{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:28:49Z","timestamp":1777307329170,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s00380-015-0686-9","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T14:14:50Z","timestamp":1431353690000},"page":"918-924","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical significance of Angiopoietin-1 in Behcet\u2019s disease patients with vascular involvement"],"prefix":"10.1007","volume":"31","author":[{"given":"Iman H.","family":"Bassyouni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Sharaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iman E.","family":"Wali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossam M.","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"issue":"3\u20134","key":"686_CR1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jaut.2009.02.011","volume":"32","author":"D Mendes","year":"2009","unstructured":"Mendes D, Correia M, Barbedo M, Vaio T, Mota M, Goncalves O, Valente J (2009) Behcet\u2019s disease\u2013\u2013a contemporary review. J Autoimmun 32(3\u20134):178\u2013188","journal-title":"J Autoimmun"},{"issue":"6","key":"686_CR2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s11926-010-0132-z","volume":"12","author":"Y Yazici","year":"2010","unstructured":"Yazici Y, Yurdakul S, Yazici H (2010) Behcet\u2019s syndrome. Curr Rheumatol Rep 12(6):429\u2013435","journal-title":"Curr Rheumatol Rep"},{"key":"686_CR3","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/01.RES.0000218275.54089.12","volume":"98","author":"NP Brindle","year":"2006","unstructured":"Brindle NP, Saharinen P, Alitalo K (2006) Signaling and functions of Angiopoietin-1 in vascular protection. Circ Res 98:1014\u20131023","journal-title":"Circ Res"},{"issue":"6","key":"686_CR4","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1042\/BST20110699","volume":"39","author":"H Singh","year":"2011","unstructured":"Singh H, Tahir TA, Alawo DO, Issa E, Brindle NP (2011) Molecular control of angiopoietin signalling. Biochem Soc Trans 39(6):1592\u20131596","journal-title":"Biochem Soc Trans"},{"issue":"7","key":"686_CR5","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1083\/jcb.201207009","volume":"199","author":"SP Ngok","year":"2012","unstructured":"Ngok SP, Geyer R, Liu M, Kourtidis A, Agrawal S, Wu C, Seerapu HR, Lewis-Tuffin LJ, Moodie KL, Huveldt D, Marx R, Baraban JM, Storz P, Horowitz A, Anastasiadis PZ (2012) VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx. J Cell Biol 199(7):1103\u20131115","journal-title":"J Cell Biol"},{"issue":"6","key":"686_CR6","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/ndt\/gfn755","volume":"24","author":"P K\u00fcmpers","year":"2009","unstructured":"K\u00fcmpers P, Hellpap J, David S, Horn R, Leitolf H, Haller H, Haubitz M (2009) Circulating angiopoietin-2 is a marker and potential mediator of endothelial cell detachment in ANCA-associated vasculitis with renal involvement. Nephrol Dial Transplant 24(6):1845\u20131850","journal-title":"Nephrol Dial Transplant"},{"issue":"10","key":"686_CR7","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1136\/ard.2008.094664","volume":"68","author":"P K\u00fcmpers","year":"2009","unstructured":"K\u00fcmpers P, David S, Haubitz M, Hellpap J, Horn R, Br\u00f6cker V, Schiffer M, Haller H, Witte T (2009) The Tie2 receptor antagonist angiopoietin 2 facilitates vascular inflammation in systemic lupus erythematosus. Ann Rheum Dis 68(10):1638\u20131643","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"686_CR8","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s00380-010-0092-2","volume":"26","author":"H Karapinar","year":"2011","unstructured":"Karapinar H, Esen O, Emiroglu Y, Akcakoyun M, Pala S, Kargin R, Izgi A, Kirma C, Esen AM (2011) Serum levels of angiopoietin-1 in patients with pulmonary hypertension due to mitral stenosis. Heart Vessels 26(5):536\u2013541","journal-title":"Heart Vessels"},{"issue":"4","key":"686_CR9","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ibd.21410","volume":"17","author":"KA Oikonomou","year":"2011","unstructured":"Oikonomou KA, Kapsoritakis AN, Kapsoritaki AI, Manolakis AC, Tiaka EK, Tsiopoulos FD, Tsiompanidis IA, Potamianos SP (2011) Angiogenin, angiopoietin-1, angiopoietin-2, and endostatin serum levels in inflammatory bowel disease. Inflamm Bowel Dis 17(4):963\u2013970","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"686_CR10","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00380-013-0425-z","volume":"29","author":"BH Zhang","year":"2014","unstructured":"Zhang BH, Guo CX, Wang HX, Lu LQ, Wang YJ, Zhang LK, Du FH, Zeng XJ (2014) Cardioprotective effects of adipokine apelin on myocardial infarction. Heart Vessels 29(5):679\u2013689","journal-title":"Heart Vessels"},{"issue":"4","key":"686_CR11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00380-011-0156-y","volume":"27","author":"Y Takahashi","year":"2012","unstructured":"Takahashi Y, Satoh M, Tabuchi T, Nakamura M (2012) Prospective, randomized, single-blind comparison of effects of 6 months\u2019 treatment with atorvastatin versus pravastatin on leptin and angiogenic factors in patients with coronary artery disease. Heart Vessels 27(4):337\u2013343","journal-title":"Heart Vessels"},{"issue":"1","key":"686_CR12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s00380-011-0125-5","volume":"27","author":"M Oda","year":"2012","unstructured":"Oda M, Toba K, Kato K, Ozawa T, Yanagawa T, Ikarashi N, Takayama T, Suzuki T, Hanawa H, Masuko M, Kobayashi H, Aizawa Y (2012) Hypocellularity and insufficient expression of angiogenic factors in implanted autologous bone marrow in patients with chronic critical limb ischemia. Heart Vessels 27(1):38\u201345","journal-title":"Heart Vessels"},{"issue":"4","key":"686_CR13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jbspin.2010.01.014","volume":"77","author":"JY Choe","year":"2010","unstructured":"Choe JY, Park SH, Kim SK (2010) Serum angiopoietin-1 level is increased in patients with Behcet\u2019s disease. Bone Spine 77(4):340\u2013344","journal-title":"Bone Spine"},{"key":"686_CR14","first-page":"1078","volume":"335","author":"International Study Group for Behcet\u2019s disease","year":"1990","unstructured":"International Study Group for Behcet\u2019s disease (1990) Criteria for diagnosis of Behcet\u2019s disease. Lancet 335:1078\u20131080","journal-title":"Lancet"},{"issue":"7","key":"686_CR15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ejim.2008.08.001","volume":"19","author":"O Harzallah","year":"2008","unstructured":"Harzallah O, Kerkeni A, Baati T, Mahjoub S (2008) Oxidative stress: correlation with Beh\u00e7et\u2019s disease duration, activity and severity. Eur J Intern Med 19(7):541\u2013547","journal-title":"Eur J Intern Med"},{"issue":"1","key":"686_CR16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tcm.2007.10.003","volume":"18","author":"T Hato","year":"2008","unstructured":"Hato T, Tabata M, Oike Y (2008) The role of angiopoietin-like proteins in angiogenesis and metabolism. Trends Cardiovasc Med 18(1):6\u201314","journal-title":"Trends Cardiovasc Med"},{"key":"686_CR17","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1189\/jlb.1105652","volume":"80","author":"D Pfaff","year":"2006","unstructured":"Pfaff D, Fiedler Y, Augustin H (2006) Emerging roles of the angiopoietin\u2013Tie and the ephrin\u2013Eph systems as regulators of cell trafficking. J Leukoc Biol 80:719\u2013726","journal-title":"J Leukoc Biol"},{"issue":"4","key":"686_CR18","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/rheumatology\/keq392","volume":"50","author":"M Michalska-Jakubus","year":"2011","unstructured":"Michalska-Jakubus M, Kowal-Bielecka O, Chodorowska G, Bielecki M, Krasowska D (2011) Angiopoietins-1 and -2 are differentially expressed in the sera of patients with systemic sclerosis: high angiopoietin-2 levels are associated with greater severity and higher activity of the disease. Rheumatology (Oxford) 50(4):746\u2013755","journal-title":"Rheumatology (Oxford)"},{"key":"686_CR19","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/cvr\/cvn048","volume":"78","author":"JS Lee","year":"2008","unstructured":"Lee JS, Song SH, Kim JM, Shin IS, Kim KL, Suh YL, Kim HZ, Koh GY, Byun J, Jeon ES, Suh W, Kim DK (2008) Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor. Cardiovasc Res 78:572\u2013580","journal-title":"Cardiovasc Res"},{"issue":"16","key":"686_CR20","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1161\/01.CIR.0000138112.90641.7F","volume":"110","author":"KW Lee","year":"2004","unstructured":"Lee KW, Lip GY, Blann AD (2004) Plasma angiopoietin-1, angiopoietin-2, angiopoietin receptor tie-2, and vascular endothelial growth factor levels in acute coronary syndromes. Circulation 110(16):2355\u20132360","journal-title":"Circulation"},{"key":"686_CR21","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/74725","volume":"6","author":"G Thurston","year":"2000","unstructured":"Thurston G, Rudge JS, Ioffe E, Zhou H, Ross L, Croll SD, Glazer N, Holash J, McDonald DM, Yancopoulos GD (2000) Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 6:460\u2013463","journal-title":"Nat Med"},{"key":"686_CR22","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1074\/jbc.M208550200","volume":"278","author":"U Fiedler","year":"2003","unstructured":"Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marm\u00e9 D, Augustin HG (2003) Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. J Biol Chem 278:1721\u20131727","journal-title":"J Biol Chem"},{"issue":"10","key":"686_CR23","doi-asserted-by":"crossref","first-page":"575","DOI":"10.4070\/kcj.2011.41.10.575","volume":"41","author":"JW Bae","year":"2011","unstructured":"Bae JW (2011) Hypertension, vascular rarefaction and angiopoietin-1. Korean Circ J 41(10):575\u2013577","journal-title":"Korean Circ J"},{"issue":"12","key":"686_CR24","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1136\/ard.2007.080432","volume":"67","author":"G Hatemi","year":"2008","unstructured":"Hatemi G, Silman A, Bang D, Bodaghi B, Chamberlain AM, Gul A, Houman MH, K\u00f6tter I, Olivieri I, Salvarani C, Sfikakis PP, Siva A, Stanford MR, St\u00fcbiger N, Yurdakul S, Yazici H, Expert Committee EULAR (2008) EULAR recommendations for the management of Behcet disease. Ann Rheum Dis 67(12):1656\u20131662","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"686_CR25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10067-007-0685-z","volume":"27","author":"JK Ahn","year":"2008","unstructured":"Ahn JK, Lee YS, Jeon CH, Koh EM, Cha HS (2008) Treatment of venous thrombosis associated with Behcet\u2019s disease: immunosuppressive therapy alone versus immunosuppressive therapy plus anticoagulation. Clin Rheumatol 27(2):201\u2013205","journal-title":"Clin Rheumatol"},{"issue":"8","key":"686_CR26","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1002\/art.34450","volume":"64","author":"AC Desbois","year":"2012","unstructured":"Desbois AC, Wechsler B, Resche-Rigon M, Piette JC, Huong Dle T, Amoura Z, Koskas F, Desseaux K, Cacoub P, Saadoun D (2012) Immunosuppressants reduce venous thrombosis relapse in Behcet\u2019s disease. Arthritis Rheum 64(8):2753\u20132760","journal-title":"Arthritis Rheum"},{"issue":"23\u201324","key":"686_CR27","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1016\/j.febslet.2008.09.021","volume":"582","author":"H Kim","year":"2008","unstructured":"Kim H, Choi JY, Lee JM, Park YS, Suh H, Song HR, Jo SA, Jo I (2008) Dexamethasone increases angiopoietin-1 and quiescent hematopoietic stem cells: a novel mechanism of dexamethasone-induced hematoprotection. FEBS Lett 582(23\u201324):3509\u20133514","journal-title":"FEBS Lett"},{"issue":"Suppl 1","key":"686_CR28","doi-asserted-by":"crossref","first-page":"S619","DOI":"10.1007\/s12032-010-9664-3","volume":"28","author":"Z Zhen","year":"2011","unstructured":"Zhen Z, Sun X, He Y, Cai Y, Wang J, Guan Z (2011) The sequence of drug administration influences the antitumor effects of bevacizumab and cyclophosphamide in a neuroblastoma model. Med Oncol 28(Suppl 1):S619\u2013S625","journal-title":"Med Oncol"},{"issue":"5","key":"686_CR29","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3109\/s10165-012-0755-1","volume":"23","author":"T Takahashi","year":"2013","unstructured":"Takahashi T, Asano Y, Akamata K, Aozasa N, Taniguchi T, Noda S, Masui Y, Ichimura Y, Toyama T, Tamaki Z, Tada Y, Sugaya M, Kadono T, Sato S (2013) Dynamics of serum angiopoietin-2 levels correlate with efficacy of intravenous pulse cyclophosphamide therapy for interstitial lung disease associated with systemic sclerosis. Mod Rheumatol 23(5):884\u2013890","journal-title":"Mod Rheumatol"},{"issue":"5","key":"686_CR30","doi-asserted-by":"crossref","first-page":"R182","DOI":"10.1186\/cc11666","volume":"16","author":"A Alfieri","year":"2012","unstructured":"Alfieri A, Watson JJ, Kammerer RA, Tasab M, Progias P, Reeves K, Brown NJ, Brookes ZL (2012) Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis. Crit Care 16(5):R182","journal-title":"Crit Care"},{"issue":"6","key":"686_CR31","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1253\/circj.CJ-12-0930","volume":"77","author":"M Takahashi","year":"2013","unstructured":"Takahashi M, Suzuki E, Kumano S, Oba S, Sato T, Nishimatsu H, Kimura K, Nagano T, Hirata Y (2013) Angiopoietin-1 mediates adipose tissue-derived stem cell-induced inhibition of neointimal formation in rat femoral artery. Circ J 77(6):1574\u20131584","journal-title":"Circ J"},{"issue":"10","key":"686_CR32","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4070\/kcj.2011.41.10.590","volume":"41","author":"W Suh","year":"2011","unstructured":"Suh W, Lee JS, Kim KL, Song SH, Koh GY, Kim DK (2011) Angiopoietin-1 gene therapy attenuates hypertension and target organ damage in nitric oxide synthase inhibited spontaneously hypertensive rats. Korean Circ J 41(10):590\u2013595","journal-title":"Korean Circ J"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-015-0686-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00380-015-0686-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-015-0686-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T15:27:50Z","timestamp":1559057270000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00380-015-0686-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,12]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["686"],"URL":"https:\/\/doi.org\/10.1007\/s00380-015-0686-9","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"value":"0910-8327","type":"print"},{"value":"1615-2573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,12]]}}}