{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:18:28Z","timestamp":1792783108319,"version":"4.5.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Provincial Secretary for Higher Education and Scientific Research of Vojvodina","award":["142-451-3502\/2023-01"],"award-info":[{"award-number":["142-451-3502\/2023-01"]}],"id":[{"id":"https:\/\/ror.org\/0348qv851","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100022424","name":"Ministry of Scientific and Technological Development, Higher Education and Information Society","doi-asserted-by":"publisher","award":["451-03-66\/2024-03\/200125"],"award-info":[{"award-number":["451-03-66\/2024-03\/200125"]}],"id":[{"id":"10.13039\/501100022424","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science, Technological Development, and Innovation of the Republic of Serbia","award":["CeRES"],"award-info":[{"award-number":["CeRES"]}],"id":[{"id":"https:\/\/ror.org\/01znas443","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Comp Physiol B"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s00360-025-01615-2","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T07:26:31Z","timestamp":1749453991000},"page":"379-392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adaptation under constant light or dark: a challenge to the pineal"],"prefix":"10.1007","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3263-9178","authenticated-orcid":false,"given":"Alisa P.","family":"Becin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Trkulja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Bradasevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Jokanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6234-0647","authenticated-orcid":false,"given":"Dijana Z.","family":"Travicic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3947-1980","authenticated-orcid":false,"given":"Marija L. J.","family":"Medar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2908-8136","authenticated-orcid":false,"given":"Silvana A.","family":"Andric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3440-8998","authenticated-orcid":false,"given":"Tatjana S.","family":"Kostic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"issue":"2","key":"1615_CR1","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.neuron.2012.04.006","volume":"74","author":"U Albrecht","year":"2012","unstructured":"Albrecht U (2012) Timing to perfection: the biology of central and peripheral circadian clocks. Neuron 74(2):246\u2013260. https:\/\/doi.org\/10.1016\/j.neuron.2012.04.006","journal-title":"Neuron"},{"key":"1615_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neures.2014.03.005","volume":"81","author":"J Andrade-Silva","year":"2014","unstructured":"Andrade-Silva J, Cipolla-Neto J, Peliciari-Garcia RA (2014) The in vitro maintenance of clock genes expression within the rat pineal gland under standard and norepinephrine-synchronized stimulation. Neurosci Res 81:1\u201310. https:\/\/doi.org\/10.1016\/j.neures.2014.03.005","journal-title":"Neurosci Res"},{"issue":"1","key":"1615_CR3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.smrv.2004.05.002","volume":"9","author":"J Arendt","year":"2005","unstructured":"Arendt J, Skene DJ (2005) Melatonin as a chronobiotic. Sleep Med Rev 9(1):25\u201339. https:\/\/doi.org\/10.1016\/j.smrv.2004.05.002","journal-title":"Sleep Med Rev"},{"issue":"2","key":"1615_CR4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.cmet.2011.01.006","volume":"13","author":"G Asher","year":"2011","unstructured":"Asher G, Schibler U (2011) Crosstalk between components of circadian and metabolic cycles in mammals. Cell Metabol 13(2):125\u2013137. https:\/\/doi.org\/10.1016\/j.cmet.2011.01.006","journal-title":"Cell Metabol"},{"issue":"2","key":"1615_CR5","doi-asserted-by":"publisher","first-page":"e12893","DOI":"10.1111\/jpi.12893","volume":"75","author":"AS Blancas-Velazquez","year":"2023","unstructured":"Blancas-Velazquez AS, Bering T, Bille S, Rath MF (2023) Role and neural regulation of clock genes in the rat pineal gland: clock modulates amplitude of rhythmic expression of Aanat encoding the melatonin\u2010producing enzyme. J Pineal Res 75(2):e12893. https:\/\/doi.org\/10.1111\/jpi.12893","journal-title":"J Pineal Res"},{"issue":"1","key":"1615_CR6","doi-asserted-by":"publisher","first-page":"8846","DOI":"10.1038\/s41598-017-08691-7","volume":"7","author":"MA Bonmati-Carrion","year":"2017","unstructured":"Bonmati-Carrion MA, Ba\u00f1o-Otalora B, Madrid JA, Rol MA (2017) Light color importance for circadian entrainment in a diurnal (Octodon degus) and a nocturnal (Rattus norvegicus) rodent. Sci Rep 7(1):8846. https:\/\/doi.org\/10.1038\/s41598-017-08691-7","journal-title":"Sci Rep"},{"issue":"4","key":"1615_CR7","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.neubiorev.2013.02.012","volume":"37","author":"E Brooks","year":"2013","unstructured":"Brooks E, Canal MM (2013) Development of circadian rhythms: role of postnatal light environment. Neurosci Biobehavioral Reviews 37(4):551\u2013560. https:\/\/doi.org\/10.1016\/j.neubiorev.2013.02.012","journal-title":"Neurosci Biobehavioral Reviews"},{"issue":"5","key":"1615_CR8","doi-asserted-by":"publisher","first-page":"e97160","DOI":"10.1371\/journal.pone.0097160","volume":"9","author":"E Brooks","year":"2014","unstructured":"Brooks E, Patel D, Canal MM (2014) Programming of mice circadian photic responses by postnatal light environment. PLoS ONE 9(5):e97160. https:\/\/doi.org\/10.1371\/journal.pone.0097160","journal-title":"PLoS ONE"},{"issue":"4","key":"1615_CR10","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1081\/CBI-100106081","volume":"18","author":"MM Canal-Corretger","year":"2001","unstructured":"Canal-Corretger MM, Vilaplana J, Cambras T, Diez-Noguera A (2001a) Effect of light on the development of the circadian rhythm of motor activity in the mouse. Chronobiol Int 18(4):683\u2013696. https:\/\/doi.org\/10.1081\/CBI-100106081","journal-title":"Chronobiol Int"},{"issue":"4","key":"1615_CR11","doi-asserted-by":"publisher","first-page":"R1023","DOI":"10.1152\/ajpregu.2001.280.4.R1023","volume":"280","author":"MM Canal-Corretger","year":"2001","unstructured":"Canal-Corretger MM, Vilaplana J, Cambras T, D\u00edez-Noguera A (2001b) Functioning of the rat circadian system is modified by light applied in critical postnatal days. Am J Physiology-Regulatory Integr Comp Physiol 280(4):R1023\u2013R1030. https:\/\/doi.org\/10.1152\/ajpregu.2001.280.4.R1023","journal-title":"Am J Physiology-Regulatory Integr Comp Physiol"},{"key":"1615_CR9","doi-asserted-by":"publisher","unstructured":"Cao X, Yang Y, Selby CP, Liu Z, Sancar A (2021) Molecular mechanism of the repressive phase of the mammalian circadian clock. Proceedings of the National Academy of Sciences, 118(2), e2021174118. https:\/\/doi.org\/10.1073\/pnas.2021174118","DOI":"10.1073\/pnas.2021174118"},{"issue":"2","key":"1615_CR12","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.neuroscience.2010.09.009","volume":"171","author":"E Christ","year":"2010","unstructured":"Christ E, Pfeffer M, Korf HW, von Gall C (2010) Pineal melatonin synthesis is altered in Period1 deficient mice. Neuroscience 171(2):398\u2013406. https:\/\/doi.org\/10.1016\/j.neuroscience.2010.09.009","journal-title":"Neuroscience"},{"key":"1615_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v022.i04","volume":"22","author":"S Dray","year":"2007","unstructured":"Dray S, Dufour AB (2007) The ade4 package: implementing the duality diagram for ecologists. J Stat Softw 22:1\u201320. https:\/\/doi.org\/10.18637\/jss.v022.i04","journal-title":"J Stat Softw"},{"issue":"7483","key":"1615_CR14","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nature12985","volume":"505","author":"JR Friedman","year":"2014","unstructured":"Friedman JR, Nunnari J (2014) Mitochondrial form and function. Nature 505(7483):335\u2013343. https:\/\/doi.org\/10.1038\/nature12985","journal-title":"Nature"},{"issue":"3","key":"1615_CR15","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0304-3940(00)01129-0","volume":"286","author":"C Fukuhara","year":"2000","unstructured":"Fukuhara C, Dirden JC, Tosini G (2000) Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions. Neurosci Lett 286(3):167\u2013170. https:\/\/doi.org\/10.1016\/S0304-3940(00)01129-0","journal-title":"Neurosci Lett"},{"issue":"10","key":"1615_CR16","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1016\/j.bbamcr.2015.05.030","volume":"1853","author":"IA Gak","year":"2015","unstructured":"Gak IA, Radovic SM, Dukic AR, Janjic MM, Stojkov-Mimic NJ, Kostic TS, Andric SA (2015) Stress triggers mitochondrial biogenesis to preserve steroidogenesis in Leydig cells. Biochim Et Biophys Acta (BBA)-Molecular Cell Res 1853(10):2217\u20132227. https:\/\/doi.org\/10.1016\/j.bbamcr.2015.05.030","journal-title":"Biochim Et Biophys Acta (BBA)-Molecular Cell Res"},{"issue":"4","key":"1615_CR17","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrm3311","volume":"13","author":"DG Hardie","year":"2012","unstructured":"Hardie DG, Ross FA, Hawley SA (2012) AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 13(4):251\u2013262. https:\/\/doi.org\/10.1038\/nrm3311","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"1615_CR18","doi-asserted-by":"publisher","first-page":"e12616","DOI":"10.1111\/jpi.12616","volume":"68","author":"H Hertz","year":"2020","unstructured":"Hertz H, Carstensen MB, Bering T, Rohde K, M\u00f8ller M, Granau AM, Klein DC, Rath MF (2020) The Lhx4 homeobox transcript in the rat pineal gland: adrenergic regulation and impact on transcripts encoding melatonin-synthesizing enzymes. J Pineal Res 68(1):e12616. https:\/\/doi.org\/10.1111\/jpi.12616","journal-title":"J Pineal Res"},{"key":"1615_CR19","doi-asserted-by":"crossref","unstructured":"Kassambara A, Mundt F (2017) Package \u2018factoextra\u2019. Extract and visualize the results of multivariate data analyses, 76(2). doi:https:\/\/CRAN.R-project.org\/package=factoextra","DOI":"10.32614\/CRAN.package.factoextra"},{"issue":"7","key":"1615_CR20","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1074\/jbc.R600036200","volume":"282","author":"DC Klein","year":"2007","unstructured":"Klein DC (2007) Arylalkylamine N-acetyltransferase:the timezyme. J Biol Chem 282(7):4233\u20134237. https:\/\/doi.org\/10.1074\/jbc.R600036200","journal-title":"J Biol Chem"},{"key":"1615_CR21","doi-asserted-by":"publisher","unstructured":"Klein DC, Weller JL, Moore RY (1971) Melatonin metabolism: neural regulation of pineal serotonin: acetyl coenzyme AN-acetyltransferase activity. Proceedings of the National Academy of Sciences, 68(12), 3107\u20133110. https:\/\/doi.org\/10.1073\/pnas.68.12.3107","DOI":"10.1073\/pnas.68.12.3107"},{"issue":"5","key":"1615_CR22","doi-asserted-by":"publisher","first-page":"e12986","DOI":"10.1111\/jpi.12986","volume":"76","author":"HW Korf","year":"2024","unstructured":"Korf HW, von Gall C (2024) Mouse models in circadian rhythm and melatonin research. J PinealResearch 76(5):e12986. https:\/\/doi.org\/10.1111\/jpi.12986","journal-title":"J PinealResearch"},{"issue":"4","key":"1615_CR23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1600-079X.1985.tb00712.x","volume":"2","author":"G Krakowski","year":"1985","unstructured":"Krakowski G, Cieciura L (1985a) Ultrastructural studies on the pinealocyte mitochondria during the daytime and at night. J Pineal Res 2(4):315\u2013324. https:\/\/doi.org\/10.1111\/j.1600-079X.1985.tb00712.x","journal-title":"J Pineal Res"},{"issue":"4","key":"1615_CR24","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/j.1600-079X.1985.tb00711.x","volume":"2","author":"G Krakowski","year":"1985","unstructured":"Krakowski G, Cieciura L (1985b) Stereologic studies on mitochondrial configuration in the rat pinealocytes. J Pineal Res 2(4):305\u2013314. https:\/\/doi.org\/10.1111\/j.1600-079X.1985.tb00711.x","journal-title":"J Pineal Res"},{"issue":"12","key":"1615_CR25","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3390\/biomedicines8120579","volume":"8","author":"A Kubi\u0161tov\u00e1","year":"2020","unstructured":"Kubi\u0161tov\u00e1 A, Spi\u0161sk\u00e1 V, Petr\u017eelkov\u00e1 L, Hrubcov\u00e1 L, Moravcov\u00e1 S, Maierov\u00e1 L, Bendov\u00e1 Z (2020) Constant light in critical postnatal days affects circadian rhythms in locomotion and gene expression in the Suprachiasmatic nucleus, retina, and pineal gland later in life. Biomedicines 8(12):579. https:\/\/doi.org\/10.3390\/biomedicines8120579","journal-title":"Biomedicines"},{"issue":"3","key":"1615_CR26","doi-asserted-by":"publisher","first-page":"321","DOI":"10.2174\/1871530323666230803095118","volume":"24","author":"G Lisco","year":"2024","unstructured":"Lisco G, Giagulli VA, De Pergola G, Guastamacchia E, Jirillo E, Vitale E, Triggiani V (2024) Chronic stress as a risk factor for type 2 diabetes: endocrine, metabolic, and immune implications. Endocr Metabolic Immune Disorders-Drug Targets (Formerly Curr Drug Targets-Immune Endocr Metabolic Disorders) 24(3):321\u2013332. https:\/\/doi.org\/10.2174\/1871530323666230803095118","journal-title":"Endocr Metabolic Immune Disorders-Drug Targets (Formerly Curr Drug Targets-Immune Endocr Metabolic Disorders)"},{"key":"1615_CR27","doi-asserted-by":"crossref","unstructured":"Logan RW, Williams WP III, McClung CA Circadian rhythms and addiction: mechanistic insights and future directions. Behavioral neuroscience, 128(3):387.","DOI":"10.1037\/a0036268"},{"key":"1615_CR58","doi-asserted-by":"publisher","unstructured":"Ma C, Shen B, Chen L, Yang G (2024) Impacts of circadian disruptions on behavioral rhythms in mice. FASEB J 38(22):e70183. https:\/\/doi.org\/10.1096\/fj.202401536R","DOI":"10.1096\/fj.202401536R"},{"key":"1615_CR28","doi-asserted-by":"publisher","first-page":"653602","DOI":"10.3389\/fendo.2021.653602","volume":"12","author":"DZ Marinkovic","year":"2021","unstructured":"Marinkovic DZ, Medar ML, Becin AP, Andric SA, Kostic TS (2021) Growing up under constant light: A challenge to the endocrine function of the Leydig cells. Front Endocrinol 12:653602. https:\/\/doi.org\/10.3389\/fendo.2021.653602","journal-title":"Front Endocrinol"},{"issue":"1","key":"1615_CR29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/life11010019","volume":"11","author":"ML Medar","year":"2020","unstructured":"Medar ML, Marinkovic DZ, Kojic Z, Becin AP, Starovlah IM, Kravic-Stevovic T, Andric SA, Kostic TS (2020) Dependence of Leydig cell\u2019s mitochondrial physiology on luteinizing hormone signaling. Life 11(1):19. https:\/\/doi.org\/10.3390\/life11010019","journal-title":"Life"},{"key":"1615_CR30","doi-asserted-by":"publisher","first-page":"878533","DOI":"10.3389\/fevo.2022.878533","volume":"10","author":"MK Oosthuizen","year":"2022","unstructured":"Oosthuizen MK, Bennett NC (2022) Clocks ticking in the dark: a review of biological rhythms in subterranean African mole-rats. Front Ecol Evol 10:878533. https:\/\/doi.org\/10.3389\/fevo.2022.878533","journal-title":"Front Ecol Evol"},{"issue":"2","key":"1615_CR31","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41580-019-0179-2","volume":"21","author":"A Patke","year":"2020","unstructured":"Patke A, Young MW, Axelrod S (2020) Molecular mechanisms and physiological importance of circadian rhythms. Nat Rev Mol Cell Biol 21(2):67\u201384. https:\/\/doi.org\/10.1038\/s41580-019-0179-2","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6158","key":"1615_CR32","doi-asserted-by":"publisher","first-page":"1243417","DOI":"10.1126\/science.1243417","volume":"342","author":"CB Peek","year":"2013","unstructured":"Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC (2013) Circadian clock NAD\u2009+\u2009cycle drives mitochondrial oxidative metabolism in mice. Science 342(6158):1243417. https:\/\/doi.org\/10.1126\/science.1243417","journal-title":"Science"},{"key":"1615_CR33","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.yfrne.2018.01.001","volume":"49","author":"M Picard","year":"2018","unstructured":"Picard M, McEwen BS, Epel ES, Sandi C (2018) An energetic view of stress: focus on mitochondria. Front Neuroendocr 49:72\u201385. https:\/\/doi.org\/10.1016\/j.yfrne.2018.01.001","journal-title":"Front Neuroendocr"},{"issue":"7","key":"1615_CR34","doi-asserted-by":"publisher","first-page":"e3002671","DOI":"10.1371\/journal.pbio.3002671","volume":"22","author":"N Preminger","year":"2024","unstructured":"Preminger N, Schuldiner M (2024) Beyond fission and fusion\u2014Diving into the mysteries of mitochondrial shape. PLoS Biol 22(7):e3002671. https:\/\/doi.org\/10.1371\/journal.pbio.3002671","journal-title":"PLoS Biol"},{"issue":"3","key":"1615_CR35","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.ncl.2019.05.001","volume":"37","author":"KJ Reid","year":"2019","unstructured":"Reid KJ (2019) Assessment of circadian rhythms. Neurol Clin 37(3):505\u2013526. https:\/\/doi.org\/10.1016\/j.ncl.2019.05.001","journal-title":"Neurol Clin"},{"issue":"22","key":"1615_CR36","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1016\/0024-3205(87)90001-4","volume":"40","author":"RJ Reiter","year":"1987","unstructured":"Reiter RJ (1987) The melatonin message: duration versus coincidence hypotheses. Life Sci 40(22):2119\u20132131. https:\/\/doi.org\/10.1016\/0024-3205(87)90001-4","journal-title":"Life Sci"},{"issue":"04","key":"1615_CR37","doi-asserted-by":"publisher","first-page":"335","DOI":"10.4155\/fmc-2020-0326","volume":"13","author":"RJ Reiter","year":"2021","unstructured":"Reiter RJ, Sharma R, Pires de Campos Zuccari DA, de Almeida Chuffa LG, Manucha W, Rodriguez C (2021) Melatonin synthesis in and uptake by mitochondria: implications for diseased cells with dysfunctional mitochondria. Future Med Chem 13(04):335\u2013339. https:\/\/doi.org\/10.4155\/fmc-2020-0326","journal-title":"Future Med Chem"},{"issue":"1","key":"1615_CR38","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1111\/jnc.14120","volume":"143","author":"K Rohde","year":"2017","unstructured":"Rohde K, Bering T, Furukawa T, Rath MF (2017) A modulatory role of the Rax homeobox gene in mature pineal gland function: investigating the Photoneuroendocrine circadian system of a Rax conditional knockout mouse. J Neurochem 143(1):100\u2013111. https:\/\/doi.org\/10.1111\/jnc.14120","journal-title":"J Neurochem"},{"key":"1615_CR39","unstructured":"Sachs M (2023) Cosinor: Tools for Estimating and Predicting the Cosinor Model. R package version 1.2.3. https:\/\/CRAN.R-project.org\/package=cosinor"},{"issue":"2","key":"1615_CR40","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000145376","volume":"109","author":"RL Salisbury","year":"1981","unstructured":"Salisbury RL, Krieg RJ, Seibel HR (1981) A light and electron microscopic study of the pineal body of the Nutria (Myocastor coypus). Cells Tissues Organs 109(2):137\u2013148. https:\/\/doi.org\/10.1159\/000145376","journal-title":"Cells Tissues Organs"},{"issue":"3","key":"1615_CR41","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.cmet.2018.01.011","volume":"27","author":"K Schmitt","year":"2018","unstructured":"Schmitt K, Grimm A, Dallmann R, Oettinghaus B, Restelli LM, Ishihara N, Mihara K, Ripperger JA, Albrecht U, Frank S (2018) Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics. Cell Metabol 27(3):657\u2013666. https:\/\/doi.org\/10.1016\/j.cmet.2018.01.011","journal-title":"Cell Metabol"},{"issue":"3","key":"1615_CR42","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.molmed.2017.01.003","volume":"23","author":"D Sebasti\u00e1n","year":"2017","unstructured":"Sebasti\u00e1n D, Palac\u00edn M, Zorzano A (2017) Mitochondrial dynamics: coupling mitochondrial fitness with healthy aging. Trends Mol Med 23(3):201\u2013215. https:\/\/doi.org\/10.1016\/j.molmed.2017.01.003","journal-title":"Trends Mol Med"},{"issue":"2","key":"1615_CR43","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.molbrainres.2003.10.019","volume":"120","author":"V Simonneaux","year":"2004","unstructured":"Simonneaux V, Poirel VJ, Garidou ML, Nguyen D, Diaz-Rodriguez E, Pevet P (2004) Daily rhythm and regulation of clock gene expression in the rat pineal gland. Mol Brain Res 120(2):164\u2013172","journal-title":"Mol Brain Res"},{"issue":"3","key":"1615_CR44","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1093\/icb\/icy017","volume":"58","author":"I Sokolova","year":"2018","unstructured":"Sokolova I (2018) Mitochondrial adaptations to variable environments and their role in animals\u2019 stress tolerance. Integr Comp Biol 58(3):519\u2013531. https:\/\/doi.org\/10.1093\/icb\/icy017","journal-title":"Integr Comp Biol"},{"issue":"6","key":"1615_CR45","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1177\/0748730412461247","volume":"27","author":"R Stephenson","year":"2012","unstructured":"Stephenson R, Lim J, Famina S, Caron AM, Dowse HB (2012) Sleep-wake behavior in the rat: Ultradian rhythms in a light-dark cycle and continuous bright light. J Biol Rhythm 27(6):490\u2013501. https:\/\/doi.org\/10.1177\/0748730412461247","journal-title":"J Biol Rhythm"},{"issue":"10","key":"1615_CR46","doi-asserted-by":"publisher","first-page":"E1239","DOI":"10.1152\/ajpendo.00554.2011","volume":"302","author":"NJ Stojkov","year":"2012","unstructured":"Stojkov NJ, Janjic MM, Bjelic MM, Mihajlovic AI, Kostic TS, Andric SA (2012) Repeated immobilization stress disturbed steroidogenic machinery and stimulated the expression of cAMP signaling elements and adrenergic receptors in Leydig cells. Am J Physiology-Endocrinology Metabolism 302(10):E1239\u2013E1251","journal-title":"Am J Physiology-Endocrinology Metabolism"},{"issue":"1","key":"1615_CR47","first-page":"81","volume":"44","author":"J Swietos\u0142awski","year":"1993","unstructured":"Swietos\u0142awski J, Karasek M (1993) Day-night changes in the ultrastructure of pinealocytes in the Syrian hamster: a quantitative study. Endokrynologia Polska 44(1):81\u201387 PMID: 8050394","journal-title":"Endokrynologia Polska"},{"issue":"3","key":"1615_CR48","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/nrg.2016.150","volume":"18","author":"JS Takahashi","year":"2017","unstructured":"Takahashi JS (2017) Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet 18(3):164\u2013179. https:\/\/doi.org\/10.1038\/nrg.2016.150","journal-title":"Nat Rev Genet"},{"issue":"12","key":"1615_CR49","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.3390\/ijms17122124","volume":"17","author":"DX Tan","year":"2016","unstructured":"Tan DX, Manchester LC, Qin L, Reiter RJ (2016) Melatonin: a mitochondrial targeting molecule involving mitochondrial protection and dynamics. Int J Mol Sci 17(12):2124. https:\/\/doi.org\/10.3390\/ijms17122124","journal-title":"Int J Mol Sci"},{"issue":"2","key":"1615_CR50","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1074\/jbc.M209241200","volume":"278","author":"SA Tischkau","year":"2003","unstructured":"Tischkau SA, Mitchell JW, Tyan SH, Buchanan GF, Gillette MU (2003) Ca2+\/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the Suprachiasmatic nucleus circadian clock. J Biol Chem 278(2):718\u2013723. https:\/\/doi.org\/10.1074\/jbc.M209241200","journal-title":"J Biol Chem"},{"key":"1615_CR51","doi-asserted-by":"publisher","unstructured":"Travnickova-Bendova Z, Cermakian N, Reppert SM, Sassone-Corsi P (2002) Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK\/BMAL1 activity. Proceedings of the National Academy of Sciences, 99(11), 7728\u20137733. https:\/\/doi.org\/10.1073\/pnas.102075599","DOI":"10.1073\/pnas.102075599"},{"issue":"5","key":"1615_CR52","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.3390\/ijms23052778","volume":"23","author":"C von Gall","year":"2022","unstructured":"von Gall C (2022) The effects of light and the circadian system on rhythmic brain function. Int J Mol Sci 23(5):2778. https:\/\/doi.org\/10.3390\/ijms23052778","journal-title":"Int J Mol Sci"},{"issue":"7","key":"1615_CR53","doi-asserted-by":"publisher","first-page":"a039107","DOI":"10.1101\/cshperspect.a039107","volume":"14","author":"JC Walton","year":"2022","unstructured":"Walton JC, Bumgarner JR, Nelson RJ (2022) Sex differences in circadian rhythms. Cold Spring Harb Perspect Biol 14(7):a039107. https:\/\/doi.org\/10.1101\/cshperspect.a039107","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"1615_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5334\/jcr.ab","volume":"13","author":"NE Waly","year":"2015","unstructured":"Waly NE, Hallworth R (2015) Circadian pattern of melatonin MT1 and MT2 receptor localization in the rat Suprachiasmatic nucleus. J Circadian Rhythm 13:1. https:\/\/doi.org\/10.5334\/jcr.ab","journal-title":"J Circadian Rhythm"},{"issue":"1","key":"1615_CR55","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1146\/annurev-physiol-021909-135919","volume":"72","author":"DK Welsh","year":"2010","unstructured":"Welsh DK, Takahashi JS, Kay SA (2010) Suprachiasmatic nucleus: cell autonomy and network properties. Annu Rev Physiol 72(1):551\u2013577. https:\/\/doi.org\/10.1146\/annurev-physiol-021909-135919","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"1615_CR56","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1159\/000327430","volume":"94","author":"P Wongchitrat","year":"2011","unstructured":"Wongchitrat P, Felder-Schmittbuhl MP, Govitrapong P, Phansuwan-Pujito P, Simonneaux V (2011) A noradrenergic sensitive endogenous clock is present in the rat pineal gland. Neuroendocrinology 94(1):75\u201383. https:\/\/doi.org\/10.1159\/000327430","journal-title":"Neuroendocrinology"},{"issue":"4","key":"1615_CR57","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1530\/JME-18-0101","volume":"61","author":"Y Yamanaka","year":"2018","unstructured":"Yamanaka Y, Yamada Y, Honma KI, Honma S (2018) Cryptochrome deficiency enhances transcription but reduces protein levels of pineal Aanat. J Mol Endocrinol 61(4):219\u2013229. https:\/\/doi.org\/10.1530\/JME-18-0101","journal-title":"J Mol Endocrinol"}],"container-title":["Journal of Comparative Physiology B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00360-025-01615-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00360-025-01615-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00360-025-01615-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T18:18:43Z","timestamp":1757182723000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00360-025-01615-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["1615"],"URL":"https:\/\/doi.org\/10.1007\/s00360-025-01615-2","relation":{},"ISSN":["0174-1578","1432-136X"],"issn-type":[{"value":"0174-1578","type":"print"},{"value":"1432-136X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"17 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the experiments and protocols were approved by the Local Ethical Committee for the Protection of Animals Used for Experimental Purposes at the University of Novi Sad (No. 323-07-0-08975\/2019-05), operating under the National Council for Animal Welfare rules and following statements of National Law for Animal Welfare (copyright March 2009).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that the research was conducted without commercial or financial relationships that could create a conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}