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Electrocardiogram (ECG), echocardiography, and blood sampling were conducted before a 20-min WB-NMES session and at 0 and 10\u00a0min after termination of WB-NMES. Their tolerable maximum intensity was recorded using numeric rating scale. Arrhythmia was not detected during neuromuscular electrical stimulation or during 10\u00a0min of recovery. Blood pressure, heart rate, left ventricular ejection fraction, and diastolic function remained unchanged; however, mild mitral regurgitation was transiently observed during WB-NMES in a single male participant. A decrease in blood glucose and an increase in blood lactate levels were observed, but no changes in blood fluidity, sublingual microcirculation, blood levels of noradrenaline, or oxidative stress were shown. 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Ltd. After fixation of the database, the data and results of analyses were reported to MTG Ltd. MTG Co. Ltd. was not involved in the implementation, analysis, or reporting of this study. Dr. Yasu reports receiving grant support and lecture fees from AstraZeneca K.K., Ono Pharmaceutical Co., Ltd., and Kowa Co. Ltd, grant support from MTG Co. Ltd., lecture fees from Actelion Pharmaceuticals Ltd, Sanofi S.A., Daiichi Sankyo Co, Ltd, and Takeda Pharmaceutical Co. Ltd. There are no other conflicts of interest of each author.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by our institutional ethics committee (Approval Number: Nikko 29012). 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