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The aim of this prospective study was to investigate the influence of long-term physical activity on serum sRAGE levels. 109 subjects were recruited, and 98 completed the study. Participants were asked to perform exercise within the calculated training pulse for 8\u00a0months. The performance gain was measured\/quantified by bicycle stress tests at the beginning and end of the observation period. sRAGE was measured at baseline and after 2\/6\/8\u00a0months by ELISA. Backwards, multiple linear regression analysis was performed to investigate the association of co-variables age, sex, BMI, and performance at baseline, HbA<jats:sub>1<\/jats:sub>c, and lipoprotein a with baseline sRAGE levels. We identified BMI and lipoprotein a as significant predictors for baseline sRAGE levels. Compared to subjects with a performance gain\u00a0\u2264\u00a04.9% subjects with a gain\u00a0&gt;\u00a05% showed a significant increase in sRAGE levels up to 22%. sRAGE serum levels correlate negatively with lipoprotein a levels and BMI and long-term physical activity leads to a significant increase in serum sRAGE levels (9\u201322%), whereby the sRAGE increase is most pronounced in subjects with initially low-performance levels, suggesting that in particular, these subject profit the most from increased physical activity. The sport-mediated increase of sRAGE might be a sign of decreased AGE-mediated inflammation and highlight the protective effect of sports on CVD and other disease which are at least partly mediated by an increased inflammation status.<\/jats:p><jats:p><jats:italic>Clinical trials registration<\/jats:italic>NCT02097199.<\/jats:p>","DOI":"10.1007\/s00380-018-1125-5","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:46:12Z","timestamp":1516794372000},"page":"893-900","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Long-term physical activity leads to a significant increase in serum sRAGE levels: a sign of decreased AGE-mediated inflammation due to physical activity?"],"prefix":"10.1007","volume":"33","clinical-trial-number":[{"clinical-trial-number":"nct02097199","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9016-2975","authenticated-orcid":false,"given":"Michael","family":"Sponder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana-Alexandra","family":"Campean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Emich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Fritzer-Szekeres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Litschauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senta","family":"Graf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Dalos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Strametz-Juranek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"issue":"2","key":"1125_CR1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.33549\/physiolres.930430","volume":"53","author":"V Jakus","year":"2004","unstructured":"Jakus V, Rietbrock N (2004) Advanced glycation end-products and the progress of diabetic vascular complications. 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