinelli\u00a0F, Torroni\u00a0G, Said\u00a0D, Al Maazmi\u00a0A, Dua\u00a0HS (2020) Epi-off-lenticule-on corneal collagen cross-linking in thin keratoconic corneas. Int Ophthalmol 40(12):3403\u20133412. https:\/\/doi.org\/10.1007\/s10792-020-01526-x","journal-title":"Int Ophthalmol"},{"issue":"2","key":"2467_CR13","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3928\/1081597X-20161206-01","volume":"33","author":"S Kling","year":"2017","unstructured":"Kling\u00a0S, Hafezi\u00a0F (2017) An Algorithm to Predict the Biomechanical Stiffening Effect in Corneal Cross-linking. J\u00a0Refract Surg 33(2):128\u2013136. https:\/\/doi.org\/10.3928\/1081597X-20161206-01","journal-title":"J Refract Surg"},{"key":"2467_CR14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ajo.2020.12.011","volume":"224","author":"F Hafezi","year":"2021","unstructured":"Hafezi\u00a0F, Kling\u00a0S, Gilardoni\u00a0F, Hafezi\u00a0N, Hillen\u00a0M, Abrishamchi\u00a0R, Gomes\u00a0JAP, Mazzotta\u00a0C, Randleman\u00a0JB, Torres-Netto\u00a0EA (2021) Individualized Corneal Cross-linking With Riboflavin and UV\u2011A in Ultrathin Corneas: The Sub400 Protocol. Am J Ophthalmol 224:133\u2013142. https:\/\/doi.org\/10.1016\/j.ajo.2020.12.011","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"2467_CR15","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1167\/iovs.11-9385","volume":"53","author":"P Kamaev","year":"2012","unstructured":"Kamaev\u00a0P, Friedman\u00a0MD, Sherr\u00a0E, Muller\u00a0D (2012) Photochemical kinetics of corneal cross-linking with riboflavin. Invest Ophthalmol Vis Sci 53(4):2360\u20132367. https:\/\/doi.org\/10.1167\/iovs.11-9385","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"2467_CR16","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.2.7.6","volume":"2","author":"O Richoz","year":"2013","unstructured":"Richoz\u00a0O, Hammer\u00a0A, Tabibian\u00a0D, Gatzioufas\u00a0Z, Hafezi\u00a0F (2013) The Biomechanical Effect of Corneal Collagen Cross-Linking (CXL) With Riboflavin and UV\u2011A is Oxygen Dependent. Transl Vis Sci Technol 2(7):6. https:\/\/doi.org\/10.1167\/tvst.2.7.6","journal-title":"Transl Vis Sci Technol"},{"issue":"6","key":"2467_CR17","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1167\/iovs.19-26686","volume":"60","author":"TG Seiler","year":"2019","unstructured":"Seiler\u00a0TG, Batista\u00a0A, Frueh\u00a0BE, Koenig\u00a0K (2019) Riboflavin Concentrations at the Endothelium During Corneal Cross-Linking in Humans. Invest Ophthalmol Vis Sci 60(6):2140\u20132145. https:\/\/doi.org\/10.1167\/iovs.19-26686","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"2467_CR18","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.1167\/iovs.13-13748","volume":"55","author":"A Hammer","year":"2014","unstructured":"Hammer\u00a0A, Richoz\u00a0O, Arba Mosquera\u00a0S, Tabibian\u00a0D, Hoogewoud\u00a0F, Hafezi\u00a0F (2014) Corneal biomechanical properties at different corneal cross-linking (CXL) irradiances. Invest Ophthalmol Vis Sci 55(5):2881\u20132884. https:\/\/doi.org\/10.1167\/iovs.13-13748","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"2467_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-021-00240-8","volume":"8","author":"C Mazzotta","year":"2021","unstructured":"Mazzotta\u00a0C, Raiskup\u00a0F, Hafezi\u00a0F, Torres-Netto\u00a0EA, Armia Balamoun\u00a0A, Giannaccare\u00a0G, Bagaglia\u00a0SA (2021) Long term results of accelerated 9\u202fmW corneal crosslinking for early progressive keratoconus: the Siena Eye-Cross Study\u00a02. Eye Vis (Lond) 8(1):16. https:\/\/doi.org\/10.1186\/s40662-021-00240-8","journal-title":"Eye Vis (Lond)"},{"issue":"2","key":"2467_CR20","doi-asserted-by":"publisher","first-page":"137","DOI":"10.5005\/jp-journals-10025-1171","volume":"7","author":"C Mazzotta","year":"2018","unstructured":"Mazzotta\u00a0C, Romani\u00a0A, Burroni\u00a0A (2018) Pachymetry-based Accelerated Crosslinking: The \u201cM Nomogram\u201d for Standardized Treatment of All-thickness Progressive Ectatic Corneas. International Journal of Keratoconus and Ectatic Corneal Diseases 7(2):137\u2013144. https:\/\/doi.org\/10.5005\/jp-journals-10025-1171","journal-title":"International Journal of Keratoconus and Ectatic Corneal Diseases"},{"issue":"7","key":"2467_CR21","doi-asserted-by":"publisher","first-page":"e724","DOI":"10.3928\/1081597X-20250515-09","volume":"41","author":"NJ Lu","year":"2025","unstructured":"Lu\u00a0NJ, Torres-Netto\u00a0EA, Aydemir\u00a0ME, Kling\u00a0S, Hafezi\u00a0N, Kollros\u00a0L, Hafezi\u00a0F (2025) A Transepithelial Corneal Cross-linking (CXL) Protocol Providing the Same Biomechanical Strengthening as Accelerated Epithelium-off CXL. J\u00a0Refract Surg 41(7):e724\u2013e730. https:\/\/doi.org\/10.3928\/1081597X-20250515-09","journal-title":"J Refract Surg"}],"container-title":["Die Ophthalmologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-026-02467-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00347-026-02467-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00347-026-02467-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:26:10Z","timestamp":1785500770000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00347-026-02467-z"}},"subtitle":["Individualisierte Fluenzanpassung als Paradigmenwechsel in der CXL-Behandlung d\u00fcnner Hornhautzust\u00e4nde","Individualized adaptation of fluence as paradigm shift in CXL treatment of thin corneal conditions"],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["2467"],"URL":"https:\/\/doi.org\/10.1007\/s00347-026-02467-z","relation":{},"ISSN":["2731-720X","2731-7218"],"issn-type":[{"value":"2731-720X","type":"print"},{"value":"2731-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]},"assertion":[{"value":"2 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"F.\u00a0Hafezi erkl\u00e4rt folgenden Interessenkonflikt: CMO, EMAGine AG; N.L.\u00a0Hafezi CEO, EMAGine AG. M.\u00a0Hillen, S.\u00a0Kling, M.E.\u00a0Aydemir und E.A.\u00a0Torres-Netto geben an, dass kein Interessenkonflikt besteht.","order":1,"name":"Ethics","label":"Interessenkonflikt","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}}]}}