{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T22:36:50Z","timestamp":1787351810254,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s00380-020-01604-1","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T05:02:43Z","timestamp":1586754163000},"page":"1307-1315","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pulmonary vasodilators can lead to various complications in pulmonary \u201carterial\u201d hypertension associated with congenital heart disease"],"prefix":"10.1007","volume":"35","author":[{"given":"Ayako","family":"Chida-Nagai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Sagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Tsujioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokuni","family":"Yamazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhito","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,13]]},"reference":[{"key":"1604_CR1","doi-asserted-by":"publisher","first-page":"D42","DOI":"10.1016\/j.jacc.2013.10.032","volume":"62","author":"MM Hoeper","year":"2013","unstructured":"Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DB (2013) Definitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol 62:D42\u201350","journal-title":"J Am Coll Cardiol"},{"key":"1604_CR2","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1164\/ajrccm.162.5.9912045","volume":"162","author":"J Mandel","year":"2000","unstructured":"Mandel J, Mark EJ, Hales CA (2000) Pulmonary veno-occlusive disease. Am J Respir Crit Care Med 162:1964\u20131973","journal-title":"Am J Respir Crit Care Med"},{"key":"1604_CR3","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/j.1365-2559.1978.tb01734.x","volume":"2","author":"CA Wagenvoort","year":"1978","unstructured":"Wagenvoort CA, Beetstra A, Spijker J (1978) Capillary haemangiomatosis of the lungs. Histopathology 2:401\u2013406","journal-title":"Histopathology"},{"key":"1604_CR4","first-page":"1198","volume":"80","author":"GG Pietra","year":"1989","unstructured":"Pietra GG, Edwards WD, Kay JM, Rich S, Kernis J, Schloo B, Ayres SM, Bergofsky EH, Brundage BH, Detre KM (1989) Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute. Prim Pulm Hypertens Regist Circ 80:1198\u20131206","journal-title":"Prim Pulm Hypertens Regist Circ"},{"key":"1604_CR5","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1161\/CIRCULATIONAHA.117.028351","volume":"136","author":"C Hadinnapola","year":"2017","unstructured":"Hadinnapola C, Bleda M, Haimel M, Screaton N, Swift A, Dorfmuller P, Preston SD, Southwood M, Hernandez-Sanchez J, Martin J, Treacy C, Yates K, Bogaard H, Church C, Coghlan G, Condliffe R, Corris PA, Gibbs S, Girerd B, Holden S, Humbert M, Kiely DG, Lawrie A, Machado R, MacKenzie Ross R, Moledina S, Montani D, Newnham M, Peacock A, Pepke-Zaba J, Rayner-Matthews P, Shamardina O, Soubrier F, Southgate L, Suntharalingam J, Toshner M, Trembath R, Vonk Noordegraaf A, Wilkins MR, Wort SJ, Wharton J, Graf S, Morrell NW (2017) Phenotypic characterization of EIF2AK4 mutation carriers in a large cohort of patients diagnosed clinically with pulmonary arterial hypertension. Circulation 136:2022\u20132033","journal-title":"Circulation"},{"key":"1604_CR6","doi-asserted-by":"publisher","first-page":"1801913","DOI":"10.1183\/13993003.01913-2018","volume":"53","author":"G Simonneau","year":"2019","unstructured":"Simonneau G, Montani D, Celermajer DS, Denton CP, Gatzoulis MA, Krowka M, Williams PG, Souza R (2019) Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J 53:1801913","journal-title":"Eur Respir J"},{"key":"1604_CR7","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1017\/S1047951117000397","volume":"27","author":"J Muneuchi","year":"2017","unstructured":"Muneuchi J, Oda S, Shimizu D (2017) Rapidly progressive pulmonary veno-occlusive disease in an infant with Down syndrome. Cardiol Young 27:1402\u20131405","journal-title":"Cardiol Young"},{"key":"1604_CR8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/ped.12349","volume":"56","author":"T Saji","year":"2014","unstructured":"Saji T (2014) Clinical characteristics of pulmonary arterial hypertension associated with Down syndrome. Pediatr Int 56:297\u2013303","journal-title":"Pediatr Int"},{"key":"1604_CR9","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jpeds.2016.08.063","volume":"180","author":"D Bush","year":"2017","unstructured":"Bush D, Abman SH, Galambos C (2017) Prominent intrapulmonary bronchopulmonary anastomoses and abnormal lung development in infants and children with Down syndrome. J Pediatr 180:156\u2013162.e151","journal-title":"J Pediatr"},{"key":"1604_CR10","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00439-014-1419-3","volume":"133","author":"L Ma","year":"2014","unstructured":"Ma L, Chung WK (2014) The genetic basis of pulmonary arterial hypertension. Hum Genet 133:471\u2013479","journal-title":"Hum Genet"},{"key":"1604_CR11","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/ajmg.a.36282","volume":"164a","author":"M Tahara","year":"2014","unstructured":"Tahara M, Shimozono S, Nitta T, Yamaki S (2014) Medial defects of the small pulmonary arteries in fatal pulmonary hypertension in infants with trisomy 13 and trisomy 18. Am J Med Genet A 164a:319\u2013323","journal-title":"Am J Med Genet A"},{"key":"1604_CR12","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.humpath.2006.06.007","volume":"38","author":"M Colombat","year":"2007","unstructured":"Colombat M, Mal H, Groussard O, Capron F, Thabut G, Jebrak G, Brugiere O, Dauriat G, Castier Y, Leseche G, Fournier M (2007) Pulmonary vascular lesions in end-stage idiopathic pulmonary fibrosis: histopathologic study on lung explant specimens and correlations with pulmonary hemodynamics. Hum Pathol 38:60\u201365","journal-title":"Hum Pathol"},{"key":"1604_CR13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/rcr2.7","volume":"1","author":"T Sato","year":"2013","unstructured":"Sato T, Tsujino I, Tanino M, Ohira H, Nishimura M (2013) Broad and heterogeneous vasculopathy in pulmonary fibrosis and emphysema with pulmonary hypertension. Respirol Case Rep 1:10\u201313","journal-title":"Respirol Case Rep"},{"key":"1604_CR14","doi-asserted-by":"publisher","first-page":"e115219","DOI":"10.1371\/journal.pone.0115219","volume":"9","author":"H Lederer","year":"2014","unstructured":"Lederer H, Muggli B, Speich R, Treder U, Stricker H, Goede J, Ulrich S, Stampfli SF, Breitenstein A (2014) Haemosiderin-laden sputum macrophages for diagnosis in pulmonary veno-occlusive disease. PLoS ONE 9:e115219","journal-title":"PLoS ONE"},{"key":"1604_CR15","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3949\/ccjm.75.4.258","volume":"75","author":"OC Ioachimescu","year":"2008","unstructured":"Ioachimescu OC, Stoller JK (2008) Diffuse alveolar hemorrhage: diagnosing it and finding the cause. Cleve Clin J Med 75:264\u2013265","journal-title":"Cleve Clin J Med"},{"key":"1604_CR16","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1253\/circj.69.216","volume":"69","author":"A Ogawa","year":"2005","unstructured":"Ogawa A, Matsubara H, Fujio H, Miyaji K, Nakamura K, Morita H, Saito H, Kusano KF, Emori T, Date H, Ohe T (2005) Risk of alveolar hemorrhage in patients with primary pulmonary hypertension\u2013anticoagulation and epoprostenol therapy. Circ J 69:216\u2013220","journal-title":"Circ J"},{"key":"1604_CR17","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1111\/j.1745-7262.2006.00194.x","volume":"8","author":"G Yuncu","year":"2006","unstructured":"Yuncu G, Ozkurt S, Sinik Z, Kiter G (2006) Hemoptysis developing soon after use of sildenafil: an observation on two cases. Asian J Androl 8:757\u2013758","journal-title":"Asian J Androl"},{"key":"1604_CR18","first-page":"119","volume":"51","author":"R Dixit","year":"2009","unstructured":"Dixit R, Jakhmola P, Sharma S, Arya M, Parmej AR (2009) Recurrent haemoptysis following sildenafil administration. Indian J Chest Dis Allied Sci 51:119\u2013120","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"1604_CR19","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.hrtlng.2012.02.003","volume":"41","author":"JL Pereira e Silva","year":"2012","unstructured":"Pereira e Silva JL, Araujo Neto CA, Marchiori E (2012) Pulmonary hemorrhage after the use of sildenafil. Heart lung 41:407\u2013408","journal-title":"Heart lung"},{"key":"1604_CR20","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.healun.2010.04.023","volume":"29","author":"KT Kudelko","year":"2010","unstructured":"Kudelko KT, Nadeau K, Leung AN, Liu J, Haddad F, Zamanian RT, De Jesus PV (2010) Epoprostenol-associated pneumonitis: diagnostic use of a T-cell proliferation assay. J Heart Lung Transplant 29:1071\u20131075","journal-title":"J Heart Lung Transplant"},{"key":"1604_CR21","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1213\/01.ANE.0000130615.28893.52","volume":"99","author":"H Morimatsu","year":"2004","unstructured":"Morimatsu H, Goto K, Matsusaki T, Katayama H, Matsubara H, Ohe T, Morita K (2004) Rapid development of severe interstitial pneumonia caused by epoprostenol in a patient with primary pulmonary hypertension. Anesth Analg 99:1205\u20131207","journal-title":"Anesth Analg"},{"key":"1604_CR22","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1378\/chest.116.2.566","volume":"116","author":"S Kesten","year":"1999","unstructured":"Kesten S, Dainauskas J, McLaughlin V, Rich S (1999) Development of nonspecific interstitial pneumonitis associated with long-term treatment of primary pulmonary hypertension with prostacyclin. Chest 116:566\u2013569","journal-title":"Chest"},{"key":"1604_CR23","doi-asserted-by":"publisher","first-page":"641","DOI":"10.7326\/0003-4819-158-9-201305070-00003","volume":"158","author":"G Raghu","year":"2013","unstructured":"Raghu G, Behr J, Brown KK, Egan JJ, Kawut SM, Flaherty KR, Martinez FJ, Nathan SD, Wells AU, Collard HR, Costabel U, Richeldi L, de Andrade J, Khalil N, Morrison LD, Lederer DJ, Shao L, Li X, Pedersen PS, Montgomery AB, Chien JW, O'Riordan TG (2013) Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial. Ann Intern Med 158:641\u2013649","journal-title":"Ann Intern Med"},{"issue":"Suppl 1","key":"1604_CR24","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.rmed.2016.11.003","volume":"122","author":"SD Nathan","year":"2017","unstructured":"Nathan SD, Behr J, Cottin V, Collard HR, Hoeper MM, Martinez FJ, Wells AU (2017) Idiopathic interstitial pneumonia-associated pulmonary hypertension: a target for therapy? Respir Med 122(Suppl 1):S10\u201313","journal-title":"Respir Med"},{"key":"1604_CR25","doi-asserted-by":"publisher","first-page":"1801914","DOI":"10.1183\/13993003.01914-2018","volume":"53","author":"SD Nathan","year":"2019","unstructured":"Nathan SD, Barbera JA, Gaine SP, Harari S, Martinez FJ, Olschewski H, Olsson KM, Peacock AJ, Pepke-Zaba J, Provencher S, Weissmann N, Seeger W (2019) Pulmonary hypertension in chronic lung disease and hypoxia. Eur Respir J 53:1801914","journal-title":"Eur Respir J"},{"key":"1604_CR26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/1750-1172-7-99","volume":"7","author":"Y Kida","year":"2012","unstructured":"Kida Y, Ohshimo S, Ota K, Tamura T, Otani T, Une K, Sadamori T, Iwasaki Y, Bonella F, Hattori N, Hirohashi N, Guzman J, Costabel U, Kohno N, Tanigawa K (2012) KL-6, a Human MUC1 Mucin, as a prognostic marker for diffuse alveolar hemorrhage syndrome. Orphanet J Rare Dis 7:99","journal-title":"Orphanet J Rare Dis"},{"key":"1604_CR27","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1254\/jjp.89.197","volume":"89","author":"K Ayajiki","year":"2002","unstructured":"Ayajiki K, Okamura T, Noda K, Toda N (2002) Functional study on nitroxidergic nerve in isolated dog pulmonary arteries and veins. Jpn J Pharmacol 89:197\u2013200","journal-title":"Jpn J Pharmacol"},{"key":"1604_CR28","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1097\/00000542-199512000-00004","volume":"83","author":"A Benzing","year":"1995","unstructured":"Benzing A, Brautigam P, Geiger K, Loop T, Beyer U, Moser E (1995) Inhaled nitric oxide reduces pulmonary transvascular albumin flux in patients with acute lung injury. Anesthesiology 83:1153\u20131161","journal-title":"Anesthesiology"},{"key":"1604_CR29","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1164\/ajrccm.154.5.8912751","volume":"154","author":"M Rossetti","year":"1996","unstructured":"Rossetti M, Guenard H, Gabinski C (1996) Effects of nitric oxide inhalation on pulmonary serial vascular resistances in ARDS. Am J Respir Crit Care Med 154:1375\u20131381","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-020-01604-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00380-020-01604-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-020-01604-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T01:32:30Z","timestamp":1744162350000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00380-020-01604-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,13]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["1604"],"URL":"https:\/\/doi.org\/10.1007\/s00380-020-01604-1","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"value":"0910-8327","type":"print"},{"value":"1615-2573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,13]]},"assertion":[{"value":"20 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Authors have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}