{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:55:36Z","timestamp":1754261736388},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T00:00:00Z","timestamp":1526601600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s00380-018-1187-4","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T07:34:17Z","timestamp":1526628857000},"page":"1350-1357","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Aortic elasticity deterioration proves intrinsic abnormality of the ascending aorta in pediatric Turner syndrome unrelated to the aortic valve morphology"],"prefix":"10.1007","volume":"33","author":[{"given":"Christiane","family":"Pees","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian A.","family":"Heno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"H\u00e4usler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana-Alexandra","family":"Ertl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talin","family":"Gulesserian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Michel-Behnke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,18]]},"reference":[{"key":"1187_CR1","doi-asserted-by":"publisher","first-page":"3897","DOI":"10.1210\/jc.2006-0558","volume":"91","author":"K Stochholm","year":"2006","unstructured":"Stochholm K, Juul S, Juel K, Naeraa RW, Gravholt CH (2006) Prevalence, incidence, diagnostic delay, and mortality in Turner syndrome. J Clin Endocrinol Metab 91:3897\u20133902","journal-title":"J Clin Endocrinol Metab"},{"key":"1187_CR2","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1210\/er.2011-1059","volume":"33","author":"KH Mortensen","year":"2012","unstructured":"Mortensen KH, Andersen NH, Gravholt CH (2012) Cardiovascular phenotype in Turner syndrome-integrating cardiology, genetics, and endocrinology. Endocr Rev 33:677\u2013714","journal-title":"Endocr Rev"},{"key":"1187_CR3","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/j.1365-2265.2007.02807.x","volume":"66","author":"M El-Mansoury","year":"2007","unstructured":"El-Mansoury M, Barren\u00e4s ML, Bryman I, Hanson C, Larsson C, Wilhelmsen L, Landin-Wilhelmsen K (2007) Chromosomal mosaicism mitigates stigmata and cardiovascular risk factors in Turner syndrome. Clin Endocrinol 66:744\u2013751","journal-title":"Clin Endocrinol"},{"key":"1187_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1136\/jech.40.2.97","volume":"40","author":"WH Price","year":"1986","unstructured":"Price WH, Clayton JF, Collyer S, De Mey R, Wilson J (1986) Mortality ratios, life expectancy, and causes of death in patients with Turner\u2019s syndrome. J Epidemiol Community Health 40:97\u2013102","journal-title":"J Epidemiol Community Health"},{"key":"1187_CR5","doi-asserted-by":"publisher","first-page":"e54977","DOI":"10.1371\/journal.pone.0054977","volume":"8","author":"K Groote De","year":"2013","unstructured":"De Groote K, Cools M, De Schepper J, Craen M, Fran\u00e7ois I, Devos D, Carbonez K, Eyskens B, De Wolf D (2013) Cardiovascular pathology in males and females with 45, X\/46, XY mosaicism. Plos One 8:e54977","journal-title":"Plos One"},{"key":"1187_CR6","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s002469900416","volume":"20","author":"D Prandstraller","year":"1999","unstructured":"Prandstraller D, Mazzanti L, Picchio FM, Magnani C, Bergamaschi R, Perri A, Tsingos E, Cacciari E (1999) Turner\u2019s syndrome: cardiologic profile according to the different chromosomal patterns and long-term clinical follow-up of 136 non pre selected patients. Pediatr Cardiol 20:108\u2013112","journal-title":"Pediatr Cardiol"},{"key":"1187_CR7","doi-asserted-by":"publisher","first-page":"58","DOI":"10.5603\/EP.2015.0010","volume":"66","author":"R Kriksciuniene","year":"2015","unstructured":"Kriksciuniene R, Ostrauskas R, Zilaitiene B (2015) Aortopathies in Turner syndrome-new strategies for evaluation and treatment. Endokrynol Pol 66:58\u201365","journal-title":"Endokrynol Pol"},{"key":"1187_CR8","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1016\/j.jacc.2008.02.035","volume":"51","author":"V Sachdev","year":"2008","unstructured":"Sachdev V, Matura LA, Sidenko S, Ho VB, Arai AE, Rosing DR, Bondy CA (2008) Aortic valve disease in Turner syndrome. J Am Coll Cardiol 51:1904\u20131909","journal-title":"J Am Coll Cardiol"},{"key":"1187_CR9","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1532-429X-13-24","volume":"13","author":"KH Mortensen","year":"2011","unstructured":"Mortensen KH, Hjerrild BE, Stochholm K, Andersen NH, S\u00f8rensen KE, Lundorf E, H\u00f8rlyck A, Pedersen EM, Christiansen JS, Gravholt CH (2011) Dilation of the ascending aorta in Turner syndrome\u2014a prospective cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 13:24","journal-title":"J Cardiovasc Magn Reson"},{"key":"1187_CR10","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1161\/CIRCULATIONAHA.111.088633","volume":"126","author":"M Carlson","year":"2012","unstructured":"Carlson M, Airhart N, Lopez L, Silberbach M (2012) Moderate aortic enlargement and bicuspid aortic valve are associated with aortic dissection in Turner syndrome\u2014report of the international Turner syndrome aortic dissection registry. Circulation 126:2220\u20132226","journal-title":"Circulation"},{"key":"1187_CR11","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1017\/S1047951106000928","volume":"16","author":"CH Gravholt","year":"2006","unstructured":"Gravholt CH, Landin-Wilhelmsen K, Stochholm K, Hjerrild BE, Ledet T, Djurhuus CB, Sylv\u00e9n L, Baandrup U, \u00d8stergaard Kristensen B, Christiansen JS (2006) Clinical and epidemiological description of aortic dissection in Turner\u2019s syndrome. Cardiol Young 16:430\u2013436","journal-title":"Cardiol Young"},{"key":"1187_CR12","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1097\/HCO.0b013e3283129b89","volume":"23","author":"CA Bondy","year":"2008","unstructured":"Bondy CA (2008) Aortic Dissection in Turner Syndrome. Curr Opin Cardiol 23:519\u2013526","journal-title":"Curr Opin Cardiol"},{"key":"1187_CR13","doi-asserted-by":"publisher","first-page":"e1622","DOI":"10.1542\/peds.2007-2807","volume":"121","author":"L Lopez","year":"2008","unstructured":"Lopez L, Arheart KL, Colan SD, Stein NS, Lopez-Mitnik G, Lin AE, Reller MD, Ventura R, Silberbach M (2008) Turner syndrome is an independent risk factor for aortic dilation in the young. Pediatrics 121:e1622\u20131627","journal-title":"Pediatrics"},{"key":"1187_CR14","doi-asserted-by":"publisher","first-page":"5161","DOI":"10.1210\/jc.2005-0677","volume":"90","author":"JE Ostberg","year":"2005","unstructured":"Ostberg JE, Donald AE, Halcox JPJ, Storry C, McCarthy C, Conway GS (2005) Vasculopathy in Turner syndrome: arterial dilatation and intimal thickening without endothelial dysfunction. J Clin Endocrinol Metab 90:5161\u20135166","journal-title":"J Clin Endocrinol Metab"},{"key":"1187_CR15","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.amjcard.2012.06.043","volume":"110","author":"C Pees","year":"2012","unstructured":"Pees C, Michel-Behnke I (2012) Morphology of the bicuspid aortic valve and elasticity of the adjacent aorta in children. Am J Cardiol 110:1354\u20131360","journal-title":"Am J Cardiol"},{"key":"1187_CR16","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3109\/03014460.2013.776110","volume":"40","author":"A Gleiss","year":"2013","unstructured":"Gleiss A, Lassi M, Bl\u00fcmel P, Borkenstein M, Kapelari K, Mayer M, Schemper M, H\u00e4usler G (2013) Austrian height and body proportion references for children aged 4 to under 19 years. Ann Hum Biol 40:324\u2013332","journal-title":"Ann Hum Biol"},{"key":"1187_CR17","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/0002-9149(89)90430-X","volume":"64","author":"MJ Roman","year":"1989","unstructured":"Roman MJ, Devereux RB, Kramer-Fox R, O\u00b4Loughlin J (1989) Two-dimensional echocardiographic aortic root dimensions in normal children and adults. Am J Cardiol 64:507\u2013512","journal-title":"Am J Cardiol"},{"key":"1187_CR18","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0894-7317(03)00335-3","volume":"16","author":"WA Zoghbi","year":"2003","unstructured":"Zoghbi WA, Enriquez-Sarano M, Foster E, Grayburn PA, Kraft CD, Levine RA, Nihoyannopoulos P, Otto CM, Quinones MA, Rakowski H, Stewart WJ, Waggoner A, Weissman NJ (2003) American Society of Echocardiography. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr 16:777\u2013802","journal-title":"J Am Soc Echocardiogr"},{"key":"1187_CR19","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1136\/hrt.2005.081539","volume":"92","author":"AE Warren","year":"2006","unstructured":"Warren AE, Boyd ML, O\u00b4Connell C, Dodds L (2006) Dilatation of the ascending aorta in paediatric patients with bicuspid aortic valve: frequency, rate of progression and risk factors. Heart 92:1496\u20131500","journal-title":"Heart"},{"key":"1187_CR20","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1161\/01.CIR.80.1.78","volume":"80","author":"T Hirai","year":"1989","unstructured":"Hirai T, Sasayama S, Kawasaki T, Yagi S (1989) Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis. Circulation 80:78\u201386","journal-title":"Circulation"},{"key":"1187_CR21","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/0002-9149(87)90908-8","volume":"59","author":"C Stefanadis","year":"1987","unstructured":"Stefanadis C, Wooley CF, Bush CA, Kolibash AJ, Boudoulas H (1987) Aortic distensibility abnormalities in coronary artery disease. Am J Cardiol 59:1300\u20131304","journal-title":"Am J Cardiol"},{"key":"1187_CR22","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S0022-3476(97)70340-8","volume":"130","author":"M Soergel","year":"1997","unstructured":"Soergel M, Kirschstein M, Busch C, Danne T, Gellermann J, Holl R, Krull F, Reichert H, Reusz GS, Rascher W (1997) Oscillometric 24-h ambulatory blood pressure values in healthy children and adolescents: a multicenter trial including 1141 subjects. J Pediatr 130:178\u2013184","journal-title":"J Pediatr"},{"key":"1187_CR23","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/0002-9149(86)90771-X","volume":"57","author":"RB Devereux","year":"1986","unstructured":"Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, Reichek N (1986) Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 57:450\u2013458","journal-title":"Am J Cardiol"},{"key":"1187_CR24","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.jjcc.2016.03.006","volume":"69","author":"K Groote De","year":"2017","unstructured":"De Groote K, Devos D, Van Herck K, De Wolf D, Van der Straaten S, Rietzschel E, Raes A, Vandekerckhove K, Panzer J, De Wilde H, De Schepper J (2017) Increased aortic stiffness in prepubertal girls with Turner syndrome. J Cardiol 69:201\u2013207","journal-title":"J Cardiol"},{"key":"1187_CR25","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12968-017-0331-0","volume":"19","author":"DG Devos","year":"2017","unstructured":"Devos DG, De Groote K, Babin D, Demulier L, Taeymans Y, Westenberg JJ, Van Bortel L, Segers P, Achten E, De Schepper J, Rietzschel E (2017) Proximal aortic stiffening in Turner patients may be present before dilation can be detected: a segmental functional MRI study. J Cardiovasc Magn Reson 19:27","journal-title":"J Cardiovasc Magn Reson"},{"key":"1187_CR26","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1136\/hrt.2004.048371","volume":"91","author":"JP Baguet","year":"2005","unstructured":"Baguet JP, Douchin S, Pierre H, Rossignol AM, Bost M, Mallion JM (2005) Structural and functional abnormalities of large arteries in the Turner syndrome. Heart 91:1442\u20131446","journal-title":"Heart"},{"key":"1187_CR27","doi-asserted-by":"publisher","first-page":"454","DOI":"10.2214\/AJR.10.4973","volume":"196","author":"HK Kim","year":"2011","unstructured":"Kim HK, Gottliebson W, Hor K, Backeljauw P, Gutmark-Little I, Salisbury SR, Racadio JM, Helton-Skally K, Fleck R (2011) Cardiovascular anomalies in Turner syndrome: spectrum, prevalence, and cardiac MRI findings in a pediatric and young adult population. Am J Roentgenol 196:454\u2013560","journal-title":"Am J Roentgenol"},{"key":"1187_CR28","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1532-429X-15-47","volume":"15","author":"KH Mortensen","year":"2013","unstructured":"Mortensen KH, Erlandsen M, Andersen NH, Gravholt CH (2013) Prediction of aortic dilation in Turner syndrome\u2014enhancing the use of serial cardiovascular magnetic resonance. J Cardiovasc Magn Reson 15:47","journal-title":"J Cardiovasc Magn Reson"},{"key":"1187_CR29","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1542\/peds.2004-1369","volume":"115","author":"ML Loscalzo","year":"2005","unstructured":"Loscalzo ML, Van PL, Ho VB, Bakalov VK, Rosing DR, Malone CA, Dietz HC, Bondy CA (2005) Association between fetal lymphedema and congenital cardiovascular defects in Turner syndrome. Pediatrics 115:732\u2013735","journal-title":"Pediatrics"},{"key":"1187_CR30","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1136\/jmedgenet-2013-101720","volume":"50","author":"C Bondy","year":"2013","unstructured":"Bondy C, Bakalov VK, Cheng C, Olivieri L, Rosing DR, Arai AE (2013) Bicuspid aortic valve and aortic coarctation are linked to deletion of the X chromosome short arm in Turner syndrome. J Med Genet 50:662\u2013665","journal-title":"J Med Genet"},{"key":"1187_CR31","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1161\/CIRCIMAGING.113.000526","volume":"6","author":"LJ Olivieri","year":"2013","unstructured":"Olivieri LJ, Baba RY, Arai AE, Bandettini WP, Rosing DR, Bakalov V, Sachdev V, Bondy CA (2013) Spectrum of aortic valve abnormalities associated with aortic dilation across age groups in Turner syndrome. Circ Cardiovasc Imaging 6:1018\u20131023","journal-title":"Circ Cardiovasc Imaging"},{"key":"1187_CR32","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrcardio.2009.191","volume":"6","author":"I El-Hamamsy","year":"2009","unstructured":"El-Hamamsy I, Yacoub MH (2009) Cellular and molecular mechanisms of thoracic aortic aneurysms. Nat Rev Cardiol 6:771\u2013786","journal-title":"Nat Rev Cardiol"},{"key":"1187_CR33","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/s12265-012-9349-8","volume":"5","author":"JE Wagenseil","year":"2012","unstructured":"Wagenseil JE, Mecham RP (2012) Elastin in large artery stiffness and hypertension. J Cardiovasc Transl Res 5:264\u2013273","journal-title":"J Cardiovasc Transl Res"},{"key":"1187_CR34","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1093\/humrep\/deg499","volume":"18","author":"CS Kaisenberg von","year":"2003","unstructured":"von Kaisenberg CS, Prols F, Nicolaides KH, Maass N, Meinhold-Heerlein I, Brand-Saberi B (2003) Glycosaminoglycans and proteoglycans in the skin of aneuploid fetuses with increased nuchal translucency. Hum Reprod Oxf Engl 18:2544\u20132561","journal-title":"Hum Reprod Oxf Engl"},{"key":"1187_CR35","first-page":"598","volume":"10","author":"RV Iozzo","year":"1996","unstructured":"Iozzo RV, Murdoch AD (1996) Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function. FASEB J Off Publ Fed Am Soc Exp Biol 10:598\u2013614","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"1187_CR36","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0021-9150(02)00231-9","volume":"165","author":"AD Theocharis","year":"2002","unstructured":"Theocharis AD, Karamanos NK (2002) Decreased biglycan expression and differential decorin localization in human abdominal aortic aneurysms. Atherosclerosis 165:221\u2013230","journal-title":"Atherosclerosis"},{"key":"1187_CR37","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1530\/EJE-11-0002","volume":"164","author":"R Giordano","year":"2011","unstructured":"Giordano R, Forno D, Lanfranco F, Manieri C, Ghizzoni L, Ghigo E (2011) Metabolic and cardiovascular outcomes in a group of adult patients with Turner\u2019s syndrome under hormonal replacement therapy. Eur J Endocrinol 164:819\u2013826","journal-title":"Eur J Endocrinol"},{"key":"1187_CR38","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1016\/j.amjcard.2013.06.019","volume":"112","author":"C Pees","year":"2013","unstructured":"Pees C, Laccone F, Hagl M, Debrauwer V, Moser E, Michel-Behnke I (2013) Usefulness of losartan on the size of the ascending aorta in an unselected cohort of children, adolescents, and young adults with Marfan syndrome. Am J Cardiol 112:1477\u20131483","journal-title":"Am J Cardiol"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00380-018-1187-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-018-1187-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-018-1187-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T21:56:33Z","timestamp":1558130193000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00380-018-1187-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,18]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["1187"],"URL":"https:\/\/doi.org\/10.1007\/s00380-018-1187-4","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"value":"0910-8327","type":"print"},{"value":"1615-2573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,18]]},"assertion":[{"value":"31 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no conflicts of interest relevant to this article to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}