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Anamnestisch bestanden Hypothyreose, Psoriasis und Diabetes mellitus Typ II. Funduskopisch zeigten sich am linken Auge Aderhautfalten, eine amelanotische, temporal der Fovea gelegene L\u00e4sion sowie eine exsudative Ablatio retinae. Die\u00a0optische\u00a0Koh\u00e4renztomographie (OCT)\u00a0zeigte eine choroidale Raumforderung ohne subretinale Exsudation, die Indocyaningr\u00fcnangiographie (ICGA) eine hypocyaneszente, gef\u00e4\u00dffreie L\u00e4sion. Sonographisch fand sich eine inhomogene Raumforderung mit retroskleraler Fl\u00fcssigkeit (positives T-Zeichen). Laborchemisch bestanden ein\u00a0erh\u00f6htes C-reaktives Protein (CRP), erh\u00f6hte Leberwerte und positive\u00a0antinukle\u00e4re Antik\u00f6rper\u00a0(ANA). Der R\u00f6ntgen-Thorax war unauff\u00e4llig. Diese Befunde st\u00fctzten die Verdachtsdiagnose einer nodul\u00e4ren granulomat\u00f6sen Skleritis. Differentialdiagnostisch wurden Aderhautmelanom, uveales Lymphom, prim\u00e4res vitreoretinales Lymphom und chorioidales H\u00e4mangiom erwogen. Unter Kortisontherapie mit Prednisolon zeigten sich rasche Visusbesserung und vollst\u00e4ndige, stabile R\u00fcckbildung der L\u00e4sion. Der Fall verdeutlicht, dass die Abgrenzung entz\u00fcndlicher von neoplastischen intraokularen Raumforderungen zu den schwierigsten Situationen der Ophthalmoonkologie z\u00e4hlt und klinische Erfahrung sowie konsequente multimodale Bildgebung erfordert, um \u00dcbertherapie und Verz\u00f6gerungen der Tumordiagnostik zu vermeiden. Das Vorliegen von wichtigen Befunden in der multimodalen Diagnostik (Aderhautfalten, normalen Aderhautgef\u00e4\u00dfen in der ICGA, T-Zeichen im Ultraschall) k\u00f6nnen die korrekte nicht-invasive differentialdiagnostische Einordnung erm\u00f6glichen.<\/jats:p>","DOI":"10.1007\/s00347-026-02480-2","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:30:38Z","timestamp":1783672238000},"page":"820-824","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aderhautfalten als diagnostischer Hinweis auf eine unklare posteriore Raumforderung","Choroidal folds as a\u00a0diagnostic indication for a\u00a0posterior mass of unknown etiology"],"prefix":"10.1007","volume":"123","author":[{"given":"Zaynab","family":"Khattabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos E.","family":"Bechrakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kiefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"issue":"12","key":"2480_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13121991","volume":"13","author":"E Bolletta","year":"2023","unstructured":"Bolletta\u00a0E, De Simone\u00a0L, Pellegrini\u00a0M, Preziosa\u00a0C, Mastrofilippo\u00a0V, Adani\u00a0C, Gentile\u00a0P, Gozzi\u00a0F, Cimino\u00a0L (2023) Optical Coherence Tomography in Inflammatory and Neoplastic Lesions Deforming the Choroidal Profile. 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