{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:48:49Z","timestamp":1777160929825,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Comp Physiol B"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Nestling white-footed mice (<jats:italic>Peromyscus leucopus<\/jats:italic>) are born in the earliest days of spring in cold climates. If the nestlings are by accident exposed to ambient temperatures near freezing (0\u20137\u00a0\u00b0C) at early ages (2\u201310 days old), they may experience body temperatures (<jats:italic>T<\/jats:italic>\n            <jats:sub>b<\/jats:sub>s) equally low. During such hypothermia, although their heart keeps beating, they become apneic (cease inhaling and exhaling). However, they have an exceptional ability (e.g., compared to <jats:italic>Mus musculus<\/jats:italic>) to tolerate these conditions for at least several hours, after which they revive if rewarmed by parents. This paper addresses the physiology of the apneic period. We show that apneic, hypothermic nestlings undergo physiologically important exchanges of gases with the atmosphere. These gas exchanges do not occur across the skin. Instead they occur via the trachea and lungs even though the animals are apneic. Most significantly, when hypothermic neonates are in apnea in ordinary air, they take up O<jats:sub>2<\/jats:sub> steadily from the atmosphere throughout the apneic period, and the evidence available indicates that this O<jats:sub>2<\/jats:sub> uptake is essential for the nestlings\u2019 survival. At <jats:italic>T<\/jats:italic>\n            <jats:sub>b<\/jats:sub>s of 2\u20137\u00a0\u00b0C, the nestlings\u2019 rate of O<jats:sub>2<\/jats:sub> consumption varies quasi-exponentially with <jats:italic>T<\/jats:italic>\n            <jats:sub>b<\/jats:sub> and averages 0.04 mL O<jats:sub>2<\/jats:sub> g<jats:sup>\u2212\u20091<\/jats:sup> h<jats:sup>\u2212\u20091<\/jats:sup>, closely similar to the rate expressed by adult mammalian hibernators in hibernation at similar <jats:italic>T<\/jats:italic>\n            <jats:sub>b<\/jats:sub>s. Morphometric analysis indicates that, at all focal ages, O<jats:sub>2<\/jats:sub> transport along the full length of the trachea can take place by diffusion at rates adequate to meet the measured rates of metabolic O<jats:sub>2<\/jats:sub> consumption.<\/jats:p>","DOI":"10.1007\/s00360-024-01585-x","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T03:36:28Z","timestamp":1728358588000},"page":"123-139","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Apneic uptake of atmospheric O2 by deeply hypothermic nestlings of the white-footed mouse (Peromyscus leucopus): circulation and lungs"],"prefix":"10.1007","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8606-634X","authenticated-orcid":false,"given":"Richard W.","family":"Hill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-8503","authenticated-orcid":false,"given":"Jacob J.","family":"Manteuffel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7477-9956","authenticated-orcid":false,"given":"Bradley A.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"1585_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1152\/ajplegacy.1951.166.1.75","volume":"166","author":"EF Adolph","year":"1951","unstructured":"Adolph EF (1951) Responses to hypothermia in several species of infant mammals. 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Animals were captured and held under permit of the State of Michigan.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All authors declare that they have no financial or other conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}