{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:36:44Z","timestamp":1785206204904,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Science Centre, Poland","award":["2013\/09\/D\/NZ5\/00252"],"award-info":[{"award-number":["2013\/09\/D\/NZ5\/00252"]}]},{"name":"Department of Scientific Research and Structural Funds of Medical College, Jagiellonian University","award":["K\/ZDS\/004596"],"award-info":[{"award-number":["K\/ZDS\/004596"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s00380-016-0930-y","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T19:20:46Z","timestamp":1482348046000},"page":"714-725","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Left ventricular reverse remodeling is not related to biopsy-detected extracellular matrix fibrosis and serum markers of fibrosis in dilated cardiomyopathy, regardless of the definition used for LVRR"],"prefix":"10.1007","volume":"32","author":[{"given":"Pawe\u0142","family":"Rubi\u015b","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Wi\u015bniowska-\u015amia\u0142ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Biernacka-Fija\u0142kowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucyna","family":"Rudnicka-Sosin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wypasek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Kozanecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Dziewi\u0119cka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Faltyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Karabinowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lusine","family":"Khachatryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Hlawaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Le\u015bniak-Sobelga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kostkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"P\u0142azak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Podolec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"930_CR1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","volume":"35","author":"JN Cohn","year":"2000","unstructured":"Cohn JN, Ferrari F, Sharpe N (2000) Cardiac remodeling\u2014concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. J Am Coll Cardiol 35:569\u2013582","journal-title":"J Am Coll Cardiol"},{"key":"930_CR2","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.jacc.2011.06.058","volume":"58","author":"A Gonzalez","year":"2011","unstructured":"Gonzalez A, Ravassa S, Beaumont J, Lopez B, D\u0131ez J (2011) New targets to treat the structural remodeling of the myocardium. J Am Coll Cardiol 58:1833\u20131843","journal-title":"J Am Coll Cardiol"},{"key":"930_CR3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00380-015-0648-2","volume":"31","author":"Y Ikeda","year":"2016","unstructured":"Ikeda Y, Inomata T, Iida Y, Iwamoto-Ishida M, Nabeta T, Ishii S, Sato T, Yanagisawa T, Mizutani T, Naruke T, Koitabashi T, Takeuchi I, Nishii M, Ako J (2016) Time course of left ventricular reverse remodeling in response to pharmacotherapy: clinical implication for heart failure prognosis in patients with idiopathic dilated cardiomyopathy. Heart Vessels 31:545\u2013554","journal-title":"Heart Vessels"},{"key":"930_CR4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","volume":"29","author":"P Elliott","year":"2007","unstructured":"Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P, Dubourg O, K\u00fchl U, Maisch B, McKenna WJ, Monserrat L, Pankuweit S, Rapezzi C, Seferovic P, Tavazzi L, Keren A (2007) Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on myocardial and pericardial diseases. Eur Heart J 29:270\u2013277","journal-title":"Eur Heart J"},{"key":"930_CR5","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","volume":"33","author":"JJ McMurray","year":"2012","unstructured":"McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, B\u00f6hm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, K\u00f8ber L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, R\u00f8nnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A (2012) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Eur Heart J 33:1787\u20131847","journal-title":"Eur Heart J"},{"key":"930_CR6","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.jacc.2010.11.030","volume":"57","author":"M Merlo","year":"2011","unstructured":"Merlo M, Pyxaras SA, Pinamonti B, Barbati G, Di Lenarda A, Sinagra G (2011) Prevalence and prognostic significance of left ventricular reverse remodeling in dilated cardiomyopathy receiving tailored medical treatment. J Am Coll Cardiol 57:1468\u20131476","journal-title":"J Am Coll Cardiol"},{"key":"930_CR7","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0002-9149(02)03404-5","volume":"91","author":"CM Yu","year":"2003","unstructured":"Yu CM, Fung WH, Lin H, Zhang Q, Sanderson JE, Lau CP (2003) Predictors of left ventricular reverse remodeling after cardiac resynchronization therapy for heart failure secondary to idiopathic dilated or ischemic cardiomyopathy. Am J Cardiol 91:684\u2013688","journal-title":"Am J Cardiol"},{"key":"930_CR8","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.echo.2012.07.015","volume":"25","author":"S Scandura","year":"2012","unstructured":"Scandura S, Ussia GP, Capranzano P, Caggegi A, Sarkar K, Cammalleri V, Mangiafico S, Chiarand\u00e0 M, Imm\u00e8 S, Di Pasqua F, Pistritto AM, Millan G, Tamburino C (2012) Left cardiac chambers reverse remodeling after percutaneous mitral valve repair with the MitraClip system. J Am Soc Echocardiogr 25:1099\u20131105","journal-title":"J Am Soc Echocardiogr"},{"key":"930_CR9","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s00380-013-0415-1","volume":"29","author":"T Nabeta","year":"2014","unstructured":"Nabeta T, Inomata T, Iida Y, Ikeda Y, Iwamoto M, Ishii S, Sato T, Watanabe I, Naruke T, Shinagawa H, Koitabashi T, Takeuchi I, Nishii M, Inoue Y, Izumi T (2014) Baseline cardiac magnetic resonance imaging versus baseline endomyocardial biopsy for the prediction of left ventricular reverse remodeling and prognosis in response to therapy in patients with idiopathic dilated cardiomyopathy. Heart Vessels 29:784\u2013792","journal-title":"Heart Vessels"},{"key":"930_CR10","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cardiores.2005.12.009","volume":"69","author":"S Rutschow","year":"2006","unstructured":"Rutschow S, Li J, Schultheiss HP, Pauschinger M (2006) Myocardial proteases and matrix remodeling in inflammatory heart disease. Cardiovasc Res 69:646\u2013656","journal-title":"Cardiovasc Res"},{"key":"930_CR11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ijcard.2007.02.004","volume":"124","author":"P Timonen","year":"2008","unstructured":"Timonen P, Magga J, Risteli J, Punnonen K, Vanninen E, Turpeinen A, Tuomainen P, Kuusisto J, Vuolteenaho O, Peuhkurinen K (2008) Cytokines, interstitial collagen and ventricular remodelling in dilated cardiomyopathy. Int J Cardiol 124:293\u2013300","journal-title":"Int J Cardiol"},{"key":"930_CR12","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0002-9149(99)80686-9","volume":"75","author":"G Klappacher","year":"1995","unstructured":"Klappacher G, Franzen P, Haab D, Mehrabi M, Binder M, Plesch K, Pacher R, Grimm M, Pribill I, Eichler HG (1995) Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis. Am J Cardiol 75:913\u2013918","journal-title":"Am J Cardiol"},{"key":"930_CR13","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1161\/01.CIR.62.5.1054","volume":"62","author":"WL Henry","year":"1980","unstructured":"Henry WL, Gardin JM, Ware JH (1980) Echocardiographic measurements in normal subjects from infancy to old age. Circulation 62:1054\u20131061","journal-title":"Circulation"},{"key":"930_CR14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","volume":"16","author":"RM Lang","year":"2015","unstructured":"Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 16:233\u2013270","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"930_CR15","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1253\/circj.CJ-12-0507","volume":"77","author":"JO Choi","year":"2013","unstructured":"Choi JO, Kim EY, Lee GY, Lee SC, Park SW, Kim DK, Oh JK, Jeon ES (2013) Predictors of left ventricular reverse remodeling and subsequent outcome in nonischemic dilated cardiomyopathy. Circ J 77:462\u2013469","journal-title":"Circ J"},{"key":"930_CR16","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1161\/CIRCULATIONAHA.107.186093","volume":"116","author":"LT Cooper","year":"2007","unstructured":"Cooper LT, Baughman KL, Feldman AM, Frustaci A, Jessup M, Kuhl U, Levine GN, Narula J, Starling RC, Towbin J, Virmani R (2007) The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Circulation 116:2216\u20132233","journal-title":"Circulation"},{"key":"930_CR17","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0735-1097(94)90735-8","volume":"23","author":"AE Steimle","year":"1994","unstructured":"Steimle AE, Stevenson LW, Fonarow GC, Hamilton MA, Moriguchi JD (1994) Prediction of improvement in recent-onset cardiomyopathy after referral for heart transplantation. J Am Coll Cardiol 23:553\u2013559","journal-title":"J Am Coll Cardiol"},{"key":"930_CR18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jacc.2012.07.072","volume":"61","author":"M Kubanek","year":"2013","unstructured":"Kubanek M, Sramko M, Maluskova J, Kautznerova D, Weichet J, Lupinek P, Vrbska J, Malek I, Kautzner J (2013) Novel predictors of left ventricular reverse remodeling in individuals with recent-onset dilated cardiomyopathy. J Am Coll Cardio 61:54\u201363","journal-title":"J Am Coll Cardio"},{"key":"930_CR19","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-016-0815-0","author":"S Ishii","year":"2016","unstructured":"Ishii S, Inomata T, Fujita T, Iida Y, Ikeda Y, Nabeta T, Yanagisawa T, Naruke T, Mizutani T, Koitabashi T, Takeuchi I, Ako J (2016) Clinical significance of endomyocardial biopsy in conjunction with cardiac magnetic resonance imaging to predict left ventricular reverse remodeling in idiopathic dilated cardiomyopathy. Heart Vessels. doi:\n                        10.1007\/s00380-016-0815-0","journal-title":"Heart Vessels"},{"key":"930_CR20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2459\/JCM.0b013e328332e938","volume":"11","author":"CM Porciani","year":"2010","unstructured":"Porciani CM, Lilli A, Cappelli F, Pappone A, Perini AP, Pieragnoli P, Ricciardi G, Rao CM, Prinzen FW, Michelucci A, Padeletti L (2010) Echo\/Doppler-derived time intervals are able to predict left ventricular reverse remodeling after cardiac resynchronization therapy. J Cardiovasc Med (Hagerstown) 11:157\u2013163","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"930_CR21","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ijcard.2010.10.125","volume":"146","author":"C Ceconi","year":"2011","unstructured":"Ceconi C, Freedman SB, Tardif JC, Hildebrandt P, McDonagh T, Gueret P, Parrinello G, Robertson M, Steg PG, Tendera M, Ford I, Fox K, Ferrari R (2011) Effect of heart rate reduction by ivabradine on left ventricular remodeling in the echocardiographic substudy of BEAUTIFUL. Int J Cardiol 146:408\u2013414","journal-title":"Int J Cardiol"},{"key":"930_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-016-0805-2","author":"Y Ikeda","year":"2016","unstructured":"Ikeda Y, Inomata T, Fujita T, Iida Y, Nabeta T, Ishii S, Maekawa E, Yanagisawa T, Mizutani T, Naruke T, Koitabashi T, Takeuchi I, Ako J (2016) Cardiac fibrosis detected by magnetic resonance imaging on predicting time course diversity of left ventricular reverse remodeling in patients with idiopathic dilated cardiomyopathy. Heart Vessels. doi:\n                        10.1007\/s00380-016-0805-2","journal-title":"Heart Vessels"},{"key":"930_CR23","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.ejheart.2008.06.019","volume":"10","author":"S Umar","year":"2008","unstructured":"Umar S, Bax JJ, Klok M, van Bommel RJ, Hessel MH, den Adel B, Bleeker GB, Henneman MM, Atsma DE, van der Wall EE, Schalij MJ, van der Laarse A (2008) Myocardial collagen metabolism in failing hearts before and during cardiac resynchronization therapy. Eur J Heart Fail 10:878\u2013883","journal-title":"Eur J Heart Fail"},{"key":"930_CR24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/eurheartj\/ehi579","volume":"27","author":"C D\u2019Ascia","year":"2006","unstructured":"D\u2019Ascia C, Cittadini A, Monti MG, Riccio G, Sacc\u00e0 L (2006) Effects of biventricular pacing on interstitial remodelling, tumor necrosis factor-alpha expression, and apoptotic death in failing human myocardium. Eur Heart J 27:201\u2013206","journal-title":"Eur Heart J"},{"key":"930_CR25","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.healun.2006.05.011","volume":"25","author":"AH Bruggink","year":"2006","unstructured":"Bruggink AH, van Oosterhout MF, de Jonge N, Ivangh B, van Kuik J, Voorbij RH, Cleutjens JP, Gmelig-Meyling FH, de Weger RA (2006) Reverse remodeling of the myocardial extracellular matrix after prolonged left ventricular assist device support follows a biphasic pattern. J Heart Lung Transplant 25:1091\u20131098","journal-title":"J Heart Lung Transplant"},{"key":"930_CR26","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S1053-2498(03)00205-5","volume":"23","author":"H Milting","year":"2004","unstructured":"Milting H, Jacob M, Kassner A, Heimann P, Mannherz HG, Becker G, Meyer HE, B\u00f6thig D, Arusoglu L, Morshuis M, K\u00f6rfer R, El Banayosy A (2004) The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron microscopy and amino acid analysis reveals low degree of reverse remodeling. J Heart Lung Transplant 23:396\u2013404","journal-title":"J Heart Lung Transplant"},{"key":"930_CR27","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ijcard.2010.08.048","volume":"153","author":"P Francia","year":"2011","unstructured":"Francia P, Balla C, Ricotta A, Uccellini A, Frattari A, Modestino A, Borro M, Simmaco M, Salvati A, De Biase L, Volpe M (2011) Plasma osteopontin reveals left ventricular reverse remodelling following cardiac resynchronization therapy in heart failure. Int J Cardiol 153:306\u2013310","journal-title":"Int J Cardiol"},{"key":"930_CR28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ijcard.2010.04.053","volume":"151","author":"V Polyakova","year":"2011","unstructured":"Polyakova V, Loeffler I, Hein S, Miyagawa S, Piotrowska I, Dammer S, Risteli J, Schaper J, Kostin S (2011) Fibrosis in endstage human heart failure: severe changes in collagen metabolism and MMP\/TIMP profiles. Int J Cardiol 151:18\u201333","journal-title":"Int J Cardiol"},{"key":"930_CR29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.trsl.2016.02.006","volume":"172","author":"SS Sakamuri","year":"2016","unstructured":"Sakamuri SS, Takawale A, Basu R, Fedak PW, Freed D, Sergi C, Oudit GY, Kassiri Z (2016) Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure. Transl Res 172:30\u201344","journal-title":"Transl Res"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00380-016-0930-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-016-0930-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-016-0930-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T17:29:32Z","timestamp":1495906172000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00380-016-0930-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["930"],"URL":"https:\/\/doi.org\/10.1007\/s00380-016-0930-y","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"value":"0910-8327","type":"print"},{"value":"1615-2573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,21]]}}}