{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:35:45Z","timestamp":1769600145832,"version":"3.49.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s00380-020-01689-8","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T18:03:52Z","timestamp":1599761032000},"page":"127-135","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbits: iMap-IVUS and pathological analysis"],"prefix":"10.1007","volume":"36","author":[{"given":"Takafumi","family":"Kurosawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2108-7734","authenticated-orcid":false,"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsumasa","family":"Sudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Haruta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Hagikura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadateru","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Hiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Shiomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"issue":"9131","key":"1689_CR1","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/S0140-6736(98)07019-6","volume":"352","author":"UK Prospective Diabetes Study (UKPDS) Group","year":"1998","unstructured":"UK Prospective Diabetes Study (UKPDS) Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352(9131):837\u2013853","journal-title":"Lancet"},{"issue":"3","key":"1689_CR2","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1056\/NEJMoa1001288","volume":"363","author":"ACCORD Study Group; ACCORD Eye Study Group, Chew EY, Ambrosius WT, Davis MD, Danis RP, Gangaputra S, Greven CM, Hubbard L, Esser BA, Lovato JF, Perdue LH, Goff DC Jr, Cushman WC, Ginsberg HN, Elam MB, Genuth S, Gerstein HC, Schubart U, Fine LJ","year":"2010","unstructured":"ACCORD Study Group; ACCORD Eye Study Group, Chew EY, Ambrosius WT, Davis MD, Danis RP, Gangaputra S, Greven CM, Hubbard L, Esser BA, Lovato JF, Perdue LH, Goff DC Jr, Cushman WC, Ginsberg HN, Elam MB, Genuth S, Gerstein HC, Schubart U, Fine LJ (2010) Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med 363(3):233\u2013244","journal-title":"N Engl J Med"},{"issue":"1","key":"1689_CR3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2337\/dc08-9025","volume":"32","author":"DM Nathan","year":"2009","unstructured":"Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B (2009) Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 32(1):193\u2013203","journal-title":"Diabetes Care"},{"issue":"1","key":"1689_CR4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.2337\/dc10-1420","volume":"34","author":"Anderson RJ, Bahn GD, Moritz TE, Kaufman D, Abraira C, Duckworth W; VADT Study Group","year":"2011","unstructured":"Anderson RJ, Bahn GD, Moritz TE, Kaufman D, Abraira C, Duckworth W; VADT Study Group (2011) Blood pressure and cardiovascular disease risk in the veterans affairs diabetes trial. Diabetes Care 34(1):34\u201338","journal-title":"Diabetes Care"},{"issue":"5","key":"1689_CR5","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1097\/MOL.0000000000000340","volume":"27","author":"J Zhong","year":"2016","unstructured":"Zhong J, Kankanala S, Rajagopalan S (2016) Dipeptidyl peptidase-4 inhibition: insights from the bench and recent clinical studies. Curr Opin Lipidol 27(5):484\u2013492","journal-title":"Curr Opin Lipidol"},{"issue":"4","key":"1689_CR6","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1152\/physrev.00047.2003","volume":"84","author":"R Stocker","year":"2004","unstructured":"Stocker R, Keaney JF Jr (2004) Role of oxidative modifications in atherosclerosis. Physiol Rev 84(4):1381\u20131478","journal-title":"Physiol Rev"},{"issue":"5","key":"1689_CR7","doi-asserted-by":"publisher","first-page":"351","DOI":"10.5551\/jat.7591","volume":"18","author":"Y Mizuno","year":"2011","unstructured":"Mizuno Y, Jacob RF, Mason RP (2011) Inflammation and the development of atherosclerosis. J Atheroscler Thromb 18(5):351\u2013358","journal-title":"J Atheroscler Thromb"},{"issue":"1","key":"1689_CR8","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/cvr\/cvs246","volume":"96","author":"S Kroller-Schon","year":"2012","unstructured":"Kroller-Schon S, Knorr M, Hausding M, Oelze M, Schuff A, Schell R, Sudowe S, Scholz A, Daub S, Karbach S, Kossmann S, Gori T, Wenzel P, Schulz E, Grabbe S, Klein T, M\u00fcnzel T, Daiber A (2012) Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition. Cardiovasc Res 96(1):140\u2013149","journal-title":"Cardiovasc Res"},{"issue":"7","key":"1689_CR9","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1161\/01.ATV.0000075947.28567.50","volume":"23","author":"M Shiomi","year":"2003","unstructured":"Shiomi M, Ito T, Yamada S, Kawashima S, Fan J (2003) Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit). Arterioscler Thromb Vasc Biol 23(7):1239\u20131244","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"22","key":"1689_CR10","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1056\/NEJMoa1110874","volume":"365","author":"SJ Nicholls","year":"2011","unstructured":"Nicholls SJ, Ballantyne CM, Barter PJ, Chapman MJ, Erbel RM, Libby P, Raichlen JS, Uno K, Borgman M, Wolski K, Nissen SE (2011) Effect of two intensive statin regimens on progression of coronary disease. N Engl J Med 365(22):2078\u20132087","journal-title":"N Engl J Med"},{"issue":"1","key":"1689_CR11","doi-asserted-by":"publisher","first-page":"133","DOI":"10.4244\/EIJV5I1A21","volume":"5","author":"S Sathyanarayana","year":"2009","unstructured":"Sathyanarayana S, Carlier S, Li W, Thomas L (2009) Characterisation of atherosclerotic plaque by spectral similarity of radiofrequency intravascular ultrasound signals. EuroIntervention 5(1):133\u2013139","journal-title":"EuroIntervention"},{"issue":"1","key":"1689_CR12","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jjcc.2011.07.012","volume":"59","author":"T Araki","year":"2012","unstructured":"Araki T, Nakamura M, Utsunomiya M, Sugi K (2012) Visualization of coronary plaque in type 2 diabetes mellitus patients using a new 40 MHz intravascular ultrasound imaging system. J Cardiol 59(1):42\u201349","journal-title":"J Cardiol"},{"issue":"2","key":"1689_CR13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s10554-010-9789-7","volume":"27","author":"HM Garcia-Garcia","year":"2011","unstructured":"Garcia-Garcia HM, Gogas BD, Serruys PW, Bruining N (2011) IVUS-based imaging modalities for tissue characterization: similarities and differences. Int J Cardiovasc Imaging 27(2):215\u2013224","journal-title":"Int J Cardiovasc Imaging"},{"issue":"11","key":"1689_CR14","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1177\/1535370213493704","volume":"238","author":"QF Lin","year":"2013","unstructured":"Lin QF, Luo YK, Zhao ZW, Cai W, Zhen XC, Chen LL (2013) Atherosclerotic plaque identification by virtual histology intravascular ultrasound in a rabbit abdominal aorta model of vulnerable plaque. Exp Biol Med (Maywood) 238(11):1223\u20131232","journal-title":"Exp Biol Med (Maywood)"},{"issue":"6","key":"1689_CR15","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.12.010","volume":"23","author":"K Fukuda","year":"2014","unstructured":"Fukuda K, Iihara K, Maruyama D, Yamada N, Ishibashi-Ueda H (2014) Relationship between carotid artery remodeling and plaque vulnerability with T1-weighted magnetic resonance imaging. J Stroke Cerebrovasc Dis 23(6):1462\u20131470","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"3","key":"1689_CR16","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jacc.2011.07.053","volume":"59","author":"J Matsubara","year":"2012","unstructured":"Matsubara J, Sugiyama S, Sugamura K, Nakamura T, Fujiwara Y, Akiyama E, Kurokawa H, Nozaki T, Ohba K, Konishi M, Maeda H, Izumiya Y, Kaikita K, Sumida H, Jinnouchi H, Matsui K, Kim-Mitsuyama S, Takeya M, Ogawa H (2012) A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice. J Am Coll Cardiol 59(3):265\u2013276","journal-title":"J Am Coll Cardiol"},{"issue":"21","key":"1689_CR17","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1161\/CIRCULATIONAHA.111.041418","volume":"124","author":"Z Shah","year":"2011","unstructured":"Shah Z, Kampfrath T, Deiuliis JA, Zhong J, Pineda C, Ying Z, Xu X, Lu B, Moffatt-Bruce S, Durairaj R, Sun Q, Mihai G, Maiseyeu A, Rajagopalan S (2011) Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation 124(21):2338\u20132349","journal-title":"Circulation"},{"issue":"7","key":"1689_CR18","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1271\/bbb.130105","volume":"77","author":"H Iwaya","year":"2013","unstructured":"Iwaya H, Fujii N, Hagio M, Hara H, Ishizuka S (2013) Contribution of dipeptidyl peptidase IV to the severity of dextran sulfate sodium-induced colitis in the early phase. Biosci Biotechnol Biochem 77(7):1461\u20131466","journal-title":"Biosci Biotechnol Biochem"},{"issue":"1","key":"1689_CR19","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1365-2249.2009.03991.x","volume":"158","author":"J Schade","year":"2009","unstructured":"Schade J, Schmiedl A, Kehlen A, Veres TZ, Stephan M, Pabst R, von Horsten S (2009) Airway-specific recruitment of T cells is reduced in a CD26-deficient F344 rat substrain. Clin Exp Immunol 158(1):133\u2013142","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"1689_CR20","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/S0002-9440(10)62266-3","volume":"166","author":"N Busso","year":"2005","unstructured":"Busso N, Wagtmann N, Herling C, Chobaz-Peclat V, Bischof-Delaloye A, So A, Grouzmann E (2005) Circulating CD26 is negatively associated with inflammation in human and experimental arthritis. Am J Pathol 166(2):433\u2013442","journal-title":"Am J Pathol"},{"issue":"2","key":"1689_CR21","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s00395-015-0465-x","volume":"110","author":"S Steven","year":"2015","unstructured":"Steven S, Hausding M, Kroller-Schon S, Mader M, Mikhed Y, Stamm P, Zinssius E, Pfeffer A, Welschof P, Agdauletova S, Sudowe S, Li H, Oelze M, Schulz E, Klein T, Munzel T, Daiber A (2015) Gliptin and GLP-1 analog treatment improves survival and vascular inflammation\/dysfunction in animals with lipopolysaccharide-induced endotoxemia. Basic Res Cardiol 110(2):6","journal-title":"Basic Res Cardiol"},{"key":"1689_CR22","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.atherosclerosis.2017.06.920","volume":"265","author":"M Sudo","year":"2017","unstructured":"Sudo M, Li Y, Hiro T, Takayama T, Mitsumata M, Shiomi M, Sugitani M, Matsumoto T, Hao H, Hirayama A (2017) Inhibition of plaque progression and promotion of plaque stability by glucagon-like peptide-1 receptor agonist: serial in vivo findings from iMap-IVUS in Watanabe heritable hyperlipidemic rabbits. Atherosclerosis 265:283\u2013291","journal-title":"Atherosclerosis"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-020-01689-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00380-020-01689-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-020-01689-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:21:42Z","timestamp":1631233302000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00380-020-01689-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["1689"],"URL":"https:\/\/doi.org\/10.1007\/s00380-020-01689-8","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"value":"0910-8327","type":"print"},{"value":"1615-2573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,10]]},"assertion":[{"value":"16 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experimental protocol was approved by the Animal Care and Use Committee of Nihon University (No. AP15M012). All procedures performed in studies involving animals were in accordance with the ethical standards of the institution.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement on the welfare of animals"}}]}}