{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:23:20Z","timestamp":1769761400479,"version":"3.49.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K16505"],"award-info":[{"award-number":["19K16505"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K16136"],"award-info":[{"award-number":["20K16136"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Heart Vessels"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s00380-020-01716-8","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T10:21:46Z","timestamp":1604312506000},"page":"424-429","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs"],"prefix":"10.1007","volume":"36","author":[{"given":"Ai","family":"Goto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Hagiwara-Nagasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Kambayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Nunoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Izumi-Nakaseko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Takei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"1716_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/15563650.2017.1370096","volume":"56","author":"B Alyahya","year":"2018","unstructured":"Alyahya B, Friesen M, Nauche B, Lalibert\u00e9 M (2018) Acute lamotrigine overdose: a systematic review of published adult and pediatric cases. Clin Toxicol 56:81\u201389","journal-title":"Clin Toxicol"},{"key":"1716_CR2","first-page":"1299","volume":"3","author":"R Irifune","year":"2017","unstructured":"Irifune R, Matsuda M, Tagaya M, Hara K, Tamura R (2017) Marked elevation of the atrial pacing threshold in a patient with sinus dysfunction on lamotrigine therapy. Open J Clin Med Case Rep 3:1299","journal-title":"Open J Clin Med Case Rep"},{"key":"1716_CR3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1097\/WNF.0b013e3181e8ac66","volume":"33","author":"WJ Strimel","year":"2010","unstructured":"Strimel WJ, Woodruff A, Cheung P, Kirmani BF, Stephen Huang SK (2010) Brugada-like electrocardiographic pattern induced by lamotrigine toxicity. Clin Neuropharmacol 33:265\u2013267","journal-title":"Clin Neuropharmacol"},{"key":"1716_CR4","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.repc.2013.01.009","volume":"32","author":"R Rodrigues","year":"2013","unstructured":"Rodrigues R, Amador P, Rassi L, Seixo F, Parreira L, Fonseca N, Soares L (2013) Brugada pattern in a patient medicated with lamotrigine (article in Portuguese; title and abstract were also provided in English). Rev Port Cardiol 32:807\u2013810","journal-title":"Rev Port Cardiol"},{"key":"1716_CR5","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.hrcr.2016.11.006","volume":"3","author":"KMW Leong","year":"2017","unstructured":"Leong KMW, Seligman H, Varnava AM (2017) Proarrhythmogenic effects of lamotrigine during ajmaline testing for Brugada syndrome. HeartRhythm Case Rep 3:167\u2013171","journal-title":"HeartRhythm Case Rep"},{"key":"1716_CR6","first-page":"829","volume":"266","author":"DG Lang","year":"1993","unstructured":"Lang DG, Wang CM, Cooper BR (1993) Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells. J Pharmacol Exp Ther 266:829\u2013835","journal-title":"J Pharmacol Exp Ther"},{"key":"1716_CR7","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/BF00373920","volume":"430","author":"X Xie","year":"1995","unstructured":"Xie X, Lancaster B, Peakman T, Garthwaite J (1995) Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurons. Pfl\u00fcgers Arch 430:437\u2013446","journal-title":"Pfl\u00fcgers Arch"},{"key":"1716_CR8","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/j.1528-1157.1997.tb01135.x","volume":"38","author":"C Zona","year":"1997","unstructured":"Zona C, Avoli M (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38:522\u2013525","journal-title":"Epilepsia"},{"key":"1716_CR9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0014-2999(03)01625-X","volume":"467","author":"AH Hainsworth","year":"2003","unstructured":"Hainsworth AH, McNaughton NCL, Pereverzev A, Schneider T, Randall A (2003) Actions of sipatrigine, 202W92 and lamotrigine on R-type and T-type Ca2+ channel currents. Eur J Pharmacol 467:77\u201380","journal-title":"Eur J Pharmacol"},{"key":"1716_CR10","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/jat.1395","volume":"29","author":"S Polak","year":"2009","unstructured":"Polak S, Wisniowska B, Brandys J (2009) Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs\u2019 cardiotoxic properties. J Appl Toxicol 29:183\u2013206","journal-title":"J Appl Toxicol"},{"key":"1716_CR11","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1038\/bjp.2008.240","volume":"154","author":"A Sugiyama","year":"2008","unstructured":"Sugiyama A (2008) Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts. Br J Pharmacol 154:1528\u20131537","journal-title":"Br J Pharmacol"},{"key":"1716_CR12","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1056\/NEJMoa071968","volume":"358","author":"M Ha\u00efssaguerre","year":"2008","unstructured":"Ha\u00efssaguerre M, Derval N, Sacher F, Jesel L, Deisenhofer I, de Roy L, Pasqui\u00e9 JL, Nogami A, Babuty D, Yli-Mayry S, De Chillou C, Scanu P, Mabo P, Matsuo S, Probst V, Le Scouarnec S, Defaye P, Schlaepfer J, Rostock T, Lacroix D, Lamaison D, Lavergne T, Aizawa Y, Englund A, Anselme F, O\u2019Neill M, Hocini M, Lim KT, Knecht S, Veenhuyzen GD, Bordachar P, Chauvin M, Jais P, Coureau G, Chene G, Klein GJ, Cl\u00e9menty J (2008) Sudden cardiac arrest associated with early repolarization. N Engl J Med 358:2016\u20132023","journal-title":"N Engl J Med"},{"key":"1716_CR13","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2131\/jts.40.33","volume":"40","author":"Y Yamazaki-Hashimoto","year":"2015","unstructured":"Yamazaki-Hashimoto Y, Nakamura Y, Ohara H, Cao X, Kitahara K, Izumi-Nakaseko H, Ando K, Yamazaki H, Ikeda T, Yamazaki J, Sugiyama A (2015) Fluvoxamine by itself has potential to directly induce long QT syndrome at supra-therapeutic concentrations. J Toxicol Sci 40:33\u201342","journal-title":"J Toxicol Sci"},{"key":"1716_CR14","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0160-5402(89)90015-6","volume":"22","author":"A Van de Water","year":"1989","unstructured":"Van de Water A, Verheyen J, Xhonneux R, Reneman RS (1989) An improved method to correct the QT interval of the electrocardiogram for changes in heart rate. J Pharmacol Methods 22:207\u2013217","journal-title":"J Pharmacol Methods"},{"key":"1716_CR15","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1006\/taap.1998.8494","volume":"152","author":"A Sugiyama","year":"1998","unstructured":"Sugiyama A, Hashimoto K (1998) Effects of gastrointestinal prokinetic agents, TKS159 and cisapride, on the in situ canine heart assessed by cardiohemodynamic and electrophysiological monitoring. Toxicol Appl Pharmacol 152:261\u2013269","journal-title":"Toxicol Appl Pharmacol"},{"key":"1716_CR16","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1254\/jphs.11019SC","volume":"116","author":"A Takahara","year":"2011","unstructured":"Takahara A, Wagatsuma H, Aritomi S, Konda T, Akie Y, Nakamura Y, Sugiyama A (2011) Measurements of cardiac ion channel subunits in the chronic atrioventricular block dog. J Pharmacol Sci 116:132\u2013135","journal-title":"J Pharmacol Sci"},{"key":"1716_CR17","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.seizure.2016.06.004","volume":"40","author":"N Ishizue","year":"2016","unstructured":"Ishizue N, Niwano S, Saito M, Fukaya H, Nakamura H, Igarashi T, Fujiishi T, Yoshizawa T, Oikawa J, Satoh A, Kishihara J, Murakami M, Niwano H, Miyaoka H, Ako J (2016) Polytherapy with sodium channel-blocking antiepileptic drugs is associated with arrhythmogenic ST-T abnormality in patients with epilepsy. Seizure 40:81\u201387","journal-title":"Seizure"}],"container-title":["Heart and Vessels"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-020-01716-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00380-020-01716-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00380-020-01716-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T07:44:38Z","timestamp":1612943078000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00380-020-01716-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,2]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["1716"],"URL":"https:\/\/doi.org\/10.1007\/s00380-020-01716-8","relation":{},"ISSN":["0910-8327","1615-2573"],"issn-type":[{"value":"0910-8327","type":"print"},{"value":"1615-2573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,2]]},"assertion":[{"value":"26 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors indicated no potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}