{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:17:28Z","timestamp":1789676248826,"version":"4.0.1"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005969","name":"University of Bologna","doi-asserted-by":"crossref","award":["FARB\u2014Warm up to wake"],"award-info":[{"award-number":["FARB\u2014Warm up to wake"]}],"id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Comp Physiol B"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s00360-021-01421-6","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:03:16Z","timestamp":1641772996000},"page":"349-360","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mitochondrial respiration in rats during hypothermia resulting from central drug administration"],"prefix":"10.1007","volume":"192","author":[{"given":"Gianluca","family":"Sgarbi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timna","family":"Hitrec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Amici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Baracca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Di Cristoforo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Liuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Luppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Solaini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Squarcio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Zamboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3556-305X","authenticated-orcid":false,"given":"Matteo","family":"Cerri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"1421_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1006\/bbrc.1994.1200","volume":"199","author":"A Baracca","year":"1994","unstructured":"Baracca A, Barzanti V, Lenaz G, Solaini G (1994) Dietary lipids and 5\u2032-nucleotidase activity of rat cell plasma membranes. Biochem Biophys Res Commun 199:99\u2013105","journal-title":"Biochem Biophys Res Commun"},{"key":"1421_CR2","doi-asserted-by":"publisher","first-page":"6338","DOI":"10.1074\/jbc.M114.631788","volume":"290","author":"S Barbato","year":"2015","unstructured":"Barbato S, Sgarbi G, Gorini G, Baracca A, Solaini G (2015) The inhibitor protein (IF1) of the F1F0-ATPase modulates human osteosarcoma cell bioenergetics. J Biol Chem 290:6338\u20136348","journal-title":"J Biol Chem"},{"key":"1421_CR3","doi-asserted-by":"publisher","first-page":"R1306","DOI":"10.1152\/ajpregu.00579.2002","volume":"284","author":"JL Barger","year":"2003","unstructured":"Barger JL, Brand MD, Barnes BM, Boyer BB (2003) Tissue-specific depression of mitochondrial proton leak and substrate oxidation in hibernating arctic ground squirrels. Am J Physiol Regul Integr Comp Physiol 284:R1306-1313","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1421_CR4","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0047-6374(95)01640-6","volume":"84","author":"S Barogi","year":"1995","unstructured":"Barogi S, Baracca A, Parenti Castelli G, Bovina C, Formiggini G, Marchetti M, Solaini G, Lenaz G (1995) Lack of major changes in ATPase activity in mitochondria from liver, heart, and skeletal muscle of rats upon ageing. Mech Ageing Dev 84:139\u2013150","journal-title":"Mech Ageing Dev"},{"key":"1421_CR5","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/S0306-4522(01)00251-2","volume":"105","author":"WW Blessing","year":"2001","unstructured":"Blessing WW, Nalivaiko E (2001) Raphe magnus\/pallidus neurons regulate tail but not mesenteric arterial blood flow in rats. Neuroscience 105:923\u2013929","journal-title":"Neuroscience"},{"key":"1421_CR6","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0014-5793(04)00294-7","volume":"563","author":"F Bosetti","year":"2004","unstructured":"Bosetti F, Baracca A, Lenaz G, Solaini G (2004) Increased state 4 mitochondrial respiration and swelling in early post-ischemic reperfusion of rat heart. FEBS Lett 563:161\u2013164","journal-title":"FEBS Lett"},{"key":"1421_CR7","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1002\/jcp.22850","volume":"227","author":"HR Bouma","year":"2012","unstructured":"Bouma HR, Verhaag EM, Otis JP, Heldmaier G, Swoap SJ, Strijkstra AM, Henning RH, Carey HV (2012) Induction of torpor: mimicking natural metabolic suppression for biomedical applications. J Cell Physiol 227:1285\u20131290","journal-title":"J Cell Physiol"},{"key":"1421_CR8","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.bbabio.2010.01.009","volume":"1797","author":"JC Brown","year":"2010","unstructured":"Brown JC, Staples JF (2010) Mitochondrial metabolism during fasting-induced daily torpor in mice. Biochim Biophys Acta 1797:476\u2013486","journal-title":"Biochim Biophys Acta"},{"key":"1421_CR9","doi-asserted-by":"publisher","first-page":"R1833","DOI":"10.1152\/ajpregu.00310.2007","volume":"293","author":"JC Brown","year":"2007","unstructured":"Brown JC, Gerson AR, Staples JF (2007) Mitochondrial metabolism during daily torpor in the dwarf Siberian hamster: role of active regulated changes and passive thermal effects. Am J Physiol Regul Integr Comp Physiol 293:R1833\u2013R1845","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1421_CR10","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1146\/annurev-physiol-022516-034133","volume":"79","author":"M Cerri","year":"2017","unstructured":"Cerri M (2017) The central control of energy expenditure: exploiting torpor for medical applications. Annu Rev Physiol 79:167\u2013186","journal-title":"Annu Rev Physiol"},{"key":"1421_CR11","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.neuroscience.2009.10.068","volume":"165","author":"M Cerri","year":"2010","unstructured":"Cerri M, Zamboni G, Tupone D, Dentico D, Luppi M, Martelli D, Perez E, Amici R (2010) Cutaneous vasodilation elicited by disinhibition of the caudal portion of the rostral ventromedial medulla of the free-behaving rat. Neuroscience 165:984\u2013995","journal-title":"Neuroscience"},{"key":"1421_CR12","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1523\/JNEUROSCI.3596-12.2013","volume":"33","author":"M Cerri","year":"2013","unstructured":"Cerri M, Mastrotto M, Tupone D, Martelli D, Luppi M, Perez E, Zamboni G, Amici R (2013) The inhibition of neurons in the central nervous pathways for thermoregulatory cold defense induces a suspended animation state in the rat. J Neurosci 33:2984\u20132993","journal-title":"J Neurosci"},{"key":"1421_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lssr.2016.09.001","volume":"11","author":"M Cerri","year":"2016","unstructured":"Cerri M, Tinganelli W, Negrini M, Helm A, Scifoni E, Tommasino F, Sioli M, Zoccoli A, Durante M (2016) Hibernation for space travel: impact on radioprotection. Life Sci Space Res 11:1\u20139","journal-title":"Life Sci Space Res"},{"key":"1421_CR14","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.neubiorev.2021.03.037","volume":"128","author":"M Cerri","year":"2021","unstructured":"Cerri M, Hitrec T, Luppi M, Amici R (2021) Be cool to be far: exploiting hibernation for space exploration. Neurosci Biobehav Rev 128:218\u2013232","journal-title":"Neurosci Biobehav Rev"},{"key":"1421_CR15","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s00424-018-2244-7","volume":"471","author":"A Chouker","year":"2019","unstructured":"Chouker A, Bereiter-Hahn J, Singer D, Heldmaier G (2019) Hibernating astronauts-science or fiction? Pflugers Arch 471:819\u2013828","journal-title":"Pflugers Arch"},{"key":"1421_CR16","first-page":"241","volume":"32","author":"S De Rosa","year":"2017","unstructured":"De Rosa S, Antonelli M, Ronco C (2017) Hypothermia and kidney: a focus on ischaemia-reperfusion injury. Nephrol Dial Transplant 32:241\u2013247","journal-title":"Nephrol Dial Transplant"},{"key":"1421_CR17","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0305-0491(85)90151-8","volume":"82","author":"NJ Fedotcheva","year":"1985","unstructured":"Fedotcheva NJ, Sharyshev AA, Mironova GD, Kondrashova MN (1985) Inhibition of succinate oxidation and K+ transport in mitochondria during hibernation. Comp Biochem Physiol B 82:191\u2013195","journal-title":"Comp Biochem Physiol B"},{"key":"1421_CR18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0305-0491(88)90107-1","volume":"91","author":"SC Gehnrich","year":"1988","unstructured":"Gehnrich SC, Aprille JR (1988) Hepatic gluconeogenesis and mitochondrial function during hibernation. Comp Biochem Physiol B 91:11\u201316","journal-title":"Comp Biochem Physiol B"},{"key":"1421_CR19","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","volume":"177","author":"AG Gornall","year":"1949","unstructured":"Gornall AG, Bardawill CJ, David MM (1949) Determination of serum proteins by means of the biuret reaction. J Biol Chem 177:751\u2013766","journal-title":"J Biol Chem"},{"key":"1421_CR20","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/apha.12747","volume":"219","author":"TA Gorr","year":"2017","unstructured":"Gorr TA (2017) Hypometabolism as the ultimate defence in stress response: how the comparative approach helps understanding of medically relevant questions. Acta Physiol (oxf) 219:409\u2013440","journal-title":"Acta Physiol (oxf)"},{"key":"1421_CR21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.lssr.2018.01.002","volume":"16","author":"Y Griko","year":"2018","unstructured":"Griko Y, Regan MD (2018) Synthetic torpor: a method for safely and practically transporting experimental animals aboard spaceflight missions to deep space. Life Sci Space Res (amst) 16:101\u2013107","journal-title":"Life Sci Space Res (amst)"},{"key":"1421_CR22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.cbpa.2013.09.002","volume":"167","author":"K Grimpo","year":"2014","unstructured":"Grimpo K, Kutschke M, Kastl A, Meyer CW, Heldmaier G, Exner C, Jastroch M (2014) Metabolic depression during warm torpor in the Golden spiny mouse (Acomys russatus) does not affect mitochondrial respiration and hydrogen peroxide release. Comp Biochem Physiol A Mol Integr Physiol 167:7\u201314","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"1421_CR23","doi-asserted-by":"publisher","first-page":"R180","DOI":"10.1152\/ajpregu.00427.2016","volume":"313","author":"AB Heim","year":"2017","unstructured":"Heim AB, Chung D, Florant GL, Chicco AJ (2017) Tissue-specific seasonal changes in mitochondrial function of a mammalian hibernator. Am J Physiol Regul Integr Comp Physiol 313:R180\u2013R190","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1421_CR24","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.resp.2004.03.014","volume":"141","author":"G Heldmaier","year":"2004","unstructured":"Heldmaier G, Ortmann S, Elvert R (2004) Natural hypometabolism during hibernation and daily torpor in mammals. Respir Physiol Neurobiol 141:317\u2013329","journal-title":"Respir Physiol Neurobiol"},{"key":"1421_CR25","doi-asserted-by":"publisher","first-page":"15482","DOI":"10.1038\/s41598-017-15606-z","volume":"7","author":"KDW Hendriks","year":"2017","unstructured":"Hendriks KDW, Lupi E, Hardenberg MC, Hoogstra-Berends F, Deelman LE, Henning RH (2017) Differences in mitochondrial function and morphology during cooling and rewarming between hibernator and non-hibernator derived kidney epithelial cells. Sci Rep 7:15482","journal-title":"Sci Rep"},{"key":"1421_CR26","doi-asserted-by":"publisher","first-page":"15462","DOI":"10.1038\/s41598-019-51841-2","volume":"9","author":"T Hitrec","year":"2019","unstructured":"Hitrec T, Luppi M, Bastianini S, Squarcio F, Berteotti C, Lo Martire V, Martelli D, Occhinegro A, Tupone D, Zoccoli G, Amici R, Cerri M (2019) Neural control of fasting-induced torpor in mice. Sci Rep 9:15462","journal-title":"Sci Rep"},{"key":"1421_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2021.592288","volume":"15","author":"T Hitrec","year":"2021","unstructured":"Hitrec T, Squarcio F, Cerri M, Martelli D, Occhinegro A, Piscitiello E, Tupone D, Amici R, Luppi M (2021) Reversible tau phosphorylation induced by synthetic torpor in the spinal cord of the rat. Front Neuroanat 15:592288","journal-title":"Front Neuroanat"},{"key":"1421_CR28","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/s41586-020-2387-5","volume":"583","author":"S Hrvatin","year":"2020","unstructured":"Hrvatin S, Sun S, Wilcox OF, Yao H, Lavin-Peter AJ, Cicconet M, Assad EG, Palmer ME, Aronson S, Banks AS, Griffith EC, Greenberg ME (2020) Neurons that regulate mouse torpor. Nature 583:115\u2013121","journal-title":"Nature"},{"key":"1421_CR29","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1002\/j.1460-2075.1985.tb04049.x","volume":"4","author":"M Klingenberg","year":"1985","unstructured":"Klingenberg M, Winkler E (1985) The reconstituted isolated uncoupling protein is a membrane potential driven H+ translocator. EMBO J 4:3087\u20133092","journal-title":"EMBO J"},{"key":"1421_CR30","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.cbpa.2013.01.008","volume":"164","author":"M Kutschke","year":"2013","unstructured":"Kutschke M, Grimpo K, Kastl A, Schneider S, Heldmaier G, Exner C, Jastroch M (2013) Depression of mitochondrial respiration during daily torpor of the Djungarian hamster, Phodopus sungorus, is specific for liver and correlates with body temperature. Comp Biochem Physiol A Mol Integr Physiol 164:584\u2013589","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"issue":"Pt 2","key":"1421_CR31","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1042\/bj3360501","volume":"336","author":"N Leducq","year":"1998","unstructured":"Leducq N, Delmas-Beauvieux MC, Bourdel-Marchasson I, Dufour S, Gallis JL, Canioni P, Diolez P (1998) Mitochondrial permeability transition during hypothermic to normothermic reperfusion in rat liver demonstrated by the protective effect of cyclosporin A. Biochem J 336(Pt 2):501\u2013506","journal-title":"Biochem J"},{"key":"1421_CR32","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1146\/annurev.med.59.061506.110403","volume":"59","author":"CC Lee","year":"2008","unstructured":"Lee CC (2008) Is human hibernation possible? Annu Rev Med 59:177\u2013186","journal-title":"Annu Rev Med"},{"key":"1421_CR33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3389\/fnana.2019.00057","volume":"13","author":"M Luppi","year":"2019","unstructured":"Luppi M, Hitrec T, Di Cristoforo A, Squarcio F, Stanzani A, Occhinegro A, Chiavetta P, Tupone D, Zamboni G, Amici R, Cerri M (2019) Phosphorylation and dephosphorylation of tau protein during synthetic torpor. Front Neuroanat 13:57","journal-title":"Front Neuroanat"},{"key":"1421_CR34","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1086\/physzool.28.1.30152176","volume":"28","author":"AW Martin","year":"1955","unstructured":"Martin AW, Fuhrman FA (1955) The relationship between summated tissue respiration and metabolic rate in the mouse and dog. Physiol Zool 28:18\u201334","journal-title":"Physiol Zool"},{"key":"1421_CR35","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1086\/316667","volume":"72","author":"SL Martin","year":"1999","unstructured":"Martin SL, Maniero GD, Carey C, Hand SC (1999) Reversible depression of oxygen consumption in isolated liver mitochondria during hibernation. Physiol Biochem Zool 72:255\u2013264","journal-title":"Physiol Biochem Zool"},{"key":"1421_CR36","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.cmet.2014.02.007","volume":"19","author":"SF Morrison","year":"2014","unstructured":"Morrison SF, Madden CJ, Tupone D (2014) Central neural regulation of brown adipose tissue thermogenesis and energy expenditure. Cell Metab 19:741\u2013756","journal-title":"Cell Metab"},{"key":"1421_CR37","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1086\/501053","volume":"79","author":"HM Muleme","year":"2006","unstructured":"Muleme HM, Walpole AC, Staples JF (2006) Mitochondrial metabolism in hibernation: metabolic suppression, temperature effects, and substrate preferences. Physiol Biochem Zool 79:474\u2013483","journal-title":"Physiol Biochem Zool"},{"key":"1421_CR38","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.bpc.2016.10.002","volume":"219","author":"S Nath","year":"2016","unstructured":"Nath S (2016) The thermodynamic efficiency of ATP synthesis in oxidative phosphorylation. Biophys Chem 219:69\u201374","journal-title":"Biophys Chem"},{"key":"1421_CR39","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"2007","unstructured":"Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates. Elsevier, San Diego"},{"key":"1421_CR40","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/BF02515154","volume":"154","author":"DJ Pehowich","year":"1984","unstructured":"Pehowich DJ, Wang LCH (1984) Seasonal changes in mitochondrial succinate dehydrogenase activity in a hibernator, Spermophilus richardsonii. J Comp Physiol B 154:495\u2013501","journal-title":"J Comp Physiol B"},{"key":"1421_CR41","first-page":"54","volume":"11","author":"A Puspitasari","year":"2021","unstructured":"Puspitasari A, Cerri M, Takahashi A, Yoshida Y, Hanamura K, Tinganelli W (2021) Hibernation as a tool for radiation protection in space exploration. Life (basel) 11:54","journal-title":"Life (basel)"},{"key":"1421_CR42","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1152\/physrev.1997.77.3.731","volume":"77","author":"DF Rolfe","year":"1997","unstructured":"Rolfe DF, Brown GC (1997) Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev 77:731\u2013758","journal-title":"Physiol Rev"},{"issue":"Pt 2","key":"1421_CR43","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1042\/bj3270443","volume":"327","author":"G Solaini","year":"1997","unstructured":"Solaini G, Baracca A, Gabellieri E, Lenaz G (1997) Modification of the mitochondrial F1-ATPase epsilon subunit, enhancement of the ATPase activity of the IF1-F1 complex and IF1-binding dependence of the conformation of the epsilon subunit. Biochem J 327(Pt 2):443\u2013448","journal-title":"Biochem J"},{"key":"1421_CR44","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.bbabio.2008.04.034","volume":"1777","author":"G Solaini","year":"2008","unstructured":"Solaini G, Harris DA, Lenaz G, Sgarbi G, Baracca A (2008) The study of the pathogenic mechanism of mitochondrial diseases provides information on basic bioenergetics. Biochim Biophys Acta 1777:941\u2013945","journal-title":"Biochim Biophys Acta"},{"key":"1421_CR45","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1242\/jeb.092973","volume":"217","author":"JF Staples","year":"2014","unstructured":"Staples JF (2014) Metabolic suppression in mammalian hibernation: the role of mitochondria. J Exp Biol 217:2032\u20132036","journal-title":"J Exp Biol"},{"key":"1421_CR46","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00360-008-0282-8","volume":"178","author":"JF Staples","year":"2008","unstructured":"Staples JF, Brown JC (2008) Mitochondrial metabolism in hibernation and daily torpor: a review. J Comp Physiol B 178:811\u2013827","journal-title":"J Comp Physiol B"},{"key":"1421_CR47","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.resuscitation.2011.09.023","volume":"83","author":"P Susantitaphong","year":"2012","unstructured":"Susantitaphong P, Alfayez M, Cohen-Bucay A, Balk EM, Jaber BL (2012) Therapeutic hypothermia and prevention of acute kidney injury: a meta-analysis of randomized controlled trials. Resuscitation 83:159\u2013167","journal-title":"Resuscitation"},{"key":"1421_CR48","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41586-020-2163-6","volume":"583","author":"TM Takahashi","year":"2020","unstructured":"Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T (2020) A discrete neuronal circuit induces a hibernation-like state in rodents. Nature 583:109\u2013114","journal-title":"Nature"},{"key":"1421_CR49","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2170\/jjphysiol.47.87","volume":"47","author":"M Takaki","year":"1997","unstructured":"Takaki M, Nakahara H, Kawatani Y, Utsumi K, Suga H (1997) No suppression of respiratory function of mitochondrial isolated from the hearts of anesthetized rats with high-dose pentobarbital sodium. Jpn J Physiol 47:87\u201392","journal-title":"Jpn J Physiol"},{"key":"1421_CR50","doi-asserted-by":"publisher","first-page":"352","DOI":"10.3390\/ijms20020352","volume":"20","author":"W Tinganelli","year":"2019","unstructured":"Tinganelli W, Hitrec T, Romani F, Simoniello P, Squarcio F, Stanzani A, Piscitiello E, Marchesano V, Luppi M, Sioli M, Helm A, Compagnone G, Morganti AG, Amici R, Negrini M, Zoccoli A, Durante M, Cerri M (2019) Hibernation and radioprotection: gene expression in the liver and testicle of rats irradiated under synthetic torpor. Int J Mol Sci 20:352","journal-title":"Int J Mol Sci"},{"key":"1421_CR51","doi-asserted-by":"publisher","first-page":"14512","DOI":"10.1523\/JNEUROSCI.1980-13.2013","volume":"33","author":"D Tupone","year":"2013","unstructured":"Tupone D, Madden CJ, Morrison SF (2013) Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat. J Neurosci 33:14512\u201314525","journal-title":"J Neurosci"},{"key":"1421_CR52","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/0005-2728(80)90156-5","volume":"591","author":"K Van Dam","year":"1980","unstructured":"Van Dam K, Westerhoff HV, Krab K, van der Meer R, Arents JC (1980) Relationship between chemiosomotic flows and thermodynamic forces in oxidative phosphorylation. Biochim Biophys Acta 591:240\u2013250","journal-title":"Biochim Biophys Acta"},{"key":"1421_CR53","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s00360-017-1084-7","volume":"187","author":"MA Vicent","year":"2017","unstructured":"Vicent MA, Borre ED, Swoap SJ (2017) Central activation of the A1 adenosine receptor in fed mice recapitulates only some of the attributes of daily torpor. J Comp Physiol B 187:835\u2013845","journal-title":"J Comp Physiol B"},{"key":"1421_CR54","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/673050","volume":"2012","author":"Z Wang","year":"2012","unstructured":"Wang Z, Zhang J, Ying Z, Heymsfield SB (2012) Organ-tissue level model of resting energy expenditure across mammals: new insights into Kleiber\u2019s Law. ISRN Zool 2012:673050","journal-title":"ISRN Zool"},{"key":"1421_CR55","doi-asserted-by":"publisher","first-page":"16823","DOI":"10.1073\/pnas.1011099107","volume":"107","author":"IN Watt","year":"2010","unstructured":"Watt IN, Montgomery MG, Runswick MJ, Leslie AG, Walker JE (2010) Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria. Proc Natl Acad Sci USA 107:16823\u201316827","journal-title":"Proc Natl Acad Sci USA"},{"key":"1421_CR56","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/s42003-020-01192-w","volume":"3","author":"M Wikstrom","year":"2020","unstructured":"Wikstrom M, Springett R (2020) Thermodynamic efficiency, reversibility, and degree of coupling in energy conservation by the mitochondrial respiratory chain. Commun Biol 3:451","journal-title":"Commun Biol"},{"key":"1421_CR57","doi-asserted-by":"publisher","first-page":"R110","DOI":"10.1152\/ajpregu.00016.2003","volume":"285","author":"DV Zaretsky","year":"2003","unstructured":"Zaretsky DV, Zaretskaia MV, DiMicco JA (2003) Stimulation and blockade of GABA(A) receptors in the raphe pallidus: effects on body temperature, heart rate, and blood pressure in conscious rats. Am J Physiol Regul Integr Comp Physiol 285:R110\u2013R116","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1421_CR58","doi-asserted-by":"publisher","first-page":"6378","DOI":"10.1038\/s41467-020-20050-1","volume":"11","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Reis F, He Y, Park JW, DiVittorio JR, Sivakumar N, van Veen JE, Maesta-Pereira S, Shum M, Nichols I, Massa MG, Anderson S, Paul K, Liesa M, Ajijola OA, Xu Y, Adhikari A, Correa SM (2020) Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice. Nat Commun 11:6378","journal-title":"Nat Commun"}],"container-title":["Journal of Comparative Physiology B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00360-021-01421-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00360-021-01421-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00360-021-01421-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T07:05:50Z","timestamp":1667027150000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00360-021-01421-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["1421"],"URL":"https:\/\/doi.org\/10.1007\/s00360-021-01421-6","relation":{},"ISSN":["0174-1578","1432-136X"],"issn-type":[{"value":"0174-1578","type":"print"},{"value":"1432-136X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]},"assertion":[{"value":"16 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}