{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:14:56Z","timestamp":1783509296037,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s00380-019-01364-7","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T12:38:04Z","timestamp":1551357484000},"page":"1360-1369","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Real-world survival data of device-related thrombus following left atrial appendage closure: 4-year experience from a single center"],"prefix":"10.1007","volume":"34","author":[{"given":"Yuan","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Duenninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Muenzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Keil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Fazakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangtao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"key":"1364_CR1","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/S0140-6736(09)61343-X","volume":"374","author":"DR Holmes","year":"2009","unstructured":"Holmes DR, Reddy VY, Turi ZG, Doshi SK, Sievert H, Buchbinder M, Mullin CM, Sick P, PROTECT AF Investigators (2009) Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial. Lancet 374:534\u2013542","journal-title":"Lancet"},{"key":"1364_CR2","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1161\/CIRCULATIONAHA.110.976449","volume":"123","author":"VY Reddy","year":"2011","unstructured":"Reddy VY, Holmes D, Doshi SK, Neuzil P, Kar S (2011) Safety of percutaneous left atrial appendage closure: results from the Watchman left atrial appendage system for embolic protection in patients with AF (PROTECT AF) clinical trial and the continued access registry. Circulation 123:417\u2013424","journal-title":"Circulation"},{"key":"1364_CR3","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1002\/ccd.26238","volume":"87","author":"J Ledwoch","year":"2016","unstructured":"Ledwoch J, Franke J, Gonzaga M, Bertog S, Braut A, Hofmann I, Vaskelyte L, Gafoor S, Reddy V, Sievert H (2016) Left atrial appendage closure: first in man with the 4th generation WATCHMAN device. Catheter Cardiovasc Interv 87:787\u2013794","journal-title":"Catheter Cardiovasc Interv"},{"key":"1364_CR4","doi-asserted-by":"publisher","first-page":"867","DOI":"10.4244\/EIJ-D-17-00493","volume":"13","author":"U Landmesser","year":"2017","unstructured":"Landmesser U, Schmidt B, Nielsen-Kudsk JE, Lam SCC, Park JW, Tarantini G, Cruz-Gonzalez I, Geist V, Della Bella P, Colombo A, Zeus T, Omran H, Piorkowski C, Lund J, Tondo C, Hildick-Smith D (2017) Left atrial appendage occlusion with the AMPLATZER Amulet device: periprocedural and early clinical\/echocardiographic data from a global prospective observational study. EuroIntervention 13:867\u2013876","journal-title":"EuroIntervention"},{"key":"1364_CR5","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.4244\/EIJY15M01_06","volume":"11","author":"A Tzikas","year":"2016","unstructured":"Tzikas A, Shakir S, Gafoor S, Omran H, Berti S, Santoro G, Kefer J, Landmesser U, Nielsen-Kudsk JE, Cruz-Gonzalez I, Sievert H, Tichelb\u00e4cker T, Kanagaratnam P, Nietlispach F, Aminian A, Kasch F, Freixa X, Danna P, Rezzaghi M, Vermeersch P, Stock F, Stolcova M, Costa M, Ibrahim R, Schillinger W, Meier B, Park JW (2016) Left atrial appendage occlusion for stroke prevention in atrial fibrillation: multicentre experience with the AMPLATZER Cardiac Plug. EuroIntervention 11:1170\u20131179","journal-title":"EuroIntervention"},{"key":"1364_CR6","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1093\/eurheartj\/ehw210","volume":"37","author":"P Kirchhof","year":"2016","unstructured":"Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, ESC Scientific Document Group (2016) 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J 37:2893\u20132962","journal-title":"Eur Heart J"},{"key":"1364_CR7","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1093\/eurheartj\/ehs292","volume":"33","author":"SR Gangireddy","year":"2012","unstructured":"Gangireddy SR, Halperin JL, Fuster V, Reddy VY (2012) Percutaneous left atrial appendage closure for stroke prevention in patients with atrial fibrillation: an assessment of net clinical benefit. Eur Heart J 33:2700\u20132708","journal-title":"Eur Heart J"},{"key":"1364_CR8","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.echo.2011.02.010","volume":"24","author":"S Ayirala","year":"2011","unstructured":"Ayirala S, Kumar S, O\u2019Sullivan DM, Silverman DI (2011) Echocardiographic predictors of left atrial appendage thrombus formation. J Am Soc Echocardiogr 24:499\u2013505","journal-title":"J Am Soc Echocardiogr"},{"key":"1364_CR9","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.jcin.2013.02.014","volume":"6","author":"B Plicht","year":"2013","unstructured":"Plicht B, Konorza TF, Kahlert P, Al-Rashid F, Kaelsch H, J\u00e1nosi RA, Buck T, Bachmann HS, Siffert W, Heusch G, Erbel R (2013) Risk factors for thrombus formation on the Amplatzer Cardiac Plug after left atrial appendage occlusion. JACC Cardiovasc Interv 6:606\u2013613","journal-title":"JACC Cardiovasc Interv"},{"key":"1364_CR10","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.amjcard.2016.01.039","volume":"117","author":"ML Main","year":"2016","unstructured":"Main ML, Fan D, Reddy VY, Holmes DR, Gordon NT, Coggins TR, House JA, Liao L, Rabineau D, Latus GG, Huber KC, Sievert H, Wright RF, Doshi SK, Douglas PS (2016) Assessment of device-related thrombus and associated clinical outcomes with the WATCHMAN left atrial appendage closure device for embolic protection in patients with atrial fibrillation (from the PROTECT-AF Trial). Am J Cardiol 117:1127\u20131134","journal-title":"Am J Cardiol"},{"key":"1364_CR11","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jcin.2016.11.029","volume":"10","author":"J Saw","year":"2017","unstructured":"Saw J, Tzikas A, Shakir S, Gafoor S, Omran H, Nielsen-Kudsk JE, Kefer J, Aminian A, Berti S, Santoro G, Nietlispach F, Moschovitis A, Cruz-Gonzalez I, Stammen F, Tichelb\u00e4cker T, Freixa X, Ibrahim R, Schillinger W, Meier B, Sievert H, Gloekler S (2017) Incidence and clinical impact of device-associated thrombus and peri-device leak following left atrial appendage closure with the amplatzer cardiac plug. JACC Cardiovasc Interv 10:391\u2013399","journal-title":"JACC Cardiovasc Interv"},{"key":"1364_CR12","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.118.035090","author":"SR Dukkipati","year":"2018","unstructured":"Dukkipati SR, Kar S, Holmes DR Jr, Doshi SK, Swarup V, Gibson DN, Maini B, Gordon NT, Main ML, Reddy VY (2018) Device-related thrombus after left atrial appendage closure: incidence, predictors, and outcomes. Circulation. \n                    https:\/\/doi.org\/10.1161\/circulationaha.118.035090","journal-title":"Circulation"},{"key":"1364_CR13","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1016\/j.jacc.2018.01.076","volume":"71","author":"L Fauchier","year":"2018","unstructured":"Fauchier L, Cinaud A, Brigadeau F, Lepillier A, Pierre B, Abbey S, Fatemi M, Franceschi F, Guedeney P, Jacon P, Paziaud O, Venier S, Deharo JC, Gras D, Klug D, Mansourati J, Montalescot G, Piot O, Defaye P (2018) Device-related thrombosis after percutaneous left atrial appendage occlusion for atrial fibrillation. J Am Coll Cardiol 71:1528\u20131536","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"1364_CR14","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s00380-017-0971-x","volume":"32","author":"H Kaneko","year":"2017","unstructured":"Kaneko H, Neuss M, Weissenborn J, Butter C (2017) Predictors of thrombus formation after percutaneous left atrial appendage closure using the WATCHMAN device. Heart Vessels 32(9):1137\u20131143","journal-title":"Heart Vessels"},{"key":"1364_CR15","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.hlc.2018.08.022","volume":"2","author":"M Peyrol","year":"2018","unstructured":"Peyrol M, Cautela J, Salaun E, Miola C, Franceschi F, Thuny F, Pinto J, Laine M, Maximovitch A, Paganelli F, Armero S, Bonello L (2018) Device-related thrombus after left atrial appendage occlusion with the amulet device. Heart Lung Circ 2:22. \n                    https:\/\/doi.org\/10.1016\/j.hlc.2018.08.022","journal-title":"Heart Lung Circ"},{"key":"1364_CR16","first-page":"4","volume":"19","author":"A Tzikas","year":"2017","unstructured":"Tzikas A, Holmes DR Jr, Gafoor S, Ruiz CE, Blomstr\u00f6m-Lundqvist C, Diener HC, Cappato R, Kar S, Lee RJ, Byrne RA, Ibrahim R, Lakkireddy D, Soliman OI, Nabauer M, Schneider S, Brachmann J, Saver JL, Tiemann K, Sievert H, Camm AJ, Lewalter T (2017) Percutaneous left atrial appendage occlusion: the Munich consensus document on definitions, endpoints, and data collection requirements for clinical studies. Europace 19:4\u201315","journal-title":"Europace"},{"key":"1364_CR17","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1016\/j.jacc.2012.09.001","volume":"60","author":"AP Kappetein","year":"2012","unstructured":"Kappetein AP, Head SJ, G\u00e9n\u00e9reux P, Piazza N, van Mieghem NM, Blackstone EH, Brott TG, Cohen DJ, Cutlip DE, van Es GA, Hahn RT, Kirtane AJ, Krucoff MW, Kodali S, Mack MJ, Mehran R, Rod\u00e9s-Cabau J, Vranckx P, Webb JG, Windecker S, Serruys PW, Leon MB (2012) Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document. J Am Coll Cardiol 60:1438\u20131454","journal-title":"J Am Coll Cardiol"},{"key":"1364_CR18","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/0301-5629(95)02006-3","volume":"21","author":"D Fatkin","year":"1995","unstructured":"Fatkin D, Loupas T, Jacobs N, Feneley MP (1995) Quantification of blood echogenicity: evaluation of a semiquantitative method of grading spontaneous echo contrast. Ultrasound Med Biol 21:1191\u20131198","journal-title":"Ultrasound Med Biol"},{"key":"1364_CR19","doi-asserted-by":"publisher","first-page":"E111","DOI":"10.1002\/ccd.26903","volume":"90","author":"M Lempereur","year":"2017","unstructured":"Lempereur M, Aminian A, Freixa X, Gafoor S, Kefer J, Tzikas A, Legrand V, Saw J (2017) Device-associated thrombus formation after left atrial appendage occlusion: a systematic review of events reported with the Watchman, the Amplatzer Cardiac Plug and the Amulet. Catheter Cardiovasc Interv 90:E111\u2013E121","journal-title":"Catheter Cardiovasc Interv"},{"key":"1364_CR20","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.hrthm.2016.10.020","volume":"14","author":"Y Enomoto","year":"2017","unstructured":"Enomoto Y, Gadiyaram VK, Gianni C, Horton RP, Trivedi C, Mohanty S, Di Biase L, Al-Ahmad A, Burkhardt JD, Narula A, Janczyk G, Price MJ, Afzal MR, Atoui M, Earnest M, Swarup V, Doshi SK, van der Zee S, Fisher R, Lakkireddy DR, Gibson DN, Natale A, Reddy VY (2017) Use of non-warfarin oral anticoagulants instead of warfarin during left atrial appendage closure with the Watchman device. Heart Rhythm 14:19\u201324","journal-title":"Heart Rhythm"},{"key":"1364_CR21","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.jcin.2014.03.003","volume":"7","author":"S Kar","year":"2014","unstructured":"Kar S, Hou D, Jones R, Werner D, Swanson L, Tischler B, Stein K, Huibregtse B, Ladich E, Kutys R, Virmani R (2014) Impact of Watchman and Amplatzer devices on left atrial appendage adjacent structures and healing response in a canine model. JACC Cardiovasc Interv 7:801\u2013809","journal-title":"JACC Cardiovasc Interv"},{"key":"1364_CR22","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1111\/j.1540-8167.2012.02360.x","volume":"23","author":"L Massarenti","year":"2012","unstructured":"Massarenti L, Yilmaz A (2012) Incomplete endothelialization of left atrial appendage occlusion device 10\u00a0months after implantation. J Cardiovasc Electrophysiol 23:1384\u20131385","journal-title":"J Cardiovasc Electrophysiol"},{"key":"1364_CR23","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jacep.2016.05.006","volume":"3","author":"A Sedaghat","year":"2017","unstructured":"Sedaghat A, Schrickel JW, Andri\u00e9 R, Schueler R, Nickenig G, Hammerstingl C (2017) Thrombus formation after left atrial appendage occlusion with the amplatzer amulet device. JACC Clin Electrophysiol 3:71\u201375","journal-title":"JACC Clin Electrophysiol"},{"key":"1364_CR24","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.jacc.2011.11.028","volume":"59","author":"JF Viles-Gonzalez","year":"2012","unstructured":"Viles-Gonzalez JF, Kar S, Douglas P, Dukkipati S, Feldman T, Horton R, Holmes D, Reddy VY (2012) The clinical impact of incomplete left atrial appendage closure with the Watchman Device in patients with atrial fibrillation: a PROTECT AF (Percutaneous Closure of the Left Atrial Appendage Versus Warfarin Therapy for Prevention of Stroke in Patients with Atrial Fibrillation) substudy. J Am Coll Cardiol 59:923\u2013929","journal-title":"J Am Coll Cardiol"},{"key":"1364_CR25","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.ijcard.2015.11.160","volume":"204","author":"U Ketterer","year":"2016","unstructured":"Ketterer U, D\u2019Ancona G, Siegel I, Ortak J, Ince H, Kische S (2016) Percutaneous left atrial appendage occlusion: device thrombosis in clopidogrel non-responders. Int J Cardiol 204:196\u2013197","journal-title":"Int J Cardiol"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00380-019-01364-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-019-01364-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-019-01364-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T19:27:35Z","timestamp":1582831655000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00380-019-01364-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,28]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["1364"],"URL":"https:\/\/doi.org\/10.1007\/s00380-019-01364-7","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"value":"0910-8327","type":"print"},{"value":"1615-2573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,28]]},"assertion":[{"value":"23 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}